Category: 21865-50-9

Application of 21865-50-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21865-50-9 as follows.

General procedure: A mixture of starting compound (2.69 mmol), CuCl2.2H2O (10 mol %) in DMSO (5 mL) stirred at 100 C. The reaction progress was monitored by thin layer chromatography (PMA was used for stain solution). The reaction mixture was poured into ice cold water. The crude product was purified by column chromatography using ethyl acetate and petroleum ether as eluent to afford carbazoles.

According to the analysis of related databases, 21865-50-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dalvi, Bhakti A.; Lokhande, Pradeep D.; Tetrahedron Letters; vol. 59; 22; (2018); p. 2145 – 2149;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H12BrN

To a solution of 6-bromo-2,3,4,9-tetrahydro-lH-carbazole (150 mg, 0.61 mmol) inDMF (5 ml) was added NaH (60% in mineral oil, 37 mg, 0.92 mmol) and tetrabutylammonium iodide (340 mg, 0.92 mmol). The resulting mixture was stirred at room temperature for 10 min and followed by addition of l-(3-chloropropoxy)-3,5- dimethylbenzene (121 mg, 0.61 mmol). The reaction mixture was stirred at room temperature overnight, poured into H2O (30 ml), and extracted with EtOAc (3 x 30 ml). The organic layers were combined, dried over MgSO4, filtered and cone, in vacuo. The crude product was purified by silica gel flash chromatography (EtOAc/hexane, 0-20%) to give the title compound (colorless oil, 182 mg). The yield: 72.4%.

The synthetic route of 21865-50-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ITHERX PHARMACEUTICALS, INC.; WO2009/103022; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary