Category: 3959-07-7

Wu, Zhenyu; Huang, Xiubing; Li, Xiangjun; Hai, Guangtong; Li, Baozhen; Wang, Ge published the artcile< Covalent-organic frameworks with keto-enol tautomerism for efficient photocatalytic oxidative coupling of amines to imines under visible light>, Application In Synthesis of 3959-07-7, the main research area is amine imine covalent organic framework photocatalytic oxidation.

Photocatalytic oxidation of organic mols. into highly value-added products is an innovative and challenging research which has gradually attracted remarkable attention of scientists. In this work, it is demonstrated that the COF-TpPa with keto-enol tautomerism equilibrium structure shows excellent performance (yield>99% after 8 h) in the selective photocatalytic oxidative coupling of amines to imines under visible light irradiation It is revealed that three kinds of reactive oxygen species (superoxide radical, hydroxyl radical and singlet oxygen) participate in this photocatalytic oxidation reaction. In addition, hydrogen protons cleaved from the benzyl are proven to be reduced to hydrogen in the conduction band of COF-TpPa in anaerobic atm., accompanied with the formation of imines. The direct hydrogen evolution from amine provides an effective way to extract clean energy from organic mol. as well as the production of value-added chems. As a contrast, COF-LZU1 with similar structure and chem. composition to COF-TpPa but without keto-enol tautomerism exhibits worse optical properties and photocatalytic performance. It is also demonstrated that keto-enol tautomerism favors the adsorption of benzylamine based on the characterization results and theor. calculations

Science China: Chemistry published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vikram, V.; Amperayani, K. R.; Umadevi, P. published the artcile< Derivatives of 3-(Methoxycarbonyl)thiophene Thiourea as Potential Potent Bacterial Acetyl-CoA Carboxylase Inhibitors>, Recommanded Product: 4-Bromobenzylamine, the main research area is methoxy carbonyl thiophene preparation antibacterial antifungal mol docking.

Novel thiourea derivatives containing a 3-(methoxycarbonyl)thiophene pharmacophore were synthesized and tested for activity against Gram-pos. (Salmonella typhi and Klebsiella pneumonia) and Gram-neg. (Micrococcus luteus and Staphylococcus aureus) bacterial strains and fungal strains (Aspergillus niger and Fusarium oxysporum), as well as the binding energies of the synthesized compounds to the bacterial acetyl-CoA carboxylase were determined The pharmacokinetic characteristics (ADMEt) of the synthesized compounds were calculated According to both the in vitro and in silico results, the highest activity against all the strains and the highest binding efficiency to the bacterial acetyl-CoA carboxylase was characteristic Me 2-[3-(4-ethylbenzyl)thioureido]thiophene-3-carboxylate. The calculated pharmacokinetic characteristics showed that all the synthesized compounds were safe to administer orally. It was concluded that the 3-(methoxycarbonyl)thiophene thiourea derivatives could act as potent inhibitors of bacterial acetyl-CoA carboxylase.

Russian Journal of Organic Chemistry published new progress about Antibacterial agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Chang; Zhang, Chao; Lu, Tong-Bu published the artcile< Graphdiyne anchored ultrafine Ag nanoparticles for highly efficient and solvent-free catalysis of CO2 cycloaddition>, Synthetic Route of 3959-07-7, the main research area is silver nanoparticle carbon dioxide cycloaddition graphdiyne.

Apart from photo-/electro-catalytic CO2 reduction, an important alternative route to CO2 utilization is to use this inert mol. as a C1 source to synthesize value-added chems.; however, the practical application is limited by the low conversion efficiency. Herein, we reported a composite catalyst of 3D sponge-like pyrenyl-graphdiyne (Pyr-GDY) anchored ultrafine Ag nanoparticles (Ag/Pyr-GDY), with the average size of Ag NPs of only 1.6 nm. The porous 3D Pyr-GDY component can not only anchor and stabilize the capping agent free ultrafine Ag NPs by virtue of the strong affinity between alkynyl groups and Ag, but also enhance the local concentration of CO2 due to the porous nature of 3D Pyr-GDY. As a result, the optimized Ag/Pyr-GDY catalyst displays a record-high activity towards the catalysis of CO2 cycloaddition with propargylamines under ambient temperature and pressure, with a TON of 20 488 and a yield of 83%, and is 15.3 times more active than the most efficient catalyst Ag27-MOF (TON = 1333, yield = 34%). Moreover, our catalysis was performed in a solvent-free system, which provides an economic, green and practical avenue for carbon capture, utilization and storage (CCUS).

Materials Chemistry Frontiers published new progress about Concentration (process). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jimenez-Almarza, Alicia; Lopez-Magano, Alberto; Mas-Balleste, Ruben; Aleman, Jose published the artcile< Tuning the Activity-Stability Balance of Photocatalytic Organic Materials for Oxidative Coupling Reactions>, Quality Control of 3959-07-7, the main research area is imine preparation; amine oxidative coupling photocatalytic; amines; imines; organic materials; oxidative coupling; photocatalysis.

In the series of materials reported herein, the triazine-based material shows the optimal compromise between activity and stability when studied for the oxidative coupling of amines, achieving imine products. Accordingly, while significant leaching of mol. active fragments was ruled out for triazine-based polymers, other materials of the series show a significant chem. erosion as a result of the reaction with the amine substrates. Consequently, only a triazine-based material allowed performing several catalytic cycles (up to seven) with yields higher than 80%. The applicability of this heterogeneous catalyst had been proven with a variety of substrates, confirming its stability and obtaining diverse imine coupling products with excellent yields.

ACS Applied Materials & Interfaces published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ahammed, Khondakar Sayef; Pal, Ritesh; Chakraborty, Jeet; Kanungo, Ajay; Purnima, Polnati Sravani; Dutta, Sanjay published the artcile< DNA Structural Alteration Leading to Antibacterial Properties of 6-Nitroquinoxaline Derivatives>, Reference of 3959-07-7, the main research area is DNA structure nitroquinoxaline derivative antibacterial activity.

Structural integrity of the bacterial genome plays an important role in bacterial survival. Cellular consequences of an intolerable amount of change in the DNA structure are not well understood in bacteria. We have stated that binding of synthetic 6-nitroquinoxaline derivatives with DNA led to change in its global structure, subsequently culminating with over-supercoiled form through in-path intermediates. This structural change results in induction of programmed cell death like physiol. hallmarks, which is dependent on substitution driven structural modulation properties of the scaffold. A sublethal dose of a representative derivative significantly inhibits DNA synthesis, produces fragmented nucleoids, and alters membrane architecture. We have also shown that exposure to the compound changes the native morphol. of Staphylococcus aureus cells and significantly disrupts preformed biofilms. Thus, our study gives new insight into bacterial responses to local or global DNA structural changes induced by 6-nitroquinoxaline small mols.

Journal of Medicinal Chemistry published new progress about Antibacterial agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yu, Bangkui; Zou, Suchen; Liu, Hongchi; Huang, Hanmin published the artcile< Palladium-Catalyzed Ring-Closing Reaction via C-N Bond Metathesis for Rapid Construction of Saturated N-Heterocycles>, Product Details of C7H8BrN, the main research area is spirocycle preparation palladium catalyzed ring closure aminodiene aminal; fused ring preparation palladium catalyzed ring closure aminodiene aminal.

The ring-closing reactions based on chem. bond metathesis enable the efficient construction of a wide variety of cyclic systems which receive broad interest from medicinal and organic communities. However, the analogous reaction with C-N bond metathesis as a strategic fundamental step remains an unanswered challenge. Herein, we report the design of a new fundamental metallic C-N bond metathesis reaction that enables the palladium-catalyzed ring-closing reaction of aminodienes with aminals. The reactions proceed efficiently under mild conditions and exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5- to 16-membered N-heterocycles bearing diverse frameworks and functional groups.

Journal of the American Chemical Society published new progress about Alkadienes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (amino). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Venu, Boosa; Shirisha, Varimalla; Vishali, Bilakanti; Naresh, Gutta; Kishore, Ramineni; Sreedhar, Inkollu; Venugopal, Akula published the artcile< A Cu-BTC metal-organic framework (MOF) as an efficient heterogeneous catalyst for the aerobic oxidative synthesis of imines from primary amines under solvent free conditions>, Application In Synthesis of 3959-07-7, the main research area is metal organic framework catalyst amine aerobic oxidation imine synthesis; physicochem property.

A Cu-BTC (MOF-199) [copper(II)-benzene-1,3,5-tricarboxylate] catalyst has been synthesized and evaluated for imine synthesis from amine compounds under neat conditions. The performance of the Cu-BTC MOF was significantly higher than that of the CuO supported on Al2O3, TiO2 and SiO2 catalysts. The role of surface Lewis acid sites on the catalyst in the formation of imine products was illustrated by the pyridine-IR studies. The recovered Cu-BTC catalyst demonstrated consistent activity for five cycles under similar exptl. conditions. The physicochem. properties of the catalysts were analyzed by XRD, BET-SA, FT-IR, UV-DRS, SEM, TEM, XPS and pyridine adsorbed DRIFT spectroscopy.

New Journal of Chemistry published new progress about Green chemistry. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Shaofeng; Geng, Furong; Dong, Jianyu; Liu, Long; Su, Lebin; Zhou, Yongbo published the artcile< General and practical synthesis of naphtho[2,1-d]oxazoles from naphthols and amines>, Product Details of C7H8BrN, the main research area is naphthol amine oxidative cyclization; naphthooxazole preparation.

A general and practical synthesis of naphtho[2,1-d]oxazoles from readily available naphthols and amines was developed using TEMPO as the oxygen source with outstanding functional group tolerance, especially for the construction of the naphthoxazole-related bioactive mol. PBNI and naphthoxazole-doped materials, as well as the polyaryloxazole-related ADN derivative This protocol allowed the rapid assembly of a small library of naphtho[2,1-d]oxazole skeletons (55 examples) that are difficult to be prepared by other methods. The ESR (EPR) and 18O-labeled experiments indicated that the radical adducts of TEMPO with naphthalenone radicals may serve as key intermediates.

Organic Chemistry Frontiers published new progress about Aromatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Ya; Huang, Dai-Chuan; Liu, Chang; Song, Zi-Long; Liu, Jing-Rui; Guo, Shu-Ke; Tan, Jun-Yang; Qiu, Run-Ling; Jin, Bing; Zhang, Haifeng; Mulholland, Nick; Han, Xinya; Xia, Qinfei; Ali, Abdallah S.; Guo, Dale; Deng, Yun; Gu, Yu-Cheng; Zhang, Ming-Zhi published the artcile< Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study>, Computed Properties of 3959-07-7, the main research area is streptochlorin analog synthesis antifungal agent mol docking; Antifungal activity; Imidazole; Molecular docking; Natural products; Streptochlorin.

Streptochlorin is a small mol. of indole alkaloid isolated from marine Streptomyces sp., it is a promising lead compound due to its potent bioactivity in preventing many phytopathogens in our previous study, but further structural modifications are required to improve its antifungal activity. Our work in this paper focused on the replacement of oxazole ring in streptochlorin with the imidazole ring, to discover novel analogs. Based on this design strategy, three series of streptochlorin analogs were efficiently synthesized through sequential Vilsmeier-Haack reaction, Van Leusen imidazole synthesis and halogenation reaction. Some of the analogs displayed excellent activity in the primary assay, and this is highlighted by compounds I and II, the growth inhibition against Alternaria Leaf Spot and Rhizoctorzia solani under 50μg/mL are 97.5% and 90.3%, resp., even more active than those of streptochlorin, pimprinine and Osthole. Mol. docking models indicated that streptochlorin binds with Thermus thermophiles Leucyl-tRNA Synthetase in a similar mode to AN2690, offering a perspective on the mode of action study for antifungal activities of streptochlorin derivatives Further study is still ongoing with the aim of discovering synthetic analogs, with improved antifungal activity and clear mode of action.

Bioorganic & Medicinal Chemistry published new progress about Cyclization. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Zhihui; Yang, Tianbao; Tang, Niu; Ou, Yifeng; Yin, Shuang-Feng; Kambe, Nobuaki; Qiu, Renhua published the artcile< UV-Light-Induced N-Acylation of Amines with α-Diketones>, Synthetic Route of 3959-07-7, the main research area is amide preparation; amine alpha diketone photoinduced acylation.

Herein, a mild method for N-acylation of primary and secondary amines with α-diketones induced by UV light is reported. Forty-six examples with various functional groups are explored at room temperature with irradiation by three 26 W UV lamps (350-380 nm). The yield reaches 97%. The gram scale experiment product yield is 76%. Moreover, this system can be applied to the synthesis of several amino acid derivatives Mechanistic studies show that benzoin is generated in situ from benzil under UV irradiation

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary