Category: 25195-52-2

Christiansen, Elisabeth’s team published research in ACS Medicinal Chemistry Letters in 2013 | CAS: 25195-52-2

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene

Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzeneOn May 9, 2013 ,《Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Christiansen, Elisabeth; Hansen, Steffen V. F.; Urban, Christian; Hudson, Brian D.; Wargent, Edward T.; Grundmann, Manuel; Jenkins, Laura; Zaibi, Mohamed; Stocker, Claire J.; Ullrich, Susanne; Kostenis, Evi; Kassack, Matthias U.; Milligan, Graeme; Cawthorne, Michael A.; Ulven, Trond. The article conveys some information:

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist (I) with favorable physicochem. and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing. In the experiment, the researchers used 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene)

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 1-Bromo-2-((methylsulfonyl)methyl)benzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fier, Patrick S.’s team published research in Journal of the American Chemical Society in 2019 | CAS: 25195-52-2

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 25195-52-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Fier, Patrick S.; Maloney, Kevin M. published an article on January 30 ,2019. The article was titled 《NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization》, and you may find the article in Journal of the American Chemical Society.Recommanded Product: 25195-52-2 The information in the text is summarized as follows:

Primary alkyl and aryl sulfonamides underwent chemoselective deamination reactions with benzaldehyde and K2CO3 in the presence of a pyrrolotriazolium chloride via N-benzylidenesulfonamides to yield sulfinate salts; the sulfinates were converted in situ to Me and aryl sulfones, sulfonic acids, and sulfonamides. Reaction of the sulfinates with MeI in DMF yielded Me sulfones, while oxidation with H2O2 in the presence of tungstic acid yielded sulfonic acids. Reaction of the sulfinate generated from celecoxib with 15NH4OH yielded the corresponding 15N-labeled sulfonamide; coupling reactions of the celecoxib-derived sulfinate with iodobenzene and a chloropyridine yielded aryl sulfones, while desulfonative coupling with Ph triflate yielded a biphenylpyrazole. The method tolerated nearly all common functional groups, including primary amines, and was used for the late-stage derivatization of several complex pharmaceutical compounds In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2Recommanded Product: 25195-52-2)

1-Bromo-2-((methylsulfonyl)methyl)benzene(cas: 25195-52-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Recommanded Product: 25195-52-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary