Category: 2567-29-5

On April 22, 2022, Wang, Hui; Yang, Ren-Yin; Xu, Bo published an article.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Synthesis of Cyclopropenes and Fluorinated Cyclopropanes via Michael Initiated Ring Closure of Alkyl Triflones. And the article contained the following:

A facile synthesis of cyclopropenes and fluorinated cyclopropanes from readily available alkyl triflones was developed. The reaction, regardless of electronic effect, gave products in good to excellent yields and moderate diastereoselectivity. The mechanism may involve tandem Michael addition of triflones/intramol. nucleophilic cyclization (elimination of -SO2CF3)/elimination of fluoride. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to cyclopropene fluorinated cyclopropane preparation diastereoselective, alkyl triflone chalcone michael initiated ring closure, michael initiated ring closure, alkyl triflones, cyclopropenes, fluorinated cyclopropanes and other aspects.Application In Synthesis of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On May 31, 2022, Zhang, Naichen; Ye, Yuanzhi; Bai, Lu; Liu, Jingjing; Wang, Han; Luan, Xinjun published an article.Safety of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Transition metal-free dearomatization of halonaphthols with C(sp3)-electrophiles. And the article contained the following:

The first intermol. electrophilic dearomatization of halonaphthols I (R1 = H, 7-MeO, 6-Me3Si, 3-Cl, etc.) with benzyl/allyl bromides R2Br (R2 = PhCH2, PhCHMe, 4-MeO2CC6H4CH2, H2C:CHCH2, PhCH:CH, etc.) is described. Halonaphthols are used as carbon nucleophiles in dearomatization to form three-dimensional cyclic enones II with excellent chemoselectivity, in which etherification of phenolic hydroxyl group could be restrained by using cesium carbonate as the base. A wide range of cyclic enones was directly prepared from various substituted benzyl/allyl bromides and halonaphthols. Mechanistic investigations suggest a direct SN2 reaction pathway. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Safety of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to allylic bromide fluoronaphthol chemoselective electrophilic allylation dearomatization, allyl benzyl fluoro naphthalenone preparation, fluoronaphthol chemoselective electrophilic benzylation benzyl bromide dearomatization and other aspects.Safety of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 10, 2022, Wang, Yanwei; Zhao, Zhiwei; Pan, Deng; Wang, Siyi; Jia, Kangping; Ma, Dengke; Yang, Guoqing; Xue, Xiao-Song; Qiu, Youai published an article.Product Details of 2567-29-5 The title of the article was Metal-Free Electrochemical Carboxylation of Organic Halides in the Presence of Catalytic Amounts of an Organomediator. And the article contained the following:

Herein, an electroreductive carboxylation of organic carbon-halogen bonds (X=Br and Cl) promoted by catalytic amounts of naphthalene as an organic mediator is reported. This transformation proceeds smoothly under mild conditions with a broad substrate scope of 59 examples, affording the valuable and versatile carboxylic acids in moderate to excellent yields without the need of costly transition metal, wasted stoichiometric metal reductants, or sacrificial anodes. Further late-stage carboxylations of natural product and drug derivatives demonstrate its synthetic utility. Mechanistic studies confirmed the activation of carbon-halogen bonds via single-electron transfer and the key role of naphthalene in this reaction. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Product Details of 2567-29-5

The Article related to carboxylic acid aryl alkyl preparation, aryl chloride bromide carbon dioxide electroreductive carboxylation naphthalene catalyst, co2 utilization, carboxylation, electroreduction, organic halides, organic reductive mediator and other aspects.Product Details of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 1, 2020, Sun, Nannan; Ma, Xiaojun; Zhou, Kaifeng; Zhu, Chen; Cao, Zhonglian; Wang, Yonghui; Xu, Jun; Fu, Wei published an article.Reference of 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. And the article contained the following:

In this study, authors designed and synthesized a series of N-sulfonamide-tetrahydroquinolines by mol. modeling and scaffold hopping strategy, aiming at improving the metabolic stabilities. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as compound II with moderate binding affinity and inhibitory activity of Th17 cell differentiation. Binding mode of compound II with RORγt-LBD was revealed by mol. docking. Moreover, compound II showed lower intrinsic clearance in mouse liver microsomes compared with compound I and potent in-vivo efficacy and safety in psoriasis models, which can be used as a good starting point for the further optimization. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Reference of 4-(Bromomethyl)-1,1′-biphenyl

The Article related to sulfonamido tetrahydroquinoline preparation rror inverse agonist sar safety, inverse agonists, metabolic stability, n-sulfonamide-tetrahydroquinolines, psoriasis, retinoic acid receptor-related orphan receptor γt (rorγt), th17 cells and other aspects.Reference of 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 19, 2022, Wang, Jixin; Duan, Zhili; Liu, Xingchen; Dong, Shoucheng; Chen, Kaixin; Li, Jie published an article.Name: 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Salt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes. And the article contained the following:

The authors herein report the preparation of solid and salt-stabilized silylzinc pivalates from the corresponding silyllithium reagents via transmetalation with Zn(OPiv)2. These resulting organosilylzinc pivalates show enhanced air and moisture stability and unique reactivity in the silylative difunctionalization of alkenes. Thus, a practical chelation-assisted Ni-catalyzed regioselective alkyl and benzylsilylation of alkenes was developed, which provides an easy method to access alkyl silanes with broad substrate scope and wide functional group compatibility. Kinetic experiments highlight that the OPiv-coordination is crucial to improve the reactivity of silylzinc pivalates. Also, late-stage functionalizations of druglike mols. and versatile modifications of the products illustrate the synthetical utility of this protocol. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Name: 4-(Bromomethyl)-1,1′-biphenyl

The Article related to silylzinc pivalate preparation reactivity nickel catalyzed carbosilylation alkene, organosilane preparation, silyllithium reagent transmetalation zinc pivalate, alkene difunctionalizations, carbosilylation, cross-coupling, nickel, silylzinc pivalates and other aspects.Name: 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 1, 2022, Meng, Depei; Lyu, Yichong; Ni, Chuanfa; Zhou, Min; Li, Yang; Hu, Jinbo published an article.Electric Literature of 2567-29-5 The title of the article was S-(Trifluoromethyl)Benzothioate (TFBT): A KF-Based Reagent for Nucleophilic Trifluoromethylthiolation. And the article contained the following:

S-(Trifluoromethyl)benzothioate (TFBT) was developed as an inexpensive, bench-stable and user-friendly trifluoromethylthiolation reagent which was easily synthesized by using KF as the only fluorine source. By using TFBT, trifluoromethylthiolates with various counterions was readily obtained. The synthetic application of TFBT was demonstrated by trifluoromethylthiolation-halogenation of arynes, bis(trifluoromethylthiolation)-halogenation of 1,2-benzdiynes, nucleophilic substitution of alkyl halides, deoxytrifluoromethylthiolation of alcs., and cross-coupling with aryl and vinyl boronic acids. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to trifluoromethyl benzothioate preparation aryne halogenation trifluoromethylthiolation, halo trifluoromethylthio arene preparation, s-(trifluoromethyl)benzothioate, aryne, multifunctionalization, potassium fluoride, trifluoromethylthiolation and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On June 27, 2022, Huang, Ming-Yao; Zhao, Yu-Tao; Zhang, Cheng-Da; Zhu, Shou-Fei published an article.Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl The title of the article was Highly Regio-, Stereo-, and Enantioselective Copper-Catalyzed B-H Bond Insertion of α-Silylcarbenes: Efficient Access to Chiral Allylic gem-Silylboranes. And the article contained the following:

Herein, we report the development of a method for highly regio-, stereo-, and enantioselective B-H bond insertion reactions of α-silylcarbenes generated from 1-silylcyclopropenes in the presence of a chiral copper(I)/bisoxazoline catalyst for the construction of chiral γ,γ-disubstituted allylic gem-silylboranes, which cannot be prepared by any other known methods. This reaction is the first highly enantioselective carbene insertion reaction of α-silylcarbenes ever to be reported. The method shows general applicability for various 3,3-disubstituted silylcyclopropenes and exclusively affords E-products. The novel chiral γ,γ-disubstituted allylic gem-silylborane products are versatile allylic bimetallic reagents with high stability and have great synthetic potential, especially for the construction of complex mols. with continuous chiral centers. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl

The Article related to regioselective stereoselective enantioselective copper catalyst insertion silylcarbene mechanism, crystal structure mol allylic silyl borane preparation chiral, asymmetric catalysis, b−h bond insertion, carbenes, copper catalysis, cyclopropenes and other aspects.Recommanded Product: 4-(Bromomethyl)-1,1′-biphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 20, 2021, Zhang, Rongyi; Li, Qigang; Xie, Qiqiang; Ni, Chuanfa; Hu, Jinbo published an article.Related Products of 2567-29-5 The title of the article was Difluorocarbene-Induced Ring-Opening Difluoromethylation-Halogenation of Cyclic (Thio)Ethers with TMSCF2X (X=Br, Cl). And the article contained the following:

The ring-opening difluoromethylation-halogenation of cyclic (thio)ethers is reported through a simple strategy relying on carbon-chalcogen bond activation with difluorocarbene. The reaction proceeds through in situ protonation of the previously little-known difluoromethylene oxonium or sulfonium ylide intermediate followed by ring-opening with halide ion to afford halogenated acyclic difluoromethyl (thio)ethers that can then be employed for further elaboration. TMSCF2X (X=Br, Cl) are unique reagents to achieve this synthetic purpose, which serve as both the difluorocarbene source and the halide ion source. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to halogenated acyclic difluoromethyl ether thioether preparation, cyclic ether trimethylsilyl difluoromethyl halide ring opening difluoromethylation halogenation, difluorocarbene, difluoromethyl ether, orthogonal synthesis, oxonium ylide, ring-opening and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On December 20, 2021, Wang, Qian; Tao, Quan; Dong, Hui; Ni, Chuanfa; Xie, Xiaoming; Hu, Jinbo published an article.Related Products of 2567-29-5 The title of the article was Fluorination Triggers Fluoroalkylation: Nucleophilic Perfluoro-tert-butylation with 1,1-Dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF) and CsF. And the article contained the following:

Perfluoro-tert-butylation reaction has long remained a challenging task. We now report the use of 1,1-dibromo-2,2-bis(trifluoromethyl)ethylene (DBBF, I) as a practical reagent for perfluoro-tert-butylation reactions for the first time. Through a consecutive triple-fluorination process with DBBF and CsF, the (CF3)3C- species can be liberated and observed, which is able to serve as a robust nucleophilic perfluoro-tert-butylating agent for various electrophiles. The power of this synthetic protocol is evidenced by the efficient synthesis of structurally diverse perfluoro-tert-butylated mols. Multiple applications demonstrate the practicability of this method, as well as the superiority of perfluoro-tert-butylated compounds as sensitive probes. The perfluoro-tert-butylated product was successfully applied in 1H- and 19F-magnetic resonance imaging (MRI) experiment with an ultra-low field (ULF) MRI system. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Related Products of 2567-29-5

The Article related to electrophile fluorination fluoroalkylation dibromo bistrifluoromethylethylene magnetic resonance imaging safety, perfluoro tert butylated compound preparation, fluorination, fluoroalkylation, imaging probes, magnetic resonance imaging, perfluoro-tert-butylation and other aspects.Related Products of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Shichao; Li, Muyao; Li, Shu-Sen; Wang, Jianbo published an article in 2022, the title of the article was Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates.Electric Literature of 2567-29-5 And the article contains the following content:

A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions. The experimental process involved the reaction of 4-(Bromomethyl)-1,1′-biphenyl(cas: 2567-29-5).Electric Literature of 2567-29-5

The Article related to palladium catalyzed coupling benzyl bromide bmida nitrogen tosylhydrazone, trans alkenyl mida boronate preparation, methyliminodiacetyl boronate palladium catalyzed stereoselective reaction benzyl bromide, alkenyl methyliminodiacetyl boronate stereoselective synthesis and other aspects.Electric Literature of 2567-29-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary