Category: 3959-07-7

Sun, Chen; Zhao, Huimin; Li, Wei; Jia, Yudi; Yang, Yi; Peng, Ying; Zheng, Jiang published the artcile< Icotinib induces mechanism-based inactivation of recombinant human CYP3A4/5 possibly via heme destruction by ketene intermediate>, Formula: C7H8BrN, the main research area is icotinib recombinant human CYPA heme destruction ketene intermediate.

Icotinib (ICT) is an antitumor drug approved by China National Medical Products Administration and is found to be effective against non-small cell lung cancer. The present study aimed at the interaction of ICT with CYP3A. ICT exhibited time-, concentration-, and NADPH-dependent inhibitory effect on recombinant human CYP3A4/5. About 60% of CYP3A activity was suppressed by ICT at 50 μM after 30 min. The observed enzyme inhibition could not be recovered by dialysis. Nifedipine protected CYP3A from the inactivation by ICT. The inhibitory effects of ICT on CYP3A were influenced neither by glutathione/N-acetyl lysine nor by superoxide dismutase/catalase. Incubation of ICT with human hepatic microsomes produced a ketene reactive intermediate trapped by 4-bromobenzylamine. CYP3A4 dominated the metabolic activation of ICT to the ketene intermediate. Et and vinyl analogs of ICT did not induce inactivation of recombinant human CYP3A4/5, which indicates that acetylenic bioactivation of ICT contributed to the enzyme inactivation. Moreover, the metabolic activation of ICT resulted in heme destruction. In conclusion, this study demonstrated that ICT was a mechanism-based inactivator of recombinant human CYP3A4/5, and heme destruction by the ketene metabolite may be responsible for the observed CYP3A inactivation.

Drug Metabolism & Disposition published new progress about Animal gene, CYP3A Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Liu Zeng; Zhang, Xing Xing; Liu, Ming Ming; Wu, Jing; Ma, Duo; Diao, Liang Zhuo; Li, Qingshan; Huang, Yan Shuang; Zhang, Rui; Ruan, Ban Feng; Liu, Xin Hua published the artcile< Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis>, Quality Control of 3959-07-7, the main research area is pterostilbene NLRP3 inflammasome inhibitor colitis.

Studies have shown that the abnormal activation of the NLRP3 inflammasome is involved in a variety of inflammatory-based diseases. In this study, a high content screening model targeting the activation of inflammasome was first established and pterostilbene was discovered as the active scaffold. Based on this finding, total of 50 pterostilbene derivatives were then designed and synthesized. Among them, compound 47 was found to be the best one for inhibiting cell pyroptosis [inhibitory rate (IR) = 73.09% at 10μM], showing low toxicity and high efficiency [against interleukin-1β (IL-1β): half-maximal inhibitory concentration (IC50) = 0.56μM]. Further studies showed that compound 47 affected the assembly of the NLRP3 inflammasomes by targeting NLRP3. The in vivo biol. activity showed that this compound significantly alleviated dextran sodium sulfate (DSS)-induced colitis in mice. In general, our study provided a novel lead compound directly targeting the NLRP3 protein, which is worthy of further research and structural optimization.

Journal of Medicinal Chemistry published new progress about Apoptosis-regulating proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (ASC, expression not affected by inhibitor, and inhibition of ASC oligomerization). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Shan; Zhang, Rong-Hong; Zhang, Hong; Wang, Yu-Chan; Yang, Dan; Zhao, Yong-Long; Yan, Guo-Yi; Xu, Guo-Bo; Guan, Huan-Yu; Zhou, Yan-Hua; Cui, Dong-Bing; Liu, Ting; Li, Yong-Jun; Liao, Shang-Gao; Zhou, Meng published the artcile< Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities>, Formula: C7H8BrN, the main research area is diamino pyrimidine preparation SAR antitumor antiangiogenesis FAK inhibitor human; Anti-angiogenesis; Antitumor; DAPY; FAK inhibitor; Structure-activity relationship.

A series of 2,4-diamino pyrimidine (DAPY) derivatives I (R1 = 2-ClC6H4, 4-MeOC6H4, 4-BrC6H4, etc.), II (R2 = 4-H2NC6H4, 4-MeOC6H4, 2-O2NC6H4, etc.) were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymic activities of FAK, and the IC50s of I (R1 = 2-ClC6H4) and II (R2 = 2-MeOC6H4) were 2.75 and 1.87 nM, resp. They exhibited strong antiproliferative effects against seven human cancer cells, with IC50 values against two FAK-overexpressing pancreatic cancer cells (PANC-1 and BxPC-3) of 0.98μM, 0.55μM, and 0.11μM, 0.15μM, resp. Moreover, the above two compounds obviously suppressed the colony formation, migration, and invasion of PANC-1 cells in a dose-dependent manner. Meanwhile, these two compounds could induce the apoptosis of PANC-1 cells and arrest the cell cycle in G2/M phase according to the flow cytometry assay. Western blot revealed that these compounds effectively inhibited the FAK/PI3K/Akt signal pathway and significantly decreased the expression of cyclin D1 and Bcl-2. In addition, the above compounds potently inhibited the antiproliferative of HUVECs and obviously altered the cell morphol and also significantly inhibited the migration, tube formation of HUVECs and severely impaired the angiogenesis in the zebrafish model. Overall, these results revealed the potential of these compounds as promising candidates for further preclin. studies.

European Journal of Medicinal Chemistry published new progress about Angiogenesis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dong, Guangping; Iyamu, Iredia D.; Vilseck, Jonah Z.; Chen, Dongxing; Huang, Rong published the artcile< Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1>, Category: bromides-buliding-blocks, the main research area is peptidomimetic inhibitor preparation antitumor mol docking protein terminal methyltransferase; cell-permeable inhibitor; peptidomimetic inhibitor; protein N-terminal methyltransferase; structure-based drug design.

A series of new peptidomimetic inhibitors I (R = 3-bromophenyl, cyclohexylmethyl, 2-(4-phenylphenyl)ethyl, etc.) was designed and synthesized. Through a focused optimization of DC113, a new cell-potent peptidomimetic inhibitor GD562 (IC50 = 0.93 ± 0.04μM) is discovered. GD562 exhibited improved inhibition of the cellular N-terminal methylation levels of both the regulator of chromosome condensation 1 and the oncoprotein SET with an IC50 value of ∼50μM in human colorectal cancer HCT116 cells. Notably, the inhibitory activity of GD562 for the SET protein increased over 6-fold compared with the previously reported cell-potent inhibitor DC541. Furthermore, GD562 also exhibited over 100-fold selectivity for NTMT1 against several other methyltransferases. Thus, this study provided a valuable probe to investigate the biol. functions of NTMT1.

Molecules published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fan, Xiao-Nan; Ou, Hui-Dan; Deng, Wei; Yao, Zi-Jian published the artcile< Air-Stable Half-Sandwich Iridium Complexes as Aerobic Oxidation Catalysts for Imine Synthesis>, Product Details of C7H8BrN, the main research area is iridium half sandwich iminoketone complex preparation oxidation catalyst; imine preparation aerobic oxidation amine iridium iminoketone catalyst; benzyl alc amine coupling preparation benzylideneaniline iridium iminoketone catalyst; crystal structure iridium half sandwich iminoketone complex; mol structure iridium half sandwich iminoketone complex.

Several N,O-coordinate half-sandwich iridium complexes I (1-5, R = H, 4-MeO, 4-Cl, 2-Me, 3-Br) containing constrained bulky β-enaminoketonato ligands were prepared and clearly characterized. Single-crystal X-ray diffraction characterization of these complexes indicates that the iridium center adopts a distorted octahedral geometry. Complexes 1-5 showed good catalytic efficiency in the oxidative homocoupling of primary amines, dehydrogenation of secondary amines, and the oxidative cross-coupling of amines and alcs., which furnished various types of imines in good yields and high selectivities using O2 as an oxidant under mild conditions. No distinctive substituent effects of the iridium catalysts were observed in these reactions. The diverse catalytic activity, broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in industrial processes. Half-sandwich iridium complexes were synthesized which exhibited high catalytic activity for oxidative homocoupling of primary amines, dehydrogenation of secondary amines, and oxidative cross-coupling of alcs. and amines under mild conditions using clean O2 as the oxidative reagent. The broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in industrial processes.

Inorganic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Peiqi; Guo, Zhifen; Liu, Xin; Lv, Hui; Che, Yan; Bai, Rong; Chi, Yanhong; Xing, Hongzhu published the artcile< A visible-light-responsive metal-organic framework for highly efficient and selective photocatalytic oxidation of amines and reduction of nitroaromatics>, Application of C7H8BrN, the main research area is metal organic framework photooxidation photoreduction catalyst.

Photocatalysis is a green synthetic method for organics transformation. We present here the synthesis of a novel visible-light-responsive metal-organic framework and its photocatalytic application. The prepared MOF is highly efficient for the self-coupling of primary amines and oxidative dehydrogenation of secondary amines to selectively produce imines assisted by the green and economic oxidant of mol. oxygen. Studies reveal that both energy transfer and electron transfer from the photoexcited MOF to mol. oxygen are important for amine oxidation, where the highly reactive species of superoxide radicals and singlet oxygen together account for the high catalytic performance. The photogenerated electrons of the MOF have also been utilized for the reduction of aromatic nitroarenes. Results show that they are highly selective for the reduction of nitroarenes to produce anilines in the presence of hydrazine hydrate. The work demonstrates the enormous potential of photoactive MOFs for converting organic substrates into valuable chems.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Coupling reaction catalysts. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Mingkai; Zou, Yong; Zhang, Sai; Qu, Yongquan published the artcile< In situ Re-construction of Pt Nanoparticles Interface for Highly Selective Synthesis of Primary Amines>, Category: bromides-buliding-blocks, the main research area is platinum nanoparticle primary amine selective synthesis.

Regulation of the catalyst interface by adsorbates has been demonstrated as an efficacious methodol. to enhance the catalytic selectivity. Herein, we demonstrated an in situ modifications induced by reactants to re-construct the local interface of Pt nanoparticles anchored on the CoFe layered double hydroxides (CoFe-LDH) supports for a highly selective synthesis of primary amines from reductive amination of aldehydes and ammonia. The strong metal-support interaction between Pt metals and CoFe-LDH supports results in the highly electron-enriched surface of Pt and thereby makes the surface of Pt nanoparticles favor the enrichment of NH4+ species and adsorption of NH3. Such a tailored interface can create an interfacial stereo-hindrance effect and effectively slug the reaction kinetics of side-reactions, further preventing the formation of side-products. We anticipate that such an in situ re-construction of metal interface by reactants and afterwards the constructed local environment of active sites may provide a new approach for the optimization of metal catalysts.

ChemCatChem published new progress about Adsorbed substances. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thorve, Pradip Ramdas; Maji, Biplab published the artcile< Deaminative Olefination of Methyl N-Heteroarenes by an Amine Oxidase Inspired Catalyst>, Reference of 3959-07-7, the main research area is diaryl olefin preparation diastereoselective; methyl heteroarene primary amine deaminative olefination phenanthrolinedione catalyst.

The bioinspired o-quinone cofactor catalyzed aerobic primary amine ArCH2NH2 (Ar = Ph, 2-chlorophenyl, furan-2-yl, etc.) dehydrogenation for a cascade olefination reaction with nine different Me N-heteroarenes, including pyrimidines such as 4-Me pyrimidine, N-benzyl-4-methylpyrimidin-2-amine and N,N-dibenzyl-4-methylpyrimidin-2-amine, 2-methylpyrazine, pyridines such as 4-methylpyridine, 5-bromo-2-methylpyridine, 2-methylpyridine, etc.; quinolines such as 2-methylquinoline, 2,6-dimethylquinoline, 6-methoxy-2-methylquinoline and 4-methylquinoline, 2-methylquinoxaline, benzimidazoles such as 1-benzyl-2-methyl-1H-1,3-benzodiazole and 1-benzyl-5,6-dichloro-2-methyl-1H-1,3-benzodiazole, 2-methyl-1,3-benzoxazole, 2-methyl-1,3-benzothiazole and 2,4,6-trimethyl-1,3,5-triazine were explored. An o-quinone catalyst phd (1,10-phenanthroline-5,6-dione) combined with a Bronsted acid such as TfOH catalyzed the reaction. N-Heteroaryl stilbenoids RCH=CHAr (R = pyridin-2-yl, pyrimidin-4-yl, 1,3-benzoxazol-2-yl, etc.) were synthesized in high yields and (E)-selectivities under mild conditions using oxygen (1 atm) as the sole oxidant without the need of transition-metal salt, ligand, stoichiometric base, or oxidant.

Organic Letters published new progress about Aryl alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitsudome, Takato; Sheng, Min; Nakata, Ayako; Yamasaki, Jun; Mizugaki, Tomoo; Jitsukawa, Koichiro published the artcile< A cobalt phosphide catalyst for the hydrogenation of nitriles>, Formula: C7H8BrN, the main research area is nitrile cobalt phosphide hydrogenation catalyst.

The study of metal phosphide catalysts for organic synthesis is rare. We present, for the first time, a well-defined nano-cobalt phosphide (nano-Co2P) that can serve as a new class of catalysts for the hydrogenation of nitriles to primary amines. While earth-abundant metal catalysts for nitrile hydrogenation generally suffer from air-instability (pyrophoricity), low activity and the need for harsh reaction conditions, nano-Co2P shows both air-stability and remarkably high activity for the hydrogenation of valeronitrile with an excellent turnover number exceeding 58000, which is over 20- to 500-fold greater than that of those previously reported. Moreover, nano-Co2P efficiently promotes the hydrogenation of a wide range of nitriles, which include di- and tetra-nitriles, to the corresponding primary amines even under just 1 bar of H2 pressure, far milder than the conventional reaction conditions. Detailed spectroscopic studies reveal that the high performance of nano-Co2P is attributed to its air-stable metallic nature and the increase of the d-electron d. of Co near the Fermi level by the phosphidation of Co, which thus leads to the accelerated activation of both nitrile and H2. Such a phosphidation provides a promising method for the design of an advanced catalyst with high activity and stability in highly efficient and environmentally benign hydrogenations.

Chemical Science published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sangouard, Gontran; Zorzi, Alessandro; Wu, Yuteng; Ehret, Edouard; Schuettel, Mischa; Kale, Sangram; Diaz-Perlas, Cristina; Vesin, Jonathan; Bortoli Chapalay, Julien; Turcatti, Gerardo; Heinis, Christian published the artcile< Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer>, Related Products of 3959-07-7, the main research area is macrocycle compound acoustic liquid transfer MDM2 p53 PPI; acoustic droplet ejection; combinatorial synthesis; macrocycles; picomole scale; protein-protein interactions.

Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein-protein interactions. However, the development of macrocycles as drugs is hindered by the lack of large combinatorial macrocyclic libraries, which are cumbersome, expensive, and time consuming to make, screen, and deconvolute. Here, we established a strategy for synthesizing and screening combinatorial libraries on a picomolar scale by using acoustic droplet ejection to combine building blocks at nanoliter volumes, which reduced the reaction volumes, reagent consumption, and synthesis time. As a proof-of-concept, we assembled a 2700-member target-focused macrocyclic library that we could subsequently assay in the same microtiter synthesis plates, saving the need for addnl. transfers and deconvolution schemes. We screened the library against the MDM2-p53 protein-protein interaction and generated micromolar and sub-micromolar inhibitors. Our approach based on acoustic liquid transfer provides a general strategy for the development of macrocycle ligands.

Angewandte Chemie, International Edition published new progress about Affinity (binding). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary