Category: 108-85-0

In an article, author is Ge, Yirong, once mentioned the application of 108-85-0, Computed Properties of C6H11Br, Name is Bromocyclohexane, molecular formula is C6H11Br, molecular weight is 163.06, MDL number is MFCD00003819, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category.

SNHG16 knockdown inhibits tumorigenicity of neuroblastoma in children via miR-15b-5p/PRPS1 axis

Neuroblastoma is an important problem in children. Long noncoding RNAs (lncRNAs) exhibit important roles in tumorigenicity of neuroblastoma. However, the role and mechanism of lncRNA small nucleolar RNA host gene 16 (SNHG16) in neuroblastoma tumorigenicity remain poorly understood. Forty-six neuroblastoma samples and 28 normal tissues were harvested. The levels of SNHG16, microRNA-15b-5p (miR-15b-5p), and phosphoribosyl pyrophosphate synthetase 1 (PRPS1) were detected via quantitative reverse transcription PCR or western blot. Cell proliferation as well as cycle distribution were measured via 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H-tetrazolium bromide or flow cytometry. Cell metastasis was investigated via epithelial-mesenchymal transition or transwell assay. The target relationship of miR-15b-5p and SNHG16 or PRPS1 was explored via starBase and dual-luciferase reporter assay. The role of SNHG16 in neuroblastoma in vivo was analyzed using a xenograft model. We found SNHG16 and PRPS1 levels were increased in neuroblastoma tissues and cells. SNHG16 knockdown inhibited cell proliferation, increased the cell cycle distribution at G0/G1 phase, and decreased the cells at S phase. SNHG16 overexpression caused an opposite effect. SNHG16 silence suppressed neuroblastoma cell metastasis. PRPS1 knockdown constrained cell proliferation and metastasis and regulated cell cycle distribution. miR-15b-5p was sponged by SNHG16 and directly targeted PRPS1. miR-15b-5p knockdown or PRPS1 overexpression mitigated the influence of SNHG16 silence on cell cycle, proliferation, and metastasis. SNHG16 knockdown reduced xenograft tumor growth. In conclusion, SNHG16 downregulation suppressed neuroblastoma tumorigenicity by regulating cell cycle, proliferation, and metastasis via miR-15b-5p/PRPS1 axis.

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Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, in an article , author is Marverti, Gaetano, once mentioned of 108-85-0, Safety of Bromocyclohexane.

The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines

Ovarian cancer is the most lethal gynecological malignancy, often because of the frequent insurgence of chemoresistance to the drugs currently used. Thus, new therapeutical agents are needed. We tested the toxicity of 16 new DNA-intercalating agents to cisplatin (cDDP)-sensitive human ovarian carcinoma cell lines and their resistant counterparts. The compounds were the complexes of Pt(II) or Pd(II) with bipyridyl (bipy) and phenanthrolyl (phen) and with four different thiourea ancillary ligands. Within each of the four series of complexes characterized by the same thiourea ligand, the Pd(phen) drugs invariably showed the highest anti-proliferative efficacy. This paralleled both a higher intracellular drug accumulation and a more efficient DNA intercalation than all the other metal-bidentate ligand combinations. The consequent inhibition of topoisomerase II activity led to the greatest inhibition of DNA metabolism, evidenced by the inhibition of the expression of the folate cycle enzymes and a marked perturbation of cell-cycle distribution in both cell lines. These findings indicate that the particular interaction of Pd(II) with phenanthroline confers the best pharmacokinetic and pharmacodynamic properties that make this class of DNA intercalators remarkable inhibitors, even of the resistant cell growth.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 108-85-0, you can contact me at any time and look forward to more communication. Safety of Bromocyclohexane.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, belongs to bromides-buliding-blocks compound. In a document, author is Yuan, Keyu, introduce the new discover, Product Details of 108-85-0.

MicroRNA-485-5p reduces keratinocyte proliferation and migration by regulating ITGA5 expression in skin wound healing

Purpose: To determine the effect of miR-485-5p on keratinocyte proliferation and migration. Methods: Human primary keratinocytes (HaCaT cells) were treated with different concentrations of transforming growth factor-beta 1 (TGF)-beta 1. miR-485-5p expression levels were determined using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and wound healing assays were performed to investigate the regulatory effects of miR-485-5p on cell viability and migration of HaCaT cells. Downstream target gene expression of miR-485-5p was determined using a luciferase activity assay. Results: In HaCaT cells, miR-485-5p was time- and dose-dependently downregulated by TGF-beta 1 treatment (p < 0.05). Forced expression of miR-485-5p decreased cell viability and migration of HaCaT cells (p < 0.05). Knockdown of miR-485-5p enhanced HaCaT cell viability and migration. Integrin subunit alpha-5 (ITGA5) was predicted and verified to be a downstream target of miR-485-5p in HaCaT cells. Overexpression of ITGA5 attenuated the miR-485-5p-induced decrease of HaCaT cell viability and migration (p < 0.05). Conclusion: MiR-485-5p reduces cell proliferation and migration of keratinocytes through the regulation of ITGA5. This mechanism provides a potential therapeutic strategy for skin wound healing. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 108-85-0 is helpful to your research. Product Details of 108-85-0.

Related Products of 108-85-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, belongs to bromides-buliding-blocks compound. In a article, author is Zhang, Weifeng, introduce new discover of the category.

A dual functional Janus membrane combining superwettability with electrostatic force for controllable anionic/cationic emulsion separation and in situ surfactant removal

In the oil/water emulsion treatment field, the separation of dispersed tiny oil droplets and the removal of surfactants are both significant in order to obtain purified water. Superwetting materials have proved to be an ideal solution for stabilized emulsion separation. However, most of the previous studies only focus on the separation of oil from water while neglecting the removal of surfactants. With the purpose of realizing in situ emulsion separation and surfactant removal, a dual functional Janus membrane is designed inspired by mussel-inspired chemistry and an EDC/NHS coupling reaction. After modification, abundant amino groups and carboxyl groups are decorated on two sides of the microfiltration membrane substrate, respectively (denoted as the -NH2 side and -COOH side). Combining special wettability with electrostatic interaction, the as-prepared membrane is able to separate stabilized oil-in-water emulsions and remove anionic/cationic surfactants simultaneously. The -NH2 side is used for the treatment of anionic emulsions with the surfactant sodium dodecyl sulfate (SDS), while the -COOH side is used for the treatment of cationic emulsions with the surfactant hexadecyl trimethyl ammonium bromide (CTAB). More importantly, the separation efficiencies are all above 99.5% and the surfactant removal efficiencies are up to 95.7%. To our knowledge, this is the first time to treat both dispersed oil droplets and surfactants using superwetting materials. The excellent recyclability and stability of the Janus material make it a potential candidate for application in the industrial field.

Related Products of 108-85-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 108-85-0.

Reference of 108-85-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, belongs to bromides-buliding-blocks compound. In a article, author is Zhang, Dongdong, introduce new discover of the category.

Synthesis of carbon fibers support graphitic carbon nitride immobilize ZnBr2 catalyst in the catalytic reaction between styrene oxide and CO2

Chemically fixing CO2 into the fine chemicals is a sustainable route to the utilization of CO2 and meets the requirements of green chemistry. Generally, an important intermediate, high-valued cyclic carbonates, is produced by catalyzed cycloaddition of CO2 with epoxides during the CO2 fixation. However, most of the catalysts for cycloaddition can hardly meet the standards of the green chemistry, including highly efficient, low cost, easily recoverable and recyclable etc. Therefore, in this work, an environmentally friendly composite Zn-CN/C catalyst for the cycloaddition of styrene oxide and CO2 was successfully prepared by a facile method. To this end, zinc bromide was immobilized by graphitic carbon nitride (gCN) and then supported on carbon fibers. Meanwhile, the crystal structure, types of chemical bonding, surface morphologies, and electronic transmission of the prepared catalyst were also investigated. Furthermore, the catalytic performance was evaluated by the cycloaddition reactions of styrene oxide and CO2, a satisfactory result of the moderate yield of 50-90% with a good selectivity (> 99%) was obtained. Finally, a credible mechanism of the reaction was proposed.

Reference of 108-85-0, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 108-85-0.

Reference of 108-85-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, belongs to bromides-buliding-blocks compound. In a article, author is Berezin, A. S., introduce new discover of the category.

Trinuclear copper(ii) bromide complex [C3H5N3Br](2n)[Cu3Br8](n). Structure, magnetic properties and DFT calculations

Halidocuprates(ii) show unusual magnetic properties and a high degree of structural flexibility. We present the results of crystallographic, electron paramagnetic resonance (EPR) spectroscopic and magnetochemical analyses of a new [HL](2n)[Cu3Br8](n) compound (HL = 3-amino-4-bromopyrazolium) – the first example of an inorganic polymer built from trimeric [Cu3Br8](2-) units with a 5-membered nitrogen-containing heterocycle as an organic counter ion. The EPR spectrum of the polycrystalline sample exhibited a signal at g approximately equal to 2.06 broadened owing to spin-spin interactions between copper ions. The EPR and magnetochemical data indicate a ferromagnetic intertrimer interaction with Theta = 13 K and an antiferromagnetic intratrimer interaction with J = 310 K between the nearest-neighbor copper(ii) ions, which is in agreement with DFT calculations.

Reference of 108-85-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 108-85-0.

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 108-85-0, Name is Bromocyclohexane, formurla is C6H11Br. In a document, author is Wang, Jianchun, introducing its new discovery. Name: Bromocyclohexane.

Modular and regioselective synthesis of all-carbon tetrasubstituted olefins enabled by an alkenyl Catellani reaction

All-carbon tetrasubstituted olefins have been found in numerous biologically important compounds and organic materials. However, regio- and stereocontrolled construction of this structural motif still constitutes a significant synthetic challenge. Here, we show that a modular and regioselective synthesis of all-carbon tetrasubstituted olefins can be realized via alkenyl halide- or triflate-mediated palladium/norbornene catalysis, which is enabled by a modified norbornene containing a C2 amide moiety. This new norbornene co-catalyst effectively suppressed undesired cyclopropanation pathways, which have previously been a main obstacle for developing such reactions. Diverse cyclic and acyclic alkenyl bromides or triflates with a wide range of functional groups can be employed as substrates. Various substituents can be introduced at the alkene C1 and C2 positions regioselectively simply by changing the coupling partners. Initial mechanistic studies provide insights on the rate-limiting step as well as the structure of the actual active ligand in this system.

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Chemistry is an experimental science, Recommanded Product: Bromocyclohexane, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 108-85-0, Name is Bromocyclohexane, molecular formula is C6H11Br, belongs to bromides-buliding-blocks compound. In a document, author is Aguiar, Kelly L. N. P..

Study of the modification of bentonite for the formation of nanocomposite hydrogels with potential applicability in conformance control

In this work, the structure of bentonite clay was modified by ion exchange mechanism using 30%, 60% and 100% of its cation exchange capacity (CEC) with the surfactants hexadecyltrimethylammonium bromide, tetramethylammonium bromide, and trimethylphenylammonium bromide. The organically modified clay samples were characterized by Fourier-transform infrared spectrometry (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The clays modified with hexadecyltrimethylammonium bromide presented the best results and were used for the formation of nanocomposite hydrogels and the systems were characterized by FTIR, TGA, SEM and rheological analysis. Thus, it was observed that the systems produced with 100% hexadecyltrimethylammonium bromide modified clay presented better properties and nanofiller showed better reinforcement capacity due to the greater interaction between the organophilic clay and the polymeric matrix.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 108-85-0. Recommanded Product: Bromocyclohexane.

Chemistry is an experimental science, Recommanded Product: 108-85-0, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 108-85-0, Name is Bromocyclohexane, molecular formula is C6H11Br, belongs to bromides-buliding-blocks compound. In a document, author is Desaeger, Johan A..

Evaluation of new chemical and biological nematicides for managing Meloidogyne javanica in tomato production and associated double-crops in Florida

BACKGROUNDTwo field experiments were conducted to determine the efficacy and field performance of three new non-fumigant chemical nematicides (fluensulfone, fluopyram, and fluazaindolizine) and two biological nematicides (Burkholderia rinojensis strain A396 and Purpureocillium lilacinus strain 251) for management of root-knot nematodes (Meloidogyne javanica) on tomato and associated double-crops in Florida. RESULTSIn experiment 1, soil fumigation with metam potassium increased plant growth and reduced root galling on tomato by 77% relative to that of the untreated soil. All non-fumigant chemical nematicides reduced root galling on tomato (47-85% reduction); however, only fluensulfone showed a trend towards yield enhancement. In experiment 2, soil fumigation with chloropicrin increased plant growth and reduced root galling on tomato by 35% relative to that of the untreated soil; however, end-of-season populations of M. javanica in soil were larger than that of the non-fumigated soil. Fluensulfone showed a trend towards reduced root galling and enhanced fruit yield, whereas other non-fumigant nematicides did not. Double-cropped cucumber was 69% more galled when planted into soil previously fumigated with chloropicrin relative to that of untreated soil, and also showed reduced plant vigor and fruit yield. CONCLUSIONFluensulfone shows significant potential to be a component of an integrated pest management strategy for tomato in Florida. (c) 2019 Society of Chemical Industry

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 108-85-0, in my other articles. Recommanded Product: 108-85-0.

Electric Literature of 108-85-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 108-85-0, Name is Bromocyclohexane, SMILES is BrC1CCCCC1, belongs to bromides-buliding-blocks compound. In a article, author is Hussein, Mohanad A., introduce new discover of the category.

Halide Anion Triggered Reactions of Michael Acceptors with Tropylium Ion

Tropylium bromide undergoes noncatalyzed, regioselective additions to a large variety of Michael acceptors. In this way, acrylic esters are converted into beta-bromo-alpha-cycloheptatrienylpropionic esters. The reactions are interpreted as nucleophilic attack of bromide ions at the electron-deficient olefins and the approach of the tropylium ion to the incipient carbanion. Quantum chemical calculations were performed to elucidate the analogy to the amine- or phosphine-catalyzed Rauhut-Currier reactions. Subsequent synthetic transformations of the bromo-cycloheptatrienylated adducts are reported.

Electric Literature of 108-85-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 108-85-0.