Category: 3893-18-3

Zhao, Liang-Liang; Li, Xing-Shuo; Cao, Li-Li; Zhang, Rui; Shi, Xiao-Qian; Qi, Jing published the artcile< Access to dihydropyridinones and spirooxindoles: application of N-heterocyclic carbene-catalyzed [3+3] annulation of enals and oxindole-derived enals with 2-aminoacrylates>, HPLC of Formula: 3893-18-3, the main research area is dihydropyridinone preparation; spirooxindole preparation; enal aminoacrylate annulation heterocyclic carbene catalyst.

A strategy for the NHC-catalyzed synthesis of dihydropyridinones I (R = C6H5HC=CH, C6H5, 3-thienyl, et.; R1 = Me, Et), II and spirooxindoles III (R2 = Me, allyl, benzyl; R3 = Me, Et; R4 = H, 5-Me, 6-Br, etc.) has been developed via [3+3] annulation reactions of enals RHC=CHCHO or isatin-derived enals IV with 2-aminoacrylates TsNHC(=CH2)C(O)2R1 under oxidative conditions. In this efficient strategy, the 2-aminoacrylates served as nucleophiles. Modifying the standard base switched the carbon-carbon double bond formation from 5,6-positions to 3,4-positions to generate 5,6-dihydropyridinones I and 3,4-dihydropyridinones II, resp. Meanwhile, a diverse set of spirooxindole derivatives was also synthesized in good to excellent yields.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, HPLC of Formula: 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Choi, Bonnie; Capozzi, Brian; Ahn, Seokhoon; Turkiewicz, Ari; Lovat, Giacomo; Nuckolls, Colin; Steigerwald, Michael L.; Venkataraman, Latha; Roy, Xavier published the artcile< Solvent-dependent conductance decay constants in single cluster junctions>, Quality Control of 3893-18-3, the main research area is single cluster junction decay constant solvent.

Single-mol. conductance measurements have focused primarily on organic mol. systems. Here, we carry out scanning tunneling microscope-based break-junction measurements on a series of metal chalcogenide Co6Se8 clusters capped with conducting ligands of varying lengths. We compare these measurements with those of individual free ligands and find that the conductance of these clusters and the free ligands have different decay constants with increasing ligand length. We also show, through measurements in two different solvents, 1-bromonaphthalene and 1,2,4-trichlorobenzene, that the conductance decay of the clusters depends on the solvent environment. We discuss several mechanisms to explain our observations.

Chemical Science published new progress about 3893-18-3. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Quality Control of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jayabharathi, Jayaraman; Sivaraj, Sekar; Thanikachalam, Venugopal; Anudeebhana, Jagathratchagan published the artcile< Multifunctional pyridine styrylphenanthroimidazoles: electron transport materials for blue FOLEDs with low efficiency roll-off and hosts for PHOLEDs with low turn-on voltage>, Electric Literature of 3893-18-3, the main research area is electron transport material organic electroluminescent device.

We have reported pyridine styrylphenanthroimidazole derivatives, SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py, as efficient electron transport materials (ETMs) for blue fluorescent OLEDs (FOLEDs) and host materials for phosphorescent organic light emitting diodes (PHOLEDs). The optical and carrier transport abilities of pyridine styrylphenanthroimidazoles have been analyzed in terms of the linkage position as well as number of pyridine fragments. Devices with SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py as ETMs exhibit a maximum current efficiency (CE) of 14.28, 9.63 and 16.93 cd A-1, power efficiency (PE) of 9.32, 4.74 and 11.23 lm W-1 and external quantum efficiency (EQE) of 7.93, 5.50 and 8.68% relative to the widely used ETM BPhen (CE – 11.69 cd A-1; PE – 5.01 lm W-1; EQE – 5.89%). The blue PHOLEDs using SPPI-C2Py, SPPI-N1Py and SPPI-C2N1Py as hosts exhibit a CE of 34.32, 30.65 and 43.23 cd A-1, PE of 32.09, 28.32 and 40.54 lm W-1 and EQE of 18.56, 16.32 and 22.43%. The red PHOLEDs using SPPI-C2N1Py as a host exhibit a maximum CE of 25.78 cd A-1, PE of 22.68 lm W-1 and EQE of 18.56%. The yellow PHOLEDs using SPPI-C2N1Py as a host exhibit a maximum CE of 70.53 cd A-1, PE of 40.86 lm W-1 and EQE of 25.89%, resp. These findings demonstrated that the new born pyridine styrylphenanthroimidazoles can be employed as potential ETMs for blue FOLEDs and hosts for blue, red and yellow PHOLEDs.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Dipole moment. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yadav, Veena D.; Kumar, Lalan; Kumari, Poonam; Kumar, Sakesh; Singh, Maninder; Siddiqi, Mohammad I.; Yadav, Prem N.; Batra, Sanjay published the artcile< Synthesis and Assessment of Fused β-Carboline Derivatives as Kappa Opioid Receptor Agonists>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is embryonic kidney cell kappa opioid receptor agonist cAMP; beta-carboline; kappa opioid receptor agonist; molecular modeling; nitrogen heterocycle; pain.

The synthesis of 5-formyl-6-aryl-6H-indolo[3,2,1-de][1,5] naphthyridine-2-carboxylates by reaction between 1-formyl-9H-β-carbolines and cinnamaldehydes in the presence of pyrrolidine in water with microwave irradiation is described. Pharmacophoric modification of the formyl group offered several new fused β-carboline derivatives, which were investigated for their κ-opioid receptor (KOR) agonistic activity. Two compounds 4 a and 4 c produced appreciable agonist activity on KOR with EC50 values of 46±19 and 134±9 nM, resp. Moreover, compound-induced KOR signaling studies suggested both compounds to be extremely G-protein-biased agonists. The analgesic effect of 4 a was validated by the increase in tail flick latency in mice in a time-dependent manner, which was completely blocked by the KOR-selective antagonist norBNI. Moreover, unlike U50488, an unbiased full KOR agonist, 4 a did not induce sedation. The docking of 4 a with the human KOR was studied to rationalize the result.

ChemMedChem published new progress about Alkenes Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Xiaoyu; Dai, Xiaoyang; Nie, Linlin; Fang, Huihui; Chen, Jie; Ren, Zhongjiao; Cao, Weiguo; Zhao, Gang published the artcile< Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence>, Product Details of C9H7BrO, the main research area is ketoester unsaturated aldehyde tryptamine enantioselective three component coupling; indoloquinolizidine stereoselective preparation; Michael addition Pictet Spengler cyclocondensation diarylmethylhydropyrrole catalyst.

The enantioselective three-component Michael addition-Pictet-Spengler sequence of β-ketoesters, α,β-unsaturated aldehydes and tryptamines represents a facile and rapid one-pot access to highly substituted indoloquinolizidines, e.g. I, in moderate to excellent yields and good to excellent enantioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Verma, Ram Subhawan; Khatana, Anil Kumar; Mishra, Monika; Kumar, Shailesh; Tiwari, Bhoopendra published the artcile< Access to enantioenriched 4-phosphorylated δ-lactones from β-phosphorylenones and enals via carbene organocatalysis>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is carbene catalyzed cycloaddition reaction phosphorylenone enal; enantioenriched phosphorylated gamma lactone preparation crystal structure reactivity; crystal structure enantioenriched phosphorylated gamma lactone; mol structure enantioenriched phosphorylated gamma lactone.

N-heterocyclic carbene (NHC) catalyzed direct access to enantioenriched 4-phosphorylated δ-lactones from β-phosphorylenones and enals was achieved. The sterically demanding β-phosphonate-substituted enones, having competing regiomeric reaction centers, have remained elusive so far in intermol. cycloaddition reactions under NHC catalysis. All the products were obtained in excellent yield and enantioselectivity. These phosphorylated δ-lactones could be transformed into challenging multi-functionalized chiral esters and amides loaded with a β-ketophosphonate functionality.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylidenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hayashi, Yujiro; Samanta, Sampak; Gotoh, Hiroaki; Ishikawa, Hayato published the artcile< Asymmetric Diels-Alder reactions of α,β-unsaturated aldehydes catalyzed by a diarylprolinol silyl ether salt in the presence of water>, Electric Literature of 3893-18-3, the main research area is unsaturated aldehyde cyclopentadiene diarylprolinol catalyst water Diels Alder; norbornene derivative stereoselective preparation; conjugated diene unsaturated aldehyde diarylprolinol catalyst water Diels Alder; cyclohexene carboxaldehyde derivative stereoselective preparation.

The title reaction predominantly affords the exo isomer with excellent enantioselectivity. The synthesis can be carried out without organic solvents and provides the products by distillation Water increases the rate and enantioselectivity of the reaction.

Angewandte Chemie, International Edition published new progress about Bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation) (norbornenes, chiral). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhen; Huang, Meirong; Zhang, Xinhao; Chen, Jiean; Huang, Yong published the artcile< N-Heterocyclic Carbene-Catalyzed Four-Component Reaction: Chemoselective Cradical-Cradical Relay Coupling Involving the Homoenolate Intermediate>, Application In Synthesis of 3893-18-3, the main research area is beta tertiary gamma quaternary carboxylic acid chemoselective preparation; enal olefin nucleophile Togni reagent multicomponent relay coupling organocatalyst.

An organocatalytic four-component relay radical coupling to access a broad spectrum of β-tertiary-γ-quaternary carboxylic acid derivatives I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = H, Ph, 4-BrC6H4, etc.; R2 = Et, Ph, 2-furyl, etc.; R3 = OMe, OEt, HNCH2C6H5, etc.] using simple reagents was reported. This strategy was complementary to the classical closed-shell synthetic approaches and was particularly effective in introducing a quaternary carbon substituent at β-carbon. Mechanistically, relay radical coupling involving N-heterocyclic carbene-derived homoenolates was challenging due to issues associated with site-selectivity and catalyst turnover. In this report, demonstrated high site control using a triazolium N-heterocyclic carbene catalyst and a transient acyl trapping strategy to prepare diversified carboxylic acid derivatives in a single pot.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meazza, Marta; Tur, Fernando; Hammer, Niels; Jorgensen, Karl Anker published the artcile< Synergistic Diastereo- and Enantioselective Functionalization of Unactivated Alkyl Quinolines with α,β-Unsaturated Aldehydes>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is quinoline stereoselective derivative preparation; alkylquinoline unsaturated aldehyde organocatalyst cyclization; asymmetric catalysis; heterocycles; indium; organocatalysis; synergistic catalysis.

An alkyl functionalization of unactivated alkyl quinolines has been developed combining InCl3 activation with organocatalytic activation of α,β-unsaturated aldehydes in a synergistic fashion. The reaction proceeds in a highly stereoselective manner as a sequence involving two consecutive synergistic catalytic cycles (Lewis acid- and iminium ion-catalyzed) and requires neither pre-activated alkyl quinoline substrates with electron-withdrawing substituents nor highly activated electrophiles. The reaction provides selectively double- or mono-addition products in good yields and high to excellent stereoselectivities. Furthermore, based on spectroscopic and labeling experiments, the mechanisms for the reactions are discussed.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xuan, Yi-ning; Chen, Zhen-yu; Yan, Ming published the artcile< An organocatalytic cascade reaction of 2-nitrocyclohexanone and α,β-unsaturated aldehydes with unusual regioselectivity>, Name: 3-(4-Bromophenyl)acrylaldehyde, the main research area is nitrocyclohexanone aldehyde unsaturated organocatalyst conjugate addition Henry reaction; nonanone bicyclo stereoselective preparation.

An organocatalytic cascade reaction of 2-nitrocyclohexanone and α,β-unsaturated aldehydes was developed. Bicyclo[3.3.1]nonanone products, e.g., I, were obtained with good yields and excellent enantioselectivities. The reaction occurred with unusual regioselectivity. A dienolate-iminium activation mechanism was proposed. The products were transformed to eight-membered cyclic ketones, e.g., II, with high enantioselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bicyclic compounds, ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Name: 3-(4-Bromophenyl)acrylaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary