Author: Jessica.F

Ling, Bo; Yang, Wenjun; Wang, Yan-En; Mao, Jianyou published the artcile< Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Umpolung 1,4-Addition of Vinyl Bromides to Enals>, Related Products of 3893-18-3, the main research area is unsaturated carbonyl preparation cooperative catalyzed addition vinyl bromide enal.

A highly stereoselective umpolung 1,4-addition of vinyl bromides to enals is enabled by NHC/palladium cooperative catalysis, generating various valuable γ,δ-unsaturated carbonyl derivatives in excellent yields (up to 90%). A detailed mechanism investigation indicates the NHC act as both organocatalyst and ligand for palladium during this system.

Organic Letters published new progress about Addition reaction. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Related Products of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Dehua; Qu, Lailiang; Wang, Cheng; Luo, Heng; Li, Shang; Yin, Fucheng; Liu, Xingchen; Chen, Xinye; Luo, Zhongwen; Cui, Ningjie; Peng, Wan; Ji, Limei; Kong, Lingyi; Wang, Xiaobing published the artcile< Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy>, Safety of Methyl 4-(bromomethyl)-3-fluorobenzoate, the main research area is cancer therapy histone deacetylase harmine DNA damage; Cancer; DNA; DNA damage; HDAC; Harmine.

Overexpression of histone deacetylases (HDACs) are observed in different types of cancers, but histone deacetylase inhibitors (HDACIs) have not shown significant efficacy as monotherapy against solid tumors. Recently, studies demonstrated that it is promising to combine HDACIs with DNA damage agents to improve DNA damage level to gain better effect on treating solid tumor. Harmine has been demonstrated to cause DNA damage by intercalating DNA. Therefore, we designed a series of harmine-based inhibitors targeting HDAC and DNA with multi-target strategy, the most potential compound 27 could bind to DNA and cause DNA damage. Furthermore 27 caused cells apoptosis through p53 signaling pathway, and exhibited significant anti-proliferation effects against HCT-116 cells (IC50 = 1.41 μM). As a DNA damage agent, 27 displayed low toxicity in normal cells. Compound 27 was demonstrated as a dual inhibitor targeting HDAC (HDAC1 IC50 = 0.022 μM and HDAC6 IC50 = 0.45 μM) and DNA, and had the potential in the treatment of solid tumor.

Bioorganic Chemistry published new progress about Acetylation. 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Safety of Methyl 4-(bromomethyl)-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Jungwon; Kim, Siin; Choi, Geunho; Lee, Geun Seok; Kim, Donghyeok; Choi, Jungkweon; Ihee, Hyotcherl; Hong, Soon Hyeok published the artcile< Synthesis of N-aryl amines enabled by photocatalytic dehydrogenation>, Related Products of 3959-07-7, the main research area is allylic amine visible light mediated regioselective photocatalytic dehydrogenation; aryl amine preparation.

The visible-light-induced photocatalytic synthesis of N-aryl amines was achieved by the CD of allylic amines. The unusual strategy using C6F5I as an hydrogen-atom acceptor enabled the mild and controlled CD of amines beared various functional groups and activated C-H bonds, suppressed side-reaction of the reactive N-aryl amine products. Thorough mechanistic studies suggested the involvement of single-electron and hydrogen-atom transfers in a well-defined order provided a synergistic effect in the control of the reactivity. Notably, the back-electron transfer process prevented the desired product from further reacting under oxidative conditions.

Chemical Science published new progress about Allyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Xiangyu; Kaindl, Jonas; Korczynska, Magdalena; Stossel, Anne; Dengler, Daniela; Stanek, Markus; Hubner, Harald; Clark, Mary J.; Mahoney, Jake; Matt, Rachel Ann; Xu, Xinyu; Hirata, Kunio; Shoichet, Brian K.; Sunahara, Roger K.; Kobilka, Brian K.; Gmeiner, Peter published the artcile< An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor>, Related Products of 20776-50-5, the main research area is beta 2 adrenergic receptor allosteric modulator agonists binding site.

Abstract: Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because they modulate physiol. signaling and promise to be more selective than orthosteric ligands. Here we describe a newly developed allosteric modulator of the β2-adrenergic receptor (β2AR), AS408, that binds to the membrane-facing surface of transmembrane segments 3 and 5, as revealed by X-ray crystallog. AS408 disrupts a water-mediated polar network involving E1223.41 and the backbone carbonyls of V2065.45 and S2075.46. The AS408 binding site is adjacent to a previously identified mol. switch for β2AR activation formed by I3.40, P5.50 and F6.44. The structure reveals how AS408 stabilizes the inactive conformation of this switch, thereby acting as a neg. allosteric modulator for agonists and pos. allosteric modulator for inverse agonists. [graphic not available: see fulltext].

Nature Chemical Biology published new progress about Allosteric modulators. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liedholm, Brita published the artcile< Copper(I)-catalyzed replacement of bromine by chloride ion in bromobenzoic acids>, Related Products of 603-78-1, the main research area is copper catalyst bromine exchange; bromobenzoate chloride exchange reaction.

Kinetics of the exchange reactions of 2,3-dibromobenzoic acid and of 2-bromobenzoic acid, catalyzed by dichlorocuprate(I) ion, were determined A tetrahedral intermediate complex involving the dichlorocuprate anion and the Br atom undergoing replacement was suggested.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Exchange reaction. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Related Products of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yu, Peng; Hu, Jun; Wan, Rong; Li, Xi; Zheng, Shanlong; Xu, Yanhua published the artcile< Synthesis of N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide derivatives promoted by carbodiimide condensation>, HPLC of Formula: 16426-64-5, the main research area is benzoic acid thiosemicarbazide heterocyclization; thiadiazole preparation single crystal benzisothiazolinone condensation carbodiimide catalyst; acetamide preparation.

Novel N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide derivatives I [R = H, 3-CH3, 4-Cl, 2-Br, etc.] were prepared by 2-amino-5-substituted phenyl-1,3,4-thiadiazole and 2-(3-oxo-1,2-benzothiazol-2(3H)-yl) acetic acid condensation catalysis in a convenient and fast method. The intermediate compound 5-(2-chlorophenyl)-1,3,4-thiadiazol-2-amine was confirmed by single-crystal X-ray diffraction.

Journal of Chemical Research published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, HPLC of Formula: 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chu, Minzhe; Zhai, Yingying; Shang, Ningzhao; Zhang, Xiaoyu; Wang, Chun; Zhang, Yunrui; Wang, Haijun; Gao, Yongjun published the artcile< Functions of hydroxyapatite in fabricating N-doped carbon for excellent catalysts and supercapacitors>, HPLC of Formula: 3959-07-7, the main research area is hydroxyapatite nitrogen doped carbon fabrication catalyst supercapacitor.

Functions of hydroxyapatite (HAP) in fabricating nitrogen-containing carbon materials with 1,10-phenanthroline as a precursor were demonstrated. HAP can efficiently prevent 1,10-phenanthroline from subliming and promote it to graphitized carbon during the annealing process. More importantly, HAP favored the generation of active oxygen-containing groups on the final nitrogen-doped carbon NC(HAP), which exhibited excellent catalytic performance for the oxidative coupling of amines to imines (yield 84-95%) and remarkable electrochem. performance for supercapacitors. In electrochem. experiments, NC(HAP) exhibited an outstanding specific capacitance of 366 F/g at 0.5 A/g and an excellent capacitance retention of 98.5% after 5000 charge-discharge cycles at 10 A/g.

Catalysis Science & Technology published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, HPLC of Formula: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Wenjun; Li, Xin; Ye, Tingting; Wu, Wenbin; Liang, Xinmiao; Ye, Jinxing published the artcile< Asymmetric organocatalytic Michael/α-alkylation reaction of α,β-unsaturated aldehyde with chloroacetophenone>, Category: bromides-buliding-blocks, the main research area is unsaturated aldehyde chloroacetophenone Jorgensen Hayashi catalyst asym Michael alkylation; cyclopropanecarboxaldehyde stereoselective preparation.

Asym. organocatalytic Michael/α-alkylation reactions of α,β-unsaturated aldehydes with chloroacetophenones have been developed. The biol. useful cyclopropane motifs, e.g. I, were synthesized with high yields and up to >99% ee, >30:1 dr through Jorgensen-Hayashi catalyst under mild conditions.

Tetrahedron Letters published new progress about Alkylation catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carrico, Dora; Ohkanda, Junko; Kendrick, Howard; Yokoyama, Kohei; Blaskovich, Michelle A.; Bucher, Cynthia J.; Buckner, Frederick S.; Van Voorhis, Wesley C.; Chakrabarti, Debopam; Croft, Simon L.; Gelb, Michael H.; Sebti, Said M.; Hamilton, Andrew D. published the artcile< In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability>, Computed Properties of 16426-64-5, the main research area is FRI2148 prodrug preparation antimalarial Plasmodium farnesyltransferase inhibitor.

A series of protein farnesyltransferase inhibitor ester prodrugs of FTI-2148 were synthesized in order to evaluate the effects of ester structure modification on antimalarial activity and for further development of a farnesyltransferase inhibitor with in vivo activity. Evaluation against P. falciparum in red blood cells showed that all the investigated esters exhibited significant antimalarial activity, with the benzyl ester 16 showing the best inhibition (ED50 = 150 nM). Addnl., compound I displayed in vivo activity and was found to suppress parasitemia by 46.1% at a dose of 50 mg kg-1 day-1 against Plasmodium berghei in mice. The enhanced inhibition potency of the esters is consistent with improved cell membrane permeability compared to that of the free acid. The results of this study suggest that protein farnesyltransferase is a valid antimalarial drug target and that the antimalarial activity of these compounds derives from a balance between the hydrophobic character and the size and conformation of the ester moiety.

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Computed Properties of 16426-64-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Shuang-Shuang; Mo, Zu-Yu; Chen, Yan-Yan; Xu, Yan-Li published the artcile< Synthesis of Selenyl-Substituted Quinoline Derivatives via Substrate-Controlled Three-Component Domino Reactions>, Computed Properties of 29124-57-0, the main research area is cyclohexanedione aminobenzaldehyde diselenide tandem three component selenylation; selenyl dihydroacridinone preparation; alkanedione aminobenzaldehyde diselenide tandem three component selenylation; diselenoacetyl quinoline preparation.

A simple and efficient method for the preparation of selenyl-substituted quinoline derivatives through a Csp3 selenylation of in-situ generated 3-acetyl quinolines was developed. This protocol was easy to handle, scalable and good functional group tolerant, providing a rapid method to 3-selenoacetyl quinoline and 3-diselenoacetyl quinoline derivatives

Journal of Organic Chemistry published new progress about Acridines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Computed Properties of 29124-57-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary