Category: 1129-28-8

The author of 《Development of thiazolidinedione-based HDAC6 inhibitors to overcome methamphetamine addiction》 were Sharma, Chiranjeev; Oh, Yong Jin; Park, Byoungduck; Lee, Sooyeun; Jeong, Chul-Ho; Lee, Sangkil; Seo, Ji Hae; Seo, Young Ho. And the article was published in International Journal of Molecular Sciences in 2019. Computed Properties of C9H9BrO2 The author mentioned the following in the article:

Thiazolidinedione is a five-membered heterocycle that is widely used in drug discovery endeavors. In this study, we report the design, synthesis, and biol. evaluation of a series of thiazolidinedione-based HDAC6 inhibitors. In particular, compound 6b exerts an excellent inhibitory activity against HDAC6 with an IC50 value of 21 nM, displaying a good HDAC6 selectivity over HDAC1. Compound 6b dose-dependently induces the acetylation level of alpha-tubulin via inhibition of HDAC6 in human neuroblastoma SH-SY5Y cell line. Moreover, compound 6b efficiently reverses methamphetamine-induced morphol. changes of SH-SY5Y cells via regulating acetylation landscape of α-tubulin. Collectively, compound 6b represents a novel HDAC6-isoform selective inhibitor and demonstrates promising therapeutic potential for the treatment of methamphetamine addiction. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Computed Properties of C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Computed Properties of C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Wang, Kai-Min; Du, Lin; Ma, Yu-Lu; Zhao, Qi-Hua published 《A dual-functional cadmium(II) coordination polymer as a luminescent sensor for selective sensing of iron(III) ions and detecting the temperature》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Safety of Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

A Cd(II) coordination polymer (1), {[Cd2(Ccbp)2(dca)Cl(H2O)3]·4H2O} Ccbp- = 4-carboxy-1-(3-carboxybenzyl)pyridin-1-ium and dca- = dicyanamide, has been synthesized via a hydrothermal reaction and fully characterized by single-crystal x-ray structural anal., FTIR spectroscopy, powder X-ray diffraction, and TGA. Complex 1 has a 2D network structure with uncoordinated functional groups. Its solid-state luminescence properties were measured at room temperature Complex 1 exhibited a high sensitivity for Fe3+ in DMF solutions of mixed metal ions. In addition, the temperature-dependent luminescence properties of 1 have been investigated and show that the complex acts as a luminescent thermometer at 10-90 K. In the part of experimental materials, we found many familiar compounds, such as Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Safety of Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Safety of Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《A Responsive Magnetic Resonance Imaging Contrast Agent for Detection of Excess Copper(II) in the Liver In Vivo》 were Paranawithana, Namini N.; Martins, Andre F.; Clavijo Jordan, Veronica; Zhao, Piyu; Chirayil, Sara; Meloni, Gabriele; Sherry, A. Dean. And the article was published in Journal of the American Chemical Society in 2019. Related Products of 1129-28-8 The author mentioned the following in the article:

The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL1) has high selectivity for copper ions and exhibits a 43% increase in r1 relaxivity (20 MHz) upon binding to 1 equiv of Cu2+ in aqueous buffer. Interestingly, in the presence of physiol. levels of human serum albumin (HSA), the r1 relaxivity is amplified further up to 270%. Addnl. spectroscopic and X-ray absorption spectroscopy (XAS) studies show that Cu2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu2+-HSA). T1-weighted in vivo imaging demonstrates that GdL1 can detect basal, endogenous labile copper(II) ions in living mice. This offers a unique opportunity to explore the role of copper ions in the development and progression of neurol. diseases such as Wilson’s disease. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Related Products of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Related Products of 1129-28-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: Methyl 3-(bromomethyl)benzoateIn 2018 ,《A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry. The article was written by Xu, Guangwei; Wang, Tianqi; Li, Yongtao; Huang, Zhi; Wang, Xin; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong. The article contains the following contents:

Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clin. IDO1 drugs show marginal efficacy as single agents. On basis of mol. docking and pharmacophore modeling, a novel inhibitor Roxyl-WL was discovered with a half maximal inhibitory concentration (IC50) value of 1 nM against IDO1 and 10-100-fold increased potent activity compared with IDO1 drugs in clin. trials. Roxyl-WL displayed excellent kinase spectrum selectivity with no activity out of the 337 protein kinases. In vitro, Roxyl-WL effectively augmented the proliferation of T cells and reduced the number of regulatory T cell (Tregs). When administered to melanoma (B16F10) tumor-bearing mice orally, Roxyl-WL significantly suppressed tumor growth and induced immune response. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Name: Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mondal, Anirban; Visser, Paco; Doze, Anna M.; Buter, Jeffrey; Feringa, Ben L. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Pd-catalyzed sp-sp3 cross-coupling of benzyl bromides using lithium acetylides》.COA of Formula: C9H9BrO2 The article contains the following contents:

An efficient method for the cross-coupling of benzyl bromides (sp3) with lithium acetylides (sp) was developed to obtain benzylic alkynes I [R = H, 3-MeO, 4-Me, etc.; R1 = Si(CH3)3, Si(i-Pr)3, Ph, 9-phenanthryl]. The reaction proceeded within 10 min at room temperature and could be performed in the presence of organolithium-sensitive functional groups such as esters, nitriles, amides and boronic esters. The potential application of the methodol. was demonstrated in the preparation of key intermediates used in pharmaceuticals, chem. biol. and natural products. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8COA of Formula: C9H9BrO2)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. COA of Formula: C9H9BrO2 Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Cui, Yuxiao; Zhao, Wenjie; Ogasawara, Shin; Wang, Xiao-Feng; Tamiaki, Hitoshi published 《Fabrication and performance of all-solid-state dye-sensitized solar cells using synthetic carboxylated and pyridylated chlorophyll derivatives》.Journal of Photochemistry and Photobiology, A: Chemistry published the findings.Name: Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:

All-solid-state dye-sensitized solar cells (DSSCs) based on a mesoporous TiO2 electrode were fabricated using synthetic chlorophyll derivatives as a photosensitizer and 2,2′,7,7′-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9′-spirobifluorene as a hole-transport material. Me pyropheophorbides-a possessing a carboxy group in the C3-substituent as the anchoring moiety to the TiO2 surface were effective DSSCs. Direct conjugation of the COOH group with the terminus of the C3-vinyl group gave the highest solar energy-to-electricity conversion efficiency (η) of 2.25%. Insertion of a 1,3-phenylene group in the connection partially suppressed the efficiency by 25% (η = 1.68%), whereas insertion of an isomeric 1,4-phenylene moiety decreased to one third (0.75%). A pyridyl group was not useful as the sensitizer anchor due to its low binding affinity to the TiO2 electrode. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Name: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Name: Methyl 3-(bromomethyl)benzoate Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Ya-Syuan; Liang, Chien-Fu published an article in Journal of the Chinese Chemical Society (Weinheim, Germany). The title of the article was 《Cerium(III) triflate-catalyzed cycloaddition reaction in aqueous conditions to substituted naphthotriazolediones》.Recommanded Product: Methyl 3-(bromomethyl)benzoate The author mentioned the following in the article:

In this study, the cerium(III) trifluoromethanesulfonate-catalyzed cycloaddition of 1,4-naphthoquinone with functionalized azides in aqueous solutions was used to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives Moreover, this method boasts scalability and completes the synthesis of two key biol. compounds This method’s advantages are environmentally friendly reaction conditions, easy applicability in large-scale operations, broad structurally diverse products produced in high yields and the recyclability of catalysts. In the experiment, the researchers used many compounds, for example, Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: Methyl 3-(bromomethyl)benzoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Tang, Qianyun; Xiao, Wanyue; Li, Jiewei; Chen, Dapeng; Zhang, Yewei; Shao, Jinjun; Dong, Xiaochen published 《A fullerene-rhodamine B photosensitizer with pH-activated visible-light absorbance/fluorescence/photodynamic therapy》.Journal of Materials Chemistry B: Materials for Biology and Medicine published the findings.Application of 1129-28-8 The information in the text is summarized as follows:

The development of smart photosensitizers with tumor microenvironment-activable fluorescence turn-on and singlet oxygen generation plays an important role in tumor bioimaging and photodynamic therapy. Herein, a pH-activable heavy-atom-free photosensitizer (C60-RB) has been successfully synthesized through introducing a fullerene unit onto rhodamine B hydrazide. Under acidic conditions, C60-RB, having a spirolactam structure, can be activated to its ring-opened structure C60-RB-H and thus, visible-light absorbance enhancement, fluorescence turn-on and triplet excited state generation can be accomplished. In the presence of hydrion, the fullerene unit in C60-RB C60-RB-H acting as an intramol. spin converter can cause good intersystem crossing, and the energy gap between S1 and T1 (ΔEST) is lowered to 0.017 eV. Through encapsulation with amphiphilic DSPE-mPEG2000, water-soluble nanoparticles (NPs) of C60-RB are obtained. In vitro experiments indicate that C60-RB NPs are capable of universal cellular uptake and lysosomal activation (pH 4.5-5.0), and they also exhibit excellent photodynamic therapeutic effect. The fluorescence turn-on and efficient singlet oxygen generation enabled by pH-activated C60-RB NPs testify their great potential applications for cancer diagnosis and treatment. The experimental process involved the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application of 1129-28-8)

Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Application of 1129-28-8 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary