20469-65-2 Archives - Page 7 of 13 - Bromides-buliding-blocks

Rojo, Pep team published research in Organic Letters in 2021 | 20469-65-2

Recommanded Product: 1-Bromo-3,5-dimethoxybenzene, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Organic compounds having carbon bonded to bromine are called organic bromides. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 1-Bromo-3,5-dimethoxybenzene.

Rojo, Pep;Riera, Antoni;Verdaguer, Xavier research published 《 BOM-Phosphinite as an Electrophilic P-Stereogenic Transfer Reagent for the Synthesis of Bulky Phosphines: Synthesis of tert-Butyl(3,5-di-tert-butylphenyl)BisP*》, the research content is summarized as follows. BOM-tert-butylmethylphosphinite borane is an efficient electrophilic P-stereogenic transfer reagent for the synthesis of bulky tertiary phosphines. The novel methodol. relies on a one-pot deprotection/substitution on the trivalent phosphinite that takes place with very high stereospecificity. The potential of this strategy is demonstrated with the synthesis of a wide scope of tertiary phosphines in excellent enantiomeric excess. The methodol. was applied to the synthesis of a bulky P-stereogenic BisP* ligand analog.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Percec, Virgil team published research in Journal of the American Chemical Society in 2021 | 20469-65-2

20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., Computed Properties of 20469-65-2

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Computed Properties of 20469-65-2.

Percec, Virgil;Wang, Shitao;Huang, Ning;Partridge, Benjamin E.;Wang, Xuefeng;Sahoo, Dipankar;Hoffman, David J.;Malineni, Jagadeesh;Peterca, Mihai;Jezorek, Ryan L.;Zhang, Na;Daud, Hina;Sung, Paul D.;McClure, Emily R.;Song, Se Lin research published 《 An Accelerated Modular-Orthogonal Ni-Catalyzed Methodology to Symmetric and Nonsymmetric Constitutional Isomeric AB₂ to AB₉ Dendrons Exhibiting Unprecedented Self-Organizing Principles》, the research content is summarized as follows. Three libraries consisting of 30 sym. and nonsym. constitutional isomeric phenolic acids with unprecedented sequenced patterns, including two AB₂, three AB₃, eight AB₄, five AB₅, six AB₆, three AB₇, two AB₈, and one AB₉ synthesized by accelerated modular-orthogonal Ni-catalyzed borylation and cross-coupling were reported. A single etherification step with 4-(n-dodecyloxy)benzyl chloride transformed all these phenolic acids, of interest also for other applications, into self-assembling dendrons. Despite this synthetic simplicity, they led to a diversity of unprecedented self-organizing principles: lamellar structures of interest for biol. membrane mimics, helical columnar assemblies from rigid-solid angle dendrons forming Tobacco Mosaic Virus-like assemblies, columnar organizations from adaptable-solid angle dendrons forming disordered micellar-like nonhelical columns, columns from supramol. spheres, five body-centered cubic phases displaying supramol. orientational memory, rarely encountered in previous libraries forming predominantly Frank-Kasper phases, and two Frank-Kasper phases. Lessons from these self-organizing principles, discovered within a single generation of self-assembling dendrons, might help elaborate design principles for complex helical and nonhelical organizations of synthetic and biol. matter.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mou, Ze-Dong team published research in Advanced Synthesis & Catalysis in 2021 | 20469-65-2

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. COA of Formula: C8H9BrO2.

Mou, Ze-Dong;Wang, Jia-Xi;Zhang, Xia;Niu, Dawen research published 《 Stereoselective Preparation of C-Aryl Glycosides via Visible-Light-Induced Nickel-Catalyzed Reductive Cross-Coupling of Glycosyl Chlorides and Aryl Bromides》, the research content is summarized as follows. A nickel-catalyzed cross-coupling reaction of glycosyl chlorides with aryl bromides has been developed. The reaction proceeds smoothly under visible-light irradiation and features the use of bench-stable glycosyl chlorides, allowing the highly stereoselective synthesis of C-aryl glycosides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miller-Clark, Lyndsy A. team published research in Dalton Transactions in 2022 | 20469-65-2

Application In Synthesis of 20469-65-2, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 20469-65-2, formula is C8H9BrO2, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 20469-65-2

Miller-Clark, Lyndsy A.;Christ, Peter E.;Ren, Tong research published 《 Diruthenium aryl compounds – tuning of electrochemical responses and solubility》, the research content is summarized as follows. Reported herein are the two new series of diruthenium aryl compounds I, [Ru(μ-DiMeOap)₄RuAr] [DiMeOap = 2-(3,5-dimethoxyanilino)pyridinate; 1a–6a, X = 3,5-(MeO)₂; Ar = 4-Me₂C₆H₄, ^tBuC₆H₄, 4-MeOC₆H₄, 3,5-(MeO)₂C₆H₃, 4-F₃CC₆H₄, Ph] and [Ru₂(m-ⁱPrOap)₄(Ar)] [1b–5b; m-ⁱPrOap = 2-(3-iso-propoxyanilino)pyridinate; X = 3-ⁱPrO], prepared through the lithium-halogen exchange reaction with a variety of aryl halides ArX. The mol. structures of these compounds were established with X-ray diffraction studies. Addnl., these compounds were characterized using electronic absorption and voltammetric techniques. Compounds 1a–6a and 1b–5b are all in the Ru₂⁵⁺ oxidation state, with a ground state configuration of σ²π⁴δ²(π*δ*)³ (S = 3/2). Use of the modified ap ligands resulted in moderate increases of product yield when compared to the unsubstituted Ru₂(ap)₄(Ar) (ap = 2-anilinopyridinate) series. Comparisons of the electrochem. properties of 1a–6a and 1b–5b against the Ru₂(ap’)Cl starting material reveals the addition of the aryl ligand cathodically shifted the Ru₂^6+/5+ oxidation and Ru₂^5+/4+ reduction potentials. These oxidation and reductions potentials are also strongly dependent on the p-substituent of the axial aryl ligands.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Marcyk, Paul T. team published research in Journal of Medicinal Chemistry in 2021 | 20469-65-2

Marcyk, Paul T.;LeBlanc, Emmanuelle V.;Kuntz, Douglas A.;Xue, Alice;Ortiz, Francisco;Trilles, Richard;Bengtson, Stephen;Kenney, Tristan M. G.;Huang, David S.;Robbins, Nicole;Williams, Noelle S.;Krysan, Damian J.;Prive, Gilbert G.;Whitesell, Luke;Cowen, Leah E.;Brown, Lauren E. research published 《 Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity》, the research content is summarized as follows. The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has been precluded by human host toxicities and suppression of immune responses. We recently described resorcylate aminopyrazoles (RAPs) as the first class of Hsp90 inhibitors capable of discriminating between fungal (Cryptococcus neoformans, Candida albicans) and human isoforms of Hsp90 in biochem. assays. Here, we report an iterative structure-property optimization toward RAPs capable of inhibiting C. neoformans growth in culture. In addition, we report the first X-ray crystal structures of C. neoformans Hsp90 nucleotide binding domain (NBD), as the apoprotein and in complexes with the non-species-selective Hsp90 inhibitor NVP-AUY922 and three RAPs revealing unique ligand-induced conformational rearrangements, which reaffirm the hypothesis that intrinsic differences in protein flexibility can confer selective inhibition of fungal vs. human Hsp90 isoforms.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Matsuki, Hironori team published research in Angewandte Chemie, International Edition in 2021 | 20469-65-2

Matsuki, Hironori;Okubo, Keisuke;Takaki, Yuta;Niihori, Yoshiki;Mitsui, Masaaki;Kayahara, Eiichi;Yamago, Shigeru;Kobayashi, Kenji research published 《 Synthesis and Properties of a Cyclohexa-2,7-anthrylene Ethynylene Derivative》, the research content is summarized as follows. The synthesis of a cyclohexa-2,7-(4,5-diaryl)anthrylene ethynylene was achieved for the first time by using 1,8-diaryl-3,6-diborylanthracene and 1,8-diaryl-3,6-diiodoanthracene as key synthetic intermediates. The macrocycle possesses a planar conformation of approx. D_6h symmetry, because of the triple-bond linker between the anthracene units at the 2,7-positions. It was confirmed that macrocycle , bearing bulky substituents at the outer peripheral positions, behaves as a monomeric form in solution without π-stacking self-association Macrocycle has an inner-cavity size that allows specific inclusion of [9]cycloparaphenylene ([9]CPP), but not [8]CPP or [10]CPP, through an aromatic edge-to-face CH-π interaction.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Xu team published research in Organic Letters in 2021 | 20469-65-2

Lu, Xu;Kawazu, Ryohei;Song, Jizhou;Yoshigoe, Yusuke;Torigoe, Takeru;Kuninobu, Yoichiro research published 《 Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins》, the research content is summarized as follows. A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. ¹H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ma, Teng team published research in Chinese Journal of Chemistry in | 20469-65-2

Name: 1-Bromo-3,5-dimethoxybenzene, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 20469-65-2, formula is C8H9BrO2, Name is 1-Bromo-3,5-dimethoxybenzene, Name: 1-Bromo-3,5-dimethoxybenzene

Ma, Teng;Li, Xiao;Ping, Yuanyuan;Kong, Wangqing research published 《 Synthesis of gem-Difluoroalkenes via Ni-Catalyzed Three-Component Defluorinative Reductive Cross-Coupling of Organohalides, Alkenes and Trifluoromethyl Alkenes》, the research content is summarized as follows. Gem-Difluoroalkenes are considered ideal isosteres for metabolically susceptible carbonyl groups in modern drug discovery and medicinal chem. In addition, gem-difluoroalkenes are used as versatile precursors for the synthesis of difluoroalkylated compounds and monofluoroalkenes. Therefore, a great deal of effort has been devoted to developing efficient methods for their preparation The catalytic defluorinative functionalization of trifluoromethyl alkenes represents a useful strategy for the preparation of chiral gem-difluoroalkenes. However, most of these catalytic processes are still essentially limited to two-component defluorinative cross-couplings to form single C-C bonds. Due to the challenge of controlling chemoselectivity in the carbon-carbon bond forming events, three-component defluorinative cross-coupling involving multiple C-C bond formations has rarely been studied. Authors report a nickel-catalyzed three-component defluorinative reductive cross-coupling of organohalides, alkenes and trifluoromethyl alkenes. A variety of electron-rich and electron-deficient alkenes, as well as aryl and alkyl halides can efficiently participate in the formation of three-component cross-coupling products. This reaction proceeds under mild conditions and exhibits excellent functional group compatibility without requiring a pendant chelating group, providing a variety of functionalized gem-difluoroalkenes in good yields with excellent chemoselectivity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Cheng-Kun team published research in Synthesis in 2022 | 20469-65-2

Safety of 1-Bromo-3,5-dimethoxybenzene, 1-Bromo-3,5-dimethoxybenzene, also known as 1-Bromo-3,5-dimethoxybenzene, is a useful research compound. Its molecular formula is C8H9BrO2 and its molecular weight is 217.06 g/mol. The purity is usually 95%.
1-Bromo-3,5-dimethoxybenzene is used as an intermediate in the synthetic preparation of pharmaceutical inhibitors via cross-coupling reactions.
1-Bromo-3,5-dimethoxybenzene can be synthesized by using 1,3-dimethoxybenzene via iridium-catalyzed arene borylation.
1-Bromo-3,5-dimethoxybenzene (1BDMB) is a synthetic molecule that can be used as an electron acceptor in organic photovoltaic cells. 1BDMB is a salt of the sodium salt of resorcylic acid and 1,3-dibromo-5,5-dimethoxybenzene. It has been shown to have a radical mechanism for the generation of free radicals. The radical mechanism is initiated by light absorption by the ruthenium complex at the center of the molecule which induces photoinduced electron transfer from the ruthenium to 1BDMB. This process results in electron transfer from the donor to an acceptor molecule, such as oxygen or nitrogen. The pharmacokinetic properties of this compound are not well known; however, it has been demonstrated that it can be synthesized through a cross-coupling reaction with other aromatic compounds such as stemofuran., 20469-65-2.

Lin, Cheng-Kun;Hsieh, Bing-Han;Wu, Chun-Fu research published 《 Total Synthesis of Citreochlorol Monochloro Analogues via a Catalytically Enantioselective Carbonyl Allylation》, the research content is summarized as follows. An efficient synthetic route to citreochlorol analogs, halogenated polyketide secondary metabolites, was described. The key features were Krische’s enantioselective carbonyl allylation, IBr-promoted cyclization and regioselective epoxide opening. The importance of the route lies in accessing a versatile epoxy ether that enables the formation of citreochlorol monochloro derivatives

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Hao team published research in Luminescence in 2021 | 20469-65-2

Liu, Hao;Su, Huan;Chen, Zhiyuan;Zhu, Senqiang;Liu, Rui;Zhu, Hongjun research published 《 Meso-substituted boron-dipyrromethene compounds: synthesis, tunable solid-state emission, and application in blue-driven LEDs》, the research content is summarized as follows. In this work, we depict the synthesis and characterization of a series of meso-substituted boron-dipyrromethene (BODIPY) compounds Their optical and electrochem. properties were investigated systematically. All these compounds exhibited intense absorption bands in the UV and visible regions, which arise from the π-π* transitions based on their BODIPY core segments. By comparing electron-withdrawing substituents and electron-donating substituents, we found that these compounds exhibited some similar photophys. properties but exhibited different fluorescence in the solid state. All compounds were highly emissive in dichloromethane at room temperature (λ_em = 512-523 nm, Φ_PL > 0.9). When these compounds were applied in blue-driven light-emitting diodes (LEDs) as light-emitting materials, the devices showed luminescence efficiency ranging from 1.09 to 34.13 lm/W. Their luminescence and electrochem. properties could be used for understanding the structure-property relationship of BODIPY compounds and developing functional fluorescent materials.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary