Category: 3959-07-7

Doobary, Sayad; Sedikides, Alexi T.; Caldora, Henry P.; Poole, Darren L.; Lennox, Alastair J. J. published the artcile< Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-rich Substrates>, Reference of 3959-07-7, the main research area is vicinal difluoroalkane preparation difluorination unactivated alkene hypervalent iodine mediator; electrochem difluorination unactivated alkene hypervalent iodine mediator; electrochemistry; fluorination; green chemistry; hypervalent iodine; oxidation.

Fluorinated alkyl groups are important motifs in bioactive compounds, pos. influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochem. generation of a hypervalent iodine mediator using an “”ex-cell”” approach, which avoids oxidative substrate decomposition The more sustainable conditions give good to excellent yields in up to decagram scales. Of note, when handling HF reagents, personal protection is of utmost importance.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (unactivated). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gopalaiah, Kovuru; Tiwari, Ankit; Choudhary, Renu; Mahiya, Kuldeep published the artcile< Straightforward Access to 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides and Quinazolines via Iron-Catalyzed Aerobic Oxidative Condensation of Amines>, Application In Synthesis of 3959-07-7, the main research area is aminobenzenesulfonamide primary amine iron catalyst oxidative cyclocondensation; dihydrobenzothiadiazine dioxide preparation; aminobenzylamine primary amine iron catalyst oxidative cyclocondensation; quinazoline preparation.

A novel and straightforward approach for constructing 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides from 2-aminobenzenesulfonamide and benzylamines via oxidative condensation was explored. Abundant and cheap iron salt as a catalyst and air as an oxidant were employed, which makes the process more practical and economical. This reaction protocol was further applied to synthesize diverse functionalized quinazolines through oxidative condensation of 2-aminobenzylamines with benzylamines. Besides this, the use of amino acid such as phenylglycine as benzylamine surrogate was tested for the construction of 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide and quinazoline derivatives The proposed mechanistic pathway was validated by isolating the key intermediates.

ChemistrySelect published new progress about Benzothiadiazines Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Feng; Ma, Jun; Tan, Ya; Yu, Gang; Qin, Hongxin; Zheng, Lirong; Liu, Hongbo; Li, Run published the artcile< Construction of Porphyrin Porous Organic Cage as a Support for Single Cobalt Atoms for Photocatalytic Oxidation in Visible Light>, Synthetic Route of 3959-07-7, the main research area is construction porphyrin porous organic cage support single cobalt atom; oxidative coupling reaction catalyst benzylamine.

The construction of an appropriate support for a single atom catalyst plays an important role in delivering a high catalytic performance. However, most reported host materials suffer the drawbacks of low photostability and limited visible light absorption. Herein, we report a porous organic cage as a high-quality support for single metal atoms by a facile stepwise nucleophilic substitution approach. Thanks to its intrinsic advantages of extended visible light absorption, suppressed charge recombination, and improved electron transfer, the obtained single Co atoms anchored organic cage (CoP@POC) demonstrates a prominent photocatalytic efficiency for oxidation of amines into imines in visible light. An excellent reaction conversion and selectivity up to 99%, associated with a turnover frequency (TOF) of 1389 h-1 and 22 989 mmol g-1 h-1 are achieved based on organic cage and single Co atoms, resp., which outperforms most reported photocatalysts. Moreover, a negligible conversion decrease in 5 repeating cycles and no photobleaching after the reaction was detected, implying a remarkable photostability of CoP@POC.

ACS Catalysis published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Faltracco, Matteo; Cotogno, Silvia; Vande Velde, Christophe M. L.; Ruijter, Eelco published the artcile< Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji-Trost Allylation>, Formula: C7H8BrN, the main research area is diketopiperazine preparation palladium catalyst asym Tsuji Trost allylation.

The authors report the intramol. Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asym. construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, com. available starting materials.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lahtigui, Ouidad; Forster, Dan; Duchemin, Coralie; Cramer, Nicolai published the artcile< Enantioselective Access to 3-Azabicyclo[3.1.0]hexanes by CpxRhIII Catalyzed C-H Activation and Cp*IrIII Transfer Hydrogenation>, Reference of 3959-07-7, the main research area is azabicyclohexane enantioselective diastereoselective preparation; cyclopropane enantioselective diastereoselective preparation amine CH activation transfer hydrogenation; enoxysuccinimide alkenyl aldehyde enantioselective diastereoselective cyclopropanation.

A flexible two-step protocol for efficient and selective access such as 3-azabicyclo[3.1.0]hexanes I [R1 = cyclopropyl, Ph, 3-thienyl, etc.; R2 = Bn, PNB] was disclosed. A tailored CpxRhIII catalyst promoted alkenyl C-H functionalization of N-enoxysuccinimides engaging in rare cis-cyclopropanation of acrolein to access disubstituted cis-cyclopropanes in high enantio- and diastereoselectivity. Subsequently, in the presence of a broad range of primary amines, the dicarbonyl cis-cyclopropanes were efficiently and completely diastereoselectively cyclized by a Cp*IrIII catalyst via an iterative aminative transfer hydrogen to an exquisite set of substituted 3-azabicyclo[3.1.0]hexanes.

ACS Catalysis published new progress about C-H bond activation. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reese, Cassandra M.; Thompson, Brittany J.; Logan, Phillip K.; Stafford, Christopher M.; Blanton, Michael; Patton, Derek L. published the artcile< Sequential and one-pot post-polymerization modification reactions of thiolactone-containing polymer brushes>, Product Details of C7H8BrN, the main research area is homocysteine thiolactone acrylamide polymer brush amine post polymerization; surface property wettability.

Thiolactone chem. has garnered significant attention as a powerful post-polymerization modification (PPM) route to mutlifunctional polymeric materials. Here, we apply this versatile chem. to the fabrication of ultrathin, multifunctional polymer surfaces via aminolysis and thiol-mediated double modifications of thiolactone-containing polymer brushes. Polymer brush surfaces were synthesized via microwave-assisted surface-initiated polymerization of DL-homocysteine thiolactone acrylamide. Aminolysis and thiol-Michael double modifications of the thiolactone-functional brush were explored using both sequential and one-pot reactions with bromobenzyl amine and 1H,1H-perfluoro-N-decyl acrylate. XPS and argon gas cluster ion sputter depth profiling enabled quant. comparison of the sequential and one-pot PPM routes with regard to conversion and spatial distribution of functional groups immobilized throughout thickness of the brush. While one-pot conditions proved to be more effective in immobilizing the amine and acrylate within the brush, the sequential reaction enabled the fabrication of multifunctional, micropatterned brush surfaces using reactive microcontact printing.

Polymer Chemistry published new progress about Aminolysis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Jing Bo; Chen, Liu Zeng; Wang, Bao Shi; Huang, Xin; Jiao, Ming Ming; Liu, Ming Ming; Tang, Wen Jian; Liu, Xin Hua published the artcile< Novel Pyrazolo[4,3-d]pyrimidine as Potent and Orally Active Inducible Nitric Oxide Synthase (iNOS) Dimerization Inhibitor with Efficacy in Rheumatoid Arthritis Mouse Model>, COA of Formula: C7H8BrN, the main research area is pyrazolopyrimidine preparation inducible nitric oxide synthase dimerization inhibitor; antiflammatory activity SAR pyrazolopyrimidine rheumatoid arthritis mouse model.

In order to discover novel anti-inflammatory agents for treatment of arthritis and based on preliminary structure-activity relationships, four series (A-D) of total 90 new pyrazolo[4,3-d]pyrimidine compounds were designed and synthesized. All the compounds have been tested for their anti-inflammatory activities by inhibiting of LPS-induced NO production A clear structure-activity relationship has been concluded step by step, and finally 3,4,5-trimethoxystyryl-1H-pyrazolo[4,3-d]pyrimidine was found to be the most active scaffold. Among them, compound I was discovered as the most potent anti-inflammatory agent (IC50 = 3.17 μM) with low toxicity and strong inhibitory of NO release (IR = 90.4% at 10 μM). This compound also showed potent inhibition of iNOS with IC50 value of 1.12 μM. Preliminary mechanism studies indicated that it could interfere with the stability and formation of active dimeric iNOS. The anti-inflammatory effect of this compound was determined by adjuvant-induced arthritis in rat model. We believe these findings would further support the study of rational design of more efficient iNOS inhibitors in the future.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, COA of Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Russ, Nadine; Schroeder, Martin; Berger, Benedict-Tilman; Mandel, Sebastian; Aydogan, Yagmur; Mauer, Sandy; Pohl, Christian; Drewry, David H.; Chaikuad, Apirat; Mueller, Susanne; Knapp, Stefan published the artcile< Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase>, Reference of 3959-07-7, the main research area is calcium calmodulin dependent Ser Thr kinase chem probe; design synthesis diaminopyrimidine carboxamide CASK inhibitor structure property relationship.

CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) is a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kinases with roles implicated in neuronal synapses and trafficking. The lack of a canonical DFG motif, which is altered to GFG in CASK, led to the classification as a pseudokinase. However, functional studies revealed that CASK can still phosphorylate substrates in the absence of divalent metals. CASK dysfunction has been linked to many diseases, including colorectal cancer, Parkinson’s disease, and X-linked mental retardation, suggesting CASK as a potential drug target. Here, we exploited structure-based design for the development of highly potent and selective CASK inhibitors based on 2,4-diaminopyrimidine-5-carboxamides targeting an unusual pocket created by the GFG motif. The presented inhibitor design offers a more general strategy for the development of pseudokinase ligands that harbor unusual sequence motifs. It also provides a first chem. probe for studying the biol. roles of CASK.

Journal of Medicinal Chemistry published new progress about Amides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yanan; Ji, Kaihui; Wang, Jing; Li, Huafeng; Zhu, Xueyu; Ma, Pengtao; Niu, Jingyang; Wang, Jingping published the artcile< Enhanced Carrier Separation in Visible-Light-Responsive Polyoxometalate-Based Metal-Organic Frameworks for Highly Efficient Oxidative Coupling of Amines>, Computed Properties of 3959-07-7, the main research area is visible light responsive polyoxometalate metal organic framework photocatalyst; amine oxidative coupling; POM-based metal−organic frameworks; oxidative coupling of amines; photocatalytic; photosensitizers; polyoxometalates.

Photocatalytic technol. is widely studied, while it comes with drawbacks such as low sunlight utilization efficiency and high carrier recombination rates. Herein, for the first time, we present two crystalline polyoxometalate (POM)-based metal-organic frameworks (POMOFs), {[Cd(DMF)2Ru(bpy)2(dcbpy)]2(POMs)(DMF)2} xDMF (PMo-1, POMs = [PMoVI11MoVO40]4-, x = 5; SiW-2, POMs = [SiW12O40]4-, x = 4) through assembling the photosensitizer [Ru(bpy)2(H2dcbpy)]Cl2 and POMs into a single framework. The assembly not only enhances light absorption in the visible light regime but also improves carrier separation efficiency; atop of that, both POMOFs demonstrate activities in the photocatalytic oxidative coupling of amines. Particularly, PMo-1 enables the quant. completion of oxidative coupling of benzylamine reaction within 30 min (yield = 99.6%) with a high turnover frequency (TOF = 6631.6 h-1). To our knowledge, the PMo-1 catalyst outperforms any other photocatalysts previously reported in similar use cases where TOF values were usually obtained <2000 h-1. ACS Applied Materials & Interfaces published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Computed Properties of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rupanawar, Bapurao D.; Veetil, Sruthi M.; Suryavanshi, Gurunath published the artcile< Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)>, HPLC of Formula: 3959-07-7, the main research area is oxidative olefination benzylamine active methylene compound; olefination mediated hypervalent iodine.

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

European Journal of Organic Chemistry published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, HPLC of Formula: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary