Author: Jessica.F

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Synthetic Route of 4897-84-1

Wei, Mingming;Xie, Maodun;Zhang, Zhen;Wei, Yujiao;Zhang, Juan;Pan, Hongli;Li, Benlong;Wang, Jingjing;Song, Yang;Chong, Chuangke;Zhao, Rui;Wang, Jiefu;Yu, Li;Yang, Guang;Yang, Cheng research published 《 Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer》, the research content is summarized as follows. In this study, a class of novel HDACs inhibitors I (R = H, 4-CH₃OC₆H₄; R¹ = H, C₆H₅, 4-CH₃OC₆H₄, 4-OHC₆H₄; R² = H, OH; X = (CH₂)_n, n = 1, 3, 4, 5, 6, 7), II•HCl (R³ = N(CH₃)₂, 4-methylpiperazin-1-yl, morpholin-4-yl, piperidin-1-yl, pyrrolidin-1-yl; Y = (CH₂)_n, n = 5, 6, 7; Z = (CH₂)_n, n = 2, 3) was designed and synthesized based on the structure of flavones and isoflavones, followed by biol. evaluation. To be specific, a lead compound II•HCl [R³ = N(CH₃)₂; Y = (CH₂)₅; Z = (CH₂)₂ (III)] was discovered with strong anti-proliferative effects on a variety of solid tumor cells, especially for breast cancer cells with resistance to SAHA. Studies demonstrated that III could significantly inhibit the activity of HDAC 1,2,3 (class I) and 6 (class IIB), leading to a dose-dependent accumulation of acetylated histones and α-Tubulin, cell cycle arrest (G1/S phase) and apoptosis in breast cancer cells. Furthermore, the lead compound III could also antagonize the activation of STAT3 induced by HDACs inhibition in some breast cancer cells, which further reduced the level of pro-survive proteins in tumor cells and enhanced anti-tumor activity regulated by STAT3 signaling in vivo. Overall, findings demonstrated that the novel compound III might be a HDACs inhibitor candidate, which could be used as promising chemotherapeutic agent for breast cancer.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Synthetic Route of 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 2576-47-8.

Wei, Lina;Zhao, Jing;Meng, Yonghong;Guo, Yurong;Luo, Cangxue research published 《 Antibacterial activity, safety and preservative effect of aminoethyl-phloretin on the quality parameters of salmon fillets》, the research content is summarized as follows. Aminoethyl-phloretin (AEP), a novel water-soluble phloretin derivative, was synthesized from phloretin and 2-bromine ethylamine. Its antibacterial activity, safety, and preservative effect on salmon were studied. The structure of AEP was verified with UV, IR, ESI-MS and ¹H NMR, ¹³C NMR spectroscopy. HPLC anal. showed that the solubility of AEP was 430 times higher than that of phloretin. AEP exhibited a wide range of antibacterial activity on both Gram-pos. and Gram-neg. bacteria. The results of an acute oral-toxicity test in Kunming mice and a 30-days feeding subacute toxicity test on Sprague Dawley rats demonstrated that AEP was actually non-toxic. AEP also demonstated good preservative effects on salmon fish: the color, odor, taste and cooking method can maintain high-quality characteristics for 4 days; the level of fat oxidation and biogenic amines were reduced by 3.35 times and 10 times, resp.; the total bacterial and Pseudomonas spp. counts could be suppressed by 2 logarithms and 1.5 logarithms, resp., following treatment with 4 mg/mL of AEP. Thus, AEP significantly improved the solubility of phloretin, expanding its application scope and making it a promising preservative in the food industry.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., SDS of cas: 2576-47-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C6H6BBrO2.

Wei, Leping;Deng, Xin;Yu, Xiaohui;Li, Xiaohui;Wang, Wei;Zhang, Chunfang;Xiao, Jinchong research published 《 Double π-Extended Helicene Derivatives Containing Pentagonal Rings: Synthesis, Crystal Analyses, and Photophysics》, the research content is summarized as follows. Two novel double π-extended [n]helicene (n = 5, 6) derivatives (7b and 9) including pentagonal rings have been synthesized and characterized. Both of them have three isomers containing two enantiomers (P₆), (M₆), and a diastereoisomer in a meso form (P,M). X-ray single crystal analyses suggest that mols. 7b and 9 exhibit offset packing models of (P₆,P₅)- and (M₆,M₅)-isomers. Optical resolution of the resultant compound 7b was finished, and their chiroptical properties, as well as the DFT calculations, were also examined

COA of Formula: C6H6BBrO2, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 244205-40-1, formula is C6H6BBrO2, Name is (2-Bromophenyl)boronic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: (2-Bromophenyl)boronic acid.

Wei, Jingwen;Liu, Mengjia;Ye, Xiaohan;Zhang, Shuyao;Sun, Elaine;Shan, Chuan;Wojtas, Lukasz;Shi, Xiaodong research published 《 Facile synthesis of diverse hetero polyaromatic hydrocarbons (PAHs) via the styryl Diels-Alder reaction of conjugated diynes》, the research content is summarized as follows. The styryl dehydro-Diels-Alder reaction with a conjugated diyne was reported. While typical alkyne-styrene condensation requires elevated temperatures (>160°), the application of a conjugated diyne allowed for effective transformation under milder conditions (80°). The thermally stable triazole-gold (TA-Au) catalyst further improved the reaction yields (up to 95%), producing the desired alkynyl-naphthalene in a single step with mol. oxygen as the oxidant. Sequential alkyne activation resulted in various polyaromatic hydrocarbons (PAHs) in excellent yields, highlighting the efficiency of this new strategy for the preparation of PAHs with good functional group tolerance and structural diversity.

Recommanded Product: (2-Bromophenyl)boronic acid, 2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
2-Bromophenylboronic acid, also known as 2-Bromophenylboronic acid, is a useful research compound. Its molecular formula is C6H6BBrO2 and its molecular weight is 200.83 g/mol. The purity is usually 95%.
2-Bromophenylboronic acid is a glucose monitoring agent that has a ruthenium complex with an acidic environment. The nitro group and the amines are in close proximity to the boron center, and this proximity leads to a high nucleophilic character of the molecule. This reactivity allows 2-bromophenylboronic acid to be used as a fluorescence probe for acidic environments. 2-Bromophenylboronic acid also inhibits secretase enzymes, which are involved in Alzheimer’s disease and other neurodegenerative disorders. It is an inhibitor of γ-secretase, which is responsible for cleaving the amyloid precursor protein (APP), and it has shown efficacy against biphenyl, an anticancer drug that binds to benzodiazepine receptors. 2-Bromophenylboronic acid is also an enantiopure compound because all four substituents are different from each other., 244205-40-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Name: Ethyl 3-bromo-2-oxopropanoate.

Wei, Chengqian;Huang, Junjie;Luo, Yuqin;Wang, Shaobo;Wu, Sikai;Xing, Zhifu;Chen, Jixiang research published 《 Novel amide derivatives containing an imidazo[1,2-a]pyridine moiety: Design, synthesis as potential nematicidal and antibacterial agents》, the research content is summarized as follows. To discover new nematicides I (n = 1, 2, 3; R = Et, iso-Pr, 4-nitrobenzyl, etc.) a series of novel amide derivatives containing an imidazo[1,2-a]pyridine moeity I were designed and synthesized. Among the title compounds, compounds I (n = 1; R = Pr and n = 3; R = n-decyl (III)) exhibited good nematicidal activities against Aphelenchoides besseyi (rice white-tip nematode), with LC₅₀ values against of 27.3 and 35.9 mg/L, resp., which were superior to that of fosthiazate (45.4 mg/L). Meanwhile, the LC₅₀ value of compound III against Caenorhabditis elegans was 5.7 mg/L, which was superior to that of fosthiazate (77.2 mg/L). Compound III not only binds well to acetylcholinesterase (AChE) of nematodes, but also has a good inhibitory activity against AChE. Thus, AChE may be a potential target of compound III against nematodes. Unexpectedly, compound I (n = 1; R = chloromethyl (IV)) exhibited excellent antibacterial activities with EC₅₀ values of 1.2 and 3.1 mg/L against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc), resp., which were superior to those of bismerthiazol (68.6 and 77.1 mg/L) and thiodiazole copper (80.8 and 96.6 mg/L). The curative and protective activities of compound IV against bacterial leaf blight were 37.0% and 36.8% at 50 mg/L, resp., which were higher than those of thiodiazole copper (16.1% and 15.5%). In addition, compound IV may inhibit the growth of Xoo by affecting the production of cell membranes and extracellular polysaccharides. Amide derivatives containing an imidazo[1,2-a]pyridine moeity Ican be used as good lead-structures to discover new nematicidal and antibacterial agents in the future.

Name: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde, Application In Synthesis of 5392-10-9

Wei, Baosheng;Ren, Qianyi;Bein, Thomas;Knochel, Paul research published 《 Transition-Metal-Free Synthesis of Polyfunctional Triarylmethanes and 1,1-Diarylalkanes by Sequential Cross-Coupling of Benzal Diacetates with Organozinc Reagents》, the research content is summarized as follows. A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were prepared via a transition-metal-free, one-pot and two-step procedure, involving the reaction of various benzal diacetates with organozinc reagents. A sequential cross-coupling is enabled by changing the solvent from THF to toluene, and a two-step S_N1-type mechanism was proposed and evidenced by exptl. studies. The synthetic utility of the method is further demonstrated by the synthesis of several biol. relevant mols., such as an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.

Application In Synthesis of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 5445-17-0.

Watabe, Takuma;Aoki, Daisuke;Otsuka, Hideyuki research published 《 Enhancement of Mechanophore Activation in Mechanochromic Dendrimers by Functionalization of Their Surface》, the research content is summarized as follows. The mechanochem. reactions of a series of dendrimers with a mechanochromic core were systematically investigated, and drastic enhancement of their reactivity was observed after their surface functionalization. We recently reported the quant. and qual. mechano-responsive behavior characteristic of a radical-type mechanophore for mechanochromic dendrimers (MDs) with defined structures in the bulk. In the present study, we systematically investigated the mechanochem. response of a series of dendrimers with different functional groups on their surfaces by mech. grinding in the bulk. Effective activation of the mechanochromic core was achieved in higher-generation MDs with hydrogen-bonding amide groups on their surfaces. A comparison of the degree of activation of the MDs with that of linear analogs revealed that the chain overlap, mol. size, and polarity affect the efficiency of the transmission of the grinding force to the mechanochromic core.

Electric Literature of 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 20469-65-2.

Warmuth, Lucas;Weiss, Aaron;Reinhardt, Marco;Meschkov, Anna;Schepers, Ute;Podlech, Joachim research published 《 Total synthesis of decarboxyaltenusin》, the research content is summarized as follows. The total synthesis of decarboxyaltenusin (5′-methoxy-6-methyl-[1,1′-biphenyl]-3,3′,4-triol), a toxin produced by various mold fungi, had been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene, where the longest linear sequence consists of five steps. The key reaction was a palladium-catalyzed Suzuki coupling of an aromatic boronate with a brominated resorcin derivative

Application In Synthesis of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C5H7BrO3.

Wang, Zongqiang;Forelli, Nicholas;Hernandez, Yozen;Ternei, Melinda;Brady, Sean F. research published 《 Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis》, the research content is summarized as follows. In natural product discovery programs, the power of synthetic chem. is often leveraged for the total synthesis and diversification of characterized metabolites. The synthesis of structures that are bioinformatically predicted to arise from uncharacterized biosynthetic gene clusters (BGCs) provides a means for synthetic chem. to enter this process at an early stage. The recent identification of non-ribosomal peptides (NRPs) containing multiple ρ-aminobenzoic acids (PABAs) led us to search soil metagenomes for BGCs that polymerize PABA. Here, we use PABA-specific adenylation-domain sequences to guide the cloning of the lap BGC directly from soil. This BGC was predicted to encode a unique N-acylated PABA and thiazole containing structure. Chem. synthesis of this structure gave lapcin, a dual topoisomerase I/II inhibitor with nM to pM IC₅₀s against diverse cancer cell lines. The discovery of lapcin highlights the power of coupling metagenomics, bioinformatics and total chem. synthesis to unlock the biosynthetic potential contained in even complex uncharacterized BGCs.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organic compounds having carbon bonded to bromine are called organic bromides. Name: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Wang, Ziyong;Wu, Jason;Lamine, Walid;Li, Bo;Sotiropoulos, Jean-Marc;Chrostowska, Anna;Miqueu, Karinne;Liu, Shih-Yuan research published 《 C-Boron Enolates Enable Palladium Catalyzed Carboboration of Internal 1,3-Enynes》, the research content is summarized as follows. A new family of carbon-bound boron enolates CatBCR¹R²CO₂R³ (5, CatB = 1,2-C₆H₄O₂B), generated by a kinetically controlled halogen exchange between chlorocatecholborane CatBCl and silylketene acetals R¹R²C:C(OR³)(OTMS), is described. These C-boron enolates 5 are demonstrated to activate 1,3-enyne substrates R⁴CH:CHCCR⁵ in the presence of a Pd⁰/Senphos ligand complex, resulting in the first examples of a carboboration reaction of an alkyne with enolate-equivalent nucleophiles and giving boryl dienes R⁴CH:CHC(R¹R²CO₂R³):CR⁵Bpin, after transesterification with pinacol. Highly substituted dienyl boron building blocks are produced in excellent site-, regio-, and diastereoselectivity by the described catalytic cis-carboboration reaction.

Name: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary