Category: 20776-50-5

Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong published the artcile< Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita>, Category: bromides-buliding-blocks, the main research area is benzotriazinone dihydrothiazole thiol preparation nematocidal activity.

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol I (R = H, 5-OMe, 7-F, 8-NO2, etc.) was synthesized. The bioassay results showed that compounds I (R = 7-OMe, 6-NO2, 7-Cl (A)) exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound (A) showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Benzotriazines Role: AGR (Agricultural Use), BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mu, Binsong; Zhang, Le; Lv, Guanghui; Chen, Kang; Wang, Ting; Chen, Jian; Huang, Tianle; Guo, Li; Yang, Zhongzhen; Wu, Yong published the artcile< Access to Phosphine-Containing Quinazolinones Enabled by Photo-Induced Radical Phosphorylation/Cyclization of Unactivated Alkenes>, Formula: C7H6BrNO2, the main research area is iridium catalyzed phosphorylation photocyclization unactivated alkene phosphine oxide phosphite; quinazolinone phosphine containing preparation.

A mild and facile photo-induced cascade radical addition/cyclization of unactivated alkenes is reported, through which a variety of biol. valuable phosphine-containing quinazolinones could be obtained in moderate to good yields. The protocol was characterized by mild conditions, broad substrate scope, and high at. economy.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (unactivated). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Formula: C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Khalifa, Muhammad M.; Philkhana, Satish Chandra; Golden, Jennifer E. published the artcile< Synthesis of Ring-Fused, N-Substituted 4-Quinolinones Using pKa-Guided, Base-Promoted Annulations with Isatoic Anhydrides: Total Synthesis of Penicinotam>, Related Products of 20776-50-5, the main research area is isatoic anhydride ketone base promoted anionic annulation; quinolinone preparation; penicinotam total synthesis.

An anionic annulation strategy employing isatoic anhydrides and a wide assortment of enolizable partners was developed to afford over 80 novel ring-fused, N-substituted 4-quinolinones, an underrepresented privileged template. Multiple factors governing the efficiency of the transformation were determined, resulting in a reliable and tunable synthetic platform applicable for a broad range of substrates with variable deprotonation susceptibility, such as tetramic and tetronic acids, cyclic 1,3-diketones, and cycloalkanones. Application to the synthesis of bioactive, pyrrolizine-fused 4-quinolinone, penicinotam I, resulted in the most brief and highest yielding total synthesis of the alkaloid in three steps and a 36% overall yield.

Journal of Organic Chemistry published new progress about Cyclization. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Related Products of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Lei; Zhang, Wangqin; Xu, Chao; He, Jiaying; Xu, Zhenhui; Yang, Zehui; Ling, Fei; Zhong, Weihui published the artcile< Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene>, HPLC of Formula: 20776-50-5, the main research area is alkenyl quinazolinone sodium triflinate electrochem tandem trifluoromethylation cyclization; trifluoroethyl fused quinazolinone preparation.

An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkenes with Langlois reagent as a CF3 source was described. A variety of polycyclic quinazolinones were successfully synthesized in 52-81% yields under transition metal- and oxidant-free conditions. The Langlois reagent used in this strategy as a CF3 reagent possessed the advantages of bench-stablity, cost-effectivity and high-efficiency. Addnl., gram-scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol.

Advanced Synthesis & Catalysis published new progress about Electrochemical cyclization. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, HPLC of Formula: 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kong, Xiang-Fei; Guo, Xiu-Yun; Gu, Zi-Yu; Wei, Lin-Su; Liu, Lu-Lu; Mo, Dong-Liang; Pan, Cheng-Xue; Su, Gui-Fa published the artcile< Silver(I)-catalyzed selective hydroalkoxylation of C2-alkynyl quinazolinones to synthesize quinazolinone-fused eight-membered N,O-heterocycles>, Category: bromides-buliding-blocks, the main research area is quinazoline fuse oxygen nitrogen heterocycle preparation antiiflammation.

A silver-catalyzed hydroalkoxylation of C2-alkynyl quinazolinones to prepare a series of novel quinazolinone-fused eight-membered N,O-heterocycles I [X = O, N; R1 = H, 12-Me, 12-MeO, etc; R2 = H, 2-MeO, 2-Br, etc; R3=R4 = H, Me, etc; R5 = H, n-pentyl, Ph, etc] in good-to-excellent yields through a selective 8-endo-dig cyclization. Mechanistic studies revealed that the silver catalyst might aid bidentate coordination of an imine group and alkyne to facilitate 8-endo-dig cyclization to afford eight-membered N,O-heterocycles I. Also, the proposed bimetal silver intermediates might promote hydroalkoxylation rapidly for quinazolinones bearing terminal alkynes at the C2-position. Biol. evaluations revealed that most of the designed quinazolinone-fused eight-membered N,O-heterocycles I inhibited nitric-oxide generation significantly in lipopolysaccharide-stimulated RAW264.7 cells and displayed their bioactivity as potentially good anti-inflammatory agents.

Organic Chemistry Frontiers published new progress about Alkoxylation catalysts, reductive (regioselective). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Larson, Peter G.; Ferguson, David M. published the artcile< 4-Amino-2-butyl-7-methoxycarbonylthiazolo[4,5-c]quinoline>, Quality Control of 20776-50-5, the main research area is thaizoloquinoline preparation; carbonylation palladium catalyst.

4-Amino-imidazo-, oxazolo-, and thiazoloquinolines are key structural scaffolds in the design of nucleoside base analogs for use as therapeutic agents. Current strategies for arriving at diverse substitutions at the C6-C9 positions of the thiazolo- and oxazoloquinolines, however, are limited due to difficulties in arriving at the thiazoloquinoline-5N-oxide intermediate using electron deficient aromatic systems. Here, authors demonstrate a synthetic route to obtain substituted thiazoloquinolines with electron-withdrawing groups at the C7 position. The target compound, 4-amino-2-butyl-7-methoxycarbonylthiazolo[4,5-c]quinoline, is obtained in eight steps using a 7-bromo surrogate as a precursor to the successful generation of the N-oxide intermediate, and final transformation via Pd-mediated C7-acylation.

Molbank published new progress about Carbonylation. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Quality Control of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Jin; Sun, Bin; Ding, Hao; Huang, Pan-Yi; Tang, Xiao-Li; Shi, Rong-Cheng; Yan, Zhi-Yang; Yu, Chuan-Ming; Jin, Can published the artcile< Photo-triggered self-catalyzed fluoroalkylation/cyclization of unactivated alkenes: synthesis of quinazolinones containing the CF2R group>, Computed Properties of 20776-50-5, the main research area is alkenyl quinazolinone fluoroalkyl bromide tandem photochem fluoroalkylation radical cyclization; fluoroalkyl fused quinazolinone preparation green chem.

A novel photo-triggered self-catalyzed fluoroalkylation/cyclization of quinazolinones containing unactivated alkenes with various fluoroalkyl bromides was developed. This transformation exhibited excellent substrate generality with respect to both the coupling partners. This was the first example describing the Csp3-Br bond homolysis of alkyl bromides via a substrate (quinazolinones) induced energy transfer process. Addnl., the mild conditions, tolerance to a wide range of functional groups and operational simplicity make this protocol practical for the synthesis of fluorine-containing ring-fused quinazolinones.

Green Chemistry published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Computed Properties of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Bin; Tang, Xiaoli; Shi, Rongcheng; Yan, Zhiyang; Li, Bingqian; Tang, Chen; Jin, Can; Wu, Chunlei L.; Shen, Runpu P. published the artcile< Self-photocatalyzed Homolytic Dehalogenative Alkylation/Cyclization of Unactivated Alkenes Based on the Quinazolinone Skeleton via Energy Transfer>, SDS of cas: 20776-50-5, the main research area is alkyl quinazolinone preparation regioselective green chem energy transfer; unactivated alkene halide dehalogenative alkylation cyclization self photocatalysis.

A mild, external photocatalyst- and additive-free protocol for photo-induced alkylation/cyclization of unactivated alkenes with halides has been developed. This strategy showed excellent regioselectivity and simple operation to synthesize alkyl-substituted quinazolinones with a broad substrate scope. More importantly, chlorinated alkanes were also compatible with this transformation.

Asian Journal of Organic Chemistry published new progress about Bromoalkanes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, SDS of cas: 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Bin; Ding, Hao; Tian, Hai-Xia; Huang, Pan-Yi; Jin, Can; Wu, Chun-Lei; Shen, Run-Pu published the artcile< Photo-Triggered Self-Induced Homolytic Dechlorinative Sulfonylation/Cyclization of Unactivated Alkenes: Synthesis of Quinazolinones Containing a Sulfonyl Group>, Formula: C7H6BrNO2, the main research area is quinazolinone containing sulfonyl group regioselective preparation photochem green chem; sulfonyl chloride quinazolinone tandem sulfonylation heterocyclization energy transfer photocatalyst.

A self-photocatalyzed sulfonylation/cyclization of quinazolinones containing unactivated alkenes with various sulfonyl chlorides was developed. The protocol provided access to sulfonyl radicals via energy transfer from quinazolinone skeleton to sulfonyl chloride. Notably, transformations proceeded without any external photocatalysts, additives, or oxidants, providing an alternative method for fabricating sulfonylated compounds I [R = Et, cyclopropyl, Ph, etc.; R1 = H, 3-F, 2-MeO, etc.; n = 0, 1].

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Formula: C7H6BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anh, Duong T.; Hai, Pham-The; Huy, Le D.; Ngoc, Hoang B.; Ngoc, Trinh T. M.; Dung, Do T. M.; Park, Eun J.; Song, In K.; Kang, Jong S.; Kwon, Joo-Hee; Tung, Truong T.; Han, Sang-Bae; Nam, Nguyen-Hai published the artcile< Novel 4-Oxoquinazoline-Based N-Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation>, Category: bromides-buliding-blocks, the main research area is oxoquinazoline hydroxypropenamide preparation histone deacetylase inhibitor antitumor mol docking.

Two series of novel 4-oxoquinazoline-based N-hydroxypropenamides I (R = Et, Bn, 4-FC6H5, etc.) and II were designed, synthesized, and evaluated for their inhibitory and cytotoxicity activities against histone deacetylase (HDAC). The compounds showed good to potent HDAC inhibitory activity and cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung cancer). In this series, compounds with the N-hydroxypropenamide functionality impeded at position 7 on the 4-oxoquinazoline skeleton II were generally more potent than compounds I with the N-hydroxypropenamide moiety at position 6. Also, the N3-benzyl-substituted derivatives exhibited stronger bioactivity than the N3-alkyl-substituted ones. Two compounds II (R = 4-ClC6H5, and R = 4-MeC6H5) were the most potent ones. Their HDAC inhibitory activity (IC50 values, 0.041-0.044μM) and cytotoxicity (IC50 values, 0.671-1.211μM) was approx. 2- to 3-fold more potent than suberoylanilide hydroxamic acid (SAHA). Some compounds showed up to 10-fold more potent HDAC6 inhibition compared to their inhibitory activity in total HDAC extract assay. Anal. of selected compounds II (R = 4-ClC6H5, and R = 4-MeC6H5) revealed that these compounds strongly induced both early and late apoptosis and arrested SW620 cells at the G2/M phase. Docking studies were carried out on the HDAC6 isoform for series II and revealed some important features contributing to the inhibitory activity of synthesized compounds

ACS Omega published new progress about Antitumor agents. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary