Category: 401-55-8

Sheng, Jie published the artcileCombinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides, Related Products of bromides-buliding-blocks, the publication is Organic Letters (2017), 19(17), 4480-4483, database is CAplus and MEDLINE.

Using combinations of Ni(OTf)₂ and nitrogen (2,2-bipyridine, 4,4′-di-tert-butyl-2,2′-bipyridine, or 1,10-phenanthroline) and phosphine ligands [Ph₃P, Cy₃P, (4-MeOC₆H₄)₃P, or X-Phos] determined combinatorially, arylboronic acids underwent chemoselective fluoroalkylation with α-fluoro alkyl iodides mediated by K₂CO₃ in 1,4-dioxane at 80° to yield fluoroalkyl arenes such as PhCHFCH₂Ph in 66-99% yields.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C28H41N2P, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Choi, Isaac published the artcileRecyclable Ruthenium Catalyst for Distal meta-C-H Activation, HPLC of Formula: 401-55-8, the publication is Chemistry – A European Journal (2020), 26(66), 15290-15297, database is CAplus and MEDLINE.

The unprecedented hybrid-ruthenium catalysis for distal meta-C-H activation was disclosed. The hybrid-ruthenium catalyst was recyclable, as was proven by various heterogeneity tests, and fully characterized with various microscopic and spectroscopic techniques, highlighting the phys. and chem. stability. Thereby, the hybrid-ruthenium catalysis proved broadly applicable for meta-C-H alkylations of among others purine-based nucleosides and natural product conjugates. Addnl., its versatility was further reflected by meta-C-H activations through visible-light irradiation, as well as para-selective C-H activations.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shu, Wei published the artcileVisible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes, Quality Control of 401-55-8, the publication is ACS Catalysis (2018), 8(7), 6401-6406, database is CAplus.

A photoinduced cascade strategy is presented here for the remote functionalization of alkenes under redox neutral conditions. A broad portfolio of alkyl groups has been added to double bonds to produce, upon 1,5-HAT, remote C-centered radicals which can be harvested in the presence of O- or C-nucleophiles to efficiently form Csp³-O and Csp³-Csp² bonds at room temperature

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C5H6N2O2, Quality Control of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Guan, Yu-Qing published the artcileThe serendipitous effect of KF in Ritter reaction: Photo-induced amino-alkylation of alkenes, HPLC of Formula: 401-55-8, the publication is iScience (2021), 24(9), 102969, database is CAplus and MEDLINE.

The Ritter reaction has been recognized as an elegant strategy to construct the C-N bond. Its key feature is forming the carbocation for nucleophilic attack by nitriles. Herein, authors report a complementary visible-light-induced three-component Ritter reaction of alkenes, nitriles, and α-bromo nitriles/esters, thereby providing mild and rapid access to various γ-amino nitriles/acids. Mechanistic studies indicated that traceless fluoride relay, transforming KF into imidoyl fluoride intermediate, is critical for the efficient reaction switch from atom transfer radical addition (ATRA) to the Ritter reaction. This approach to amino-alkylation of alkenes is chemoselective and operationally simple.

iScience published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Yin-Na published the artcileA new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(32), 3993-3996, database is CAplus and MEDLINE.

Difluoroalkylated diarylmethanes with biol. and pharmacol. potentials were synthesized from para-quinone methides (p-QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, *fac-Ir(ppy)₃, was primarily quenched by p-QMs and the generated diarylmethane radical intermediates then underwent a radical-radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C7H6Cl2O, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mazzarella, Daniele published the artcilePhotochemical Organocatalytic Borylation of Alkyl Chlorides, Bromides, and Sulfonates, HPLC of Formula: 401-55-8, the publication is ACS Catalysis (2019), 9(7), 5876-5880, database is CAplus.

Reported herein is a photochem. strategy for the borylation of alkyl halides using bis(catecholato)diboron as the boron source. This method exploits the ability of a nucleophilic dithiocarbonyl anion organocatalyst to generate radicals via an S_N2-based photochem. catalytic mechanism, which is not reliant on the redox properties of the substrates. Therefore, it grants access to alkyl boronic esters from readily available but difficult-to-reduce electrophiles, including benzylic and allylic chlorides, bromides, and mesylates, which were inert to or unsuitable for previously reported metal-free borylation protocols.

ACS Catalysis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Yin-Na published the artcileA new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(32), 3993-3996, database is CAplus and MEDLINE.

Difluoroalkylated diarylmethanes with biol. and pharmacol. potentials were synthesized from para-quinone methides (p-QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, *fac-Ir(ppy)₃, was primarily quenched by p-QMs and the generated diarylmethane radical intermediates then underwent a radical-radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C7H6Cl2O, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gao, Yong-Chao published the artcileSulfite-Promoted C-H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur, SDS of cas: 401-55-8, the publication is Synthesis (2020), 52(17), 2541-2550, database is CAplus.

A transition-metal-free sulfite-promoted three-component C-H sulfuration between imidazoheterocycles, elemental sulfur and bromofluoroacetate was developed. Sulfites, including Na₂S₂O₄, NaHSO₃ and Na₂S₂O₃, were able to promote the formation of two C-S bonds in one step using elemental sulfur as a green sulfurating agent, allowing the rapid introduction of the synthetically useful S-fluoroacetate group into imidazoheterocycles. These new imidazoheterocycle derivatives bearing an S-fluoroacetate group can be easily modified to produce pharmaceutically attractive compounds

Synthesis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Berton, Mateo published the artcileOn-demand synthesis of organozinc halides under continuous flow conditions, Application of Ethylbromofluoroacetate, the publication is Nature Protocols (2018), 13(1), 324-334, database is CAplus and MEDLINE.

Organozinc reagents are versatile building blocks for introducing C(sp₂)-C(sp₃) and C(sp₃)-C(sp₃) bonds into organic structures. However, despite their ample synthetic versatility and broad functional group tolerance, the use of organozinc reagents in the laboratory is limited because of their instability, exothermicity and water sensitivity, as well as their labor-intensive preparation Herein, we describe an on-demand synthesis of these useful reagents under continuous flow conditions, overcoming these primary limitations and supporting widespread adoption of these reagents in synthetic organic chem. To exemplify this procedure, a solution of Et zincbromoacetate is prepared by flowing Et bromoacetate through a column containing metallic zinc. The temperature of the column is controlled by a heating jacket and a thermocouple in close contact with it. Advice on how to perform the procedure using alternative equipment is also given to allow a wider access to the methodol. Here we describe the preparation of 50 mL of solution, which takes 1 h 40 min, although up to 250-300 mL can be prepared with the same column setup at a rate of 30 mL per h. The procedure provides the reagent as a clean solution with reproducible concentration Organozinc solutions generated in flow can be coupled to a second flow reactor to perform a Reformatsky reaction or can be collected over a flask containing the required reagents for a batch Negishi reaction.

Nature Protocols published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xia, Tingting published the artcilePalladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides, Application of Ethylbromofluoroacetate, the publication is Organic Letters (2017), 19(10), 2610-2613, database is CAplus and MEDLINE.

A palladium-catalyzed Negishi cross-coupling reaction of Et bromodifluoroacetate with aryl bromides or aryl triflates to construct C(sp²)-CF₂ bonds is described. The reaction was conducted under mild reaction conditions, and no preparation of organozinc reagents is required. This is the first report encompassing the conversion of aryl triflates into products containing C-CF₂ bonds. In addition, the construction of C(sp²)-CHF bonds was achieved under mild conditions via a cross-coupling of aryl iodides with Et bromofluoroacetate.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6O3, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary