4897-84-1 Archives - Page 5 of 14 - Bromides-buliding-blocks

Tanaka, Hiroki team published research in Journal of the American Chemical Society in 2022 | 4897-84-1

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Organic compounds having carbon bonded to bromine are called organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Formula: C5H9BrO2.

Tanaka, Hiroki;Ukegawa, Naoya;Uyanik, Muhammet;Ishihara, Kazuaki research published 《 Hypoiodite-Catalyzed Oxidative Umpolung of Indoles for Enantioselective Dearomatization》, the research content is summarized as follows. Reported the oxidative umpolung of 2,3-disubstituted indoles toward enantioselective dearomative aza-spirocyclization to give the corresponding spiroindolenines using chiral quaternary ammonium hypoiodite catalysis. Mechanistic studies revealed the umpolung reactivity of C3 of indoles by iodination of the indole nitrogen atom. Moreover, the introduction of pyrazole as an electron-withdrawing auxiliary group at C2 suppressed a competitive dissociative racemic pathway and enantioselective spirocyclization proceeded to give not only spiropyrrolidines but also four-membered spiroazetidines that were otherwise difficult to access.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Qiu team published research in Journal of Organic Chemistry in 2018 | 4897-84-1

Electric Literature of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 4897-84-1.

Sun, Qiu;Zhang, Yuan-Yuan;Sun, Jing;Han, Ying;Jia, Xiaodong;Yan, Chao-Guo research published 《 Copper-Catalyzed Selective 1,2-Dialkylation of N-Heteroarenes via a Radical Addition/Reduction Process: Application for the Construction of Alkylated Dihydroazaarenes Derivatives》, the research content is summarized as follows. A highly efficient Cu-catalyzed 1,2-difunctionalization of various N-heteroarenes was developed with ether and alkyl halide at ambient temperature This transformation involves the combination of oxidative coupling by Cu/TBHP and reduction process by 1,8-diazabicyclo[5.4.0]undec-7-ene. This method provides an efficient method to prepare various substituted dihydroazaarene derivatives via a free-radical process.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stachel, Shawn J. team published research in Bioorganic & Medicinal Chemistry Letters in 2018 | 4897-84-1

Category: bromides-buliding-blocks, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Category: bromides-buliding-blocks

Stachel, Shawn J.;Egbertson, Melissa S.;Wai, Jenny;Machacek, Michelle;Toolan, Dawn M.;Swestock, John;Eddins, Donnie M.;Puri, Vanita;McGaughey, Georgia;Su, Hua-Poo;Perlow, Debbie;Wang, Deping;Ma, Lei;Parthasarathy, Gopal;Reid, John C.;Abeywickrema, Pravien D.;Smith, Sean M.;Uslaner, Jason M. research published 《 Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species》, the research content is summarized as follows. An internal HTS effort identified a novel PDE2 inhibitor series that was subsequently optimized for improved PDE2 activity and off-target selectivity. The optimized lead, compound 4, improved cognitive performance in a rodent novel object recognition task as well as a non-human primate object retrieval task. In addition, co-crystallization studies of close analog of 4 in the PDE2 active site revealed unique binding interactions influencing the high PDE isoform selectivity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sole, Daniel team published research in Chemistry – A European Journal in 2019 | 4897-84-1

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Formula: C5H9BrO2.

Sole, Daniel;Amenta, Arianna;Bennasar, M.-Lluisa;Fernandez, Israel research published 《 Palladium- and Ruthenium-Catalyzed Intramolecular Carbene C_Ar-H Functionalization of γ-Amino-α-diazoesters for the Synthesis of Tetrahydroquinolines》, the research content is summarized as follows. A synthetic method to prepare tetrahydroquinoline-4-carboxylic acid esters has been developed through the transition-metal-catalyzed intramol. aromatic C-H functionalization of α-diazoesters. Both [{Pd(IMes)(NQ)}₂] (IMes = 1,3-dimesitylimidazol-2-ylidene, NQ = 1,4-naphthoquinone) and the first-generation Grubbs catalyst proved effective for this purpose. The ruthenium catalyst was found to be the most versatile, although in a few cases the palladium complex afforded better yields or selectivities. According to DFT calculations, Pd⁰– and Ru^II-catalyzed sp²-C_Ar-H functionalization proceeds through different reaction mechanisms. Thus, the Pd⁰-catalyzed reaction involves a Pd-mediated 1,6-H migration from the sp²-C_Ar-H bond to the carbene carbon atom, followed by a reductive elimination process. In contrast, electrophilic addition of the ruthenacarbene intermediate to the aromatic ring and subsequent 1,2-proton migration are operative in the Grubbs catalyst promoted reaction.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Si, Xiaojia team published research in Organic Letters in 2019 | 4897-84-1

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Recommanded Product: Methyl 4-bromobutanoate

Si, Xiaojia;Zhang, Lumin;Hashmi, A. Stephen K. research published 《 Benzaldehyde- and Nickel-Catalyzed Photoredox C(sp³)-H Alkylation/Arylation with Amides and Thioethers》, the research content is summarized as follows. Herein a synergistic combination of a nickel catalyst and benzaldehyde for the use of amides and thioethers in C(sp³)-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a simple and cheap strategy for the direct functionalization of amides and thioethers. Readily available starting materials, mild reaction conditions, a good functional-group tolerance, and a broad substrate scope make this methodol. attractive and practical for pharmaceutical and synthetic chem.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shao, Lihua team published research in Bioorganic & Medicinal Chemistry Letters in 2019 | 4897-84-1

Shao, Lihua;Bai, Yue;Wang, Qiutang;Chen, Zizhang;Xie, Yundong;Bian, Xiaoli research published 《 Design, synthesis and evaluation of 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione-Based fibrates as potential hypolipidemic and hepatoprotective agents》, the research content is summarized as follows. Six novel target compounds, 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT) based fibrates I [R¹ = R² = Me, n = 0; R¹ = Et, R² = H, n = 0; R¹ = Me, R² = H, n = 0; R¹ = R² = H, n = 2, 3, 4], were synthesized and evaluated. All the synthesized compounds were preliminarily screened by using the Triton WR-1339-induced hyperlipidemia model, in which I [R¹ = R² = Me, n = 0] (II) exhibited more potent hypolipidemic property than pos. drug fenofibrate (FF). II also significantly decreased serum triglycerides (TG), total cholesterol (TC) and low d. lipoprotein cholesterin (LDL) in methionine solution (Mets) induced hyperlipidemic mice. Moreover, hepatic transaminases (AST and ALT) were obviously ameliorated after treatment with II and the histol. observation indicated that II ameliorated the injury in liver tissue and inhibited the hepatic lipid accumulation. In the livers of II-administrated rat, the levels of PPARα related to lipids metabolism were up-regulated. Addnl. effects such as antioxidant, anti-inflammatory and H₂S releasing action confirmed and reinforced the activity of II as a potential multifunctional hypolipidemic and hepatoprotective agent.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sheng, Ren team published research in Bioorganic & Medicinal Chemistry Letters in 2018 | 4897-84-1

Sheng, Ren;Yang, Liu;Zhang, Yanchun;Xing, Enming;Shi, Rui;Wen, Xiaoan;Wang, Heyao;Sun, Hongbin research published 《 Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design》, the research content is summarized as follows. GPR120 is an attractive target for the treatment of type 2 diabetes. In this study, a series of biphenyl derivatives were designed, synthesized by hybrid design. The selected compound 6a (4-((2′,3,3′,5-tetrafluoro-5′-(anti-3-methoxycyclobutoxy)[1,1′-biphenyl]-4-yl)oxy)butanoic acid) exhibited potent GPR120 agonist activity (EC₅₀ = 93 nM) and high selectivity over GPR40. The results of oral glucose tolerance test (OGTT) demonstrated that 6a exhibited significant glucose-lowering effect in glucose-loaded ICR male mice. Anal. of the structure-activity relationship is also presented. Compound 6a deserves further biol. evaluation and structural modifications.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schwickert, Marvin team published research in Journal of Medicinal Chemistry in 2022 | 4897-84-1

HPLC of Formula: 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 4897-84-1.

Schwickert, Marvin;Fischer, Tim R.;Zimmermann, Robert A.;Hoba, Sabrina N.;Meidner, J. Laurenz;Weber, Marlies;Weber, Moritz;Stark, Martin M.;Koch, Jonas;Jung, Nathalie;Kersten, Christian;Windbergs, Maike;Lyko, Frank;Helm, Mark;Schirmeister, Tanja research published 《 Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment》, the research content is summarized as follows. Selective manipulation of the epitranscriptome could be beneficial for the treatment of cancer and also broaden the understanding of epigenetic inheritance. Inhibitors of the tRNA methyltransferase DNMT2, the enzyme catalyzing the S-adenosylmethionine-dependent methylation of cytidine 38 to 5-methylcytidine, were designed, synthesized, and analyzed for their enzyme-binding and -inhibiting properties. For rapid screening of potential DNMT2 binders, a microscale thermophoresis assay was established. Besides the natural inhibitors S-adenosyl-L-homocysteine (SAH) and sinefungin (SFG), we identified new synthetic inhibitors based on the structure of N-adenosyl-2,4-diaminobutyric acid (Dab). Structure-activity relationship studies revealed the amino acid side chain and a Y-shaped substitution pattern at the 4-position of Dab as crucial for DNMT2 inhibition. The most potent inhibitors are alkyne-substituted derivatives, exhibiting similar binding and inhibitory potencies as the natural compounds SAH and SFG. CaCo-2 assays revealed that poor membrane permeabilities of the acids and rapid hydrolysis of an ethylester prodrug might be the reasons for the insufficient activity in cellulo.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sakamoto, Seiji team published research in ACS Central Science in 2019 | 4897-84-1

Sakamoto, Seiji;Yamaura, Kei;Numata, Tomohiro;Harada, Fumio;Amaike, Kazuma;Inoue, Ryuji;Kiyonaka, Shigeki;Hamachi, Itaru research published 《 Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA_A Receptor Using a Turn-On Probe》, the research content is summarized as follows. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The fast inhibitory actions of GABA are mainly mediated by GABA_A receptors (GABA_ARs), which are widely recognized as clin. relevant drug targets. However, it remains difficult to create screening systems for drug candidates that act on GABA_ARs because of the existence of multiple ligand-binding sites and the delicate pentameric structures of GABA_ARs. We here developed the first turn-on fluorescent imaging probe for GABA_ARs, which can be used to quant. evaluate ligand-receptor interactions under live cell conditions. Using noncovalent labeling of GABA_ARs with this turn-on probe, a new imaging-based ligand assay system, which allows discovery of pos. allosteric modulators (PAMs) for the GABA_AR, was successfully constructed. Our system is applicable to high-throughput ligand screening, and we discovered new small mols. that function as PAMs for GABA_ARs. These results highlight the power of the use of a turn-on fluorescent probe to screen drugs for complicated membrane proteins that cannot be addressed by conventional methods.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sarode, Bhagyesh R. team published research in Molecular Pharmaceutics in 2019 | 4897-84-1

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Safety of Methyl 4-bromobutanoate.

Sarode, Bhagyesh R.;Kover, Karen;Friedman, Simon H. research published 《 Visible-Light-Activated High-Density Materials for Controlled in Vivo Insulin Release》, the research content is summarized as follows. In this work, we describe the synthesis, characterization, and ultimate in vivo assessment of second-generation insulin photoactivated depot (PAD) materials. These are the first to use visible light to stimulate insulin release and have an in vivo performance that is 28-fold improved relative to first-generation materials. This improvement is due to two major factors linked to the utilized chem.: (1) we have incorporated the coumarin photocleavable group, which increases the photorelease wavelength into the visible range, enhancing tissue penetration of the light; (2) phototoggling of insulin solubility is produced by linking three insulin mols. to a central bridge via light cleaved groups, and not by bonding to a large polymer. The resulting trimer is, therefore, highly dense (87% insulin dry weight/weight) but retains the insolubility required of the approach. Only after irradiation with visible light is native, soluble insulin is released from the dermal depot. This high d. increases the amount and ease of insulin release, as the d. of photolytic groups is 10-20-fold higher than in polymer-based first-generation materials. We have synthesized new azide-terminated coumarin linkers that we react with the amine groups of insulin. Using mass spectrometry methods, we identify the sites of reaction and purify individual isomers, which we demonstrate have in vitro photolysis rates that are within a factor of 2 of each other. We then reacted these terminal azide groups with a tridentate strained alkyne linker. We show that the resulting insulin trimer is highly insoluble, but can be milled into injectable particles that release insulin only in response to light from a 406 nm light source. Finally, we demonstrate that these materials have a significantly improved in vivo performance, releasing 28-fold more insulin on a per energy basis than first-generation materials.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary