402-49-3 Archives - Page 8 of 13 - Bromides-buliding-blocks

Li, Shichao team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 402-49-3

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Application In Synthesis of 402-49-3

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organic compounds having carbon bonded to bromine are called organic bromides. Application In Synthesis of 402-49-3.

Li, Shichao;Li, Muyao;Li, Shu-Sen;Wang, Jianbo research published 《 Pd-Catalyzed coupling of benzyl bromides with BMIDA-substituted N-tosylhydrazones: synthesis of trans-alkenyl MIDA boronates》, the research content is summarized as follows. A palladium-catalyzed stereoselective synthesis of alkenyl boronates from N-methyliminodiacetyl boronate (BMIDA)-substituted N-tosylhydrazone and benzyl bromides is developed. A range of trans-alkenyl MIDA boronates as single stereoisomers were obtained in moderate yields with good functional group compatibility. The resultant boronate products may be transformed to other boron-containing compounds and may also be directly used in cross-coupling reactions.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lee, Jaeyong team published research in Organic Letters in 2022 | 402-49-3

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C8H6BrF3.

Lee, Jaeyong;Ban, Jeong Woo;Kim, Jeongseok;Yang, Sehun;Lee, Geumwoo;Dhorma, Lama Prema;Kim, Mi-hyun;Ha, Min Woo;Hong, Suckchang;Park, Hyeung-geun research published 《 Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols》, the research content is summarized as follows. The highly enantioselective aza-Michael reaction of tert-Bu β-naphthylmethoxycarbamate to cyclic enones I [X = CH₂, NH, O; n = 0, 1, 2; R = H, 4,4-di-Me, 5,5-di-Me, 6,6-dimethyl] has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0°C. The resulting aza-Michael adducts (R/S)-II [R¹ = H, 2,2-di-Me, 3,3-di-Me, 4,4-dimethyl] can be converted to versatile intermediates by selective deprotection and cyclic 1,3-aminoalcs. such as (1S,3R)-3-aminocyclohexan-1-ol, (1R,3R)-3-aminocyclopentan-1-ol, (1R,3R)-3-aminocycloheptan-1-ol, etc. by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Bo team published research in Organic & Biomolecular Chemistry in 2022 | 402-49-3

Product Details of C8H6BrF3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Li, Bo;Wu, Jun;Tang, Lei;Lian, Xu;Li, Zhongwen;Duan, Wenfang;Qin, Tong;Zhao, Xintong;Hu, Yuhua;Zhang, Chi;Li, Tianlei;Hao, Jie;Zhang, Wenxuan;Zhang, Jihong;Wu, Song research published 《 Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives》, the research content is summarized as follows. Seventeen C20-O-alkyl/benzyl oxime derivatives were synthesized by a concise and effective method. Most of these derivatives showed tens to several hundred nanomolar IC50 values against HT-29 colorectal, HGC-27 gastric and MDA-MB-231 breast cancer cells, whose antiproliferative activity is 15-240 fold better than that of salinomycin. The C20-oxime etherified derivatives can coordinate potassium ions, and further adjust the cytosolic Ca2+ concentrations in HT-29 cells. The significant improvement of the potency should be attributed to the better ion binding and transport ability of the modified derivatives In addition, the C20-O-alkyl/benzyl oxime derivatives showed much better selectivity indexes (SI) than salinomycin, indicating that they present lower neurotoxic risk.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Sourav team published research in Chemistry – An Asian Journal in 2021 | 402-49-3

Kumar, Sourav;Kumar, Manoj;Bhalla, Vandana research published 《 Pyrazine Based Type-I Sensitizing Assemblies for Photoreduction of Cu(II) in ‘One-Pot Three-Component’ CuAAC Reaction Under Aerial Conditions》, the research content is summarized as follows. Photosensitizing assemblies of pyrazine derivative PDA have been developed which exhibit a high photostability, ‘lighted’ excited state, balanced redox potential, high transportation potential and activate oxygen via type-I pathway only. These PDA assemblies in combination with Cu(II) ions catalyze the CuAAC reaction via in situ reduction of Cu(II) ions without any reducing or stabilizing agent. The present protocol has wide substrate scope with recyclability of the catalytic system up to six catalytic cycles and is applicable to gram-scale synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lanzi, Matteo team published research in Organic Letters in 2021 | 402-49-3

Quality Control of 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Organic compounds having carbon bonded to bromine are called organic bromides. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Quality Control of 402-49-3.

Lanzi, Matteo;Ali Abdine, Racha Abed;De Abreu, Maxime;Wencel-Delord, Joanna research published 《 Cyclic Diaryl λ³-Bromanes: A Rapid Access to Molecular Complexity via Cycloaddition Reactions》, the research content is summarized as follows. The synthesis of dissymetric 2,3,2′,3′,4-substituted biaryls via pericyclic reactions of cyclic diaryl λ³-bromanes were reported. The functional groups tolerance and atom economy allow access to mol. complexity in a single reaction step. Continuous flow protocol was designed for the scale-up of the reaction, while postfunctionalizations was developed taking advantage of the residual Br-atom.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lavinda, Olga team published research in Angewandte Chemie, International Edition in 2022 | 402-49-3

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 402-49-3.

Lavinda, Olga;Witt, Collin H.;Woerpel, K. A. research published 《 Origin of High Diastereoselectivity in Reactions of Seven-Membered-Ring Enolates》, the research content is summarized as follows. Unlike many reactions of their six-membered-ring counterparts, the reactions of chiral seven-membered-ring enolates e.g., 5-(tert-Butyl)-1-methylazepan-1-one are highly diastereoselective. Diastereoselectivity was observed for a range of substrates, including lactam, lactone, and cyclic ketone derivatives The stereoselectivity arises from torsional and steric interactions that develop when electrophiles approach the diastereotopic π-faces of the enolates, which are distinguished by subtle differences in the orientation of nearby atoms of the ring.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kim, WooChan team published research in Bioorganic & Medicinal Chemistry Letters in 2022 | 402-49-3

HPLC of Formula: 402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 402-49-3, formula is C8H6BrF3, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 402-49-3

Kim, WooChan;Lee, Sun-Mi;Jeong, Pyeong-Hwa;Jung, Jae-Hoon;Kim, Yong-Chul research published 《 Synthesis and structure-activity relationship studies of 1,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 1 (JAK1) inhibitors》, the research content is summarized as follows. JAK inhibitors have been considered as useful targets for the treatment of related diseases. However, first-generation JAK inhibitors have side effects such as anemia, thrombocytopenia, neutropenia and headaches which have been suggested to result from high JAK2 inhibition. Second-generation JAK inhibitors with more specific JAK isoenzyme inhibition have been studied to eliminate these adverse effects. In this study, novel 4-(1,5- or 2,5-triazole)-pyrrolopyrimidine derivatives with aromatic moieties were synthesized as JAK1 inhibitors, and an in vitro enzyme assay was used to evaluate the JAK inhibitory effects. Among these JAK1 inhibitors, the compound 23a showed an IC50 level of 72 nM, as well as being selective against other JAKs by 12 times or more: the results of mol. docking studies suggested that the high JAK1 selectivity resulted from a key interaction between the iodine atom of compound 23a and His-885 of hJAK1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Klausfelder, Barbara team published research in Chemistry – A European Journal in | 402-49-3

Klausfelder, Barbara;Blach, Patricia;de Jonge, Niels;Kempe, Rhett research published 《 Synthesis of 3,4-Dihydro-2H-Pyrroles from Ketones, Aldehydes, and Nitro Alkanes via Hydrogenative Cyclization》, the research content is summarized as follows. Syntheses of N-heterocyclic compounds that permit a flexible introduction of various substitution patterns by using inexpensive and diversely available starting materials are highly desirable. Easy to handle and reusable catalysts based on earth-abundant metals are especially attractive for these syntheses. Author report here on the synthesis of 3,4-dihydro-2H-pyrroles via the hydrogenation and cyclization of nitro ketones. The latter are easily accessible from three components: a ketone, an aldehyde and a nitroalkane. The reaction has a broad scope and 23 of the 33 products synthesized are compounds which have not yet been reported. The key to the general hydrogenation/cyclization reaction is a highly active, selective and reusable nickel catalyst, which was identified from a library of 24 earth-abundant metal catalysts.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jin, Xin team published research in Mendeleev Communications in 2022 | 402-49-3

Jin, Xin;Yang, Tingting;Xia, Chenlu;Wang, Nina;Liu, Zi;Cao, Jianguo;Ma, Liang;Huang, Guozheng research published 《 Design and synthesis of alepterolic acid and 5-fluorouracil conjugates as potential anticancer agents》, the research content is summarized as follows. Conjugates of alepterolic acid with 5-fluorouracil derivatives I (Ar = Ph, 2,4-dichlorophenyl, 1-naphthyl, etc.) have been synthesized in 70-90% yields. The cytotoxic evaluation against two human cancer cell lines, viz. MCF-7 (breast) and A549 (lung), using MTT assay showed anticancer activities of the obtained compounds

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Judge, Neil R. team published research in European Journal of Organic Chemistry in 2021 | 402-49-3

Judge, Neil R.;Chacktas, Geraud;Ma, Ling;Schink, Anke;Buckpesch, Rainer;Schmutzler, Dirk;Machettira, Anu B.;Dietrich, Hansjorg;Asmus, Elisabeth;Bierer, Donald;McLeod, Michael C. research published 《 Flexible Synthesis and Herbicidal Activity of Fully Substituted 3-Hydroxypyrazoles》, the research content is summarized as follows. The synthesis and herbicidal efficacy of a novel library of fully substituted 3-hydroxypyrazoles I (R¹ = H, Me, Et, i-Pr, 2-methoxyethyl; R² = H, 2,4-F₂, 3,4-F₂, 3-Cl, etc.; A = O, S, CH₂, etc.) is reported. An efficient, divergent approach to introduce Ph, phenoxy, phenylsulfanyl, anilino and benzyl substituents in the 4-position of the pyrazole, alongside a flexible synthesis of N1-alkyl analogs I is described via final step diversification of key intermediates. Herbicidal screening of the prepared compounds against key weed species identified the lead compound I (R¹ = Me; R² = H, 2,4-F₂; A = O), which was prepared on a multi-gram scale using an optimized synthetic route.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary