Author: Jessica.F

On July 1, 2020, Kubasov, A. S.; Turishev, E. S.; Golubev, A. V.; Bykov, A. Yu.; Zhizhin, K. Yu.; Kuznetsov, N. T. published an article.Synthetic Route of 574-98-1 The title of the article was The method for synthesis of 2-sulfonium closo-decaborate anions derivatives with exo-polyhedral aminogroups. And the article contained the following:

A method for the preparation of sulfonium derivatives of the closo-decaborate anion with the exo-polyhedral amino groups [B10H9S((CH2)nNH2)2]- (n = 1-3) has been developed. The method is based on the alkylation of the [B10H9SH]2- anion with N-bromoalkyl phthalimides and subsequent removal of the phthalimide protection with hydrazine. We could show that the interaction between the [B10H9SH]2- anion with bromomethyl phthalimide groups allowed us to prepare selectively mono-S-substituted sulfanyl derivatives [B10H9SCH2N(CO)2C6H4]2-. Due to the high stability of the sulfonium derivatives of the closo-decaborate anion, it is possible to obtain perchlorinated analogs of these compounds by chlorination of the salts n-Bu4N[B10H9S((CH2)nN(CO)2C6H4)2] (n = 1-3) with sulfuryl chloride in acetonitrile. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Synthetic Route of 574-98-1

The Article related to crystal structure mol sulfonium decaborate anion polyhedral amino preparation, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Synthetic Route of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 23, 2022, Long, Alan; Liu, Chun Yu; Liu, Chunliang; Zhou, Yasheen; Pulley, Shon R.; Graham, Keith Andrew Newton published a patent.Product Details of 1160653-94-0 The title of the patent was Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof. And the patent contained the following:

The present invention describes novel boron containing pyrazole compounds, e.g. I, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described. The experimental process involved the reaction of 3-Bromo-2-fluoro-6-methoxybenzaldehyde(cas: 1160653-94-0).Product Details of 1160653-94-0

The Article related to boron amidopyrazole preparation janus kinase inhibition autoimmune anticancer, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Product Details of 1160653-94-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 29, 2018, Zhu, Bin published a patent.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene The title of the patent was Microglial cell IL-1β secretion inhibitor, and its preparation method and application in treatment of neuroinflammatory diseases. And the patent contained the following:

The title microglial cell IL-1β secretion inhibitor is (((2,5-dibromocyclopenta-2,4-diene-1,1-diyl)bis(methylene))bis(6-alkyl-3,1-phenylene))diboronic acid, has structural formula shown as formula I in Claim 1, wherein R is C1-C10 alkyl or C3-C8 cycloalkyl. The invention also provides preparation method of above compound from cyclopenta-1,3-diene, 2-bromo-4-(bromomethyl)-1-alkylbenzene, boric acid, and bromine. The invention also provides application of the microglial cell IL-1β secretion inhibitor in preparation of drugs for treatment of neuroinflammatory diseases. The experimental process involved the reaction of 2-Bromo-4-(bromomethyl)-1-methylbenzene(cas: 259231-26-0).Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene

The Article related to bromocyclopenta dienediyl diboronic acid preparation neuroinflammatory disease treatment, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Name: 2-Bromo-4-(bromomethyl)-1-methylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 25, 2022, Yang, Xiaoxu; Ge, Shaozhong published an article.Product Details of 2567-29-5 The title of the article was Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes. And the article contained the following:

The authors have developed a Co-catalyzed regioselective 1,1,3-triborylation reaction of terminal alkynes with pinacolborane (HBpin) with a catalyst generated in situ from readily available and bench-stable Co(acac)2 and xantphos. A variety of terminal alkynes undergo this triborylation reaction, affording the corresponding 1,1,3-triborylalkanes in good yields with high selectivity. The synthetic utility of this catalytic protocol was demonstrated by developing selective stepwise functionalization of 1,1,3-triborylalkane products. The results of mechanistic studies, such as conducting control experiments and D-labeling reactions, monitoring the reaction process, and identifying reaction intermediates, suggest that this 1,1,3-triborylation reaction proceeds through 1,3-diborylation of alken-1-ylboronates formed by Co-catalyzed hydroboration of terminal alkynes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Product Details of 2567-29-5

The Article related to terminal alkyne preparation cobalt catalyzed triborylation pinacolborane, triborylalkane preparation reactivity, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Product Details of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 15, 2021, Yang, Ling; Tan, Dong-Hang; Fan, Wen-Xin; Liu, Xu-Ge; Wu, Jia-Qiang; Huang, Zhi-Shu; Li, Qingjiang; Wang, Honggen published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Photochemical Radical C-H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates. And the article contained the following:

Benzylboronates ArCH2B(MIDA) were halogenated in α-position by reaction with NBS either initiated with benzyl peroxide or photochem., giving α-haloboronates ArCHXB(MIDA). Fluorination and chlorination were performed by reactions with Selectfluor and NCS, resp., under 9-fluorenone catalysis. α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochem. radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C-Br bond in the brominated product could be readily transformed to a series of C-C, C-O, C-N, C-S, C-P, and C-I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to bmida methyliminodiacetyl boronate photochem halogenation preparation haloboronate, halogenation, ketone catalysis, organoboron, photochemistry, radical reaction, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 8, 2022, Li, Yingying; Jiang, Zhimin; Duan, Xiaoqun; Wei, Riming; Chen, Yijie; Fan, Xinxin; Liu, Jieyu; Su, Huilin published a patent.Formula: C24H27Br2P The title of the patent was Artesunate derivatives as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:

The invention relates to the tech. field of medicine, and specifically discloses artesunate derivatives I•Br- and II•Br- (n is 6-20; R1 is C1-6 alkyl) and preparation method and application thereof. Compounds I and II were prepared by using alkylation and esterification as the key steps. All the invention compounds were evaluated for their antitumor activity. The artesunate derivatives provided by the present invention have novel skeleton structure and excellent antitumor activity, and can be used for the preparation of antitumor drugs. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P

The Article related to artesunate derivative preparation antitumor treatment cancer, Terpenes and Terpenoids: Sesquiterpenes (C15), Including Ionones and other aspects.Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 2, 2015, Kang, Byeong Heon; Lee, Chang Uk; Yoo, Ja Hyeong; Park, Hye Gyeong published a patent.HPLC of Formula: 83152-22-1 The title of the patent was Mitochondria-targeting antitumor compositions. And the patent contained the following:

The title antitumor composition has excellent inhibitory effect on mol. chaperones (e.g. Hsp90 and TRAP1) in tumor cells, by connecting triphenylphosphate into mitochondria-penetrating moiety, by using 8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)adenine as mol. chaperone inhibitor. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).HPLC of Formula: 83152-22-1

The Article related to mitochondria targeting antitumor therapy, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 8, 2015, Lee, Changwook; Park, Hye-Kyung; Jeong, Hanbin; Lim, Jaehwa; Lee, An-Jung; Cheon, Keun Young; Kim, Chul-Su; Thomas, Ajesh P.; Bae, Boram; Kim, Nam Doo; Kim, Seong Heon; Suh, Pann-Ghill; Ryu, Ja-Hyoung; Kang, Byoung Heon published an article.Formula: C24H27Br2P The title of the article was Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1. And the article contained the following:

The mitochondrial pool of Hsp90 and its mitochondrial paralog, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, the authors report that the actual target protein in cancer cell mitochondria is TRAP1, and current Hsp90 inhibitors cannot effectively inactivate TRAP1 because of their insufficient accumulation in the mitochondria. To develop mitochondrial TRAP1 inhibitors, the authors determined the crystal structures of human TRAP1 complexed with Hsp90 inhibitors. The iso-Pr amine of the Hsp90 inhibitor PU-H71 was replaced with the mitochondria-targeting moiety triphenylphosphonium to produce SMTIN-P01. SMTIN-P01 showed a different mode of action from the nontargeted PU-H71, as well as much improved cytotoxicity to cancer cells. In addition, the authors determined the structure of a TRAP1-adenylyl-imidodiphosphate (AMP-PNP) complex. On the basis of comparative anal. of TRAP1 structures, the authors propose a mol. mechanism of ATP hydrolysis that is crucial for chaperone function. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P

The Article related to mitochondria hsp inhibitor crystal structure trap, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lien, Vegard Torp; Kristiansen, Margrethe Konstanse; Pettersen, Solveig; Haugen, Mads Haugland; Olberg, Dag Erlend; Waaler, Jo; Klaveness, Jo published an article in 2019, the title of the article was Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

Both the kinase MET and the WNT signaling pathway are attractive targets in cancer therapy, and synergistic effects have previously been observed in animal models upon simultaneous inhibition. A strategy towards a designed multiple ligand of MET and WNT signaling is pursued based on the two hetero biaryl systems present in both the MET inhibitor tepotinib and WNT signaling inhibitor TC-E 5001. Initial screening was conducted to find the most suitable ring systems for further optimization, whereas a second screen explored modifications towards pyridazinones and triazolo pyridazines. Up to 54% reduction of WNT signaling activity at 10 microM concentration was achieved, however, only low affinities towards MET were observed Overall, the thiophene substituted pyridazinone 40 was the best dual MET and WNT signaling inhibitor, with a 17% and 19% reduction of activity, resp. Although further optimizations are needed to achieve more potent dual inhibitors, the strategy presented herein can be valuable towards the development of a dual inhibitor of MET and WNT signaling. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to met kinase wnt inhibitor anticancer agent signaling, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 16, 2014, Stockwell, Brent R.; Welsch, Matthew; Yang, Wan Seok published a patent.HPLC of Formula: 1019442-22-8 The title of the patent was Quinazolinone-based oncogenic-ras-selective lethal compounds and their use. And the patent contained the following:

The present invention provides compounds for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided. The experimental process involved the reaction of 5-Bromo-2-isopropoxyaniline(cas: 1019442-22-8).HPLC of Formula: 1019442-22-8

The Article related to antitumor quinazolinone preparation oncogenic ras mutation cancer therapy, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 1019442-22-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary