2576-47-8 Archives - Page 8 of 14 - Bromides-buliding-blocks

Kamra, Mohini team published research in ACS Applied Bio Materials in 2020 | 2576-47-8

Computed Properties of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Computed Properties of 2576-47-8.

Kamra, Mohini;Maiti, Bappa;Saha, Pranay;Karande, Anjali A.;Bhattacharya, Santanu research published 《 Antibody-Conjugated Vitamin E-Derived Liposomes for Targeted Gene Transfer》, the research content is summarized as follows. Construction of a vitamin E-based liposomal biomaterial and its ability to deliver therapeutic genes selectively across liver cancer cells are demonstrated herein. In humans, liver regulates the levels of α-tocopherol, i.e., vitamin E, and hepatic cells carry the machinery for its transport. To exploit the presence of tocopherol transport protein, we have selected an efficient gene transfecting α-tocopherol-based twin lipid bearing a hydroxyethylated headgroup and octamethylene spacer (TH8S) for liposome formation. Also, based on the abundance of the low-d. lipoprotein receptor (LDLr) on the cellular surface in the case of hepatocellular carcinoma, anti-LDLr monoclonal antibody is used to confer the targeting ability to liposomes. A facile thiol-maleimide click chem. is used for antibody decoration on the liposomal surface. Selective delivery of reporter and therapeutic genes (GFP and p53) to cells of hepatic origin was observed using anti-LDLr-tagged TH8S liposomes. Cellular internalization by receptor-mediated endocytosis renders the bioconjugate highly specific as well as highly efficient. Compatibility of the designed material with human blood points to its safety of use in systemic circulation thereby highlighting its in vivo potential. Thus, we report here a versatile biomaterial derived from an essential vitamin that promises potential for targeted suicidal gene therapy.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Min team published research in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2020 | 2576-47-8

SDS of cas: 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. SDS of cas: 2576-47-8.

Jiang, Min;He, Kaiyong;Qiu, Tong;Sun, Jiahui;Liu, Qi;Zhang, Xueqiong;Zheng, Hua research published ã?Tumor-targeted delivery of silibinin and IPI-549 synergistically inhibit breast cancer by remodeling the microenvironmentã? the research content is summarized as follows. We induced changes in the tumor microenvironment (TME) through the synergistic actions of two drugs used in breast cancer therapy. The anti-fibrotic drug silibinin (SLB) targets tumor-associated fibroblasts and exerts immune-mediated anti-cancer effects. IPI-549, an efficient and highly selective phosphoinositide-3-kinase-gamma (PI3KÎ³) inhibitor, was applied to alter the balance of immunosuppressive cells by inhibiting PI3KÎ³ mols.; it also promotes anti-tumor immunity. We developed nanoparticle formulations to encapsulate both drugs into the targeting carrier aminoethyl anisamide-polyethylene glycol-polycaprolactone (AEAA-PEG-PCL) resp. The drugs were i.v. delivered in mice and resulted in an increase in anti-tumor efficacy and apoptotic tumor tissue compared with either IPI-549 or SLB alone in 4T1 breast cancer cell-derived tumors. Furthermore, a significant reduction in regulatory T (Treg) cells and myeloid suppressor cells (MDSCs) was observed A normalized TME structure was also observed, including angiogenesis suppression, antifibrotic effects and the inhibition of collagen formation in the tumor tissue, significantly enhancing the anti-tumor effects. In summary, this combination strategy may offer an alternative treatment for breast cancer.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Tuo team published research in Chemical Science in 2021 | 2576-47-8

Related Products of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Jiang, Tuo;Bordi, Samuele;McMillan, Angus E.;Chen, Kuang-Yen;Saito, Fumito;Nichols, Paula L.;Wanner, Benedikt M.;Bode, Jeffrey W. research published ã?An integrated console for capsule-based, automated organic synthesisã? the research content is summarized as follows. Using a combination of reagent design, hardware engineering and a simple operating system, an instrument capable of executing complex organic reactions with prepacked capsules was provided. The machine conducted coupling reactions and delivered the purified products with minimal user involvement. Two desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provided drug-like organic mols. in a fully automated manner. This system would serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Yichen team published research in Journal of Colloid and Interface Science in 2022 | 2576-47-8

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Safety of 2-Bromoethylamine hydrobromide

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 2576-47-8, formula is C2H7Br2N, The most pervasive is the naturally produced bromomethane. Safety of 2-Bromoethylamine hydrobromide

Jiang, Yichen;Li, Dazhi;Zhao, Yifei;Sun, Jianmin research published ã?Hydrogen bond donor functionalized poly(ionic liquids)@MIL-101 for the CO₂ capture and improving the catalytic CO₂ conversion with epoxideã? the research content is summarized as follows. Hydrogen bond donor functionalized poly(ionic liquids) were incorporated into MIL-101 framework for synthesis of composites PIL-R@MIL-101 (R = COOH, OH, NH₂). The effect of different hydrogen bond donors on CO₂-epoxide cycloaddition reaction was discussed through XPS, NH₃-TPD characterizations. Thereinto, PIL-COOH@MIL-101 showed efficient catalytic performance in the cycloaddition reaction of CO₂ and epichlorohydrin, 92.7% substrate conversion was obtained under 70 Â°C, 1.0 MPa, cocatalyst- and solvent-free conditions for 2.5 h. The improved activity was benefited from the synergistic effects of Lewis acidic Cr centers, carboxyl group, and nucleophilic Br^–, together with the high surface area (1178 m²/g), and good CO₂ affinity. In addition, PIL-COOH@MIL-101 also showed facile recovery method by easy centrifugation and good recycling stability. Considering the good CO₂ affinity, excellent catalytic performance in CO₂ cycloaddition reaction, better thermal and recycling stabilities, the facilely prepared functionalized poly(ionic liquid)@MIL-101 composite would exhibit promising application prospect in CO₂ capture and conversion.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiao, X. team published research in Materials Today Chemistry in 2021 | 2576-47-8

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide, Category: bromides-buliding-blocks

Jiao, X.;Li, H.;Cheng, X. research published ã?Cellulose-based fluorescent macromolecular sensors and their ability in 2, 4, 6-trinitrophenol detectionã? the research content is summarized as follows. This article deals with three cellulose-based fluorescent macromol. sensors by introducing 1,8-naphthalimide fluorophore to cellulose. First, through the etherification reaction of cellulose with BrCH2CH2NH2, -NH2 group-bearing cellulose CS 1 was obtained. Then, the -NH2 group reacts with 4-bromo-1,8-naphthalic anhydride to synthesize a naphthalimide cellulose derivative (CS 2). Finally, the recognition group was introduced by substituting Br atoms, and three cellulose fluorescent probes (CS 3, CS 4, and CS 5) were obtained eventually. Structure and fluorescence properties of the macromol. sensors were characterized and confirmed. Fluorescence detection measurements show that these probes can be used as selective and sensitive fluorescent sensors to 2,4,6-trinitrophenol (TNP). The detection limits are 0.52 Î¼M, 0.76 Î¼M, and 0.81 Î¼M, indicating good detection performance. This work provides a new method for the selective detection of TNP and also a method to enlarge the application scope of cellulose.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiao, Xinyue team published research in Journal of Photochemistry and Photobiology, A: Chemistry in 2022 | 2576-47-8

Synthetic Route of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,â?0,â?5,â?0-âtetrakis(1-âmethylpyridinium-â?-âyl)âporphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Jiao, Xinyue;Marin, Luminita;Cheng, Xinjian research published ã?Fluorescent cellulose/testing paper for the sensitive and selective recognition of explosives 2,4,6-trinitrophenol and 2,4-dinitrophenylhydrazineã? the research content is summarized as follows. 2,4,6-trinitrophenol (TNP) and 2,4-dinitrophenylhydrazine (DNH) are harmful to the environment and human beings. Trace detection of TNP and DNH is worth of developing facile methods. In this work, cellulose powder and filter paper based fluorescence sensor are synthesized. Firstly, NH₂CH₂CH₂– was introduced into cellulose through etherification reaction, and at the same time, a small mol. BODIPY with -CHO was synthesized. Then BODIPY was incorporated into cellulose by Schiff base reaction to obtain fluorescent macromol. probes. These fluorescent cellulose sensors can efficiently identify TNP and DNH, with the lowest detection limits of 2.8 x 10^-7 M and 1.6 x 10^-7 M, resp. Fluorescent filter paper is obtained via the same route. They also exhibit TNP and DNH identification ability. The method developed in filter paper not only expands the application range of cellulose, but also can efficiently identify the pollutants TNP and DNH, which is of great significance in theory and practical applications.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Javorskis, Tomas team published research in Advanced Synthesis & Catalysis in 2021 | 2576-47-8

Javorskis, Tomas;Jurys, Arminas;Bagdziunas, Gintautas;Orentas, Edvinas research published ã?Synthesis of C- and N-Substituted 1,5,2,6-Dithiadiazocanes -Electrophilic-Nucleophilic Thioamination (ENTA) Reagentsã? the research content is summarized as follows. A synthetic method is presented for S-N bond formation starting from cheap and affordable materials. Its show that (un)substituted N-protected cyclic eight-membered C2-sym. sulfenamides e.g, I have been prepared in a few steps using this procedure. The synthetic utility of these ambipolar derivatives e.g. I was demonstrated in a variety of synthetic transformations affording different S,N-heterocycles e.g. II of pharmaceutical relevance in one or two steps from simple starting materials.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Jingsheng team published research in Advanced Functional Materials in 2020 | 2576-47-8

Huang, Jingsheng;Huang, Jiaguo;Cheng, Penghui;Jiang, Yuyan;Pu, Kanyi research published ã?Near-Infrared Chemiluminescent Reporters for In Vivo Imaging of Reactive Oxygen and Nitrogen Species in Kidneysã? the research content is summarized as follows. Despite the superior sensitivity of chemiluminescence over fluorescence, most chemiluminescence reporters only emit visible light, and have low water solubility, making them poorly equipped for in vivo imaging applications. Herein two near-IR (NIR) chemiluminescent reporters (NCRs) with high renal clearance for real-time imaging of reactive oxygen and nitrogen species in the kidneys were synthesized. NCRs comprise a Î²-cyclodextrin unit and a modified dicyanomethylene-4H-pyran containing Schaapâ²s dioxetane as the renal-clearance enabler and the chemiluminescent moiety, resp. NCR1 and NCR2 specifically activate their NIR chemiluminescence towards superoxide anion (O₂^â?) and peroxynitrite (ONOO^–), resp. By virtue of their nanomolar sensitivity and high renal clearance, NCRs not only detect subtle upregulation of endogenous RONS in cells but also enable noninvasive monitoring of RONS in the kidneys under nephrotoxic exposure. The earlier activation of NCR1 relative to NCR2 implies the sequential upregulation of O₂^â? and ONOO^– during drug-induced acute kidney injury (AKI). Moreover, detection of the fluorescence of excreted NCRs permits urinalysis of AKI, detecting the upregulation of RONS at least 24 h earlier than histol. anal. Thus, this study not only introduces ultrasensitive NIR chemiluminescent probes but also provides guidelines to transform them into legitimate imaging agents for organ-specific in vivo detection.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Zhoulan team published research in Chemical Engineering Research and Design in 2021 | 2576-47-8

Huang, Zhoulan;Karami, Davood;Mahinpey, Nader research published ã?Study on the efficiency of multiple amino groups in ionic liquids on their sorbents performance for low-temperature CO₂ captureã? the research content is summarized as follows. The addition of more amino groups to ionic liquids is promising to enhance supported ionic liquid performance for low-temperature CO₂ capture. In our previous studies, 1-ethyl-3-methylimidazolium lysine ([EMIM][Lys]) impregnated on mesoporous silica SBA-15 and com. PMMA polymer supports showed moderately acceptable CO₂ capture capacities. To improve sorbents performance, an amino acid ionic liquid (AAIL) (i.e., -1-aminoethyl-3-methylimidazolium lysine ([AEMIM][Lys]) with one addnl. amino group attached to the imidazole ring) was synthesized and immobilized into SBA-15 and PMMA with different loadings. The main purpose is to develop efficient AAIL-based sorbents with high CO₂ capture capacities and to study the effect of an addnl. amino group on CO₂ adsorption uptakes. 50 wt% [AEMIM][Lys]-immobilized on PMMA exhibited the best CO₂ capture capacities of 1.5 mmol/g-sorb and 0.82 mol/mol-AAIL at adsorption-desorption conditions of 30Â° C and 100Â° C resp., and under flue gas (CO₂ composition of 15%), when compared with previous results (1.06 mmol/g-sorb and 0.54 mol/mol-AAIL for 50 wt% [EMIM][Lys] supported on PMMA) under the same condition. This higher capacity demonstrated the efficiency of an addnl. amino group, though slightly far from the theor. values (2.75 mmol/g-sorb and 1.5 mol/mol-AAIL). Cyclic performances were also conducted to assess the sorbents long-term stabilities.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hyun, Seung Yeob team published research in Theranostics in 2021 | 2576-47-8

Hyun, Seung Yeob;Le, Huong Thuy;Min, Hye-Young;Pei, Honglan;Lim, Yijae;Song, Injae;Nguyen, Yen T. K.;Hong, Suckchang;Han, Byung Woo;Lee, Ho-Young research published ã?Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70ã? the research content is summarized as follows. Cancer stem cells (CSCs) are known to cause tumor recurrence and drug resistance. The heat shock protein (HSP) system plays a major role in preserving expression and function of numerous oncoproteins, including those involved in the CSC activities. We explored novel anticancer drugs, especially those targeting HSP components required for the functional role of CSCs. Investigation of the role of the HSP system in CSCs and screening of a natural product chem. library were performed by utilizing cancer cell lines, primary cultures of patient-derived xenografts (PDXs), and their putative CSC subpopulations (i.e., those grown under sphere-forming conditions, stably transfected with reporter vectors carrying NANOG or POUSF1 promoters, or carrying high ALDH activity) in vitro and PDX and Kras^G12D/+-driven tumor models in vivo. Regulation of the HSP system was investigated by immunoprecipitation, drug affinity responsive target stability assay, binding experiments using ATP-agarose beads and biotinylated drug, and docking anal. The HSP system was activated in CSCs via transcriptional upregulation of the HSP system components, especially HSP70. Evodiamine (Evo) was identified to induce apoptosis in both CSC and bulk non-CSC populations in human lung, colon, and breast cancer cells and their sublines with chemoresistance. Evo administration decreased the multiplicity, volume, and load of lung tumors in KrasG12D/+ transgenic mice and the growth of cancer cell line- and PDX-derived tumors without detectable toxicity. Mechanistically, Evo disrupted the HSP system by binding the N-terminal ATP-binding pocket of HSP70 and causing its ubiquitin-mediated degradation Our findings illustrate HSP70 as a potential target for eliminating CSCs and Evo as an effective HSP70-targeting anticancer drug eradicating both CSCs and non-CSCs with a minimal toxicity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary