Category: 2567-29-5

On September 17, 2021, Yu, Fei; Li, Chuang; Wang, Chuangye; Zhang, Hongwei; Cao, Zhong-Yan published an article.Reference of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was (1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)-H Bonds. And the article contained the following:

A new, simple, yet easily accessible, (1-selenocyanatoethyl)benzene was designed and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C(sp3)-H bonds for the first time. This protocol was featured with mild reaction conditions and wide substrate scope. Control experiments revealed that a radical-group transfer mechanism might be involved. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to selenocyanatoalkyl arene preparation regioselective, selenocyanatoethyl benzene fluoro sulfonamide selenocyanation copper catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 31, 2021, Sarkar, Anindya; Kankanamalage, Anushka C. Galasiti; Zhang, Qian; Cheng, Heng; Sivaprakasam, Prasanna; Naglich, Joseph; Xie, Chunshan; Gangwar, Sanjeev; Boger, Dale L. published an article.Related Products of 2567-29-5 The title of the article was Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues. And the article contained the following:

A comprehensive SAR study of a putative TLR 3/8/9 agonist was conducted. Despite the excitement surrounding the potential of the first small mol. TLR3 agonist with a compound that addnl. displayed agonist activity for TLR8 and TLR9, compound I displayed disappointing activity in our hands, failing to match the potency (EC50) reported and displaying only a low efficacy for the extent of stimulated NF-κB activation and release. The evaluation of >75 analogs of I, many of which constitute minor modifications in the structure, failed to identify any that displayed significant activity and none that exceeded the modest activity found for I. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to synthesis structure activity relationship tlr3 tlr8 tlr9 agonist, sar study, tlr agonists, tlr3 agonist, toll-like receptor (tlr), General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 19, 2022, Grollier, Kevin; Ghiazza, Clement; Tlili, Anis; Billard, Thierry; Medebielle, Maurice; Vantourout, Julien C. published an article.Computed Properties of 2567-29-5 The title of the article was Electrochemical Trifluoromethylselenolation of Activated Alkyl Halides. And the article contained the following:

A practical electrochem. method for the generation of CF3Se- anion from a shelf-stable reagent (TsSeCF3) is reported allowing the metal-free trifluoromethylselenolation of activated alkyl halides RCH2X (X = Br, Cl; R = 4-F-Ph, pyridin-2-yl, 5-nitrofuran-2-yl, undecyl, etc.). Trifluoromethylselenolated compounds RCH2SeCF3 have been obtained in modest to excellent yields under the optimized reaction conditions. Finally, cyclic voltammetric and 19F NMR studies are presented and allowed to gain insight into the reaction mechanism. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Computed Properties of 2567-29-5

The Article related to trifluoromethylselenolate preparation electrochem, trifluoromethyltolueneselenosulfonate alkyl halide trifluoromethylselenolation, Aliphatic Compounds: (This Subsection Discontinued) and other aspects.Computed Properties of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 10, 2020, Yamada, Yousuke; Takashima, Hajime; Walmsley, David Lee; Ushiyama, Fumihito; Matsuda, Yohei; Kanazawa, Harumi; Yamaguchi-Sasaki, Toru; Tanaka-Yamamoto, Nozomi; Yamagishi, Junya; Kurimoto-Tsuruta, Risa; Ogata, Yuya; Ohtake, Norikazu; Angove, Hayley; Baker, Lisa; Harris, Richard; Macias, Alba; Robertson, Alan; Surgenor, Allan; Watanabe, Hayato; Nakano, Koichiro; Mima, Masashi; Iwamoto, Kunihiko; Okada, Atsushi; Takata, Iichiro; Hitaka, Kosuke; Tanaka, Akihiro; Fujita, Kiyoko; Sugiyama, Hiroyuki; Hubbard, Roderick E. published an article.Formula: C13H11Br The title of the article was Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. And the article contained the following:

UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-neg. bacteria. The most advanced, disclosed LpxC inhibitors showing antibacterial activity coordinate zinc through a hydroxamate moiety with concerns about binding to other metalloenzymes. Here, we describe the discovery, optimization, and efficacy of two series of compounds derived from fragments with differing modes of zinc chelation. A series was evolved from a fragment where a glycine moiety complexes zinc, which achieved low nanomolar potency in an enzyme functional assay but poor antibacterial activity on cell cultures. A second series was based on a fragment that chelated zinc through an imidazole moiety. Structure-guided design led to a 2-(1S-hydroxyethyl)-imidazole derivative exhibiting low nanomolar inhibition of LpxC and a min. inhibitory concentration (MIC) of 4μg/mL against Pseudomonas aeruginosa, which is little affected by the presence of albumin. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Formula: C13H11Br

The Article related to non hydroxamate palpxc inhibitor fragment discovery synthesis antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C13H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shao, Rui; Zhao, Haixia; Ding, Shumin; Li, Lianjie; Chen, Chen; Wang, Jian; Shang, Yongjia published an article in 2022, the title of the article was Silver-promoted dearomative [3+4] cycloaddition of anthranils with α-isocyanoacetates: access to benzodiazepines.SDS of cas: 2567-29-5 And the article contains the following content:

The first example of silver-promoted [3+4] cycloaddition of α-isocyanoacetates with anthranils as aromatic Michael accepters, offering access to benzo[d][1,3]diazepinones. Mechanistic studies revealed that an “oxygen migration” rearrangement process was involved in this dearomative cycloaddition reaction. Addnl., benzo[d][1,3]diazepinones were obtained efficiently as well under catalytic conditions. Broad functional groups were well tolerated under mild reaction conditions. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).SDS of cas: 2567-29-5

The Article related to anthranil isocyanoacetate silver promoter dearomative cycloaddition, dihydrobenzodiazepinone carboxylate preparation, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.SDS of cas: 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 30, 2022, Liang, Xiao; Li, Xue; Zhao, Zhiyuan; Nie, Yiming; Yao, Zefu; Ren, Wandi; Yang, Xinying; Hou, Xuben; Fang, Hao published an article.Category: bromides-buliding-blocks The title of the article was Design, synthesis and biological evaluation of hydantoin derivatives as Mcl-1 selective inhibitors. And the article contained the following:

Herein, authors designed and synthesized a series of hydantoin derivatives I (R1 = H, Ph, OCH2Ph, etc.; R2 = Me, Bn, CH2-Ph-Ph, etc.; R3 = H, 3-NO2-4-Cl) as novel myeloid cell leukemia-1 (Mcl-1) inhibitors based on authors’ previously developed lead compound Among them, compound I (R1 = -OCH2-3,4-di-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) and I (R1 = O(CH2)2-O-3,5-diMe-4-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) exhibited good binding affinities against Mcl-1 with Ki values of 0.49μM and 0.33μM resp. Especially, compound I (R1 = -OCH2-3,4-di-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) exhibited good selectivity over Bcl-xL, whereas compound I (R1 = O(CH2)2-O-3,5-diMe-4-Cl-Ph; R2 = -CH2-Ph-OCH2-4-Cl-Ph; R3 = 3-NO2-4-Cl) possessed good selectivity over both Bcl-2 and Bcl-xL. Furthermore, authors also investigated the effects of these new Mcl-1 inhibitors on cell proliferation, apoptosis and mitochondrial membrane potential, as well as the stability in plasma. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Category: bromides-buliding-blocks

The Article related to hydantoin preparation antitumor human mcl1 inhibitor apoptosis, apoptosis, cancer, hydantoin derivatives, mcl-1 inhibitors, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On January 15, 2021, Chen, Xin; Yang, Xi; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Ni, Shuaishuai; Jia, Lijun; Li, Jian published an article.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth invitro and invivo. And the article contained the following:

In this study, I [R = H, aminopropane(CO), aminocyclopropane(CO),..etc]. were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived I [R = (2,4-dichlorophenyl)-1-ethylamino(CO)] displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51μM vs 16.43μM), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that I [R = (2,4-dichlorophenyl)-1-ethylamino(CO)] had the potential to be developed as a promising neddylation inhibitor for anticancer therapy. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to benzimidazolyl methylbiphenylyl tetrazole preparation antitumor agent sar enzyme inhibitor, anticancer, benzimidazole-derived inhibitor, neddylation, cullin1-nedd8, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On July 25, 2022, Yang, Xiaoxu; Ge, Shaozhong published an article.Product Details of 2567-29-5 The title of the article was Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes. And the article contained the following:

The authors have developed a Co-catalyzed regioselective 1,1,3-triborylation reaction of terminal alkynes with pinacolborane (HBpin) with a catalyst generated in situ from readily available and bench-stable Co(acac)2 and xantphos. A variety of terminal alkynes undergo this triborylation reaction, affording the corresponding 1,1,3-triborylalkanes in good yields with high selectivity. The synthetic utility of this catalytic protocol was demonstrated by developing selective stepwise functionalization of 1,1,3-triborylalkane products. The results of mechanistic studies, such as conducting control experiments and D-labeling reactions, monitoring the reaction process, and identifying reaction intermediates, suggest that this 1,1,3-triborylation reaction proceeds through 1,3-diborylation of alken-1-ylboronates formed by Co-catalyzed hydroboration of terminal alkynes. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Product Details of 2567-29-5

The Article related to terminal alkyne preparation cobalt catalyzed triborylation pinacolborane, triborylalkane preparation reactivity, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Product Details of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 7, 2021, You, Lijun; Yuan, Wei; He, Chuan published an article.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Intermolecular Dehydrogenative C-H/Si-H Cross-Coupling for the Synthesis of Arylbenzyl Bis(silanes). And the article contained the following:

An Ir-catalyzed intermol. dehydrogenative C-H/Si-H cross-coupling reaction for the synthesis of arylbenzyl bis(silanes) is developed. This hydrosilyl group steered intermol. C-H silylation process features high chemo- and regioselectivity, giving access to a wide range of multi-functionalized organosilanes in good yields from readily available starting materials with atom economy, efficiency, and environmental benignity. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to benzhydryldimethylsilane iridium catalyzed intermol dehydrogenative cross coupling phenyldimethylsilane, crystal structure arylbenzyl bissilane, mol structure, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Quality Control of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 15, 2021, Yang, Ling; Tan, Dong-Hang; Fan, Wen-Xin; Liu, Xu-Ge; Wu, Jia-Qiang; Huang, Zhi-Shu; Li, Qingjiang; Wang, Honggen published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Photochemical Radical C-H Halogenation of Benzyl N-Methyliminodiacetyl (MIDA) Boronates: Synthesis of α-Functionalized Alkyl Boronates. And the article contained the following:

Benzylboronates ArCH2B(MIDA) were halogenated in α-position by reaction with NBS either initiated with benzyl peroxide or photochem., giving α-haloboronates ArCHXB(MIDA). Fluorination and chlorination were performed by reactions with Selectfluor and NCS, resp., under 9-fluorenone catalysis. α-Haloboronates are useful organic synthons that can be converted to a diverse array of α-substituted alkyl borons. Methods to α-haloboronates are limiting and often suffer from harsh reaction conditions. Reported herein is a photochem. radical C-H halogenation of benzyl N-methyliminodiacetyl (MIDA) boronates. Fluorination, chlorination, and bromination reactions were effective by using this protocol. Upon reaction with different nucleophiles, the C-Br bond in the brominated product could be readily transformed to a series of C-C, C-O, C-N, C-S, C-P, and C-I bonds, some of which are difficult to forge with α-halo sp2-B boronate esters. An activation effect of B(MIDA) moiety was found. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to bmida methyliminodiacetyl boronate photochem halogenation preparation haloboronate, halogenation, ketone catalysis, organoboron, photochemistry, radical reaction, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary