Category: 327-51-5

Related Products of 327-51-5,Some common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,4-dibromo-2,5-difluorobenzene (2.17 g, 10mmol), potassium carbonate (2.07 g, 15mmol), and palladium acetate (225 mg, 1.0mmol) were taken under argon atmosphere, and DMAc (30 mL) was added and suspended. Into this mixture, a pivalic-acid-toluene solution (1.03M, 2.9 mL, 3.0mmol) and a tri-cyclohexyl phosphine toluene solution (0.6M, 3.3 mL, 2.0mmol), 2-(4-propylcyclohexyl) thiazole (6.28 g, 30mmol, trans/cis=69/31) synthesized in reference example-2 was added, and it agitated at 150 degrees C for 65 hours. The mixed solvent (2:1) of chloroform and hexane was added to the reaction mixture after ending reaction, and it filtered using alumina. The rough product obtained by condensing a filtrate was ******ed from dichloromethane/hexane, and target 1,4 -bis [2-(trans-4-propylcyclohexyl) thiazole 5-yl]-2,5-difluorobenzene was obtained as a white solid (1.56 g, 30%).After silica gel column chromatography (eluate: hexane/chloroform) refines the solid obtained by condensing the filtrate of the above-mentioned recrystallization, by recrystallizing [ toluene ] by the 95%-ethanol following **, Target 1-[2-(trans-4-propylcyclohexyl) thiazole 5-yl]-4-[2-(cis-4-propylcyclohexyl) thiazole 5-yl]-2,5-difluorobenzene was obtained as a white solid (654 mg, 13%).

The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TOSOH CORPORATION; SAGAMI CHEMICAL RESEARCH INSTITUTE; Aihara, Hidenori; kikuchi, Mai; Hachiya, Hitoshi; Watanabe, Makoto; (39 pag.)JP2017/66069; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 327-51-5, A common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, molecular formula is C6H2Br2F2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Method 6 4-Bromo-2,5-difluorobenzaldehyde To 1,4-dibromo-2,5-difluorobenzene (10.28 g, 37.81 mmol) in tetrahydrofuran (80 mL) at -40 C. was isopropylmagnesium chloride lithium chloride complex (29.1 mL, 37.81 mmol) added dropwise. After 1 h at -40 C. was N,N-dimethylformamide (58 mL, 756 mmol) added and the mixture was stirred for 30 minutes at -40 C. NH4Cl (2M, aq, 100 mL) was added and the mixture was extracted with ethyl acetate. The organic phase was dried with MgSO4 and concentrated to give 4-bromo-2,5-difluorobenzaldehyde (6.20 g, 74%) as a solid. 1H NMR (500 MHz, CHLOROFORM-d) delta ppm 10.28 (d, 1H) 7.61 (dd, 1H) 7.48 (dd, 1 H).

The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; US2010/267723; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 327-51-5,Some common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(1019) (1020) intermediate 31-1 (1021) [00354] Into a 100-mL round-bottom flask that purged and maintained under an inert atmosphere of nitrogen was added 4-bromo-2-chloro-l-iodobenzene (1.20 g, 3.78 mmol), benzyl piperazine-l -carboxylate (0.924 g, 4, 19 mmol), NaOtBu (1.10 g, 1 1.4 mmol), XantPhos (0.695 g, 1.20 mmol), Pd2(dba)3 (0.393 g, 0.430 mmol), and toluene (10 mL). The reaction mixture was stirred for 4 h at 60 C and then concentrated in vacuo to provide a crude product that was purified by FCC eluting with ethyl acetate/petroleum ether (1 : 10) to afford benzyl 4-(4-bromo-2- chlorophenyl)piperazine-l -carboxylate as a colorless oil (713 mg, 46%). LCMS (ESI, m/z) 409, 41 1 [ M 1 [ j .

The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FORMA THERAPEUTICS, INC.; GUERIN, David Joseph; BAIR, Kenneth W.; CARAVELLA, Justin A.; IOANNIDIS, Stephanos; LANCIA JR., David R.; LI, Hongbin; MISCHKE, Steven; NG, Pui Yee; RICHARD, David; SCHILLER, Shawn E. R.; SHELEKHIN, Tatiana; WANG, Zhongguo; (365 pag.)WO2017/139778; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 327-51-5

1,4-dibromo-2, 5-difluorobenzene (49.3 g, 181.5 mmol), 2-methoxyphenylboronic acid (66.2 g, 435.6 mmol), a 2 M aqueous solution of Na2CO3 (363 mL, 726 mmol), DME (360 mL), toluene (360 mL), and Pd[PPh3]4 (21 g, 18.0 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (500 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtrated and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 38.5 g in 65% yield. FD-MS C20H16F2O2 : theoretical value 326, observed value 326

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301921; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 327-51-5

To a -78 C solution of 1 ,4-dibromo-2,5-difluorobenzene (2.72 g, 9.99 mmol) in dry Et20 (30 mL) under an inert atmosphere was added 2.5 M n-butyl lithium solution in hexanes (4 mL, 9.99 mmol) dropwise and the mixture left stirring for 2 h. Crushed CO2 pellets were added slowly and the mixture was allowed to warm to ambient temperature and left stirring for 1 h. After quenching with 1 M aq. HCI (10 mL) the mixture was basified with 1 M aq. NaOH (70 mL) and then washed with Et20 (2 x 50 mL). The aqueous layer was acidified with 1 M aq. HCI (80 mL) and extracted with Et20 (3 x 100 mL). The organic layer was washed with brine (50 mL), dried over Na2S04, filtered and solvent was removed in vacuo to give 4-bromo-2,5- difluoro benzoic acid (2.3 g, 97 %) as an off-white solid, which was used without further purification. SUBSTITUTE SHEET RULE 26 1 H NMR (Method B) (CDC ): delta ppm 9.50 (br s, 1 H), 7.78 (dd, J = 8.2, 6.1 Hz, 1 H), 7.46 (dd, J = 9.3, 5.4 Hz, 1 H); LC-MS (Method C) 234.9/236.9 [M-H]+; RT 3.43 min

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.

Reference:
Patent; REDX PHARMA PLC; HUXLEY, Anthony; KIRK, Ralph; RATCLIFFE, Andrew; LYTH, David; (112 pag.)WO2017/46605; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

327-51-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Into a three-necked flask, 1,4-dibromo-2,5-difluorobenzene (5.4g, 20.0mmol), compound 27 (16.1g, 42.0mmol), 2M Na2CO3 aqueous solution (40mL, 80.0mmol), DME (40mL), toluene (40mL ), Pd[PPh3]4 (1.2g, 1.0mmol) were mixed, this mixture was refluxed for 8 hr under Ar atmosphere. After the reaction was cooled to room temperature. The sample was transferred to a separatory funnel, added water (100mL), extracted with CH2Cl2 and dried in. MgSO4, filtered, and concentrated. Purifying the sample by silica gel column chromatography to obtain a white solid. Yield 11.8g, 75% yield

The synthetic route of 327-51-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Idemitsu Kosan Corporation; Kato, Tomoki; Numata, Masaki; Yoshida, K.; Nishimura, Kazuki; Eiwakuma, Toshihiro; Hosokawa, Chisio; (108 pag.)KR101500796; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

327-51-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Into a three-necked flask, to 1,4-dibromo-2,5-difluorobenzene (37.5g, 138.0mmol), 2-nitrophenylboronic acid (23.0g, 138.0mmol), 2M Na2CO3 aqueous solution (138mL, 276mmol), DME (275mL), toluene (275mL), Pd[PPh3]4 (8.0g, 6.9mmol) was added, this mixture was refluxed for 8 hr under Ar atmosphere. After the reaction was cooled to room temperature. The sample was transferred to a separatory funnel, added water (250mL), and extracted with CH2Cl2. After drying with MgSO4, filtered, and concentrated. Purification of a sample was purified by silica gel column chromatography to give a white solid. Yield 26.1g, 60% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Idemitsu Kosan Corporation; Kato, Tomoki; Numata, Masaki; Yoshida, K.; Nishimura, Kazuki; Eiwakuma, Toshihiro; Hosokawa, Chisio; (108 pag.)KR101500796; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

327-51-5, The chemical industry reduces the impact on the environment during synthesis 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, I believe this compound will play a more active role in future production and life.

Example 9 Synthesis of Compound 31 In a 1,000-mL three-necked flask were placed 8.0 g (27.8 millimoles) of 2-carbazolylphenylboronic acid, 4.0 g (12.8 millimoles) of 1,4-dibromo-2,5-difluorobenzene, and 1.6 g (1.4 millimoles) of tetrakis(triphenylphosphine)palladium(0), then 75 mL of ethanol and 150 mL of toluene were added, and the mixture was stirred. Thereafter, a solution of 14.3 g (135.0 millimoles) of sodium carbonate in 150 mL of water was thrown into the flask. The mixture was then heated to 80C and stirred for 17 hours. The reaction solution was cooled to room temperature, transferred to a 1,000-mL separatory funnel, and separated into an organic layer and an aqueous layer. The organic layer was washed three times with 200 mL of water and then dehydrated over magnesium sulfate, the magnesium sulfate was filtered off, and the solvent was distilled off under reduced pressure. The reaction mixture thus obtained was purified by recrystallization from THF and methanol to yield 5.1 g of Compound 31 as a white solid; EI-MS, 597 (M+1); melting point, 263C; glass transition temperature, 92C.

The chemical industry reduces the impact on the environment during synthesis 1,4-Dibromo-2,5-difluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nippon Steel Chemical Co., Ltd.; EP2272828; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., 327-51-5

Under a nitrogen atmosphere, 3.0 ml (2.45 mmol) of a THF solution of isopropyl magnesium bromide (manufactured by Tokyo Chemical Industry Co., 0.80 M) and 10 ml of THF were added to a 100 ml Schlenk reaction vessel. At -30 C., 800 mg (2.45 mmol) of 2,3-dibromo-5-hexylthiophene obtained in the step (B) was added dropwise to this mixture. After ripening at the same temperature for 30 minutes, it was cooled to -78 C. and 2.45 ml (2.45 mmol) of a diethyl ether solution of zinc chloride (manufactured by Sigma-Aldrich, 1.0 M) was added dropwise. After gradually raising the temperature to room temperature, the resulting white slurry solution was concentrated under reduced pressure, and 10 ml of a light boiling component was distilled off. 185 mg (0.68 mmol) of 1,4-dibromo-2,5-difluorobenzene (manufactured by Wako Pure Chemical Industries, Ltd.) as a white slurry liquid (3 bromothienyl-2-zinc chloride) obtained and tetrakis Phenylphosphine) palladium (Tokyo Chemical Industry Co., Ltd.) (26.3 mg, 0.023 mmol, 2.3 mol% based on 1,4-dibromo-2,5-difluorobenzene) and 10 ml of THF were added. After conducting the reaction at 60 C. for 15 hours, the reaction vessel was cooled with water and 3 ml of 3N hydrochloric acid was added to terminate the reaction. The mixture was extracted with toluene, and the organic phase was washed with brine and dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (hexane to hexane / dichloromethane = 10/1) and recrystallized from hexane / toluene = 6/4 to obtain 1,4-di (3- Bromo-5-hexylthienyl) -2,5-difluorobenzene (yield 64%) as a brown solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TOSOH CORPORATION; UEDA, SAORI; HACHIYA, HITOSHI; WATANABE, MAKOTO; (12 pag.)JP2015/227296; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

327-51-5, These common heterocyclic compound, 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an argon atmosphere, to a solution of 1,4-dibromo-2,5-difluorobenzene (10, 70.00 g) in diethyl ether (500 mL) was added dropwise 1.58 M n-butyl lithium solution in hexane (171 mL) at -78 C, and the mixture was stirred at same temperature for 2 min. The mixture was added quickly to the mixture of dry ice (about 300 g) and diethyl ether (600 mL), and the mixture was warmed up to room temperature. The precipitate was collected by filtration, and washed with diethyl ether. The obtained solid was treated with water (100 mL) and 1 M hydrochloric acid (500 mL), and extracted with diethyl ether. The organic layer was washed with brine and dried. The desiccant was removed by filtration and the filtrate was evaporated in vacuo. The resulting residue was washed with hexane, dried in vacuo to obtain 11a (53.29 g, 83%) as a pale yellow solid: 1H NMR (DMSO-d6) delta 7.78 (1H, dd, J = 6.4, 8.3 Hz), 7.89 (1H, dd, J = 5.9, 9.8 Hz); FAB-MS m/z 235, 237 [(M-H)-].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.

Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5235 – 5246;,
Bromide – Wikipedia,
bromide – Wiktionary