Author: Jessica.F

Balthazar, Zsolt published the artcileTwo-phase titration of anionic surfactants, I. Study of the transition point of the titration carried out according to ISO 2271, Formula: C20H18BrN3, the publication is Magyar Kemiai Folyoirat (1977), 83(7), 294-7, database is CAplus.

Some properties of the Disulphine Blue [64366-33-2]-dimidium bromide [518-67-2] indicator system, prescribed by the international standard, were examined by UV-visible spectrometry. The dyes appeared in the CHCl3 phase only in the presence of an oppositely charged surfactant. In the modeling of practical end-points, the absorbance of the CHCl3 phase was markedly influenced by the presence of an anionic or cationic surfactant. The titration end-point determined photometrically using the 2 indicators was identical within exptl. error.

Magyar Kemiai Folyoirat published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dymock, Brian W. published the artcileNovel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Medicinal Chemistry (2005), 48(13), 4212-4215, database is CAplus and MEDLINE.

The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of mol. chaperone Hsp90 has been used to design 5-amide analogs. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clin. evaluated 17-AAG.

Journal of Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Heuser, Stefan published the artcileSynthesis of novel cyclopropylic sulfones and sulfonamides acting as glucokinase activators, HPLC of Formula: 18928-94-4, the publication is Tetrahedron Letters (2006), 47(16), 2675-2678, database is CAplus.

A synthetic route towards cyclopropylic compounds, which act as glucokinase activators is described herein. The present synthesis gives easy and rapid access to a wide variety of either sulfones or sulfonamides starting from readily available late-stage intermediates.

Tetrahedron Letters published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, HPLC of Formula: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kratzer, Domenic published the artcileSynthetic Route to Sulfobetaine Methacrylates with Varying Charge Distance, Safety of Sodium 3-bromopropane-1-sulfonate, the publication is European Journal of Organic Chemistry (2014), 2014(36), 8064-8071, database is CAplus.

A general synthetic strategy is described that enables access to a library of new sulfobetaine methacrylates starting from com. available precursors. The three-step procedure allows the distance between the quaternary amine and the sulfonate group (inner charge distance) to be varied by selecting the corresponding dibromoalkane in the first step. A key step is the final esterification, in which methacrylic acid acts as solvent as well as reagent for the zwitterionic hydroxy intermediates. Thus, it is possible to synthesize monomeric precursors with up to twelve methylene groups between the pos. and the neg. charge. A selection of these monomers has been successfully tested for their ability to polymerize using free-radical polymerization

European Journal of Organic Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Safety of Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Recsei, Carl published the artcileSynthesis of bis(aryloxy)fluoromethanes using a heterodihalocarbene strategy, Computed Properties of 401-55-8, the publication is Beilstein Journal of Organic Chemistry (2021), 813-818, database is CAplus and MEDLINE.

A simple and new procedure was developed for the construction of a bis(aryloxy)fluoromethane moiety I and ROCH(F)OR [R = 4-O₂NC₆H₄, 2,5-di-ClC₆H₄], for which no existing method was available.

Beilstein Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Computed Properties of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Antoniak, Damian published the artcileAlkylation of Nitropyridines via Vicarious Nucleophilic Substitution, SDS of cas: 111-83-1, the publication is Organic Letters (2022), 24(2), 516-519, database is CAplus and MEDLINE.

Electrophilic nitropyridines reacted with sulfonyl-stabilized carbanions gave alkylated nitropyridins I [R = H, Me, n-octyl, etc.; R¹ = Me, Et, n-octyl, etc.; R² = H, OMe, SPh, etc.] products of C-H alkylation via vicarious nucleophilic substitution was reported. The process consisted of formation of the Meisenheimer-type adduct, followed by base-induced β-elimination of the sulfinic acid (e.g., PhSO₂H).

Organic Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Picard, Franck published the artcileSynthesis and Evaluation of 2′-Substituted 4-(4′-Carboxy- or 4′-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors, Formula: C7H5Br2F, the publication is Journal of Medicinal Chemistry (2002), 45(16), 3406-3417, database is CAplus and MEDLINE.

Sixteen N-acylpiperidines I (R¹ = Ph₂CH, Ph₂CHCH₂, dicyclohexylmethyl, 1-adamantyl; R² = H, F, MeO; R³ = H, HO₂C; R⁴ = H, HO₂C, HO₂CCH₂) and II (R⁵ = Ph₂CH, Ph₂N, Me₃CO, 1-adamantyl), bearing carboxylic acid moieties, were synthesized and evaluated for inhibition of rat and human steroid 5α-reductase isoenzymes types 1 and 2. In the dicyclohexylacetyl series (R¹ = dicyclohexylmethyl), fluorination in the 2-position of the benzene nucleus, exchange of the carboxy group by a carboxymethyl moiety, and combination of both structural modifications led to highly active inhibitors of the human type 2 isoenzyme [IC₅₀ values: I [R² = F, R³ = H, R⁴ = HO₂C; (III)], 11 nM; I (R² = R³ = H, R⁴ = HO₂CCH₂), 6 nM; I (R² = F, R³ = H, R⁴ = HO₂CCH₂), 7 nM; finasteride, 5 nM]. In vivo all compounds tested markedly reduced the prostate weights in castrated testosterone-treated rats. Oral activity was shown for compound I (R¹ = dicyclohexylmethyl, R² = R³ = H, R⁴ = HO₂C). From the finding that III is active in the rat, although it is a rather poor inhibitor of the rat enzyme and is a strong inhibitor of the human enzyme, it is concluded that it should be highly potent in men.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hubbard, Robert D. published the artcilePyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR), Category: bromides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(19), 5406-5409, database is CAplus and MEDLINE.

A high throughput screen of Abbott’s compound repository revealed that the pyrazolo[3,4-d]pyrimidine class of kinase inhibitors, e.g., I, possessed moderate potency for IGF-IR, a promising target for cancer chemotherapy. The synthesis and subsequent optimization of this class of compounds led to the discovery of I that possesses in vivo IGF-IR inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Decroos, Christophe published the artcileToward Stable Electron Paramagnetic Resonance Oximetry Probes: Synthesis, Characterization, and Metabolic Evaluation of New Ester Derivatives of a Tris-(para-carboxyltetrathiaaryl)methyl (TAM) Radical, Computed Properties of 55788-44-8, the publication is Chemical Research in Toxicology (2013), 26(10), 1561-1569, database is CAplus and MEDLINE.

Tris-(p-carboxyltetrathiaaryl)-Me (TAM) radicals, such as 1a (“Finland” radical), are useful EPR probes for oximetry. However, they are rapidly metabolized by liver microsomes in the presence of NADPH, with the formation of diamagnetic quinone-methide metabolites resulting from an oxidative decarboxylation of one of their carboxylate substituents. In an effort to obtain TAM derivatives potentially more metabolically stable in vivo, the authors synthesized four new TAM radicals in which the carboxylate substituents of 1a have been replaced with esters groups bearing various alkyl chains designed to render them water-soluble The new compounds were completely characterized by UV-visible and EPR spectroscopies, high resolution mass spectrometry (HRMS), and electrochem. Two of them were water-soluble enough to undergo detailed microsomal metabolic studies in comparison with 1a. They are stable in the presence of the esterases present in rat liver microsomes and cytosol, and, contrary to 1a, stable to oxidation in the presence of NADPH-supplemented microsomes. A careful study of their possible microsomal reduction under anaerobic or aerobic conditions showed that they were more easily reduced than 1a, in agreement with their higher reduction potentials. They were reduced into the corresponding anions not only under anaerobic conditions but also in the presence of dioxygen. These anions were much more stable than that of 1a and could be characterized by UV-visible spectroscopy, MS, and at the level of their protonated product. However, they were oxidized by O₂, giving back to the starting ester radicals and catalyzing a futile cycle of O₂ reduction Such reactions should be considered in the design of future stable EPR probes for oximetry in vivo.

Chemical Research in Toxicology published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Computed Properties of 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Stoelevik, Reidar published the artcileConformational analysis of 1,2-dihalotetramethylethanes and 1,2-dihalotetramethyldisilanes by molecular mechanics calculations, Computed Properties of 594-81-0, the publication is Journal of Molecular Structure (1989), 131-5, database is CAplus.

By using nonbonding atom···atom interaction potentials derived from gas-phase data on related haloalkanes, torsional potentials of the title mols. are calculated These mols. have stable anti and gauche conformations. In all mols. the anti has a lower energy than the gauche. The rotational barrier heights corresponding to a transition from gauche to anti are 0.5-1.5 kcal mol^-1 in the disilanes and 3.5-5.5 kcal mol^-1 in the ethanes. Calculated results are compared with the gas-phase observations on the disilanes.

Journal of Molecular Structure published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C10H16O2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary