Category: 4897-84-1

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Product Details of C5H9BrO2

Kai, Hiroyuki;Horiguchi, Tohru;Kameyama, Takayuki;Asahi, Kentaro;Endoh, Takeshi;Jikihara, Sae;Hasegawa, Tsuyoshi;Tanaka, Satoru;Nozu, Azusa;Takeyama, Chie;Tomari, Maki;Takahashi, Fumiyo;Tamura, Naomi;Yagi, Shigenori;Itoh, Tetsuji;Isou, Yasuyoshi research published 《 Dioxotriazine derivatives as a new class of P2X₃ receptor antagonists: Identification of a lead and initial SAR studies》, the research content is summarized as follows. P2X₃ receptor is an ATP-gated ion channel, mainly localized on peripheral sensory neurons. Currently, several clin. trials are being conducted with P2X₃ receptor antagonists for the treatment of chronic pain or cough. To identify a P2X₃ lead compound, we reexamined the HTS evaluation compounds and selected dioxotriazine derivatives from which we identified a hit compound As a result of the hit-to-lead SAR, we obtained lead compound 1 (I) which had a moderate inhibitory effect on P2X₃ receptors (IC₅₀, 128 nM). Further improvement of the potency and PK profiles of this lead compound finally led to the selected compound 74 (II, P2X₃ IC₅₀, 16.1 nM; P2X_2/3 IC₅₀, 2931 nM), which demonstrated a strong analgesic effect against allodynia on oral administration in the rat partial sciatic nerve ligation model of neuropathic pain (ED₅₀, 3.1 mg/kg).

Product Details of C5H9BrO2, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Name: Methyl 4-bromobutanoate.

Jeon, Jong Yeob;Park, Sungmin;Han, Junyoung;Maurya, Sandip;Mohanty, Angela D.;Tian, Ding;Saikia, Nayan;Hickner, Michael A.;Ryu, Chang Y.;Tuckerman, Mark E.;Paddison, Stephen J.;Kim, Yu Seung;Bae, Chulsung research published ã€?Synthesis of Aromatic Anion Exchange Membranes by Friedel-Crafts Bromoalkylation and Cross-Linking of Polystyrene Block Copolymersã€? the research content is summarized as follows. Elastomeric anion exchange membranes (AEMs) were prepared by acid-catalyzed Friedel-Crafts alkylation of the polystyrene block of polystyrene-b-poly(ethylene-co-butylene)-b-polystyrene (SEBS) using bromoalkylated tertiary alcs. and triflic acid as a catalyst, followed by amination with trimethylamine. This simple one-step bromoalkylation allowed convenient control of both the degree of functionalization and cation tether length by changing the molar ratio and the structure of the bromoalkylated tertiary alc. The resulting quaternary ammonium-functionalized ionic triblock SEBS copolymers showed a microphase-separated morphol. on the 35 nm length scale. A series of AEMs with different ion exchange capacities and ion tether lengths were systematically investigated by comparing swelling and anion conductivity Because the SEBS AEMs showed high swelling and low dimensional stability in water due to the rubbery nature of SEBS, the hard segment PS units were crosslinked by 1,6-hexanediamine for practical use. The crosslinking of SEBS AEMs reduced water uptake significantly (e.g., 155% vs. 28%) and enhanced their mech. properties. Because the backbone of the SEBS AEMs are composed of all carbon-carbon bonds, they showed good alk. stability, preserving their IEC and OH^– conductivity after testing in a 1 M NaOH solution at 80 °C for 500 h. Alk. membrane fuel cell performance was evaluated with the crosslinked SEBS AEM, and a peak power d. of 520 mW/cm² was achieved at 60 °C under H₂/O₂ conditions.

Name: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 4897-84-1, formula is C5H9BrO2, The most pervasive is the naturally produced bromomethane. Application In Synthesis of 4897-84-1

Hunt, Andrew P.;Batka, Allison E.;Hosseinzadeh, Marjan;Gregory, Jordan D.;Haque, Halima K.;Ren, Hang;Meyerhoff, Mark E.;Lehnert, Nicolai research published ã€?Nitric Oxide Generation on Demand for Biomedical Applications via Electrocatalytic Nitrite Reduction by Copper BMPA- and BEPA-Carboxylate Complexesã€? the research content is summarized as follows. Intravascular (IV) catheters are essential devices in the hospital that are used to monitor a patient’s blood and for administering drugs or nutrients. However, IV catheters are also prone to blood clotting at the point of insertion and infection by formation of robust bacterial biofilms on their surface. Nitric oxide (NO) is ideally suited to counteract both of these problems, due to its antimicrobial properties and its ability to inhibit platelet activation/aggregation. One way to equip catheters with NO releasing properties is by electrocatalytic nitrite reduction to NO by copper complexes in a multi-lumen configuration. In this work, we systematically investigate six closely related Cu(II) BMPA- and BEPA-carboxylate complexes (BMPA = bis-(2-methylpyridyl)amine; BEPA = bis-(2-ethylpyridyl)amine), using carboxylate groups of different chain lengths. The corresponding Cu(II) complexes were characterized using UV-Vis, EPR spectroscopy, and X-ray crystallog. Using detailed cyclic voltammetry (CV) and bulk electrocatalyic studies (with real-time NO quantification), in aqueous buffer, pH 7.4, we are able to derive clear reactivity relations between the ligand structures of the complexes, their Faradaic efficiencies for NO generation, their turnover frequencies (TOFs), and their redox potentials. Our results show that the complex [Cu(BEPA-Bu)](OAc) is the best catalyst with a high Faradaic efficiency over large nitrite concentration ranges and the expected best tolerance to oxygen levels. For this species, the more pos. redox potential suppresses NO disproportionation, which is a major Achilles heel of the (faster) catalysts with the more neg. reduction potentials.

Application In Synthesis of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Quality Control of 4897-84-1.

Hwang, Nicky;Sun, Liren;Noe, Daisy;Lam, Patrick Y. S.;Zhou, Tianlun;Block, Timothy M.;Du, Yanming research published ã€?Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradationã€? the research content is summarized as follows. Chronic hepatitis B (CHB) is characterized by high levels of hepatitis B virus (HBV) surface antigen (HBsAg) in blood circulation. A major goal of CHB interventions is reducing or eliminating this antigenemia; however, there are currently no approved methods that can do this. A novel family of compounds with a dihydroquinolizinone (DHQ) scaffold has been shown to reduce circulating levels of HBsAg in animals, representing a first for a small mol. Reductions of HBsAg were a result of the compound’s effect on HBsAg mRNA levels. However, com. development by Roche of a DHQ lead compound, RG-7834, was stopped due to undisclosed toxicity issues. Herein we report our effort to convert the systemic RG7834 compound to a hepatoselective DHQ analog to limit its distribution to the bloodstream and thus to other body tissues.

Quality Control of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Formula: C5H9BrO2.

Hu, Chaolei;Xu, Wenjing;Conrads, Christian Martin;Wu, Jingnan;Pich, Andrij research published �Visible light and temperature dual-responsive microgels by crosslinking of spiropyran modified prepolymers� the research content is summarized as follows. Light-responsive microgels are interesting colloidal systems with potential applications in the biotechnol. and medicine. However, synthesis of light-responsive microgels with high loading of photoswitchable mols. is still very challenging. Herein we developed a new method to synthesize light and temperature dual-responsive spiropyran-modified poly(N-vinylcaprolactam) microgels. The novel and straightforward microgels synthesis route involved: a) synthesis of poly(N-vinylcaprolactam-co-vinylformamide) copolymers via RAFT polymerization followed by the hydrolysis to obtain primary amine groups, b) attachment of carboxyl-modified spiropyran mols. to polymer chains via coupling, and c) crosslinking of spiropyran-modified polymer chains in W/O miniemulsion to form microgels. Via this method, we successfully synthesized poly(N-vinylcaprolactam) microgels containing more than 10 mol% spiropyran. The reversible light responsiveness of the spiropyran-modified copolymers and microgels in aqueous solution, which originates from the spiropyran photoisomerization under irradiation with different wavelengths, was demonstrated by UV-Vis spectroscopy. Spiropyran-modified copolymers demonstrate shift of the lower critical solution temperature (LCST) due to the polarity change of spiropyran mols. under dark, UV and visible light. Surprisingly, dynamic light scattering (DLS) results show that the microgels based on the same copolymers are less affected by UV irradiation Microgels are swollen in darkness when spiropyran mols. are in the polar, merocyanine form, and collapse after irradiation with visible light, due to the transformation of spiropyran to the relatively nonpolar, closed spirocyclic form. In addition, the spiropyran-modified microgels exhibit reversible temperature responsiveness by presenting a volume phase transition in water from a swollen state to a collapsed state with increasing temperature and the transition temperature decreased compared to the pristine microgels due to the hydrophobicity of spiropyran units.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: Methyl 4-bromobutanoate.

Hollmann, Tim;Berkhan, Gesche;Wagner, Lisa;Sung, Kwang Hoon;Kolb, Simon;Geise, Hendrik;Hahn, Frank research published �Biocatalysts from biosynthetic pathways: Enabling stereoselective, enzymatic cycloether formation on a gram scale� the research content is summarized as follows. Biosynthetic pathways of natural products contain many enzymes that contribute to the rapid assembly of mol. complexity. Enzymes that form complex structural elements with multiple stereocenters, like chiral saturated oxygen heterocycles (CSOH), are of particular interest for a synthetic application, as their use promises to significantly simplify access to these elements. Here, the biocatalytic characterization of AmbDH3, an enzyme that catalyzes intramol. oxa-Michael addition (IMOMA) is reported. This reaction essentially gives access to various types of CSOH with adjacent stereocenters, but it is not yet part of the repertoire of preparative biocatalysis. An in-depth study on the synthetic utility of AmbDH3 was performed, which made extensive use of complex synthetic precursor surrogates. The enzyme exhibited stability and broad substrate tolerance in in vitro experiments, which was in agreement with the results of mol. modeling. Its selectivity profile enabled kinetic resolution of chiral tetrahydropyrans (THPs) under control of up to four stereocenters. A systematic optimization of the reaction conditions enabled gram-scale conversions yielding preparative amounts of chiral THP. The synthetic utility of AmbDH3 was finally demonstrated by its successful application in the key step of a chemoenzymic total synthesis to the THP-containing phenylheptanoid (-)-centrolobine. These results highlight the synthetic potential of AmbDH3 and related IMOMA cyclases as a biocatalytic alternative that further develops the available chem.-synthetic IMOMA methodol.

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 4897-84-1.

Hayashi, Gosuke;Yanase, Masafumi;Nakatsuka, Yu;Okamoto, Akimitsu research published �Simultaneous and traceless ligation of peptide fragments on DNA scaffold� the research content is summarized as follows. Peptide ligation is an indispensable step in the chem. synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis. The ligation reaction is generally conducted with two peptide fragments at a high aqueous concentration to increase the reaction rate; however, this often causes unpredictable aggregation and precipitation of starting or resulting peptides due to their hydrophobicities. Here, we have developed a novel peptide ligation strategy harnessing the two intrinsic characteristics of oligodeoxynucleotides (ODNs), i.e., their hydrophilicity and hybridization ability, which allowed increases in the water solubility of peptides and the reaction kinetics due to the proximity effect, resp. Peptide-ODN conjugates that can be cleaved to regenerate native peptide sequences were synthesized using novel lysine derivatives containing conjugation handles and photolabile linkers, via solid-phase peptide synthesis and subsequent conjugation to 15-mer ODNs. Two complementary conjugates were applied to carbodiimide-mediated peptide ligation on a DNA scaffold, and the subsequent DNA removal was conducted by photoirradiation in a traceless fashion. This DNA scaffold-assisted ligation resulted in a significant acceleration of the reaction kinetics and enabled ligation of a hydrophobic peptide at a micromolar concentration On the basis of this chem., a simultaneous ligation of three different peptide fragments on two different DNA scaffolds has been conducted for the first time.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Application In Synthesis of 4897-84-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Formula: C5H9BrO2

Han, Guiyan;Liu, Na;Li, Chenglan;Tu, Jie;Li, Zhuang;Sheng, Chunquan research published ã€?Discovery of Novel Fungal Lanosterol 14α-Demethylase (CYP51)/Histone Deacetylase Dual Inhibitors to Treat Azole-Resistant Candidiasisã€? the research content is summarized as follows. Invasive fungal infections (particularly candidiasis) are emerging as severe infectious diseases worldwide. Because of serious antifungal drug resistance, therapeutic efficacy of the current treatment for candidiasis is limited and associated with high mortality. However, it is highly challenging to develop novel strategies and effective therapeutic agents to combat drug resistance. Herein, the first generation of lanosterol 14α-demethylase (CYP51)-histone deacetylase (HDAC) dual inhibitors was designed, which exhibited potent antifungal activity against azole-resistant clin. isolates. In particular, compounds 12h(II) and 15j(I) were highly active both in vitro and in vivo to treat azole-resistant candidiasis. Antifungal mechanism studies revealed that they acted by blocking ergosterol biosynthesis and HDAC catalytic activity in fungus, suppressing the function of efflux pump, yeast-to-hypha morphol. transition, and biofilm formation. Therefore, CYP51-HDAC dual inhibitors represent a promising strategy to develop novel antifungal agents against azole-resistant candidiasis.

4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., Formula: C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate, Recommanded Product: Methyl 4-bromobutanoate

Han, Hae Ji;Lee, Sung-Sik;Kang, Seok Min;Kim, Yerin;Park, Chanho;Yoo, Suah;Kim, Chul Hee;Oh, Young-Ho;Lee, Sungyul;Kim, Dong Wook research published ã€?The Effects of Structural Modifications of Bis-tert-alcohol-Functionalized Crown-Calix[4]arenes as Nucleophilic Fluorination Promotors and Relations with Computational Predictionsã€? the research content is summarized as follows. The authors prepared four structurally modified bis-tert-alc. functionalized crown ether-strapped calix[4]arene promoters, i.e., bis-tert-alc. functionalized crown-5-calix[4]arene (BA5C), bis-tert-alc. functionalized crown-7-calix[4]arene (BA7C), bis-1,1-dimethylbutanol functionalized crown 6-calix[4]arene (B3A6C), and bis-1,1-dimethylhexanol functionalized crown 6-calix[4]arene (B5AC6C). Nucleophilic fluorinations were conducted using alkali metal fluorides to study phase-transfer catalytic activities with respect to the sizes of crown ether-strapped calix[4]arene (CEC) subunits and lengths of alkyl chain spacers between tert-alc. and CEC subunits. The reactivity of potassium fluoride was significantly enhanced by BA5C promoter because its crown-5-calix[4]arene subunit had cavity size appropriate for K⁺ capture. In contrast, BA7C did not efficiently enhance cesium fluoride S_N2 fluorination because its crown-7-calix[4]arene cavity was too large to capture Cs⁺. The alkyl spacer of bis-tert-alc. functionalized CEC provided sufficient distance between F^– and Cs⁺. In particular, the three-component alkyl carbon chain of B3A6C was optimal in terms of increasing CsF reactivity. Systematic quantum chem. anal. predicted that fluorination reactions facilitated by bis-tert-alc.-substituted crown-6-calix[4]arene (BACCA) and B3A6C might proceed via separated ion-pair type pre-reaction complexes, which suggested that these two promotors act as Lewis bases that essentially sep. CsF ion-pairs. The lower (by 0.4 kcal/mol) Gibbs free energy of activation for the reaction promoted by B3A6C than that facilitated by BACCA concurred with the exptl. observed slightly greater efficiency of B3A6C than BACCA.

Recommanded Product: Methyl 4-bromobutanoate, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 4897-84-1.

Hassan, Ahmed H. E.;Cho, Min Chang;Kim, Hye In;Yang, Ji Seul;Park, Kyung Tae;Hwang, Ji Young;Jang, Choon-Gon;Park, Ki Duk;Lee, Yong Sup research published ã€?Synthesis of oxidative metabolites of CRA13 and their analogs: Identification of CRA13 active metabolites and analogs thereof with selective CB₂R affinityã€? the research content is summarized as follows. CRA13; a peripheral dual CB₁R/CB₂R agonist with clin. proven analgesic properties, infiltrates into CNS producing adverse effects due to central CB₁R agonism. Such adverse effects might be circumvented by less lipophilic compounds with attenuated CB₁R affinity. Metabolism produces less lipophilic metabolites that might be active metabolites. Some CRA13 oxidative metabolites and their analogs were synthesized as less lipophilic CRA13 analogs. Probing their CB₁R and CB₂R activity revealed the alc. metabolite I as a more potent and more effective CB₂R ligand with attenuated CB₁R affinity relative to CRA13. Also, the alc. analog II and Me ester III possessed enhanced CB₂R affinity and reduced CB₁R affinity. The CB₂R binding affinity of alc. analog II was similar to CRA13 while that of Me ester III was more potent. In silico study provided insights into the possible mol. interactions that might explain the difference in the elicited biol. activity of these compounds

Application In Synthesis of 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary