Category: 2252-45-1

Abram, Michal; Rapacz, Anna; Mogilski, Szczepan; Latacz, Gniewomir; Lubelska, Annamaria; Kaminski, Rafal M.; Kaminski, Krzysztof published the artcile< Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents>, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is epilepsy neuropathic pain anticonvulsant antinociceptive multitargeted drugs hybrid compound; Hybrid compounds; anticonvulsant activity; antinociceptive activity; epilepsy; multitargeted drugs; neuropathic pain.

We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (scPTZ), and the 6 Hz (32 mA) seizures. Compound 22(I) showed the most potent anticonvulsant activity (ED50 MES = 23.7 mg/kg, ED50 6 Hz (32 mA) = 22.4 mg/kg, ED50scPTZ = 59.4 mg/kg). In addition, 22 revealed potent efficacy in the formalin-induced tonic pain. These in vivo activities of 22 are likely mediated by several targets and may result from the inhibition of central sodium/calcium currents and transient receptor potential vanilloid 1 (TRPV1) receptor antagonism. Finally, the lead compound 22 revealed drug-like absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) properties in the in vitro assays, making it a potential candidate for further development in epilepsy and neuropathic pain indications.

ACS Chemical Neuroscience published new progress about Analgesics. 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Recommanded Product: (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koziakov, Denis; Majek, Michal; Jacobi von Wangelin, Axel published the artcile< Radical Aromatic Trifluoromethylthiolation: Photoredox Catalysis vs. Base Mediation>, Safety of (3-Bromophenyl)(trifluoromethyl)sulfane, the main research area is aryl trifluoromethyl sulfide preparation; arenediazonium salt bistrifluoromethyl disulfide photoredox trifluoromethylthiolation.

Trifluoromethyl aryl sulfides (Ar-SCF3) constitute highly attractive building blocks due to their exceptional lipophilicity and chem. properties. Related protocols of radical aromatic trifluoro-methylthiolation of arenediazonium salts were developed that are based on the facile generation of intermediate aryl radicals. Their reactions with com. F3CS-SCF3 under very mild conditions afforded a diverse set of Ar-SCF3 (< 90 % yield). Direct comparison of photoredox catalysis {eosin Y or [Ru(bpy)3]Cl2} with the weak base-mediated dark reaction documented higher synthetic efficiency of the former but higher operational simplicity of the latter strategy. European Journal of Organic Chemistry published new progress about Diazonium compounds, arene, salts Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Safety of (3-Bromophenyl)(trifluoromethyl)sulfane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary