Category: 1001-26-9

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Transesterification reactions. Thiophenols with ethyl β-ethoxyacrylates》. Authors are Croxall, W. J.; Freimiller, L. R.; Shropshire, E. Y..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Reference of Ethyl 3-Ethoxy-2-Propenoate. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

cf. C.A. 44, 9917f. PhSH (110 g.) and 144 g. EtOCH:CHCO2Et, distilled from 1 g. NaHSO4, give 91% EtOH and 87% Et β-(phenylmercapto)acrylate (I), b2.3 145-50°, n20D 1.5808; p-tolyl analog, b0.5 137-8°, n20D 1.5752, 86%; p-chlorophenyl analog, b1 147°, n20D 1.5920, 82%; 3,4-dichlorophenyl analog, b1 152-4°, n20D 1.6018, 80%. I (50 g.) and 15.8 g. KOH in 100 ml. H2O, refluxed 2 hrs., give 90% β-(phenylmercapto)acrylic acid which, recrystallized from petr. ether-Me2CO, gives 63 g. product m. 127-8.5° and 6 g. m. 83-6°; these are cis-trans isomers. β-(p-Tolylmercapto)acrylic acid, m. 136-8° and 104-7°, 92%; p-chlorophenyl analog, m. 98-112°, 90%; 3,4-dichlorophenyl analog, m. 98-128°, 87%.

As far as I know, this compound(1001-26-9)Reference of Ethyl 3-Ethoxy-2-Propenoate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

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Bromide – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Production of aryl oxygen-containing compounds via catalytic pyrolysis of bagasse lignin over La0.8M0.2FeO3 (M=La, Ca, Sr, Ba).COA of Formula: C7H12O3.

A new method named the production of aryl oxygen-containing compounds via catalytic pyrolysis of bagasse lignin (BL) over perovskites, La0.8M0.2FeO3 (M = La, Ca, Sr, Ba) was proposed. La0.8M0.2FeO3 (M = La, Ca, Sr, Ba) samples were synthesized by the sol-gel method (SG) and characterized by XRD, SEM, BET and XPS, and their catalytic pyrolysis performances were evaluated by the test of TG and the evaluation of the fixed bed microreactor. Under the action of perovskites, the pyrolysis of BL was promoted, the yields of gaseous and solid products decreased while the yield of liquid products increased by 10-20%; decarboxylation and decarbonylation could be inhibited, and it was conducive to the fracture of aliphatic hydrocarbon side chains on aromatic rings, as a result, the selectivity of CO2/CO decreased while the selectivity of hydrocarbons in gaseous products increased; the total selectivity of aryl oxygen-containing compounds increased from 56 weight% in the liquid product obtained from pure BL pyrolysis to more than 69 weight% in that of catalytic pyrolysis of BL. The spent catalyst was regenerated after controlled combustion of solid product-char, and it showed good structural and catalytic stabilities after 5 successful redox cycles.

From this literature《Production of aryl oxygen-containing compounds via catalytic pyrolysis of bagasse lignin over La0.8M0.2FeO3 (M=La, Ca, Sr, Ba)》,we know some information about this compound(1001-26-9)COA of Formula: C7H12O3, but this is not all information, there are many literatures related to this compound(1001-26-9).

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Ring-chain tautomerism in the reaction products of aminophenol and some ethoxymethyleneacetates》. Authors are Nozoe, Tetsuo; Doi, Kozo.The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Application of 1001-26-9. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

o-Aminophenol (I) (1.1 g.) and 2.2 g. di-Et (ethoxymethylene)malonate was heated at 130° 30 min. and crystallized to give quant. yield of 2-(ω,ω-diethoxyearbonylmethyl)benzoxazoline (II), prisms, m. 1401° (EtOH). II did not show coloration with alc. FeCl3 and was inert to the action of CH2N2. II (5.6 g.) was pyrolyzed at 250° and fractions b. 175-185° (A) (1.6 g.) and 195-9° (B) (2.7 g.) were collected. Redistillation of A gave benzoxazole (III), b. 180-2°, m. 30-1°; B was identified as di-Et malonate. Similar condensation of I with Et (ethoxymethylene)acetoacetate and di-Et (ethoxymethylene)cyanoacetate gave, resp., 2-(ω-acetyl-ω-ethoxycarbonylmethyl)benzoxazoline (IV), prisms, m. 146-7° (MeOH), and 2(ω-ethoxycarbonyhnethyl-ω-cyanomethyl)benzoxazoline (V), needles, m. 191-2° (MeOH). Pyrolysis of IV gave Et acetoacetate and III, and V similarly gave Et cyanoacetate and III.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Liquid-phase process for acetylene reactions, published in 1962, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Synthetic Route of C7H12O3.

Vinylation of mono- and polyhydric alcs., of mercaptans and lactams, as well as ethynylation of ketones and reaction of C2H2 with alkyl carbonates, is carried out by a liquid-phase technique having advantages with respect to safety, economy, productivity, and versatility. Reactions are carried out under pressure in the complete absence of a gas phase. Under pressure and at low temperature, C2H2 is dissolved in the reactants, and the reaction mixture is passed through a tubular reactor under pressure high enough to prevent desorption of C2H2. After lowering the pressure to atm., the product is isolated by distillation The critical feature of the process is the use of good C2H2 solvents, e.g., N-methylpyrrolidinone, methylal, dimethoxyethane, dioxane, tetraethylene glycol dimethyl ether, and pyrrolidinone. The preparation of the following compounds is described: 1,2,3-tris(vinyloxy)propane (≤50% conversion) from glycerol, together with 2-methyl-4-vinyloxymethyl-1,3-dioxolane, 2-methyl-4-hydroxymethyl-1,3-dioxolane, and the monovinyl ether of glycerol; N-vinylpyrrolidinone (50-60% conversion, 90-95% yield) from pyrrolidinone (caprolactam and substituted pyrrolidinones have been vinylated similarly); 1-ethynyl-1-cyclohexanol (51% conversion, 72% yield) from cyclohexanone, together with the glycol, 1,2-bis(1-hydroxy-1-cyclohexyl)ethyne (7.5% conversion, 11% yield); from Et2CO3, a mixture of Et 3-ethoxyacrylate, Et 3,3′-diethoxypropionate, di-Et ethoxymaleate, and di-Et α,α-diethoxysuccinate (54% conversion, 72% yield of acrylate-propionate mixture) was obtained. No specific example for the reaction of mercaptans (RSH) with C2H2 is given, but yields of RSCH:CH2 are usually 85-90%, and the major by-product is RSCH2CH2SR.

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Safety of Ethyl 3-Ethoxy-2-Propenoate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-Ethoxy-2-Propenoate, is researched, Molecular C7H12O3, CAS is 1001-26-9, about Conjugation and base properties of triethyl(β-R-acryloyloxy)stannanes. Author is Voronkov, M. G.; Toryashinova, D. D.; Chernova, V. G.; Brodskaya, E. I.; Mirskov, R. G..

IR, UV, and NMR spectral data were obtained for trans-RCH:CHCO2SnEt3 (I; R = Et2N, piperidino, morpholino, 1-pyrrolidinyl, EtO, Me, H), and the basicities of I were determined from IR spectral shifts with phenol. The long-wavelength UV bands were governed by conjugation effects, and basicities depended on conjugation and the inductive effect of the SnEt3 group.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Diethyl acetals of α-formyl esters, published in 1947, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Electric Literature of C7H12O3.

Zn (100 g., washed with dilute HCl and 3 times with H2O, MeOH, and Me2CO, dried at 100°/20 mm. for 10 min., and used immediately), 25 cc. C6H6, and a crystal of iodine, heated to reflux, and treated dropwise (about 45 min.) with 0.2 mol. of the α-Br ester and 40 cc. (0.24 mol.) HC(OEt)3 in 75 cc. dry C6H6, 25 g. Zn added, and the mixture refluxed 6 hrs., give the di-Et acetals of α-formyl Et esters: propionate, b20 99-102°, 44%; butyrate, b20 112-17°, 51%; isobutyrate, b20 104-7°, 58.5%; valerate, b20 116-20°, 56.5%; caproate, b20 132-6°, 46.5%; hexahydrobenzoate, b20 149-52°, 52.5%. The product from BrCH2CO2Et contains 39% EtOCH:CHCO2Et. NCCHBrCO2Et gives 37% EtOCH:C(CN)CO2Et, m. 49-50°. The acetal esters and 2,4-(O2N)2C6H3NHNH2 in 20% aqueous H2SO4 give 2,4-dinitrophenylhydrazones of α-formyl Et esters: propionate, m. 110-11.5°; butyrate, m. 106-8°; isobutyrate, m. 104.5-5°; valerate, m. 121-3°; caproate, m. 86.5-8°; hexahydrobenzoate, m. 150-2°. Hexahydrobenzaldehyde 2,4-dinitrophenylhydrazone, yellow m. 168-9°.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Efficient Synthesis of a Trisubstituted 1,6-Naphthyridone from Acetonedicarboxylate and Regioselective Suzuki Arylation, published in 2005-12-09, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, Related Products of 1001-26-9.

An efficient five-step synthesis of 1,6-naphthyridone I, a p38 mitogen-activated protein (MAP) kinase inhibitor intermediate, in 32% overall yield starting from acetonedicarboxylate (ADC) is described. The synthesis began with a selective monoamidation of ADC di-Me ester enolate. A novel concomitant enamine formation and an imide cyclization afforded the nitrogen differentially protected enamide imide. Treatment of this with KOCMe3 and 3-ethoxyacrylate produced lactam quant., which was converted to tetrachloronaphthyridone via a one-pot p-methoxybenzyl deprotection and bischlorination. A highly regioselective Pd(OAc)2/IMes-catalyzed Suzuki coupling completed the synthesis.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor, published in 2020-12-15, which mentions a compound: 1001-26-9, Name is Ethyl 3-Ethoxy-2-Propenoate, Molecular C7H12O3, HPLC of Formula: 1001-26-9.

Casein kinase 2 (CK2) is a constitutively expressed serine/threonine kinase that has a large diversity of cellular substrates. Thus, CK2 has been associated with a plethora of regulatory functions and dysregulation of CK2 has been linked to disease development in particular to cancer. The broad implications in disease pathol. makes CK2 an attractive target. To date, the most advanced CK2 inhibitor is silmitasertib, which has been investigated in clin. trials for treatment of various cancers, albeit several off-targets for silmitasertib have been described. To ascertain the role of CK2 inhibition in cancer, other disease and normal physiol. the development of a selective CK2 inhibitor would be highly desirable. In this study we explored the pyrazolo [1,5-a]pyrimidine hinge-binding moiety for the development of selective CK2 inhibitors. Optimization of this scaffold, which included macrocyclization, led to IC20 (31) a compound that displayed high in vitro potency for CK2 (KD = 12 nM) and exclusive selectivity for CK2. X-ray anal. revealed a canonical type-I binding mode for IC20 (31). However, the polar carboxylic acid moiety that is shared by many CK2 inhibitors including silmitasertib was required for potency but limits the cellular activity of IC20 (31) and the cellular IC50 dropped to the low micromolar range. In summary, IC20 (31) represents a highly selective and potent inhibitor of CK2, which can be used as a tool compound to study CK2 biol. and potential new applications for the treatment of diseases.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1001-26-9, is researched, SMILESS is O=C(OCC)/C=C/OCC, Molecular C7H12O3Journal, Heterocycles called Palladium-catalyzed cross-coupling of aryl iodides with ethyl 2-ethoxy- and 3-ethoxyacrylate, Author is Sakamoto, Takao; Kondo, Yoshinori; Kashiwagi, Yoshitomo; Yamanaka, Hiroshi, the main research direction is coupling iodoquinoline acrylate catalyst; iodopyridine coupling acrylate catalyst; iodobenzene coupling acrylate catalyst; quinolinylacrylic acid; cinnamate ester.Quality Control of Ethyl 3-Ethoxy-2-Propenoate.

The reaction of 3-iodoquinoline with R1CH:CR2CO2Et (one at R1 and R2 is OEt and the other is H), Pd, and K2CO3 in MeCN gave Et 3-quinolylacrylates I. Similarly prepared were pyridylacrylate esters II and 4-R3C6H4CR1:CR2CO2Et (R3 = H, OMe).

If you want to learn more about this compound(Ethyl 3-Ethoxy-2-Propenoate)Quality Control of Ethyl 3-Ethoxy-2-Propenoate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1001-26-9).

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Bromide – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vibration and electronic spectra of esters of polyenecarboxylic acids》. Authors are Kogan, G. A.; Ivanova, T. M.; Yanovskaya, L. A.; Kucherov, V. F.; Popov, E. M..The article about the compound:Ethyl 3-Ethoxy-2-Propenoatecas:1001-26-9,SMILESS:O=C(OCC)/C=C/OCC).Formula: C7H12O3. Through the article, more information about this compound (cas:1001-26-9) is conveyed.

The frequencies and integral intensities of bands in the ir and uv spectra and Raman spectra of polyene compounds X(CH:CH)nCOOEt (X = Me, OEt, COH, NO2, and CO2Et; n = 1-5) were investigated in a study of the mutual effect of functional groups of atoms through a system of conjugate bonds. Causes of changes in these parameters in the spectra of compounds in the basic and excited states were determined from an analysis of the data.

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