Category: 3959-07-7

Sun, Wenhao; Xiang, Yonggang; Jiang, Zhihui; Wang, Shengyao; Yang, Nan; Jin, Shangbin; Sun, Linhao; Teng, Huailong; Chen, Hao published the artcile< Designed polymeric conjugation motivates tunable activation of molecular oxygen in heterogeneous organic photosynthesis>, Product Details of C7H8BrN, the main research area is thioether photocatalyst oxidation; sulfoxide preparation; aryl methanamine photocatalyst oxidative coupling reaction; diaryl azapropene preparation.

Herein, the first identification of tunable mol. oxygen activation induced by polymeric conjugation in nonmetallic conjugated microporous polymers (CMP) was reported. The conjugation between these can be achieved by the introduction of alkynyl groups. CMP-A with an alkynyl bridge facilitates the intramol. charge mobility while CMP-D, lacking an alkynyl group enhances the photoexcited carrier build-up on the surface from diffusion. These different processes dominate the directed ROS generation of the superoxide radical (·O-2) and singlet oxygen (1O2), resp. This theory is substantiated by the different performances of these CMPs in the aerobic oxidation of sulfides and the dehydrogenative coupling of amines, and could provide insight into the rational design of CMPs for various heterogeneous organic photosynthesis.

Science Bulletin published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Huan-Huan; Zhan, Guo-Peng; Liu, Zi-Kun; Wu, Chuan-De published the artcile< Photocatalytic Hydrogen Evolution Coupled with Production of Highly Value-Added Organic Chemicals by a Composite Photocatalyst CdIn2S4@MIL-53-SO3Ni1/2>, COA of Formula: C7H8BrN, the main research area is photocatalytic hydrogen evolution catalyst cadmium indium sulfide; hydrogen evolution; metal-organic frameworks; photocatalysis; suspended ion catalysts; water splitting.

Photocatalytic water splitting coupled with the production of highly value-added organic chems. is of significant importance, which represents a very promising pathway for transforming green solar energy into chem. energy. Herein, we report a composite photocatalyst CdIn2S4@MIL-53-SO3Ni1/2, which is highly efficient on prompting water splitting for the production of H2 in the reduction half-reaction and selective oxidation of organic mols. for the production of highly value-added organic chems. in the oxidation half-reaction under visible light irradiation The superior photocatalytic properties of the composite photocatalyst CdIn2S4@MIL-53-SO3Ni1/2 should be ascribed to coating suspended ion catalyst (SIC), consisting of redox-active NiII ions in the anionic pores of coordination network MIL-53-SO3-, on the surface of photoactive CdIn2S4, which endows photogenerated electron-hole pairs sep. more efficiently for high rate production of H2 and selective production of highly value-added organic products, demonstrating great potential for practical applications.

Chemistry – An Asian Journal published new progress about Band gap. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Hanzhi; Zhu, Yue; Zhao, Zhiyuan; Du, Jintong; Yang, Xinying; Fang, Hao; Hou, Xuben published the artcile< Structure-based design of 2-aminopurine derivatives as CDK2 inhibitors for triple-negative breast cancer>, Recommanded Product: 4-Bromobenzylamine, the main research area is triple neg breast cancer cyclin dependent kinase 2 2aminopurine; CDK2 inhibitor; anticancer; purine; structure-based drug design; triple-negative breast cancer.

Cyclin-dependent kinase 2 (CDK2) regulates the progression of the cell cycle and is critically associated with tumor growth. Selective CDK2 inhibition provides a potential therapeutic benefit against certain tumors. Purines and related heterocycle (e.g., R-Roscovitine) are important scaffolds in the development of CDK inhibitors. Herein, we designed a new series of 2-aminopurine derivatives based on the fragment-centric pocket mapping anal. of CDK2 crystal structure. Our results indicated that the introduction of polar substitution at the C-6 position of purine would be beneficial for CDK2 inhibition. Among them, compound 11I showed good CDK2 inhibitory activity (IC50 = 19 nM) and possessed good selectivity against other CDKs. Further in vitro tests indicated that compound 11l possesses anti-proliferation activity in triple-neg. breast cancer (TNBC) cells. Moreover, mol. dynamics simulation suggested the favorable binding mode of compound 11l, which may serve as a new lead compound for the future development of CDK2 selective inhibitors.

Frontiers in Pharmacology published new progress about Antiproliferative agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xiangjun; Li, Zezhuo; Zhang, Kaiyue; Zhao, Danfeng; Huang, Xiubing published the artcile< Thermo-Enhanced Photocatalytic Activity in Aerobic Oxidative Coupling of Amines to Imines over Cu-Doped MIL-125-NH2>, Reference of 3959-07-7, the main research area is metal organic framework benzylamine oxidative coupling photocatalyst.

Photocatalytic oxidation of raw organic mols. to value-added chems. provides a cost-effective and sustainable strategy in organic synthesis. In this work, a series of Cu-doped MIL-125-NH2 with narrower band gaps were synthesized by a one-pot hydrothermal method and used as photocatalysts for thermo-enhanced aerobic oxidative coupling of amines to imines under visible light irradiation With optimal doping content, the conversion of benzylamine over MIL-125-NH2/Cu2% can reach 100% at 60°C under visible light irradiation for 8 h using mol. oxygen as oxidant. It is proved that doping MIL-125-NH2 with a suitable Cu content can broaden the visible light absorption range, promote the separation of photo-induced charge carriers and improve the photocatalytic performance. Moreover, the increase of reaction temperature of the photocatalytic system promotes the performance. Free radical capture experiments and ESR tests show that holes and superoxide free radicals are the main active species. Such an excellent photocatalytic performance can be attributed to the strong light absorption and more efficient electron-hole separation efficiency via the Cu-doping strategy in MIL-125-NH2 catalysts.

Asian Journal of Organic Chemistry published new progress about Metal-organic frameworks. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Liu Zeng; Shu, Hai Yang; Wu, Jing; Yu, Yun Long; Ma, Duo; Huang, Xin; Liu, Ming Ming; Liu, Xin Hua; Shi, Jing Bo published the artcile< Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis>, Application In Synthesis of 3959-07-7, the main research area is pyrazolopyrimidine thienopyrimidine preparation SAR antiinflammatory iNOS inhibitor arthritis; Anti-inflammatory activity; Arthritis; Drug-like properties; Thieno[3,2-d]pyrimidine; iNOS inhibitory activity.

In order to discover and develop drug-like anti-inflammatory agents against arthritis, based on “”Hit”” authours found earlier and to overcome drawbacks of toxicity, twelve series of total 89 novel pyrimidine, pyrazolo[4,3-d]pyrimidine and thieno[3,2-d]pyrimidine derivatives were designed, synthesized and screened for their anti-inflammatory activity against NO and toxicity for normal liver cells (LO2). Relationships of balance toxicity and activity have been summarized through multi-steps, and title compounds (E)-N-(4-methylbenzyl)-2-(3,4,5-trimethoxystyryl)thieno[3,2-d]pyrimidin-4-amine, (E)-4-((2-(3,4,5-trimethoxystyryl)thieno[3,2-d]pyrimidin-4-yl)amino)phenol were found to show lower toxicity (against LO2: IC50 = 2934, 2301μM, resp.) and potent effect against NO release (IR = 98.3, 97.67%, at 10μM, resp.). Furthermore, compound (E)-N-(4-methylbenzyl)-2-(3,4,5-trimethoxystyryl)thieno[3,2-d]pyrimidin-4-amine showed potent iNOS inhibitory activity with value of IC50 is 0.96μM and could interfere stability and formation of the active dimeric iNOS. It’s anti-inflammatory activity in vivo was assessed by AIA rat model. Furthermore, the results of metabolic stability, CYP, PK study in vivo, acute toxicity study and subacute toxicity assessment indicated this compound had good drug-like properties for treatment.

European Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vasu, Amrutham; Naresh, Mameda; Krishna Sai, Gajula; Divya Rohini, Yennamaneni; Murali, Boosa; Ramulamma, Madasu; Ramunaidu, Addipilli; Narender, Nama published the artcile< A heterogeneous catalytic strategy for facile production of benzimidazoles and quinoxalines from primary amines using the Al-MCM-41 catalyst>, COA of Formula: C7H8BrN, the main research area is benzimidazole preparation; quinoxaline preparation; amine phenylenediamine oxidative cross coupling aluminum MCM catalyst.

This study reported a straightforward heterogeneous catalytic (Al-MCM-41) approach to synthesize benzimidazoles I [R = n-Pr, cyclohexyl, Ph, etc.; R1 = H, 5-Me, 5,6-di-Cl, etc.; R2 = H, Bn, CH2CH2Ph] and quinoxalines II [R3 = H, 6-Me, 6-Br, etc.; R4 = H, 4-MeC6H4, 4-ClC6H4, etc.] from primary amines under solvent-free conditions. The Al-MCM-41 catalyst was prepared using a hydrothermal method and characterized by various anal. techniques. The probability and limitations of the catalytic methodol. were presented with various substrates. The catalytic method grants an attractive route to a wide variety of benzimidazole and quinoxaline moieties with good to excellent yields. The gram scale reaction and reusability (up to five cycles) of the Al-MCM-41 catalyst would greatly benefit industrial applications.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Tianbao; Lu, Huiai; Qiu, Renhua; Hong, Ling; Yin, Shuang-Feng; Kambe, Nobuaki published the artcile< Photocatalyst-free Synthesis of Indazolones under CO2 Atmosphere>, Safety of 4-Bromobenzylamine, the main research area is indazolone dihydro preparation green chem anticancer activity; amine nitroaryl methanol heterocyclization; anticancer; indazolones; metal-free; photocatalyst-free; synthetic methods.

A convenient photocatalyst-free method for the synthesis of redox-active 1,2-dihydro-3H-indazol-3-one derivatives I (R = benzyl, thiophen-2-ylmethyl, cyclopropylmethyl, iso-Pr, etc.; R1 = H, Br, 3-methylphenyl, 4-methoxyphenyl, naphth-1-yl, furan-3-yl, thiophen-3-yl; R2 = H, Cl) from (2-nitroaryl)methanols 2-O2N-4-R1-5-R2C6H2CH2OH and amines RNH2 was developed. The reaction proceeded efficiently at room temperature by irradiation of UV light under CO2 atmosphere (1.0 atm, flow) without any photocatalysts or additives. This mild, operationally simple method shows wide functional tolerance. The carbamate formed in situ from CO2 and amine is proposed to be the key of this reaction. Some of these compounds synthesized by the present method were found to exhibit high anticancer activities, which can lower the viability of cancerous cell lines such as HeLa, MCF-7 and U87.

Chemistry – An Asian Journal published new progress about Antitumor agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ling, Johanne; Bruneau-Voisine, Antoine; Journot, Guillaume; Evano, Gwilherm published the artcile< Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides and Amines>, SDS of cas: 3959-07-7, the main research area is amide preparation; alkyl iodide amine carbon monoxide carbonylative cross coupling copper; amides; carbon monoxide; carbonylation; copper catalysis; cross-coupling.

A general copper-catalyzed carbonylative cross-coupling between amines and alkyl iodides was reported to form amides RC(O)NR1R2 [R = Cy, i-Pr, CH(Et)2, etc.; R1 = H, Me, R2 = n-hexyl, CH2Bn, t-Bu, etc.]. Using a simple combination of catalytic amounts of copper(I) chloride and N,N,N’;N””,N””-pentamethyldiethylenetriamine in the presence of sodium hydroxide under carbon monoxide pressure, a broad range of alkyl iodides and amines can be efficiently coupled to the corresponding amides that are obtained in good to excellent yields. Notable features of this process were the first one relying on a base metal catalyst, includeed the availability and low cost of the catalytic system, its successful use with primary, secondary, tertiary alkyl iodides and all classes of amines with no or limited competing nucleophilic substitution without CO incorporation as well as its efficiency with complex alkyl iodides and amines. Mechanistic studies demonstrated that a radical pathway is operative and the key role of CO.

Chemistry – A European Journal published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Huiqiong; Feng, Huangdi; Wang, Fang; Huang, Liliang published the artcile< Carboxyl Transfer of α-Keto Acids toward Oxazolidinones via Decarboxylation/Fixation of Liberated CO2>, Safety of 4-Bromobenzylamine, the main research area is copper catalyst carboxyl transfer alpha keto acid decarboxylation fixation; liberated carbon dioxide decarboxylation; oxazolidinone preparation.

A novel strategy for the direct carboxyl transfer involving a decarboxylative A3 reaction of α-keto acids, primary amines, and alkynes has been developed under a Cu(I)/Cu(II) binary catalysis system. This multicomponent reaction provides a facile and efficient approach for the production of a diverse range of 2-oxazolidinones in moderate to excellent yields through a one-pot CO2 elimination-fixation procedure. The conciseness of the “”CO2 recycling”” process makes this ideal synthesis superior over classical CO2 utilization.

Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xia; Lyu, Shaoshuai; Lang, Xianjun published the artcile< Superoxide generated by blue light photocatalysis of g-C3N4/TiO2 for selective conversion of amines>, Reference of 3959-07-7, the main research area is graphitic carbon nitride titanium dioxide amine superoxide photocatalysis; Amines; Photocatalysis; Selective aerobic oxidation; Superoxide; Visible light.

Reactive oxygen species (ROS) are remarkably reactive chem. oxygen-containing mols. that not only occupy critical positions in cell signaling and homeostasis for regulating aerobic living organism’s growth and development but also broadly participate in the environmental management as extraordinary oxidizing agents. Inspired by the behaviors of ROS, we designed an artful visible light photocatalytic system for the selective conversion of amines due to the activation of oxygen (O2) to superoxide (O2·-) over g-C3N4/TiO2. Here, blue light was manipulated as a light source to circumvent the initiation of the strong nonselective hydroxyl radical (·OH) that is often generated by valence band holes (hvb+) of TiO2. Aerial O2 was employed to achieve the long-lived, exclusive ROS, O2·-, while acetonitrile, an aprotic solvent, was utilized to prolong the lifetime of O2·-. Importantly, the g-C3N4/TiO2 possesses an exceptional capability for the generation of O2·-. Based on the synergistic effect of two ingredients of the g-C3N4/TiO2 photocatalyst, the highly selective conversion of amines was achieved with superior conversions in comparison with the pristine TiO2 and g-C3N4. Furthermore, a mechanism dominated by O·- was proposed according to the kinetic studies, ESR (EPR), and ROS quenching experiments This work highlights the importance of ROS in defining the desirable outcomes over semiconductor photocatalysts.

Environmental Research published new progress about Adsorption (isotherm). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary