Category: 3959-07-7

He, Peipei; Lv, Ying; Shang, Sensen; Chen, Bo; Liang, Hongliang; Niu, Jingyang; Dai, Wen published the artcile< Defect-Rich Core-Shell Carbon Derived from Ionic Liquid for Direct Synthesis of Imines>, Synthetic Route of 3959-07-7, the main research area is imine preparation; amine self cross coupling core shell carbon preparation catalyst; ionic liquid sodium tetraphenylborate electrostatic interaction.

Herein, ionic liquid 1-ethyl-3-methylimidazolium dicyanamide and sodium tetraphenylborate were employed as joint precursors to facilely prepare micro-mesoporous core-shell carbon with sp. surface area up to 2870 m2 g-1, consisting of smooth unpenetrated shell and secondary hollow spherical carbon core. The as-obtained core-shell carbon as metal-free catalyst exhibited good performance for self-coupling and cross-coupling of amines RCH2NH2 (R = Ph, furan-2-yl, cyclohexyl, etc.), R1NH2 (R1 = Ph, n-hexyl, cyclohexyl, etc.) to achieve the corresponding symmetry RCH=NCH2R and asymmetry imines RCH=NR1 under mild and neat conditions. Excitingly, for the challenging aliphatic amine cyclohexylmethanamine, the desired imines RCH=NCH2R (R = cyclohexyl) were achieved in 55.9% yield. The nearly linearly correlation between imine yield and ID/IG indicated that the resulting defects from departure of heteroatoms during pyrolysis may be active site.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitrea, Daiana G.; Circu, Viorel published the artcile< Synthesis and characterization of novel acylthiourea compounds used in ions recognition and sensing in organic media>, Reference of 3959-07-7, the main research area is synthesis characterization acylthiourea ion recognition colorimetric sensing; Acyl thiourea; Anion recognition; Cation recognition; Colorimetric sensors; Copper (II) detection; Fluoride detection; Organic media.

A series of novel N-acyl-N’-aryl thiourea derivatives were designed and prepared with the aim to develop dual responsive receptors for anions and cations. The structure of the new products was confirmed by NMR spectroscopy (13C and 1H), elemental anal., and IR spectroscopy. Their thermal stability was studied by thermogravimetric anal. (TG) and it was found that these acyl thiourea derivatives are stable up to 160°C. The ion recognition and sensing properties of the acyl thiourea compounds were investigated by UV-VIS absorption spectroscopy in organic media upon the addition of various salts. The UV-VIS studies revealed that these acyl thiourea derivatives are able to sense biol. important ions such as fluoride and copper (II) ions.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Colorimetric sensors. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Osyanin, V. A.; Korzhenko, K. S.; Rashchepkina, D. A.; Osipov, D. V.; Klimochkin, Yu. N. published the artcile< Nucleophilic Vinylic Substitution in Perfluoroacylchromenes. Diastereoselective Synthesis of Push-Pull Enamino Ketones>, Related Products of 3959-07-7, the main research area is enamino ketone diastereoselective preparation; perfluoroacylchromene nucleophilic vinylic substitution.

The reactions of 2-perfluoroacyl-1H-benzo[f]chromenes and 6,7-dimethyl-3-trifluoroacetyl-4H-chromene with primary aliphatic amines and ammonia afforded a series of enamino ketones containing a (2-hydroxynaphthalen-1-yl)methyl or 2-hydroxybenzyl substituent in the α-position with respect to the carbonyl group, e.g., I [R = H, cyclopropyl, Bn, etc.; X = CF3, C2F5, ]. These reactions involved opening of the pyran ring, which followed aza-Michael addition as the initial step. The obtained enamino ketones were found to exist in DMSO solution as single E isomers.

Russian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Yujuan; Huang, Liliang; Feng, Huihui; Qi, Yayu; Van der Eycken, Erik V.; Feng, Huangdi published the artcile< Regio- and Chemoselective Copper-Catalyzed Formal [2+2+2] Cycloaddition of Primary Amines with Arylacetylenes to 2,4,5-Trisubstituted Pyridines>, Application In Synthesis of 3959-07-7, the main research area is pyridine preparation chemoselective regioselective; primary amine alkyne cycloaddition copper catalyst.

Synthesis of 2,4,5-trisubstituted pyridines I (R1 = Ph, 3,4-dimethoxyphenyl, furan-2-yl, etc.; R2 = Ph, 2-bromophenyl, 3-methylphenyl, etc.) via CuI/NBS-catalyzed formal intermol. [2+2+2] cycloaddition of easily available primary amines R1CH2NH2 and nonactivated terminal alkynes R2CCH is described. Moreover, this given reaction features a new mode of cycloaddition with high regio- and chemoselectivity, good atom- and step-economy, broad substrate scope, and wide functional group compatibility. Further mechanism studies indicate that this transformation starts with oxidative alkynation of the amine to form propargylamine intermediate, followed by radical addition to the alkyne and intramol. cycloaddition, delivering the pharmacol. interesting 2,4,5-trisubstituted pyridinesI.

Organic Letters published new progress about [2+2+2] Cycloaddition reaction (regio- and chemoselective). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

He, Haiping; Duan, Dehao; Li, Hong; Wei, Yifei; Nie, Liang; Tang, Bo; Wang, Hanyu; Han, Xiaowei; Huang, Panpan; Peng, Xiangjun published the artcile< Graphene oxide-catalyzed synthesis of benzothiazoles with amines and elemental sulfur via oxidative coupling strategy of amines to imines>, Name: 4-Bromobenzylamine, the main research area is benzothiazole green regioselective preparation; amine naphthalene elemental sulfur graphene oxide catalyst oxidative coupling.

The graphene oxide-catalyzed coupling and cyclization reactions of primary amines with elemental sulfur was developed to afford optically property benzothiazoles I [R = Ph, 4-MeC6H4, 2-F3C6H4, etc.], II [R1 = H, 3-CF3, 4-Me, etc.] and III [R1 = H, 2-CF3, 4-Cl, etc.; R2 = H, 6-Cl, 6-OMe, etc.]. This coupling and cyclization strategies proceeded under the oxidant system graphene oxide/O2 and constructed carbon-heteroatom (N, S) bonds with amines and elemental sulfur. Due to benzothiazoles as common chromophores, these products exhibited intriguing fluorescence properties, including outstanding Stokes shifts (up to 161 nm) and quantum yields (up to 74%). Utilizing the products’ unique fluorescence response in different solvents, β-naphthothiazole II [R1 = H] showed excellent aggregation-induced emission properties in 1,2-dichloroethane, which was 60 times higher than in THF.

Tetrahedron published new progress about Benzothiazoles Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shelp, Russell A.; Ciro, Anthony; Pu, Youge; Merchant, Rohan R.; Hughes, Jonathan M. E.; Walsh, Patrick J. published the artcile< Strain-release 2-azaallyl anion addition/borylation of [1.1.1]propellane: synthesis and functionalization of benzylamine bicyclo[1.1.1]pentyl boronates>, Safety of 4-Bromobenzylamine, the main research area is bicyclopentane diarylmethanamine preparation; benzylamine bicyclopentyl boronate preparation arylbromide Suzuki coupling palladium catalyst; benzyl ketimine propellane pinacol boronate borylation three component.

A three-component reaction between N-benzyl ketimines (C6H5)2C=NCH2Ar (Ar = 4-chlorophenyl, pyridin-3-yl, 1-benzothiophen-2-yl, etc.), [1.1.1]propellane, and pinacol boronates such as bis(pinacolato)diboron and i-PrOBpin to generate benzylamine bicyclo[1.1.1]pentane (BCP) pinacol boronates I was reported. These structures are analogs to highly sought diarylmethanamine cores, which are common motifs in bioactive mols. The versatility of the boronate esters I (Ar = Ph, 3,5-difluorophenyl, 4-trifluoromethoxyphenyl) handle via downstream functionalization through a variety of reactions, including a challenging Pd-catalyzed (hetero)arylation that exhibits a broad substrate scope was demonstrated. These methods enable the synthesis of high-value BCP benzylamines II (R1 = naphthalen-2-yl, 4-(dimethylsulfamoyl)phenyl, pyridin-4-yl, etc.) and were inaccessible by existing methods. Furthermore, the successful application of these newly developed (hetero)arylation conditions to a variety of challenging tertiary pinacol boronates, including nitrogen-containing heterocycles, 1,1-disubstituted cyclopropanes, and other BCP cores e.g., 4,4,5,5-tetramethyl-2-(1-phenylcyclopropyl)-1,3,2-dioxaborolane were demonstrated.

Chemical Science published new progress about Addition reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chu, Minzhe; Zhai, Yingying; Shang, Ningzhao; Zhang, Xiaoyu; Wang, Chun; Zhang, Yunrui; Wang, Haijun; Gao, Yongjun published the artcile< Functions of hydroxyapatite in fabricating N-doped carbon for excellent catalysts and supercapacitors>, HPLC of Formula: 3959-07-7, the main research area is hydroxyapatite nitrogen doped carbon fabrication catalyst supercapacitor.

Functions of hydroxyapatite (HAP) in fabricating nitrogen-containing carbon materials with 1,10-phenanthroline as a precursor were demonstrated. HAP can efficiently prevent 1,10-phenanthroline from subliming and promote it to graphitized carbon during the annealing process. More importantly, HAP favored the generation of active oxygen-containing groups on the final nitrogen-doped carbon NC(HAP), which exhibited excellent catalytic performance for the oxidative coupling of amines to imines (yield 84-95%) and remarkable electrochem. performance for supercapacitors. In electrochem. experiments, NC(HAP) exhibited an outstanding specific capacitance of 366 F/g at 0.5 A/g and an excellent capacitance retention of 98.5% after 5000 charge-discharge cycles at 10 A/g.

Catalysis Science & Technology published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, HPLC of Formula: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, Jungwon; Kim, Siin; Choi, Geunho; Lee, Geun Seok; Kim, Donghyeok; Choi, Jungkweon; Ihee, Hyotcherl; Hong, Soon Hyeok published the artcile< Synthesis of N-aryl amines enabled by photocatalytic dehydrogenation>, Related Products of 3959-07-7, the main research area is allylic amine visible light mediated regioselective photocatalytic dehydrogenation; aryl amine preparation.

The visible-light-induced photocatalytic synthesis of N-aryl amines was achieved by the CD of allylic amines. The unusual strategy using C6F5I as an hydrogen-atom acceptor enabled the mild and controlled CD of amines beared various functional groups and activated C-H bonds, suppressed side-reaction of the reactive N-aryl amine products. Thorough mechanistic studies suggested the involvement of single-electron and hydrogen-atom transfers in a well-defined order provided a synergistic effect in the control of the reactivity. Notably, the back-electron transfer process prevented the desired product from further reacting under oxidative conditions.

Chemical Science published new progress about Allyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Related Products of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bai, Peng; Tong, Xinli; Gao, Yiqi; Guo, Pengfei published the artcile< Oxygen-free water-promoted selective photocatalytic oxidative coupling of amines>, SDS of cas: 3959-07-7, the main research area is imine synthesis water promoted photocatalytic oxidative coupling amine; oxygen free water promoted photocatalytic oxidative coupling amine.

A novel photocatalytic selective oxidative transformation of amines to imines using water as a primary oxidant is achieved under oxygen-free conditions. In the presence a single 1%Pt@TiO2-500 catalyst, the photocatalytic oxidative coupling of benzylamine to N-benzylidenebenzylamine has been efficiently performed using water as an oxidant, in which a 99.8% conversion and a 92.5% selectivity were obtained at room temperature; meanwhile, a certain amount of hydrogen was detected that confirms the simultaneous occurrence of water splitting reaction. Further investigations revealed that the introduction of the Pt element facilitates the formation of O-holes on the surface of TiO2, which efficiently promotes the generation of active oxygen species from water and the following oxidative coupling of benzylamine. Then, the photocatalytic oxidative coupling of various aromatic and aliphatic amines with water as the primary oxidant were also studied, and excellent conversion and high selectivities to corresponding products were attained. Based on the control experiment and the catalytic principle, a possible reaction mechanism is proposed for the oxidative coupling of benzylamine with water as the primary oxidant.

Catalysis Science & Technology published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Jufeng; Ambrus, Joey I.; Russell, Cecilia C.; Baker, Jennifer R.; Cossar, Peter J.; Pirinen, Melanie J.; Sakoff, Jennette A.; Scarlett, Christopher J.; McCluskey, Adam published the artcile< Targeting the S100A2-p53 Interaction with a Series of 3,5-Bis(trifluoromethyl)benzenesulfonamides: Synthesis and Cytotoxicity>, Safety of 4-Bromobenzylamine, the main research area is benzenesulfonamide aminoalkyl trifluoromethyl preparation antitumor pancreatic cancer; S100A2; focuse libraries; p53; pancreatic cancer; protein-protein interaction.

In silico approaches identified N-(6-((4-bromobenzyl)amino)hexyl)-3,5-bis(trifluoromethyl)benzenesulfonamide I [X = (CH2)4; R1 = 4-BrC6H4; R2 = H] as a potential inhibitor of the S100A2-p53 protein-protein interaction, a validated pancreatic cancer drug target. Subsequent cytotoxicity screening revealed it to be a 2.97μM cell growth inhibitor of the MiaPaCa-2 pancreatic cell line. This is in keeping with the hypothesis that inhibiting this interaction would have an anti-pancreatic cancer effect with S100A2, the validated PC drug target. A combination of focused library synthesis [24 compounds I (X = nothing, CH2, CH2CH2; R1 = 4-BrC6H4, 3,4-Cl2C6H3, 1-naphthyl, etc.; R2 = H, Me)] and cytotoxicity screening identified a Pr alkyl diamine spacer as optimal; the nature of the terminal Ph substituent had limited impact on observed cytotoxicity, whereas N-methylation was detrimental to activity. In total 15 human cancer cell lines were examined, with most analogs showing broad-spectrum activity. Near uniform activity was observed against a panel of six pancreatic cancer cell lines: MiaPaCa-2, BxPC-3, AsPC-1, Capan-2, HPAC and PANC-1. In all cases there was good to excellent correlation between the predicted docking pose in the S100A2-p53 binding groove and the observed cytotoxicity, especially in the pancreatic cancer cell line with high endogenous S100A2 expression. This supports S100A2 as a pancreatic cancer drug target.

ChemMedChem published new progress about Amino amides Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary