Category: 2567-29-5

On June 21, 2021, Zhang, Chun; Zhang, Chao; Tang, Jie; Ye, Shengqing; Ma, Mingliang; Wu, Jie published an article.HPLC of Formula: 2567-29-5 The title of the article was Synthesis of γ-Keto Sulfones through a Three-Component Reaction of Cyclopropanols, DABCO·(SO2)2 and Alkyl Halides. And the article contained the following:

A route to γ-keto sulfones RC(O)(CH2)2SO2R1 [R = 4-FC6H4, Bn, 2-naphthyl, etc.; R1 = Me, Bn, 4-BrC6H4CH2, etc.] through a metal-free reaction of cyclopropanols, DABCO·(SO2)2 and alkyl halides was described. This reaction occurs under mild conditions in the absence of any catalysts, additives, or oxidants. Various functional groups including as ester, amino, methoxy, bromo, trifluoromethyl, nitro and carbonyl were tolerated well in this transformation and the corresponding γ-keto sulfones were afforded in 35% to 95% yields. The proposed mechanism implies that this reaction proceeded through γ-keto sulfinate intermediate generated in situ, which further undergoes nucleophilic substitution with alkyl halides leading to γ-keto sulfones. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).HPLC of Formula: 2567-29-5

The Article related to gamma keto sulfone preparation, cyclopropanol alkyl halide dabco bissulfur dioxide three component, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On August 1, 2022, Djukanovic, Dimitrije; Ganiek, Maximilian A.; Nishi, Kohei; Karaghiosoff, Konstantin; Mashima, Kazushi; Knochel, Paul published an article.Electric Literature of 2567-29-5 The title of the article was Preparation of Functionalized Amides Using Dicarbamoylzincs. And the article contained the following:

Authors report a new convenient preparation of dicarbamoylzincs of type (R1R2NCO)2Zn by the treatment of ZnCl2 and formamides R1R2NCHO with LiTMP in THF (15°C, 15 min) or by the reaction of formamides R1R2NCHO with TMP2Zn (25°C, 16 h). This second method tolerates sensitive groups such as an ester, ketone or nitro function. Reaction of these dicarbamoylzincs with allylic, benzylic, aryl, alkenyl bromides, acid chlorides, aldehydes or enones provided various polyfunctional amides in 47-97% yields. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to amide preparation dicarbamoylzinc, amides, carbamoyl, lithium, metalation, zinc, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sisto, Francesca; Carradori, Simone; Guglielmi, Paolo; Traversi, Carmen Beatrice; Spano, Mattia; Sobolev, Anatoly P.; Secci, Daniela; Di Marcantonio, Maria Carmela; Haloci, Entela; Grande, Rossella; Mincione, Gabriella published an article in 2020, the title of the article was Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. pylori strains and AGS cell proliferation.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:

This study reports on the synthesis, structural assessment, microbiol. screening against several strains of H. pylori and antiproliferative activity against human gastric adenocarcinoma (AGS) cells of a large series of carvacrol-based compounds Structural analyses consisted of elemental anal., 1H/13C/19F NMR spectra and crystallog. studies. The structure-activity relationships evidenced that among ether derivatives the substitution with specific electron-withdrawing groups (CF3 and NO2) especially in the para position of the benzyl ring led to an improvement of the antimicrobial activity, whereas electron-donating groups on the benzyl ring and ethereal alkyl chains were not tolerated with respect to the parent compound (MIC/MBC = 64/64 μg/mL). Ester derivatives (coumarin-carvacrol hybrids) displayed a slight enhancement of the inhibitory activity up to MIC values of 8-16 μg/mL. The most interesting compounds exhibiting the lowest MIC/MBC activity against H. pylori (among others, compounds 16 and 39 endowed with MIC/MBC values ranging between 2/2 to 32/32 μg/mL against all the evaluated strains) were also assayed for their ability to reduce AGS cell growth with respect to 5-Fluorouracil. Some derivatives can be regarded as new lead compounds able to reduce H. pylori growth and to counteract the proliferation of AGS cells, both contributing to the occurrence of gastric cancer. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to helicobacter gastric adenocarcinoma cell proliferation, ags cells, helicobacter pylori, carvacrol, coumarin, drug resistance, dual agent, semi-synthesis, Placeholder for records without volume info and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 5, 2022, Sblano, Sabina; Cerchia, Carmen; Laghezza, Antonio; Piemontese, Luca; Brunetti, Leonardo; Leuci, Rosalba; Gilardi, Federica; Thomas, Aurelien; Genovese, Massimo; Santi, Alice; Tortorella, Paolo; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio published an article.Electric Literature of 2567-29-5 The title of the article was A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity. And the article contained the following:

The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of the side-effects showed by the currently marketed PPARγ full agonists, is considered the major challenge for the pharmaceutical companies. Here we present a chemoinformatics search approach for new ligands that let us identify a novel PPAR pan-agonist with a very attractive activity profile being able to reduce lipid accumulation and improve insulin sensitivity. This compound represents, therefore, the potential lead of a new class of drugs for treatment of dyslipidemic type 2 diabetes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to ppar pan agonist glucose uptake chemoinformatic docking, chemoinformatics search, docking experiments, glucose uptake, ppar pan-agonist, Placeholder for records without volume info and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 12, 2020, Ongwae, George M.; Morrison, Kelly R.; Allen, Ryan A.; Kim, Seonghoon; Im, Wonpil; Wuest, William M.; Pires, Marcos M. published an article.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Broadening Activity of Polymyxin by Quaternary Ammonium Grafting. And the article contained the following:

Bacterial pathogens continue to impose a tremendous health burden across the globe. Here, we describe a novel series of polymyxin-based agents grafted with membrane-active quaternary ammonium warheads to combine two important classes of Gram-neg. antimicrobial scaffolds. The goal was to deliver a targeted quaternary ammonium warhead onto the surface of bacterial pathogens using the outer membrane homing properties of polymyxin. The most potent agents resulted in new scaffolds that retained the ability to target Gram-neg. bacteria and had limited toxicity toward mammalian cells. We showed, using a mol. dynamics approach, that the new agents retained their ability to engage in specific interactions with lipopolysaccharide mols. Significantly, the combination of quaternary ammonium and polymyxin widens the activity to the pathogen Staphylococcus aureus. Our results serve as an example of how two membrane-active agents can be combined to produce a class of novel scaffolds with potent biol. activity. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to polymyxin quaternary ammonium grafting antibiotic, antibiotic, colistin, membrane, polymyxin, quarternary ammonium, Placeholder for records without volume info and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 2, 2021, Duran-Camacho, Geraldo; Ferguson, Devin M.; Kampf, Jeff W.; Bland, Douglas C.; Sanford, Melanie S. published an article.Recommanded Product: 2567-29-5 The title of the article was Isolable Pyridinium Trifluoromethoxide Salt for Nucleophilic Trifluoromethoxylation. And the article contained the following:

An isolable pyridinium trifluoromethoxide salt is prepared from the reaction of 4-dimethylaminopyridine with the com. available liquid 2,4-dinitro(trifluoromethoxy)benzene. The salt is an effective trifluoromethoxide source for SN2 reactions to form trifluoromethyl ethers. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Recommanded Product: 2567-29-5

The Article related to pyridinium trifluoromethoxide salt preparation trifluoromethoxylation reagent, alkyl halide pyridinium trifluoromethoxide salt trifluoromethoxylation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 15, 2022, Wang, Tingting; Dong, Jianhao; Yu, Na; Tang, Weiqin; Jin, Yaping; Xu, Yixin; Yang, Jingshuai published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis and properties of a new ether-free poly(bis-alkylpiperidinium) polymer for the anion exchange membrane. And the article contained the following:

Developing anion exchange membranes (AEMs) with high performance and excellent alk. stability is a huge challenge to the fuel cell. Herein, a new bispiperidinium compound is synthesized through a nucleophilic reaction between 4,4′-trimethylenebis (1-Me piperidine) and 4-bromomethylbiphenyl. Subsequently, a novel poly(bis-alkylpiperidinium) polymer (i.e. Tmmp-Bmb-TFAc) is synthesized through the Friedel-Crafts polycondensation of bispiperidinium monomer and 1,1,1-trifluoroacetone. The synthesized ether-free Tmmp-Bmb-TFAc contains two piperidinium cations per polymer repeat unit in the main chain, which thus is employed as the AEM. The obtained AEM exhibits high ionic exchange capacity of 2.25 mmol g-1, low volume swelling of 13.6% and moderate tensile strength of 12.3 MPa in Br- form simultaneously. Meanwhile, the Tmmp-Bmb-TFAc membrane achieves a high conductivity of 45.0 mS cm-1 at 80 °C and possesses an excellent alk. stability in 1 mol L-1 KOH at 60°C within 480 h. Furthermore, no degradation of the polymer backbone is detected by 1H NMR spectra when immersing the membrane in 1 mol L-1 KOH at 80°C. This work provides a gentle and facile approach on the design and preparation of ether-free AEMs with cations in the polymer main chain. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to bisalkylpiperidinium polymer preparation anion exchange membrane thermomech morphol property, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Zhongwen; Chen, Lijun; Qiu, Kaixiong; Liu, Bo; Li, Hongtao; Yu, Fang published an article in 2022, the title of the article was Enantioselective Peroxidation of C-alkynyl imines enabled by chiral BINOL calcium phosphate.Application of 2567-29-5 And the article contains the following content:

Herein, a catalytic enantioselective addition of C-alkynyl imines, generated in-situ from N,O-acetals R1CCCH(OEt)NHR2 (R1 = Me3Si, Ph, 2-ClC6H4, 1-naphthyl, 2-thienyl, 3-pyridinyl, etc., R2 = Boc; R1 = Ph, R2 = Teoc, PhCO, Fmoc, Cbz) with hydroperoxides R3OOH (R3 = t-Bu, PhCH2, EtMe2, etc.) catalyzed by chiral BINOL calcium phosphate, affording a broad range of enantioenriched α-peroxy propargylamines (R)-R1CCCH(OOR3)NHR2 in good yields (80-99%) with high enantioselectivities (up to 94% ee) is reported. The protocol is characterized by mild conditions, easy accessibility and good practicability. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application of 2567-29-5

The Article related to alkynyl amino peroxide asym synthesis, aminal alkynyl enantioselective peroxidation hydroperoxide binol calcium phosphate imine, Aliphatic Compounds: Peroxides and Hydroperoxides and other aspects.Application of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 7, 2021, Zhou, Shaofang; Lv, Kang; Fu, Rui; Zhu, Changlei; Bao, Xiaoguang published an article.Synthetic Route of 2567-29-5 The title of the article was Nickel/Photoredox Dual Catalytic Cross-Coupling of Alkyl and Amidyl Radicals to Construct C(sp3)-N Bonds. And the article contained the following:

The construction of C(sp3)-N bonds via direct radical-radical cross-coupling under benign conditions is a desirable but challenging approach. Herein, the cross-coupling of alkyl and amidyl radicals to build aliphatic C-N bonds in a concise, mild, and oxidant-free manner is implemented by nickel/photoredox dual catalysis. In this protocol, the single electron transfer strategy is successfully employed to generate N- and C-centered radicals from sulfonyl azides/azidoformates and alkyltrifluoroborates, resp. The photocatalyst-induced triplet-triplet energy-transfer mechanism, however, might not be applicable to this reaction. The oxidative quenching pathway of the excited photocatalyst (RuII/*RuII/RuIII/RuII) combined with a possible NiI/NiII/NiIII/NiI catalytic cycle is proposed to account for the nickel/photoredox dual-catalyzed C(sp3)-N bond formation based on synergistic exptl. and computational studies. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Synthetic Route of 2567-29-5

The Article related to carbon nitrogen bond formation nickel photoredox dual catalysis, sulfonyl azide azidoformate alkyltrifluoroborate alkyl amidyl radical cross coupling, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Jie; Song, Xue; Chen, Zhi-Chao; Du, Wei; Chen, Ying-Chun published an article in 2022, the title of the article was Phosphine-catalysed intermolecular cyclopropanation reaction between benzyl bromides and activated alkenes.Reference of 4-(Bromomethyl)-1,1′-biphenyl And the article contains the following content:

While phosphine-mediated reactions were extensively explored over the past few decades, the catalytic cyclopropanation reaction via a phosphonium ylide pathway has been significantly underdeveloped, and an intermol. version still remains to be disclosed. Presented herein was a catalytic cyclopropanation reaction between readily available benzyl bromides and activated alkenes, such as α-cyano chalcones, through in situ formation of phosphonium ylide intermediates. A spectrum of densely functionalized cyclopropane derivatives was efficiently constructed with excellent diastereoselectivity, which can be further converted to five-membered heterocycles after simple transformations. Moreover, moderate enantioselectivity can be obtained by using a com. available DuPhos catalyst. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to aralkyl bromide carbonyl cyanochalcone phosphine catalyst diastereoselective cyclopropanation, carbonyl cyanocyclopropane preparation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary