Category: 3959-07-7

Lin, Hua-Chen; Knox, Gary J.; Pearson, Colin M.; Yang, Chao; Carta, Veronica; Snaddon, Thomas N. published the artcile< A Pd-H/Isothiourea Cooperative Catalysis Approach to anti-Aldol Motifs: Enantioselective α-Alkylation of Esters with Oxyallenes>, Category: bromides-buliding-blocks, the main research area is oxyallene pentafluorophenyl acetate palladium benzotetramisole enantioselective diastereoselective alkylation; pentafluorophenyl oxypentenoate preparation; methyl oxy butenyl carbamate preparation; Allenes; C1-Ammonium Enolates; Enantioselectivity; Isothioureas; Palladium Catalysis.

To complement the array of substrate-based strategies, and regulate enolate geometry at the catalyst level, a direct catalytic alkylation of esters with oxyallenes was developed. Synergizing metal hydride reactivity with Lewis base catalysis resulted in a broad reaction scope with useful levels of stereocontrol (up to >99% ee). Facile derivatization of these ambiphilic linchpins was demonstrated, providing access to high-value vicinal stereocenter-containing motifs, including 1,2-amino alcs.

Angewandte Chemie, International Edition published new progress about Alkylation catalysts, stereoselective. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yuan, Ziliang; Liu, Bing; Zhou, Peng; Zhang, Zehui; Chi, Quan published the artcile< Preparation of nitrogen-doped carbon supported cobalt catalysts and its application in the reductive amination>, Recommanded Product: 4-Bromobenzylamine, the main research area is amine preparation green chem; aldehyde reductive amination cobalt nanocatalyst.

The use of non-noble metal catalysts with high activity is of great importance for organic transformations. Herein, nitrogen-doped carbon supported cobalt catalysts with high surface area up to 981.2 m2/g were prepared via the simple pyrolysis of cobalt coordinated organic polymers with silica as the hard template. The pyrolysis temperature showed a great effect on the structure and properties of the as-prepared catalysts. The Co@NC-800 catalyst with the pyrolysis temperature of 800 °C demonstrated a high activity for the selective reductive amination of carbonyl compounds RCHO (R = CH3(CH2)6, furan-2-yl, cyclohexyl, etc.) to primary amines RCH2NH2 with ammonia and hydrogen. Structurally-diverse primary amines with yields in the range from 81.8% to 100% were attained under the optimal conditions. The Co@NC-800 catalyst could be reused without the loss of its activity. The Co@NC-800 catalyst demonstrated comparable activity as the reported heterogeneous noble metal catalysts.

Journal of Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nazari Montazer, Mohammad; Asadi, Mehdi; Bahadorikhalili, Saeed; Hosseini, Faezeh Sadat; Amanlou, Arash; Biglar, Mahmood; Amanlou, Massoud published the artcile< Design, synthesis, docking study and urease inhibitory activity evaluation of novel 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-arylacetamide derivatives>, SDS of cas: 3959-07-7, the main research area is amino thiadiazolylthio arylacetamide preparation docking pharmacokinetic urease inhibitor.

Novel 2-((5-amino-1,3,4-thiadiazol-2-yl)thio)-N-arylacetamide derivatives I [R = 4-MeOC6H4, 4-methylisoxazol-3-yl, 5-chloro-2-pyridyl, etc.] were designed, synthesized and evaluated in vitro for their urease inhibitor activities. The compounds were synthesized efficiently in three steps in high isolated yields from amines, 2-chloroacetyl chloride, hydrazinecarbothioamide and carbon disulfide. The mol. docking simulation were performed using AutoDock4 by docking all synthesized compound and standard inhibitors into the crystal structure of Jack bean urease. Comparison between the urease inhibitory activity of compounds with the IC50 of (2.85-5.83μM) and thiourea and hydroxyurea as standards inhibitors with the IC50 of (22.00 and 100.00μM, resp.) proved the high activity of the synthesized compounds against the mentioned enzyme. Docking results were in good agreement with exptl. results and indicate that synthesized compounds could interact well with the active site of the urease enzyme and among all; compound I [R = 5-methyl-2-pyridyl] showed more favorable interactions with the active site which confirm its great inhibitory activity with IC50 of 2.85μM. Therefore, compound I [R = 5-methyl-2-pyridyl] might be a promising candidate for further evaluation.

Medicinal Chemistry Research published new progress about Acetamides Role: PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun published the artcile< Organotin-catalyzed synthesis of hydroxyalkylamides from lactones via a ring-opening process>, Quality Control of 3959-07-7, the main research area is primary amine lactone dibutyltin acetate catalyst ring opening amidation; hydroxyalkylamide preparation.

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactones with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active mols. tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method.

Tetrahedron Letters published new progress about Aliphatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mugnaini, Claudia; Pasculini, Livia; Pagli, Carlotta; Brizzi, Antonella; Paolino, Marco; Gianibbi, Beatrice; Corelli, Federico published the artcile< Synthesis of pyrazolo[1,5-a]pyrimidine ring as a possible bioisosteric replacement of the 5-(1H-pyrrol-1-yl)pyrazole scaffold>, Quality Control of 3959-07-7, the main research area is pyrazolopyrimidine preparation.

Reaction of 3-amino-1H-pyrazole-4-carbonitrile with 2,4-pentanedione yielded 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, which was easily and efficiently transformed into a small library of amido derivatives I (R = 4-bromophenyl, 6-chloropyridin-3-yl, 6-(pyridin-3-yl)pyridin-3-yl, etc.). This procedure opens the way to new compounds potentially endowed with interesting biol. activities.

ARKIVOC (Gainesville, FL, United States) published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lu, Shu-Ning; Sun, Yue; Zhang, Jiajun; Chen, Zhengkai; Wu, Xiao-Feng published the artcile< Metal-free Synthesis of 5-Trifluoromethyl-1,2,4-triazoles via elemental sulfur promoted oxidative cyclization of trifluoroacetimidohydrazides with benzylic and aliphatic amines>, Category: bromides-buliding-blocks, the main research area is trifluoromethyl triazole preparation glycine transporter 1 inhibitor; aralkyl amine trifluoroacetimidohydrazide oxidative cyclization elemental sulfur promoter.

An elemental sulfur-mediated oxidative cyclization of readily available trifluoroacetimidohydrazides and aliphatic amines has been achieved, which provided a direct avenue to structurally diverse 5-trifluoromethyl-1,2,4-triazoles. In this transformation, sulfur acts as a traceless oxidizing agent. A myriad of benzyl amines and tertiary aliphatic amines were tolerated in this protocol. The reaction can be scaled up easily and also been applied to build GlyT1 inhibitor as an example of bio-active mol.

Molecular Catalysis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Hui; Li, Xia; Hao, Huimin; Dong, Xiaoyun; Sheng, Wenlong; Lang, Xianjun published the artcile< Designing fluorene-based conjugated microporous polymers for blue light-driven photocatalytic selective oxidation of amines with oxygen>, Application In Synthesis of 3959-07-7, the main research area is microporous conjugated polyfluorene polycarbazole blue light photocatalytic amine oxidation.

Conjugated microporous polymers (CMPs) have been showcased with a brilliant prospect in organic semiconductor photocatalysis, attributing to accessible mol. design, chem. stability and environmental friendliness. Here, two novel fluorene-based CMPs were designed and conveniently synthesized with carbazole as an electron donor. Importantly, subtle variation of substituent at the methylene bridge (9-position) of fluorene precursor results in different performances in which di-Me substituent was proven to be more efficient than difluoro substituent for blue light photocatalysis. MFC [9,9′-(9,9-dimethyl-9H-fluorene-2,7-diyl)bis(9H-carbazole)]-CMP has a much larger sp. surface area, a more favorable redox position, and resultantly a superior photocatalytic performance during blue light-driven selective oxidation of amines into imines with oxygen (O2) in an environmentally benign solvent ethanol (C2H5OH). This work suggests that subtle tweaking in electron acceptors could give rise to superior photocatalytic activity for CMPs in selective chem. conversions.

Applied Catalysis, B: Environmental published new progress about Band gap. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mal, Kajal; Mukhopadhyay, Chhanda published the artcile< Chromatography free expeditious green synthesis of 3-hydroxy-2-pyrrolidone derivatives under eco-friendly conditions via the oxidation of benzyl amines without catalyst>, Product Details of C7H8BrN, the main research area is hydroxypyrrolidone preparation green chem; benzyl amine dialkylacetylenedicarboxylate oxidation.

A sustainable and atom economic one-pot synthesis of biol. significant 3-hydroxy-2-pyrrolidone moieties via the reaction of benzyl amine, aniline (or another benzyl amine) and dialkylacetylenedicarboxylate without catalyst in green solvent has been developed. Some remarkable features of this green procedure are aqueous ethanol solvent, reaction without catalyst, no column chromatog. for isolation of the products, higher the value of atom economy (AE) (up to 94.30%) and lower the E-factor value (up to 0.23 g/g). The reaction principally demonstrates the scope of oxidation of benzyl amines followed by cyclization. This synthetic route is also applicable to gram-scale synthesis.

Journal of Molecular Structure published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jin, Sen; Wang, Hui; Li, Lei; Luo, Xiao; Sun, Xianshun; Zuo, Ming; Tian, Jie; Zhang, Xiaodong; Xie, Yi published the artcile< Surface modification boosts exciton extraction in confined layered structure for selective oxidation reaction>, Computed Properties of 3959-07-7, the main research area is exciton extraction layered structure selective oxidation reaction surface modification.

Extracting photogenerated species from bulk to surface is an essential process for gaining efficient semiconductor-based photocatalysis. However, compared with charged photogenerated carriers, neutral exciton exhibits negligible response to elec. field. Accordingly, traditional strategies involving band-alignment construction for boosting directional transfer of charge carriers are impracticable for extracting bulk excitons. To this issue, we here propose that the extraction of bulk exciton could be effectively implemented by surface modification. By taking confined layered bismuth oxycarbonate (Bi2O2CO3) as an example, we highlight that the incorporation of iodine atoms on the surface could modify the micro-region electronic structure and hence lead to reduced energy of surface excitonic states. Benefiting from the energy gradient between bulk and surface excitonic states, iodine-modified Bi2O2CO3 possesses high-efficiency bulk exciton extraction, and hence exhibits promoted performance in triggering 1O2-mediated selective oxidation reaction. This work presents the pos. role of surface modification in regulating excitonic processes of semiconductor-based photocatalysts.

Science China: Chemistry published new progress about Absorption spectra. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kato, Kahoko; Deng, Dian; Kita, Yusuke; Kamata, Keigo; Hara, Michikazu published the artcile< Primary amine synthesis by hydrogen-involving reactions over heterogeneous cobalt catalysts>, Reference of 3959-07-7, the main research area is primary amine selective preparation; nitrile hydrogenation cobalt catalyst; carbonyl compound reductive amination cobalt catalyst.

A composite of metallic cobalt and silica particles that exhibits high catalytic performance for the selective synthesis of primary amines RNH2 [R = heptyl, cyclohexyl, Bn, [5-(hydroxymethyl)oxolan-2-yl]methyl, etc.] via hydrogenation of nitriles RCN and reductive amination, even under mild conditions was reported. A mechanistic study revealed that the substrate nitrile and the product amine retarded the hydrogenation of secondary imine intermediates, which resulted in a selective reaction. On the basis of this knowledge, the selectivity for the primary amine was further improved by the addition of coordinating organic mols., which provided new insights into the control of selectivity toward primary amines unlike that with classical methods using ammonia.

Catalysis Science & Technology published new progress about Carbonyl compounds (organic) Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary