Category: 401-55-8

Huang, Qi published the artcileInexpensive Radical Methylation and Related Alkylations of Heteroarenes, SDS of cas: 401-55-8, the publication is Organic Letters (2018), 20(5), 1413-1416, database is CAplus and MEDLINE.

A simple method for the introduction of a Me and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-Me pyrrolidone in a microwave oven.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yan published the artcileCopper-Catalyzed Radical Cascade Difluoromethylation/Cyclization of 2-(3-Arylpropioloyl)benzaldehydes: A Route to Difluoromethylated Naphthoquinones, Application of Ethylbromofluoroacetate, the publication is Journal of Organic Chemistry (2017), 82(13), 6811-6818, database is CAplus and MEDLINE.

A novel copper-catalyzed cascade difluoromethylation/cyclization of 2-(3-arylpropioloyl)benzaldehydes has been developed. This method affords an efficient and straightforward access to structurally diverse difluoromethylated naphthoquinones in one pot, starting from readily available starting materials. The reaction represents the first trans-acyldifluoromethylation of internal alkynes, which features aldehydes as acceptors for the addition of alkenyl radicals. Furthermore, this protocol can also access monofluoromethylated naphthoquinones and difluoromethylated indanones with the same reaction conditions.

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C15H10O2, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qu, Yi published the artcileVisible-Light-Mediated [2+2+1] Carbocyclization Reactions of 1,7-Enynes with Bromofluoroacetate to Form Fused Monofluorinated Cyclopenta[c]quinolin-4-ones, HPLC of Formula: 401-55-8, the publication is Journal of Organic Chemistry (2020), 85(8), 5379-5389, database is CAplus and MEDLINE.

Herein, we describe a new protocol for photoinduced radical [2+2+1] carbocyclization reactions of 1,7-enynes with bromofluoroacetate. These reactions, which proceed via a cascade involving fluoroalkylation, 6-exo-dig and 5-endo-trig cyclizations, H-transfer step, and oxidative dehydrogenation, provide an efficient and general route to a variety of fused monofluorinated cyclopenta[c]quinolin-4-one derivatives

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xu, Zhuo-Wei published the artcileAn efficient method for the N-formylation of amines under catalyst- and additive-free conditions, Category: bromides-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(18), 1254-1258, database is CAplus.

A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives A mechanism that involves difluorocarbene is proposed for this reaction.

Tetrahedron Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C6H13I, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Deng, Qinfei published the artcilePhotoredox-catalyzed cascade addition/cyclization of N-propargyl aromatic amines: access to 3-difluoroacetylated or 3-fluoroacetylated quinolines, HPLC of Formula: 401-55-8, the publication is Organic Chemistry Frontiers (2018), 5(1), 19-23, database is CAplus.

The 3-difluoroacetylated quinolines I [R = C₆H₅, 4-CH₃CH₂CO(O)C₆H₄, 9H-fluoren-2-yl, thiophen-2-yl, etc.; R¹ = H, 6-F, 7-CH₃, 6-OCF₃, etc.; X = 2-CF₂C(O)OCH₂CH₃] and 3-fluoroacetylated quinolines I [X = 2-CHFC(O)OCH₂CH₃] were synthesized via a visible-light-induced cascade addition/cyclization of N-propargyl aromatic amines R²C₆H₄NHCH₂CCR (R² = H, 3-Me, 4-Cl, etc.) with Et bromodifluoroacetate or Et bromofluoroacetate catalyzed by fac-Ir(ppy)₃ under mild conditions. For the substrates bearing various substituents on the aniline ring and benzene ring, the reaction proceeded smoothly to give the corresponding difluoroacetylated I [X = 2-CF₂C(O)OCH₂CH₃] or fluoroacetylated quinolines I [X = 2-CHFC(O)OCH₂CH₃] in moderate to high yields.

Organic Chemistry Frontiers published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tang, Wei-Ke published the artcileIrradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature, Formula: C4H6BrFO2, the publication is Organic Letters (2019), 21(1), 196-200, database is CAplus and MEDLINE.

A cobaloxime-catalyzed photochem. synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C10H17N3O2, Formula: C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jin, Weiwei published the artcileVisible-light induced three-component alkynyl-difluoroalkylation of unactivated alkenes, Application In Synthesis of 401-55-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(57), 7924-7927, database is CAplus and MEDLINE.

A visible-light induced three-component reaction of difluoroalkyl halides, unactivated alkenes, and alkynyl sulfones is described, providing a direct and general approach to the construction of synthetically valuable β-difluoroalkylated alkynes under room temperature conditions. This represents the first intermol. alkynyl-difluoroalkylation of unactivated alkenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Han, Shuaijun published the artcileCopper-catalyzed remote C-H monofluoromethylation of 8-aminoquinolines with dimethyl phosphonate as reductant, Related Products of bromides-buliding-blocks, the publication is Tetrahedron Letters (2019), 60(40), 151077, database is CAplus.

A simple and efficient copper-catalyzed monofluoromethylation of 8-aminoquinolines with 2-bromo-2-fluoroacetate was described with HPO(OMe)₂ (di-Me phosphonate) as reductant. The reaction tolerated a variety of quinoline amides and monofluoroalkyl bromides. Significant advantages of this protocol include synthetic convenience and high reaction efficiency.

Tetrahedron Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Shuo published the artcileRegioselective Vinylation of Remote Unactivated C(sp³)-H Bonds: Access to Complex Fluoroalkylated Alkenes, Product Details of C4H6BrFO2, the publication is Angewandte Chemie, International Edition (2019), 58(5), 1499-1503, database is CAplus and MEDLINE.

Regioselective incorporation of a particular functional group into aliphatic sites by direct activation of unreactive C-H bonds is of great synthetic value. Despite advances in radical-mediated functionalization of C(sp³)-H bonds by a hydrogen-atom transfer process, the site-selective vinylation of remote C(sp³)-H bonds still remains underexplored. Reported herein is a new protocol for the regioselective vinylation of unactivated C(sp³)-H bonds. The remote C(sp³)-H activation is promoted by a C-centered radical instead of the commonly used N and O radicals. The reaction possesses high product diversity and synthetic efficiency, furnishing a plethora of synthetically valuable E alkenes bearing tri-/di-/mono-fluoromethyl and perfluoroalkyl groups.

Angewandte Chemie, International Edition published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C8H16O2, Product Details of C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ren, Rongguo published the artcileSynergistic Strategies of Cyano Migration and Photocatalysis for Difunctionalization of Unactivated Alkenes: Synthesis of Di- and Mono-Fluorinated Alkyl Nitriles, Product Details of C4H6BrFO2, the publication is Advanced Synthesis & Catalysis (2017), 359(17), 3052-3056, database is CAplus.

A general protocol for the challenging cyanofluoroalkylation of unactivated alkenes is disclosed. A broad range of synthetically useful di- and mono-fluorinated alkyl nitriles are readily obtained in good yields under mild reaction conditions [e.g, cyanohydrin I + BrCF₂CO₂Et → nitrile II (90%) under blue LED irradiation in presence of fac-Ir(ppy)₃ in DMF]. The efficient combination of intramol. cyano migration and photoredox catalysis significantly expands the field of difunctionalization of olefins.

Advanced Synthesis & Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Product Details of C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary