Author: Jessica.F

Martins, Nayara Silva published the artcileDibromination of alkenes with LiBr and H₂O₂ under mild conditions, Formula: C6H12Br2, the publication is New Journal of Chemistry (2018), 42(1), 161-167, database is CAplus.

Electron-rich and electron-poor alkenes, and alkenes bearing protecting groups can be efficiently and stereoselectively converted to trans-dibromides using LiBr/H₂O₂ and AcOH as a proton source in 1,4-dioxane. For most substrates addition of 0.1 mol% of PhTeTePh enhances the reaction rate and the yield of the products. Exptl. data suggest that the brominating agent prepared in situ is mol. bromine and that LiBr assists the activation of H₂O₂ allowing bromination to occur using AcOH as a mild proton source in uncatalyzed experiments Scale-up is feasible: 10.0 mmol of 1-octene was quant. converted to 1,2-dibromooctene in one hour of reaction at room temperature

New Journal of Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Palmer, Wylie S. published the artcileDevelopment of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead, SDS of cas: 16523-02-7, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1486-1492, database is CAplus and MEDLINE.

A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and selective JNK inhibitor, compound 24f (JNK1 and 2 IC₅₀ = 16 and 66 nM, resp.), with bioavailability in rats and suitable for further in vivo pharmacol. evaluation.

Bioorganic & Medicinal Chemistry Letters published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, SDS of cas: 16523-02-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lutteke, Ginger published the artcileFormation of bicyclic pyrroles and furans through an enone allene photocycloaddition and fragmentation sequence, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is European Journal of Organic Chemistry (2008), 925-933, database is CAplus.

The [2 + 2] photocycloaddition of dimedone-substituted allenes was studied. Irradiation of a solution of these substrates in acetonitrile at 300 nm resulted in the clean conversion of the starting materials into a mixture of photoproducts. The major product in all cases was a bicyclic pyrrole or furan fused to an eight membered ring (43-70% yield). The formation of these products is thought to be a result of a heteroatom-induced fragmentation of the straight adduct. This is supported by irradiation of 3-(penta-3,4-dienyl)cyclohex-2-en-1-one which allowed the isolation of tricyclic adduct after catalytic hydrogenation in 27 %. The minor crossed photoproducts were isolated in 10-20% yield. The observed major/minor ratio of 4:1 was not affected by the variation of substituents on the cyclohexene ring. Introduction of a substituent on the allene had a more significant effect on the ratio which changed to 2:1.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uner, Osman published the artcileMicellization and thermodynamics study of n-alkyl-4-methylpyridinium bromides in water and mixed water-ethanol media, HPLC of Formula: 143-15-7, the publication is Journal of Molecular Liquids (2022), 118765, database is CAplus.

The micellization behaviors of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were studied in water and mixed water-ethanol media by using conductivity measurements over the temperature range of 293.15-318.15 K. The critical micelle concentrations (CMC) of all n-alkyl-4-Me pyridinium bromides studied increased with increasing temperature, but they decreased with increasing hydrocarbon chain length. Their CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide in water at the temperature range of 293.15-318.15 K were determined as in the range of 43.62-46.42, 10.45-11.57, and 2.78-3.20 mM, resp. Moreover, the lowest CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were found with 15, 5, and 5 vol% ethanol additions, resp. The calculated neg. ΔG_m⁰ and ΔH_m⁰ values proved that their micellizations in water and mixed water-ethanol media were spontaneous and exothermic. Also, ΔG_m⁰ values became the more neg. with the longer the hydrocarbon chain length. Furthermore, their micellization processes in water were determined to be entropy controlled, however enthalpic contributions in the mixed water-ethanol systems started to predominate with increasing ethanol concentrations and/or temperature

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C21H37BO, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hagiwara, Keita published the artcileAn aqueous molecular tube with polyaromatic frameworks capable of binding fluorescent dyes, Category: bromides-buliding-blocks, the publication is Chemical Science (2015), 6(1), 259-263, database is CAplus and MEDLINE.

An aqueous mol. tube composed of polyaromatic frameworks with peripheral hydrophilic groups was prepared The new tube had a well-defined hydrophobic cavity with a diameter of 1̃ nm and quant. could bind two mols. of fluorescent coumarin dyes in aqueous solutions The bound coumarin dimers in a stacked fashion exhibited unusual excimer-like emissions in the confined space through efficient host-guest energy transfer.

Chemical Science published new progress about 401797-04-4. 401797-04-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic acid and ester, name is 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BBrO3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Goodman, Allan J. published the artcileCB₂ selective sulfamoyl benzamides: Optimization of the amide functionality, Synthetic Route of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(2), 309-313, database is CAplus and MEDLINE.

Previous research within our laboratories identified sulfamoyl benzamides as novel cannabinoid receptor ligands. Optimization of the amide linkage led to the reverse amide 40. The compound exhibited robust antiallodynic activity in a rodent pain model when administered i.p. Efficacy after oral administration was observed only when ABT, a cytochrome P 450 suicide inhibitor, was coadministered.

Bioorganic & Medicinal Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Synthetic Route of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caputo, Paolino published the artcilePolyalkylated gallic esters and acids, high performant warm mix asphalt and adhesion promoters for bitumen, Quality Control of 111-83-1, the publication is International Journal of Adhesion and Adhesives (2022), 103228, database is CAplus.

The main use of bitumen is the construction of road pavements due to its role as binder in asphalt concrete. For this specific scope, it is important for bitumen to have low viscosity so that the working temperature is the lowest possible. This would allow it to be easily processed while reducing the toxic fumes emanated during coating. Furthermore, the final product must be resistant to aging phenomenon and harsh weather conditions while also having a good affinity with the stones underneath in order to avoid its peeling off the road with time. To achieve all these stipulated objectives, the addition of chem. additives to asphalt concrete is being studied. In the present study, bitumen has been modified by incorporating (1% weight/weight) alkylated gallic esters and acids of alkyl chains of different length (8, 14 and 18 carbon atoms) in low amounts with the aim of improving the rheol. properties of bitumen as well as increasing the interaction forces between bitumen and stone aggregates usually employed as underneath layer for road pavement. For this purpose, gallic ester/acid additives were tested as rheol. modifiers, adhesion activators and Warm Mix Asphalt (WMA) agents through Differential Scanning Calorimetry, Thermogravimetric measurements, Dynamic Shear Rheol. and Boiling tests. The results show that alkylated gallic acids are bad WMA candidates increasing the viscosity of bitumen while corresponding gallic Me esters are excellent for WMA showing that the shorter the chain, the better the performance. Thus, C8 alkylated Me gallate decreases the overall viscosity of bitumen of about 70 Pa s at 70°C, which is nearly 4 times better than what commonly employed com. waxes provide. Furthermore, gallic ester and acid derivatives are excellent adhesion activators showing increased efficiency as the alkyl chain length increases reaching a 95% coverage on Trentino porphyry stones obtained from the boiling test carried out on the C18 alkylated Me gallate sample.

International Journal of Adhesion and Adhesives published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Quality Control of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Fengqian published the artcileCopper-Catalyzed Substrate-Controlled Carbonylative Synthesis of α-Keto Amides and Amides from Alkyl Halides, Related Products of bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202200062, database is CAplus and MEDLINE.

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. A novel copper-catalyzed highly selective double carbonylation of alkyl bromides was developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double- and mono-carbonylation can be achieved controllably under different conditions.

Angewandte Chemie, International Edition published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C13H10F2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pujala, Brahmam published the artcileDiscovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ, COA of Formula: C7H8BBrO3, the publication is ACS Medicinal Chemistry Letters (2016), 7(12), 1161-1166, database is CAplus and MEDLINE.

The aberrant activation of B-cells has been implicated in several types of cancers and hematol. disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clin. benefit in certain types of lymphoma. Simultaneous inhibition of these pathways could result in more robust responses or overcome resistance as observed in single agent use. The authors report a series of novel compounds that have low nanomolar potency against both BTK and PI3Kδ as well as acceptable PK properties that could be useful in the development of treatments against B-cell related diseases.

ACS Medicinal Chemistry Letters published new progress about 1256345-59-1. 1256345-59-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-Bromo-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BBrO3, COA of Formula: C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yohe, G. R. published the artcileCyclopentylalkylacetic acids and ω-cyclopentylethylalkylacetic acids and their bactericidal action towards B. leprae, SDS of cas: 18928-94-4, the publication is Journal of the American Chemical Society (1928), 1503-8, database is CAplus.

cf. preceding abstract Cyclopentylethanol, b₂₄ 96.5-7°, n_D²⁰ 1.4577, d₄²⁰ 0.9180; bromide, b₁₉ 75-7°, 1.4863, 1.2860. Cyclopentylbutanol, b₂ 88-92°, 1.4613, 0.9033 (70-5% yield); bromide, b₁₇ 110-1°, 1.4820, 1.1872 (60-5% yield); cyanide, b₁₇ 124-6.5°, 1.4542, 0.8887 (80-5% yield); hydrolysis with NaOH in 60% EtOH gives 80-5% of δ-cyclopentylpentanoic acid, b₂ 124-8°, 1.4594, 0.9752. Di-Et δ-cyclopentylbutylmalonate, b_2.2 154-60°, 1.4493, 0.9934 (40% yield); the acid, m. 121-4° (85% yield); heating the acid 2 hrs. at 160-80° gives 75% of ε-cyclopentylhexanoic acid, b_1.8 133-5°, m. 33-3.5°, n_D³⁵ 1.4549, d₄³⁵ 0.9518. The following di-Et cyclopentylalkylmalonates were prepared where R in the formula C₅H₉C(CO₂Et)₂R is: C₇H₁₅, b₁ 143-6°, n_D²⁰ 1.4548, d₄²⁰ 0.9749; C₈H₁₇, b₁ 160-5°, 1.4553, 0.9659; C₉H₁₉, b_0.6 152-5°, 1.4567, 0.9817; C₁₀H₂₁, b₁ 169-71°, 1.4571, 0.9560; C₁₁H₂₃, b₁ 186-9°, 1.4580, 0.9522. Di-Et β-cyclopentylethylalkylmalonates, C₅H₉(CH₂)₂C(CO₂Et)₂R: R is H, b₂ 125°, 1.4478, 1.0082; Et, b_1.9 126-9°, 1.4511, 0.9924; Pr, b_1.7 134-5°, 1.4510, 0.9873; Bu, b_1.8 136-40°, 1.4523, 0.9783; Am, b_1.1 148-50°, 1.4526, 0.9688; C₆H₁₃, 157-62°, 1.4531, 0.9624; C₇H₁₅, b₂ 172-4°, 1.4541, 0.9563; C₈H₁₇, b_1.2 182-4°, 1.4548, 0.9524. β-Cyclopentylethylalkylmalonic acids, C₅H₉(CH₂)₂C(CO₂H)₂R: R is H, m. 126.5°, Et, m. 141-3°; Pr, m. 137-8°; Bu, m. 139-40.5°; Am, m. 124-7°; C₆H₁₃, m. 129.5-30°. β-Cyclopentylalkylacetic acids, C₅H₉CH(CO₂H)R: R is C₇H₁₅, b_1.4 155-60°, 1.4594, 0.9312; C₈H₁₇, b₂ 166-9°, 1.4609, 0.9279; C₉H₁₉, b_1.4 177-8.5°, m. 37-7.5°; C₁₀H₂₁, b_1.7 189-90°, m. 34.5-6°; C₁₁H₂₃, b_1.3 193-7°, m. 43.5-5.5°. β-Cyclopentylethylalkylacetic acids, C₅H₉(CH₂)₂CH(CO₂H)R: R is H, b_2.4 115-8°, 1.4575, 0.9849; Et, b_1.3 122-4.5°, 1.4590, 0.9602; Pr, b_1.9 130-2°, 1.4595, 0.9533; Bu, b₁ 136-7°, 1.4608, 0.9435; Am, b_1.9 150-4°, 1.4610, 0.9360; C₆H₁₃, b_1.9, 157-61°, 1.4616, 0.9303; C₇H₁₅, b₂ 167-9°, 1.4621, 0.9252; C₈H₁₇, b_1.5 173-6°, 1.4629, 0.9210. Undecyl bromide, b₁₈ 134-7°, 1.4571, 1.052l. Di-Et cyclopentylmalonate, b₂ 115-7°, 1.4440, 1.0325. The greatest bactericidal action is found in the acids containing 16-18 C atoms; the β-cyclopentylethylalkylacetic acids are slightly more effective than the isomeric cyclopentylalkylacetic acids; a similar slight difference could be detected in the cyclohexyl series. Cyclopentylnonylacetic acid and cyclopentylethylheptylacetic acid, isomeric with dihydrohydnocarpic acid, are far more bactericidal than the latter compound There is no significant difference in bactericidal effect between the cyclohexyl and cyclopentyl compounds of equal mol. weight or of equal length side chain, though the figures appear to favor the cyclohexyl compounds The bactericidal action is not affected markedly by the presence of the double bond.

Journal of the American Chemical Society published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C13H10N2S, SDS of cas: 18928-94-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary