Category: 10016-52-1

These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2,8-Dibromodibenzo[b,d]furan

General procedure: 3.26 g of 2,8-dibromodibenzofuran, 1.9 g of pyridin-2-ol, 0.2 g of CuI, 0.2 g of 1,10-phenanthroline, and 6.3 g of K3PO4 were added to 200 mL of dimethylformamide (DMF) and stirred at a temperature of 160 C. for 24 hours. After cooling, 400 mL of a mixed solution including brine ice was added thereto, and a reaction mixture was precipitated, filtered, and washed with water. An organic layer obtained therefrom by washing the reaction mixture with ethyl acetate and water three times was dried by using MgSO4 and dried under reduced pressure. Column chromatography was used to obtain 1.77 g (yield: 50%) of Intermediate 1-1.

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung Display Co., Ltd.; SIM, Munki; KO, Soobyung; KIM, Sungbum; PARK, Junha; AHN, Heechoon; LEE, Hyoyoung; JEON, Mina; JUN, Mieun; HAN, Junghoon; KIM, Youngkook; HWANG, Seokhwan; (93 pag.)US2019/296253; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 10016-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(3) Synthesis of Compound (300) [0266] [0267] Into a three-necked flask, 3.80 g (10.2 mmol) of Compound (300-b), 1.39 g (4.25 mmol) of Compound (291-a), 15 ml of a 2 M aqueous solution of sodium carbonate, 30 ml of 1,2-dimethoxyethane, and 0.368 g (0.425 mmol)) of Pd(PPh3)4 were charged, and the contents were refluxed for 12 h in a nitrogen atmosphere. [0268] After the reaction, the reaction solution was added with 100 ml of methanol and ultrasonically washed for 10 min. The precipitate was separated by filtration and washed with methanol, water, and then hexane. The washed precipitate was dried, dispersed in ethyl acetate for washing, and recrystallized from toluene, to obtain a white solid. The identification was based on the molecular weight measurement by FD/MS, which showed m/e = 654 for the molecular weight of 654. The yield was 1.50 g and the percent yield was 54%.

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Co., Ltd; NAKANO, Yuki; NUMATA, Masaki; NAGASHIMA, Hideaki; EP2711363; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10016-52-1, The chemical industry reduces the impact on the environment during synthesis 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

In a 25 ml four-necked flask, 0.52 g (2.0 mmol) of 4-phenylaminodibenzofuran, 0.33 g (1.0 mmol) of 2,8-dibromodibenzofuran, 500 mg (5.2 mmol) of sodium t-butoxide, 10 ml of dehydrated toluene In addition, nitrogen bubbling was performed for 1 hour. after that,Pd2 (dba) 392 mg (0.10 mmol),After adding 58 mg (0.20 mmol) of tri-t-butylphosphonium tetrafluoroborate, the mixture was heated under reflux for 12 hours while stirring under a nitrogen stream. The formation of the desired product was confirmed by TLC and MS. The reaction solution was cooled to room temperature, and the organic layer was extracted with toluene, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to obtain a brown viscous product. The resulting gum was dissolved in 5 ml of toluene and loaded onto the column. The crude product was directly purified by silica gel column chromatography (developing solvent: toluene / hexane = 1/4) to obtain 0.51 g of the target product HTM5 in a yield of 75%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; National University Corporation Yamagata University; Sasabe, Hisahiro; Kido, Junji; Kamata, Takahiro; (21 pag.)JP2019/26556; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10016-52-1,Some common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a two-necked flask were added A-1-1 (2.5 g), B-1 (3.6 g) And sodium tert-butoxide (4.4 g) was added thereto. The flask was filled with di-gassed toluene (46 mL) and heated to 100 C. Pd [P (t-Bu) 3] 2 (200 mg), Pd And the mixture was stirred at the same temperature for 17 hours. Diluted with DCM (100 mL) and filtered through SiO2. The filtered solution was depressurized to remove the solvent, and the residue was dissolved in THF in EA and then recrystallized to obtain A-1 (final) (1.5 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,8-Dibromodibenzo[b,d]furan, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Lee Chung-hwan; Bae Jae-sun; Lee Jae-cheol; Kim Hwa-gyeong; Shin Ji-yeon; (37 pag.)KR2018/92782; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 10016-52-1

Dibromodibenzo [b, d] furan (1.0 g, 3.07 mmol, 1.0 eq) was dissolved in tetrahydrofuran (35 ml) followed by the addition of Tetrahydrofuran To a 25 ml flaskThe mixture was gradually added at 45 and stirred. After completion of the reaction, the reaction mixture was distilled under reduced pressure to remove the solvent. The solvent was distilled off (100 ml X 3), and the filtrate was dried over MgSO 4, filtered, and dried to obtain dibenzo [b, d] furan-2,8-diylbis ) Phenyl) methanol (1.7 g). The solution was dissolved in 35 ml of methanol and 35 ml of hydrogen chloride, followed by heating and stirring at 80 C for 2 hours. After the reaction was completed, the solvent was distilled off to remove the solvent, and then a small amount of distilled water was added thereto. After the work-up, water was removed with MgSO 4 and filtered to obtain G-4 (1.3 g, yield 63.17%

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Korea Jiao Tong University Academic Cooperation; Lee, Ji Hun; Choe, Sung Hyun; Yun, Poo Yong; Yun, Moo Sang; (25 pag.)KR101638767; (2016); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10016-52-1.

To a 1 L reaction flask was added toluene solvent (450 ml), 2,8-dibromodibenzofuran (11.74 g, 36 mmol),Intermediate I-21 (36.22 g, 90 mmol), Pd2 (dba) 3 (990 mg, 1.08 mmol),BINAP (1.65 g, 16.5 mmol) and sodium tert-butoxide (9.9 g, 100.8 mmol),Dissolved by stirring, and refluxed under nitrogen for 24 hours.After completion of the reaction, the reaction solution was washed with dichloromethane and distilled water and then evaporated.The organic layer was dried over anhydrous magnesium sulfate. After filtered, solvent was removed, and purified by column chromatography using cyclohexane: ethyl acetate = 10:1 as eluent.Finally, solid compound 21 (25.81 g, yield 74%) was obtained, and the solid purity was 99.6% by HPLC.

The synthetic route of 2,8-Dibromodibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Zhao Qian; Liu Hui; Han Chunxue; (55 pag.)CN110407829; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, Adding some certain compound to certain chemical reactions, such as: 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10016-52-1.

13.04 g of 2,8-dibromodibenzofuran, 6.77 g of diphenylamine, 0.180 g of palladium(II) acetate, 4.610 g of sodium t-butoxide, and 700 ml of xylene were loaded into a 1-1 three-necked flask, and 32 ml of a 0.1-mol/l solution of tri-t-butylphosphine in xylene were slowly dropped into the flask while the mixture was stirred with a stirrer. Then, a nitrogen atmosphere was established in the container, and the resultant mixture was subjected to a reaction at 110C for 7.5 hours. After that, the resultant was subjected to each of a separation treatment and purification by column chromatography three times. As a result, 10.23 g of a white solid were obtained. The solid was identified as Intermediate 24 by FD-MS.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10016-52-1.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2159217; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 10016-52-1

Example 1.11.15 9-(4′-(8-bromodibenzo[b,d]furan-2-yl)-[1,1′-biphenyl]-4-yl)-9H-carbazole (Compound 15) A mixture of 9-(4′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1′-biphenyl]-4-yl)-9H-carbazole (1.75 g, 4.42 mmol), 2,8-dibromodibenzo[b,d]furan (2.52 g, 7.74 mmol), tetrakis(triphenylphosphine) palladium(0) (0.25 g, 0.22 mmol), potassium carbonate (1.83 g, 13.26 mmol), 1,4-dioxane (40.00 mL), and water (8.00 mL) was degassed with bubbling argon for 30 minutes. The reaction mixture was then heated to 80 C. and was stirred overnight (16.5 hours), maintaining an argon atmosphere. Consumption of the starting material was confirmed by thin-layer chromatography and the reaction was cooled to room temperature. The product was extracted with dichloromethane, dried, and purified by silica gel column chromatography with dichloromethane in hexanes as the eluent. The product fractions were then dried and the product was collected to yield Compound 15 (1.09 g, 44%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10016-52-1.

Reference:
Patent; NITTO DENKO CORPORATION; Zheng, Shijun; (40 pag.)US9425408; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., 10016-52-1

A single-mouth flask was taken, 3.26 g of 3,6-dibromodibenzothiophene was added, sealed and vacuum-dried with nitrogen three times, and 100 mL of anhydrous tetrahydrofuran (THF) was dissolved and dissolved under a nitrogen atmosphere.The device was then placed in a dry ice/acetone bath at -78 C for 15 min.13.75 mL of a n-hexane solution of n-butyllithium was weighed using a syringe.The mixture was added dropwise to a reaction flask, and reacted at -78 C for 1.5 h under a nitrogen atmosphere to obtain a reaction system.3.74 mL of diphenylphosphonium chloride was added to the reaction system, and the mixture was allowed to react at room temperature for 12 hours.The reaction solution was quenched with 50 mL of water and extracted with 3¡Á50 mL of dichloromethane.The organic phase was collected and dried over anhydrous sodium sulfate. The dichloromethane solution was spun off using a rotary evaporator.The crude product was then dissolved in 50 mL of dichloromethane, silica gel powder was added and the solvent was dried.Purification by chromatography gave an arylphosphine derivative. The obtained arylphosphine derivative and 0.6 gThe sulfur powder was dissolved in a dichloromethane solution and allowed to react at room temperature overnight.The dichloromethane solution was spun off using a rotary evaporator. Then the crude product was dissolved to 50 mLAdd silica gel to the dichloromethane and spin dry the solvent.Purification by chromatography gave 1.91 g of a white solid.The yield was 37.1%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Tao Ye; Li Huanhuan; Jiang Yunbo; Zhi Yibin; Chen Runfeng; Huang Wei; (11 pag.)CN109912654; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, This compound has unique chemical properties. The synthetic route is as follows., 10016-52-1

30.0 g (92.03 mmol) of 2,8-dibromodibenzo [b, d] furan, 25.1 g (184.06 mmol) of 1- (3-hydroxyphenyl) ethanone in a 500 mL reactor,1.8 g (9.20 mmol) of iodo copper,1,10-phenanthroline 3.3 g (18.41 mmol),Add 38.2 g (276.09 mmol) of anhydrous potassium carbonate, add 400 ml of N, N-dimethylformamide and stir at reflux for 24 hours under a nitrogen atmosphere.After completion of the reaction, extracted with ethyl acetate, distilled water,Filtered by anhydrous magnesium sulfate,Purified by silica gel chromatography, 20.9 g (52% yield) of an intermediate compound [2-1] as an off-white solid were prepared

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Teuri L Co., Ltd.; Kang Ji-seung; Moon Bong-seok; Jin Seong-min; Hong Won-gi; Ha Min-su; Lee Gyu-seong; Jin Sang-jun; Park No-gil; Lee Hyeon-u; Byun U-geun; (50 pag.)KR2019/139404; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary