Category: 3344-70-5

Reference of 3344-70-5, These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Phenothiazine and 1,12-dibromododecane (molar ratio = 1:10), potassium hydroxide and DMSO were added to a three-necked flask, filledwith nitrogen, and stirred at room temperature for 12 hours. The reaction mixture was washed with water and extracted with dichloromethane. , Drying over anhydrous, vortexing, andsilica gel column chromatographywith petroleum ether aseluent to give a colorless liquid in a yield of 76.5percent.

Statistics shows that 1,12-Dibromododecane is playing an increasingly important role. we look forward to future research findings about 3344-70-5.

Reference:
Patent; Jiangxi Agricultural University; Hong Yanping; Jiang Yan; Yin Xiaoli; Wu Guoqiang; Liao Xiaoning; Wang Chunrong; Li Liyu; (27 pag.)CN107698999; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3344-70-5, These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.0 g of compound 3,2.63 g of 1,12-dibromododecane,0.43 g of potassium hydroxide and 0.16 g of tetrabutylammonium bromide,Was added to a mixture of 10 ml of dichloromethane and 6.5 ml of water,The mixture was stirred at room temperature under nitrogen for 24 hours,Washed twice with 30 ml of water,Washed once with 15 ml of saturated brine,The organic layer was separated,After adding anhydrous sodium sulfate to remove water,The solvent was removed on a rotary evaporator,(200: 300 mesh silica gel column chromatography elution (ethyl acetate / petroleum ether volume ratio of l: 30-l: 10),To give 1.19 g of the compound 4 as a pale yellow liquid,Yield 90percent.

Statistics shows that 1,12-Dibromododecane is playing an increasingly important role. we look forward to future research findings about 3344-70-5.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Chang, Xiao; Zhang, Laiqi; Wang, Guixia; (10 pag.)CN106117220; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

3344-70-5, name is 1,12-Dibromododecane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C12H24Br2

General procedure: 5,5-dimethylhydantion (3.03 g, 23.6 mmol) and K2CO3 (12.05 g, 87.2 mmol) were dissolved in acetone. Then the mixture were stirred at ambient temperature for 30 min before addition of 3 equivalent 1,6-dibromohexane. After 3 h the acetone solvent was removed by evaporation. 100 mL ethyl acetate was added to extract the product, which were further purified by column chromatography eluting with EtOAc/hexane (3:10, v/v). Compound 8 was obtained as a white powder (6.01 g, 87.7percent). 1H NMR (500 MHz, CDCl3) delta 6.03 (s, H), 3.49 (t, J = 7.0 Hz, 2H), 3.40 (t, J = 6.0 Hz, 2H), 1.89-1.82 (m, 2H), 1.67-1.60 (m, 2H), 1.52-1.41 (m, 8H), 1.37- 1.30 (m, 2H); 13C NMR (126 MHz, CDCl3) delta 177.4, 156.6, 58.7, 38.4, 33.8, 32.6, 27.9, 27.7, 25.8, 25.1. HRMS m/z: [M+H]+ calcd. for C11H20BrN2O2+, 291.0703; found: 291.0700.

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Lingdong; Zhao, Yuebiao; Zhou, Hao; Ning, Anhong; Zhang, Fengxiang; Zhao (Kent), Zongbao; Tetrahedron Letters; vol. 58; 4; (2017); p. 321 – 325;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 3344-70-5, These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: All compounds were prepared according to previously described procedures [16,17]. Briefly, a phenol derivative (0.015 mol) and a dibromoalkane (0.0075 mol) were dissolved in a mixture of ethanol and water (9/1) containing an alkaline hydroxide (0.015 mol). The mixture was heated under microwave irradiation in an Initiator? Biotage oven for 20 min at 120 ¡ãC. After cooling, the precipitate was filtered and thoroughly washed with water, ethanol and ether.

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Cappoen, Davie; Forge, Delphine; Vercammen, Frank; Mathys, Vanessa; Kiass, Mehdi; Roupie, Virginie; Anthonissen, Roel; Verschaeve, Luc; Vanden Eynde, Jean Jacques; Huygen, Kris; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 731 – 738;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 3344-70-5,Some common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, molecular formula is C12H24Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1.0 g of compound 3,2.63 g of 1,12-dibromododecane,0.43 g of potassium hydroxide and 0.16 g of tetrabutylammonium bromide,Was added to a mixture of 10 ml of dichloromethane and 6.5 ml of water,The mixture was stirred at room temperature under nitrogen for 24 hours,With 30 millilitersWashed twice with water, washed once with 15 ml of saturated brine, the organic layer was separated, dried over anhydrous sodium sulfate,The solvent was removed on a rotary evaporator and purified by chromatography on a 200-300 mesh silica gel column (eluent ethyl acetate / petroleum ether volume ratio1: 30-1: 10) to give 1.19 g of compound 4 as a pale yellow liquid in 90percent yield.

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Dai, Shengping; Yang, Willow; Deng, Sea; Wang, Guixia; (8 pag.)CN106117224; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding some certain compound to certain chemical reactions, such as: 3344-70-5, name is 1,12-Dibromododecane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3344-70-5. 3344-70-5

Take 1.19 g of compound 6,3.15 g of 1,2-dibromododecane, 0.15 g of tetrabutylammonium bromide, 0.36 g of hydroxidePotassium, 14 ml of water and 22 ml of methylene chloride, and the mixture was stirred at room temperature for 24 hours under a nitrogen atmosphere. The organic layer was separated with 15 mlLiter of methylene chloride. The organic layer was collected and the organic layer was washed with 15 ml of saturated brine,Layer, dried over anhydrous sodium sulfate. After removal of water, the solvent was removed by rotary distillation under reduced pressure. The resulting crude product was washed with 200-300 mesh silica gel column(Eluent: petroleum ether / ethyl acetate, 100: 1 by volume) to give compound 7, 1.20 g of an off-white solid, yield75.60percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,12-Dibromododecane.

Reference:
Patent; Guilin University of Technology; Kong, Xiangfei; Xia, Liting; Yao, Wei; Gong, Hongkang; Wang, Guixia; (8 pag.)CN106588941; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary