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Rotbergs, J’s team published research in Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija in 1967 | 82-73-5

Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Rotbergs, J.; Cema, G.; Oskaja, V. published the artcile< Condensation dicarboxylic acid anhydrides with compounds containing active methylene groups. V. 3-Bromophthalic anhydride condensation with some β-dicarbonyl compounds>, Computed Properties of 82-73-5, the main research area is INDANS VIA PHTHALIC ANHYDRIDE; BENZALINDANS VIA PHTHALIC ANHYDRIDE.

Condensation of 4.54 g. 3-bromophthalic anhydride (I) with 2.6 g. Et acetoacetate in 10 g. Ac2O and 4 g. Et3N at room temperature and treatment on the following day with 20 g. ice and 10 ml. concentrated HCl yielded 5.1 g. product, which after dissolving in a mixture of 750 ml. hot H2O and 150 ml. concentrated HCl gave 2.5 g. 4-bromoindan-1,3-dione (II), decomposed 158-9°; dioxime decomposed 285°. Boiling a mixture of 0.44 g. II, 0.21 g. BzH, 10 ml. EtOH, and 0.05 ml. piperidine gave, after addition of 0.2 ml. AcOH, 0.6 g. 4-bromo-2-benzalindan-1,3-dione, m. 144-6° (EtOH). Similarly prepared was 78% 4-bromo-2-(p-nitrobenzal)indan-1,3-dione, m. 283-4° (AcOH). Reaction of 2.27 g. I with 1 g. Ac2CH2, 5 g. Ac2O, and 1 g. Et3N for 24 hrs. gave 0.82 g. III, m. 165-6° (MeOH). Similarly were prepared: 41% IV (with BzCH2Ac), m. 182-3° (EtOH); 53% V (with Bz2CH2), m. 186-7° (EtOAc); 66% VI (with di-Et malonate), m. 126-7° (MeOH). Unlike the condensation product of I with Et acetoacetate, III-VI are stable when refluxed with dilute HCl.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Qin, Pengjin’s team published research in Angewandte Chemie, International Edition in 2020-09-28 | 1530-33-2

Angewandte Chemie, International Edition published new progress about Alkatrienes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Application of C21H22BrP.

Qin, Pengjin; Wang, Li-An; O’Connor, Joseph M.; Baldridge, Kim K.; Li, Yifan; Tufekci, Burak; Chen, Jiyue; Rheingold, Arnold L. published the artcile< Transition-Metal Catalysis of Triene 6π Electrocyclization: The π-Complexation Strategy Realized>, Application of C21H22BrP, the main research area is triene electrocyclization transition metal pi complexation catalysis; catalysis; cycloaromatization; electrocyclization; transition metals; triene.

Triene 6π electrocyclization, wherein a conjugated triene undergoes a concerted stereospecific cycloisomerization to a cyclohexadiene, is a reaction of great historical and practical significance. In order to circumvent limitations imposed by the normally harsh reaction conditions, chemists have long sought to develop catalytic variants based upon the activating power of metal-alkene coordination. Herein, we demonstrate the first successful implementation of such a strategy by utilizing [(C5H5)Ru(NCMe)3]PF6 as a precatalyst for the disrotatory 6π electrocyclization of highly substituted trienes that are resistant to thermal cyclization. Mechanistic and computational studies implicate hexahapto transition-metal coordination as responsible for lowering the energetic barrier to ring closure. This work establishes a foundation for the development of new catalysts for stereoselective electrocyclizations.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Jin’s team published research in Green Chemistry in 2021 | 20776-50-5

Green Chemistry published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Computed Properties of 20776-50-5.

Yang, Jin; Sun, Bin; Ding, Hao; Huang, Pan-Yi; Tang, Xiao-Li; Shi, Rong-Cheng; Yan, Zhi-Yang; Yu, Chuan-Ming; Jin, Can published the artcile< Photo-triggered self-catalyzed fluoroalkylation/cyclization of unactivated alkenes: synthesis of quinazolinones containing the CF2R group>, Computed Properties of 20776-50-5, the main research area is alkenyl quinazolinone fluoroalkyl bromide tandem photochem fluoroalkylation radical cyclization; fluoroalkyl fused quinazolinone preparation green chem.

A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides was developed. This transformation exhibited excellent substrate generality with respect to both the coupling partners. This was the first example describing the Csp3-Br bond homolysis of alkyl bromides via a substrate (quinazolinones) induced energy transfer process. Addnl., the mild conditions, tolerance to a wide range of functional groups and operational simplicity make this protocol practical for the synthesis of fluorine-containing ring-fused quinazolinones.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Liang’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2019 | 3959-07-7

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Liang, Liang; Luo, Dong; Zuo, Tao; Zhou, Xiao-Ping; Li, Dan published the artcile< Control over the synthesis of homovalent and mixed-valence cubic cobalt-imidazolate cages>, COA of Formula: C7H8BrN, the main research area is cobalt Schiff imidazolecarboxaldehyde benzylamine complex preparation isothermal magnetization; crystal structure cobalt Schiff imidazolecarboxaldehyde benzylamine complex.

Cubic cobalt-imidazolate cages were successfully synthesized via subcomponent self-assembly in different solvents under solvothermal conditions. The homovalent CoII and mixed-valence CoIII,II-imidazolate cages are assembled with control over the mixed solvent ratio of N,N-diethylformamide/ethanol, resp.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shang, Yong’s team published research in Nature Communications in 2021-12-31 | 6942-39-8

Nature Communications published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Product Details of C8H6BrFO2.

Shang, Yong; Wu, Chenggui; Gao, Qianwen; Liu, Chang; Li, Lisha; Zhang, Xinping; Cheng, Hong-Gang; Liu, Shanshan; Zhou, Qianghui published the artcile< Diversity-oriented functionalization of 2-pyridones and uracils>, Product Details of C8H6BrFO2, the main research area is alkyl pyridone aryl preparation; aryl thymine alkyl preparation; pyridone alkyl halide alkene alkylation; alkene aryl halide pyridone arylation.

A palladium/norbornene cooperative catalysis enabled dual-functionalization of iodinated 2-pyridones I (R = H, Me, Bn, mesityl, MOM, PMB; R1 = CH3, F, Cl, CH2OCH3, CH2C(O)2CH3, 4-ethoxy-4-oxobutyl) and uracils like 6-iodo-1,3-bis(phenylmethyl)-2,4(1H,3H)-pyrimidinedione and 5-iodo-1,3-bis(phenylmethyl)-2,4(1H,3H)-pyrimidinedione. The success of this research depends on the use of two unique norbornene derivatives as the mediator. Readily available alkyl halides R2X (R2 = Me, 4-ethoxy-4-oxobutyl, Bn, etc.; X = Br, I)/tosylate like Me tosylate and aryl bromides R2Br are utilized as ortho-alkylating and -arylating reagents, resp. Widely accessible ipso-terminating reagents, including H/DCO2Na, boronic acid like methylboronic acid/ester like pinacol phenylboronate, terminal alkene R3CH=CH2 (R3 = CH3, CH=CHC6H5, CH=CH2, etc.) and alkyne like triisopropylsilylethyne are compatible with this protocol. Thus, a large number of valuable 2-pyridone derivatives, II including deuterium/CD3-labeled 2-pyridones, bicyclic 2-pyridones, 2-pyridone-fenofibrate conjugate, axially chiral 2-pyridone (97% ee), as well as uracil and thymines III and 1,3-dibenzyl-6-methyl-5-((triisopropylsilyl)ethynyl)pyrimidine-2,4(1H,3H)-dione can be quickly prepared in a predictable manner (79 examples reported), which will be very useful in new drug discovery.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Valero, Guillem’s team published research in Tetrahedron Letters in 2009-04-29 | 3893-18-3

Tetrahedron Letters published new progress about Cyclization catalysts, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.

Valero, Guillem; Schimer, Jiri; Cisarova, Ivana; Vesely, Jan; Moyano, Albert; Rios, Ramon published the artcile< Highly enantioselective organocatalytic synthesis of piperidines. Formal synthesis of (-)-paroxetine>, SDS of cas: 3893-18-3, the main research area is malonmonoamide unsaturated aldehyde stereoselective cyclization secondary amine catalyst; piperidinone asym synthesis; paroxetine asym formal synthesis.

A highly enantioselective organocatalytic synthesis of piperidines is reported starting from protected malonmonoamides and α,β-unsaturated aldehydes. The reaction is catalyzed by simple and com. available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-paroxetine, a blockbuster drug, in only 3 steps.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Puspendra’s team published research in Journal of Physics: Conference Series in 2021 | 576-83-0

Journal of Physics: Conference Series published new progress about Bond angle, torsional. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Product Details of C9H11Br.

Singh, Puspendra; Singh, Priyanka; Shabbani, Gulam; Butcher, Ray J. published the artcile< Synthesis and single crystal X-ray studies of dimesityl ditelluride: [2,4,6-Me3C6H2Te]2>, Product Details of C9H11Br, the main research area is mesityl ditelluride preparation crystal structure supramol synthon.

The reaction of freshly prepared mesityl magnesium bromide with tellurium powder in anhydrous THF provided the dimesityl ditelluride: [2,4,6-Me3C6H2Te]2. A suitable needle- shaped crystal of dimesityl ditelluride was developed by evaporation of a solution in chloroform. The Te compound was developed with the orthorhombic space group Iba2 with a = 15.2916(7) Å, b = 15.7225(7) Å, c = 14.5272(7) Å and α, β,γ = 90°. The geometry about the central tellurium atoms adopt a bent-shaped geometry with torsion angle C10-Te2-Te1- C1 = 87.0(3)° and this may be considered a cisoid conformation. Intermol. C-H…·Te interactions give rise to a two-dimensional supramol. synthons in its crystalline state. The crystal packing diagram shows Te….H [Te1…·H5A, 3.2557(5) Å & Te1…·H8C, 3.2578(5) Å] hydrogen-bonding interactions which are responsible for associative forces.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Albano, Gianluigi’s team published research in Chemistry – A European Journal in 2020-12-21 | 3480-11-3

Chemistry – A European Journal published new progress about Chirality. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Synthetic Route of 3480-11-3.

Albano, Gianluigi; Aronica, Laura Antonella; Minotto, Alessandro; Cacialli, Franco; Di Bari, Lorenzo published the artcile< Chiral Oligothiophenes with Remarkable Circularly Polarized Luminescence and Electroluminescence in Thin Films>, Synthetic Route of 3480-11-3, the main research area is chiral oligothiophene remarkable circularly polarized luminescence electroluminescence thin film; CP-OLED; circularly polarized electroluminescence; circularly polarized luminescence; oligothiophenes; thin films.

This work reports the first observation of circularly polarized electroluminescence (CPEL) in thin films of self-organized oligothiophenes. Four new 1,4-phenylene and 9H-carbazole-based oligothiophenes were ad hoc designed to ensure efficient spontaneous formation of chiral supramol. order. They were easily synthesized and their chiroptical properties in thin films were measured. Circularly polarized luminescence (CPL) spectra revealed glum in the order of 10-2 on a wide wavelengths range, originating from their self-organized chiral supramol. organization. These mols. have reasonable properties as organic semiconductors and for this reason they can constitute the active layer of circularly-polarized organic light-emitting diodes (CP-OLEDs). Thus, we could investigate directly their electroluminescence (EL) and CPEL, without resorting to blends, but rather in a simple multilayer device with basic architecture. This is the first example of a CP-OLED with active layer made only of a small organic compound

Chemistry – A European Journal published new progress about Chirality. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Synthetic Route of 3480-11-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Honnanayakanavar, Jyoti M’s team published research in Organic & Biomolecular Chemistry in 2021 | 3959-07-7

Organic & Biomolecular Chemistry published new progress about Amidation (regioselective). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Honnanayakanavar, Jyoti M.; Nanubolu, Jagadeesh Babu; Suresh, Surisetti published the artcile< Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201>, Computed Properties of 3959-07-7, the main research area is fused tricyclic dihydroimidazoquinazolinone preparation regioselective; aminoimidazoline carboxylic acid arylation amidation cyclocondensation copper catalyst.

Herein, a copper-catalyzed tandem reaction of 2-aminoimidazolines I (R = n-Bu, Ph, furan-2-ylmethyl, pyridin-4-ylmethyl, etc.) and ortho-halo(hetero)aryl carboxylic acids R1C(O)OH (R1 = 2-bromophenyl, 2-bromo-4,5-difluorophenyl, 2-bromopyridin-3-yl, 4-chloropyridin-3-yl, etc.) that causes the regioselective formation of angularly fused tricyclic 1,2-dihydroimidazo[1,2-a]quinazolin-5(4H)-one derivs II (R2 = H, OMe, F; R3 = H, OMe, Cl, Br, F, NO2; R4 = H, F), III and IV was presented. The reaction involved in the construction of the core six-membered pyrimidone moiety proceeded via regioselective N-arylation-condensation. The presented protocol has been successfully applied to accomplish the total synthesis of TIC10/ONC201 V, which is an active angular isomer acting as a tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL): a sought after anticancer clin. agent.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Katkova, Svetlana A’s team published research in Journal of Molecular Structure in 2022-04-05 | 115843-99-7

Journal of Molecular Structure published new progress about Crystal structure. 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, Application of C6H4BrClFN.

Katkova, Svetlana A.; Mikherdov, Alexander S.; Sokolova, Elina V.; Novikov, Alexander S.; Starova, Galina L.; Kinzhalov, Mikhail A. published the artcile< Intermolecular (Isocyano group)···PtII interactions involving coordinated isocyanides in cyclometalated PtII complexes>, Application of C6H4BrClFN, the main research area is platinum isocyanide cyclometalated complex preparation crystal structure DFT luminescence.

A series of platinum(II) isocyanide complexes [Pt(ppy)Cl(CNR)] (ppy = 2-phenylpyridinato-C2,N; R = Mes 1, C6H2-2,6-Me2-4-Br 2, C6H2-2-F-3-Cl-4-Br 3, naphthalen-2-yl 4) were prepared and characterized by high resolution ESI-MS, 1D and 2D NMR, IR, UV-visible absorption, and photoluminescence spectroscopies, as well as single-crystal x-ray diffraction. Anal. of x-ray diffraction data allowed the authors to identify (isocyano group)···PtII interactions where the nitrogen atom of the isocyano group acts as a π-hole donor toward a d2z-orbital of PtII. The presence of these noncovalent interactions was confirmed by DFT calculations followed by NCI anal. and topol. anal. of the electron d. distribution within the framework of Bader’s theory (QTAIM method). Processing of CSD data allowed verification of the contacts between coordinated isocyano moieties and various d9 and d8- metal-centers (AuI, AuIII, AgI, PtII, PdII, NiII, RhI) to be performed.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary