Category: 1001-26-9

Radl, Stanislav; Blahovcova, Michaela; Tkadlecova, Marcela; Havlicek, Jaroslav published the article 《Synthetic studies connected with the preparation of N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a zaleplon regioisomer》. Keywords: chloropyrazolopyrimidincarbonitrile boronate Suzuki Miyaura coupling; zaleplon regioisomer preparation.They researched the compound: Ethyl 3-Ethoxy-2-Propenoate( cas:1001-26-9 ).Related Products of 1001-26-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1001-26-9) here.

N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a principal impurity of zaleplon, was prepared by Suzuki-Miyaura cross-coupling of appropriate boronates with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile. Various methods of preparation of both components were described, as well as approaches based on the final modification of the 5-(3-aminophenyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile moiety prepared by Suzuki-Miyaura cross-coupling. All the prepared compounds were unambiguously identified by NMR. IR, UV, and mass spectra of these compounds were also given.

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Bromide – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Methyl β-(m-chloroanilino)acrylate》. Authors are Gray, F. W.; Mosher, Harry S.; Whitmore, F. C.; Oakwood, T. S..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).COA of Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

HCCCO2Me (9.5 g.) and 9.0 g. m-ClC6H4NH2 (I) stirred 70 hrs. at 25-30°, and the mixture chilled and filtered yielded 11.2 g. Me β-(m-chloroanilino)acrylate (II), colorless needles from MeOH, m. 148-50° (m.p. greatly dependent on rate of heating), cyclized to 4-hydroxy-7-chloroquinoline (IIA) (Price, et al. (C.A. 40, 5741.1)). I.HCl (19.8 g.) in 150 cc. water at 10° treated with 17.7 g. (MeO)2CHCH2CO2Me, and the mixture warmed to 25° after 15 min. and stirred overnight yielded 24 g. material (III), m. 123-6° (from MeOH), analyzing correctly for II, but attempted cyclization by heating 2 g. with Ph2O gave only a small amount (0.15 g.) of 1,3-bis(m-chlorophenylurea) (IV), m. 248°. I (5.1 g.) and 4.5 g. MeOCH:CHCO2Me heated 1 hr. at 100° and 740 mm., then 1 hr. at 50° and 15 mm., the solution added dropwise to 150 cc. boiling Ph2O, the mixture refluxed 1 hr., cooled, left at room temperature 4 hrs., and filtered yielded 2 g. IV, white, crystalline needles from MeOH, m. 250°. EtOCH:CHCO2Et (7.6 g.) and 6.8 g. I yielded 1.3 g. IV, m. 250°. This method for preparing IIA offers another method for synthesizing antimalarials of the chloroquine type.

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Application In Synthesis of Ethyl 3-Ethoxy-2-Propenoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Schiff bases of mixed β-dicarbonyl compounds as tetradentate ligands in unsymmetrical chelate complexes. Author is Jaeger, Ernst G.; Seidel, Dietrich.

1,2-Benzenediamine was condensed with 1-methoxy-1-butene-3-one or Et 2-(ethoxymethylene)acetate (I) and then with I, 3-(ethoxymethylenepentane-2,4-dion, or di-Et ethoxymethylenemalonate to give CH3C(O)CR:CHNHC6H4(NHCH:CR1C(O)R2-2) (R = H, R1 = CH3, R2 = CO2Et; R = CO2Et, R1 = Me, R2 = COMe; R = CO2Et, R1 = OEt, R2 = CO2Et). The unsym. Schiff bases form Ni and Co complexes.

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COA of Formula: C7H12O3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Improved syntheses of 4(3H)-pyrimidinones. Author is Adams, V. Dean; Anderson, Richard C..

The pyrimidinones I (R = Me, Et; R1 = Me, Ph) were preparedby treating RC(OEt)3 with R1COCH2CO2Et and NH3. I (R = H, Me, Et; R1 = H) were prepared by treating RC(OEt)3 with EtOCH:CHCO2Et and NH3. EtOCH:CHCO2Et and NH3 (2:1 molar) gave Et 2(1H)-pyridone-5-carboxylate, but with excess NH3 gave di-Et 3,5-pyridinedicarboxylate.

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Application In Synthesis of Ethyl 3-Ethoxy-2-Propenoate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about A one-pot method for the synthesis of naphthyridines via modified Friedlander reaction. Author is Zhichkin, Pavel; Cillo Beer, Catherine M.; Rennells, W. Martin; Fairfax, David J..

A one-pot method for the preparation of 1,8-naphthyridine derivatives is reported. The method involves the dimetalation of an appropriate N-2-pyridylpivalamide or tert-butylcarbamate followed by reaction with a β-dimethylamino- or β-alkoxyacrolein derivative This method is also applicable to 1,6-naphthyridines.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about PS-BQ: an efficient polymer-supported cocatalyst for the Wacker reaction in supercritical carbon dioxide.Related Products of 1001-26-9.

Using polystyrene-supported benzoquinone (PS-BQ) as cocatalyst with palladium chloride, the acetalization of terminal olefins with electron-withdrawing groups, i.e., acrylate esters, acrylonitrile, Me vinyl ketone and acrolein, was carried out smoothly in supercritical carbon dioxide under oxygen atm.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, New Journal of Chemistry called Synthesis, theoretical conformational study and x-ray structures of 2,2′-dimethyl-4,4′-bipyrimidine and 6,6′-dimethyl-2,2′-bipyrazine, Author is Regnouf de Vains, J.-B.; Lehn, J.-M.; Ghermani, N. E.; Dusausoy, O.; Dusausoy, Y.; Papet, A.-L.; Marsura, A.; Friant, P.; Rivail, J. L., which mentions a compound: 1001-26-9, SMILESS is O=C(OCC)/C=C/OCC, Molecular C7H12O3, Application of 1001-26-9.

The synthesis of 2,2′-dimethyl-4,4′-bipyrimidine (I) and 6,6′-dimethyl-2,2′-bipyrazine is described. In these compounds the s-trans mol. conformation has been observed and could be interpreted in terms of weak C-H…N interactions. The crystal stacking in the two compounds is formed by parallel mol. planes which are 3.46 Å apart. A semi-empirical calculation shows that, irresp. of the medium, the mols. conserve this preferential conformation.

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Category: bromides-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Development of orally active nonpeptidic inhibitors of human neutrophil elastase. Author is Ohmoto, Kazuyuki; Yamamoto, Tetsuya; Okuma, Motohiro; Horiuchi, Toshihide; Imanishi, Hirotoshi; Odagaki, Yoshihiko; Kawabata, Kazuhito; Sekioka, Tomohiko; Hirota, Yasushi; Matsuoka, Shozo; Nakai, Hisao; Toda, Masaaki; Cheronis, John C.; Spruce, Lyle W.; Gyorkos, Albert; Wieczorek, Maciej.

5-Amino-2-phenylpyrimidin-6-ones, some desamino derivatives, miscellaneous derivatives, and oxadiazoles were synthesized and biol. evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. The aminophenylpyrimidinones contained an α-keto-1,3,4-oxadiazole moiety to bind covalently to the Ser-195 hydroxy group of human neutrophil elastase (HNE), an enzyme whose excess is believed to contribute to inflammatory diseases such as emphysema. Many of the aminophenylpyrimidinones tested showed useful pharmacokinetic profiles when given orally to rats. Oxadiazolyl pyrimidine I was selected for clin. evaluation based on its oral potency, duration of action, enzyme selectivity, safety profile, and ease of synthesis. Structure-activity relationships of the inhibition of aminophenylpyrimidinone derivative binding to HNE are discussed.

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Bromide – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Rubbery copolymers from unsaturated ketones》. Authors are Cooper, W.; Bird, T. B.; Catterall, E..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Application In Synthesis of Ethyl 3-Ethoxy-2-Propenoate. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

The preparation and properties of copolymers of unsaturated ketones and acrylate esters and of unsaturated ketones and butadiene (I) are described, including details of the polymerization reactions and the structures of the copolymers, with graphical and tabulated data. In addition, the preparation and properties of the compounded vulcanized copolymers are described and the mechanism of vulcanization of the ketone-acrylate copolymers by S is discussed, with particular reference to crosslinking reactions. Prepared by the method of Hays, et al. (C.A. 47, 493g), the yield of methylvinyl ketone (II) was 65-70%, b135 35°, d420 0.8420, nD15 1.4120; and methylisopropenyl ketone (III) 70-75% yield, b200 59°, d420 0.852, nD20 1.4235. Prepared by the method of McMahon, et al. (C.A. 43, 564g), ethylvinyl ketone (IV), 60% yield, b740 102°, d420 0.8468, nD20 1.4183, and propylvinyl ketone (V), 50% yield, b130 71, d420 0.8500, nD20 1.4222. The ultraviolet spectra of II, III, IV, and V are shown. Data on copolymers Bu, Pr, Et, and EtO acrylates with II, III, IV, and V, resp., are given. A general discussion follows the paper. 15 references.

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Bromide – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A new facile synthesis of 2-aminothiazole-5-carboxylates, published in 2001-03-12, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Product Details of 1001-26-9.

A facile method was developed for the synthesis of 2-aminothiazole-5-carboxylates. The method involves reaction of Et β-ethoxyacrylate with N-bromosuccinimide (NBS) to give a novel intermediate, α-bromo-α-formylacetate hemiacetal. Cyclization of the in-situ formed hemiacetal with thioureas afforded 2-aminothiazole-5-carboxylates in 60-98% yields.

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Bromide – Wikipedia,
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