Category: 401-55-8

《Full-spectrum fluoromethyl sulfonation via modularized multicomponent coupling》 was published in CCS Chemistry in 2022. These research results belong to Li, Kejie; Wang, Ming; Jiang, Xuefeng. Name: Ethylbromofluoroacetate The article mentions the following:

Modular free-assembly construction of mono-, di-, and tri-fluoromethyl sulfones was comprehensively achieved by a combination of halides, a sulfur dioxide surrogate, and halofluorocarbons. The industrial raw material thiourea dioxide served as the sulfur dioxide source, combined with readily available fluorocarbon sources such as 2-bromo-2-fluoroacetate and chlorodifluoromethane employed as fluoromethyl reagents. Notably, four Me sulfone-containing pharmaceuticals were modified into three types of fluoromethyl sulfones, displaying their great potential for drug discovery via the current strategy. Mechanistic studies further demonstrated that C-F···H-N interactions between thiourea dioxide and halofluorocarbons play a key role in stabilizing monofluoromethyl electrophiles and difluorocarbene species. The results came from multiple reactions, including the reaction of Ethylbromofluoroacetate(cas: 401-55-8Name: Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Name: Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: EthylbromofluoroacetateOn November 20, 2020 ,《Copper-Catalyzed Decarboxylative Functionalization of Conjugated β,γ-Unsaturated Carboxylic Acids》 appeared in ACS Catalysis. The author of the article were Zhang, Wei; Wang, Chengming; Wang, Qiu. The article conveys some information:

Copper-catalyzed decarboxylative coupling reactions of conjugated β,γ-unsaturated carboxylic acids have been achieved for allylic amination, alkylation, sulfonylation, and phosphinoylation. This approach was effective for a broad scope of amino, alkyl, sulfonyl, and phosphinoyl radical precursors as well as various conjugated β,γ-unsaturated carboxylic acids. These reactions also feature high regioselectivity, good functional group tolerance, and simple operation procedure. Mechanistic studies show that the reaction proceeds via copper-catalyzed electrophilic addition onto an olefin followed by decarboxylation, with radical intermediates involved. These insights present a modular and powerful strategy to access versatilely functionalized allyl-containing skeletons from readily available and stable carboxylic acids. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Name: Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Name: Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 401-55-8On May 15, 2020 ,《Acylation of Aryl Halides and α-Bromo Acetates with Aldehydes Enabled by Nickel/TBADT Cocatalysis》 appeared in Organic Letters. The author of the article were Fan, Pei; Zhang, Chang; Zhang, Linchuan; Wang, Chuan. The article conveys some information:

In this protocol aryl halides and α-bromo esters were efficiently cross-coupled with an array of aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provided a concise approach to a variety of ketones with high compatibility of various functional groups. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 401-55-8On September 30, 2020 ,《Sulfite-Promoted C-H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur》 was published in Synthesis. The article was written by Gao, Yong-Chao; Huang, Zi-Hao; Zhang, Zhao-Sheng; Xie, Jin-Xin; Cui, Zi-Ning; Tang, Ri-Yuan. The article contains the following contents:

A transition-metal-free sulfite-promoted three-component C-H sulfuration between imidazoheterocycles, elemental sulfur and bromofluoroacetate was developed. Sulfites, including Na2S2O4, NaHSO3 and Na2S2O3, were able to promote the formation of two C-S bonds in one step using elemental sulfur as a green sulfurating agent, allowing the rapid introduction of the synthetically useful S-fluoroacetate group into imidazoheterocycles. These new imidazoheterocycle derivatives bearing an S-fluoroacetate group can be easily modified to produce pharmaceutically attractive compounds In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Recommanded Product: 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Recommanded Product: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of EthylbromofluoroacetateOn March 18, 2022, Lu, Dengfu; Li, Yadong; Wang, Peng; Wang, Zijie; Yang, Daoyi; Gong, Yuefa published an article in ACS Catalysis. The article was 《Cu-Catalyzed C(sp3)-N Coupling and Alkene Carboamination Enabled by Ligand-Promoted Selective Hydrazine Transfer to Alkyl Radicals》. The article mentions the following:

In this work, di-tert-Bu hydrazodiformate was found to be a unique effective amination reagent in Cu-catalyzed C(sp3)-N bond formation reactions that involve alkyl radical intermediates. This method was applicable to both electron-deficient and electron-rich radicals, and were able to achieve the direct C-N coupling of activated bromides, as well as the carboamination of general alkenes based on this chem. Mechanistic studies suggested that the hydrazodiformate forms a reducing dinuclear complex with Cu and the ligand which, upon 1e-oxidation, turns into an open-shell species with the major spin d. on N atoms. With the assistance of a ligand, this species can selectively deliver the hydrazine moiety onto an alkyl radical (prior to halide transfer), leading to the formation of a C(sp3)-N bond. The products obtained with this amination method could be easily deprotected to afford alkyl hydrazines and further derived to primary amines or N-heterocycles. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8Quality Control of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Quality Control of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lv, Xu-Lu; Wang, Cong; Wang, Qiao-Li; Shu, Wei published an article in Organic Letters. The title of the article was 《Rapid Synthesis of γ-Arylated Carbonyls Enabled by the Merge of Copper- and Photocatalytic Radical Relay Alkylarylation of Alkenes》.Synthetic Route of C4H6BrFO2 The author mentioned the following in the article:

The development of mild and practical methods for the γ-arylation of carbonyl compounds is an ongoing challenge in organic synthesis. The first formal γ-arylation of carbonyl compounds via radical relay cross-coupling of α-bromocarbonyl precursors with boronic acids in the presence of alkenes is reported. This directing-group-free protocol allows for the rapid and straightforward access to a wide range of γ-arylated esters, ketones, and amides under ambient conditions with excellent functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of Ethylbromofluoroacetate(cas: 401-55-8Synthetic Route of C4H6BrFO2)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Synthetic Route of C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C4H6BrFO2On June 7, 2019, Wan, Yimei; Shang, Tianbo; Lu, Zenghui; Zhu, Gangguo published an article in Organic Letters. The article was 《Photocatalytic 1,1-Hydrofluoroalkylation of Alkynes with a Concurrent Vicinal Acylation: An Access to Fluoroalkylated Cyclic Ketones》. The article mentions the following:

A visible-light-induced 1,1-hydrofluoroalkylation of alkynes with a concomitant vicinal acylation is developed using THF (THF) as the hydrogen atom source. Various fluoroalkylated cyclic ketones, such as indanones, chroman-4-ones, 2,3-dihydroquinolin-4(1H)-ones, and 3,4-dihydronaphthalen-1(2H)-ones, can be efficiently synthesized with excellent trans-diastereoselectivity. The reaction represents the first example of 1,1-hydrofluoroalkylation of alkynes, thus providing a novel method for the construction of fluoroalkanes. In the experiment, the researchers used many compounds, for example, Ethylbromofluoroacetate(cas: 401-55-8COA of Formula: C4H6BrFO2)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.COA of Formula: C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, synthesis and fungicidal activity of 3,4-dichloroisothiazolocoumarin-containing strobilurins》 was written by Lv, You; Li, Kun; Gao, Wei; Hao, Zesheng; Wang, Weibo; Liu, Xiaoyu; Tang, Liangfu; Fan, Zhijin. Application In Synthesis of Ethylbromofluoroacetate And the article was included in Molecular Diversity on April 30 ,2022. The article conveys some information:

Twenty-one novel 3,4-dichloroisothiazolocoumarin-containing strobilurins I (R1 = H, F, Cl, Me, Et; R2 = H, 6-Me, 8-Me, 8-Cl), II were rationally designed and synthesized. Preliminary bioassay showed that compounds I (R1 = H, R2 = 8-Cl (III); R1 = Cl, R2 = 6-Me; R1 = Me, R2 = 6-Me) exhibited over 80% inhibitory rate against Sclerotinia sclerotiorum at 50μg/mL, compound III exhibited good activity against S. sclerotiorum with median effective concentration (EC50) of 4.08μ/mL, while the pos. control coumoxystrobin showed EC50 of 1.00μg/mL. In addition, compound I (R1 = H, R2 = 6-Me) showed better fungicidal activity with a lower EC50 value of 7.65μg/mL against Botrytis cinerea than that of pos. control trifloxystrobin with its EC50 value of 21.96μg/mL. In this study, it was indicated that 3,4-dichloroisothiazolocoumarin-containing strobilurins I, II were promising fungicide lead deserved for further study. After reading the article, we found that the author used Ethylbromofluoroacetate(cas: 401-55-8Application In Synthesis of Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application In Synthesis of Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Wei-Ke; Xu, Zhuo-Wei; Xu, Jun; Tang, Fei; Li, Xiao-Xuan; Dai, Jian-Jun; Xu, Hua-Jian; Feng, Yi-Si published an article in Organic Letters. The title of the article was 《Irradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature》.Application of 401-55-8 The author mentioned the following in the article:

A cobaloxime-catalyzed photochem. synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Ze-Ying; Zhou, Sen; Yang, Kai; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published their research in Organic Letters on August 7 ,2020. The article was titled 《Tetrahydroxydiboron-Promoted Radical Addition of Alkynols》.Recommanded Product: 401-55-8 The article contains the following contents:

Tetrahydroxydiboron has previously been used as a borylation or reducing reagent in organic synthesis. Herein, we present a novel tetrahydroxydiboron-promoted radical addition of internal alkynes followed by intramol. oxidation of alc. through 1,5-hydrogen atom transfer. Preliminary mechanistic studies showed that the process might be initiated through N,N-dimethylformamide-assisted homolytic cleavage of tetrahydroxydiboron. This process provides a convenient synthesis of fluoroalkyl-substituted alkenes with a pendant aldehyde or ketone moiety. In the experimental materials used by the author, we found Ethylbromofluoroacetate(cas: 401-55-8Recommanded Product: 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Recommanded Product: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary