Category: 5392-10-9

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde, Application In Synthesis of 5392-10-9

Wei, Baosheng;Ren, Qianyi;Bein, Thomas;Knochel, Paul research published 《 Transition-Metal-Free Synthesis of Polyfunctional Triarylmethanes and 1,1-Diarylalkanes by Sequential Cross-Coupling of Benzal Diacetates with Organozinc Reagents》, the research content is summarized as follows. A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were prepared via a transition-metal-free, one-pot and two-step procedure, involving the reaction of various benzal diacetates with organozinc reagents. A sequential cross-coupling is enabled by changing the solvent from THF to toluene, and a two-step S_N1-type mechanism was proposed and evidenced by exptl. studies. The synthetic utility of the method is further demonstrated by the synthesis of several biol. relevant mols., such as an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.

Application In Synthesis of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.

Wang, Ying;Xu, Ning;Li, Weiwei;Li, Jiaojiao;Huo, Yijun;Zhu, Wenrong;Liu, Qiang research published 《 Synthesis of 1,3-diselenyl-dihydroisobenzofurans via electrochemical radical selenylation with substituted o-divinylbenzenes and diselenides》, the research content is summarized as follows. An efficient electrochem. method for the direct synthesis of complicated 1,3-diselenyl-dihydroisobenzofurans was developed under external oxidant free conditions at room temperature from substituted o-divinylbenzenes and diselenides. A radical mechanism was proposed for this novel and practical transformation.

Category: bromides-buliding-blocks, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C9H9BrO3.

Uenishi, Saho;Kakigi, Rina;Hideshima, Kumiko;Miyawaki, Akari;Matsuoka, Junpei;Ogata, Tokutaro;Tomioka, Kiyoshi;Yamamoto, Yasutomo research published 《 Asymmetric total synthesis of (-)-javaberine A and (-)-epi-javaberine A based on catalytic intramolecular hydroamination of N-methyl-2-(2-styrylaryl)ethylamine》, the research content is summarized as follows. Asym. total synthesis of (-)-javaberine A (I) and its epimer was achieved by utilizing two methods for isoquinoline synthesis, asym. hydroamination of N-methyl-2-(2-styrylaryl)ethylamine and Bischler-Napieralski cyclization. Intramol. asym. hydroamination of N-Me aminoalkene 4 was catalyzed by lithium amide-chiral bisoxazoline to give tetrahydroisoquinoline (S)-laudanosine with good enantioselectivity in excellent yield. N-Demethylation of (S)-laudanosine was accomplished by Polonovski-type reaction to give (S)-norlaudanosine. Condensation of (S)-norlaudanosine with homoveratric acid, and subsequent Bischler-Napieralski cyclization, LiAlH₄ reduction, and O-demethylation furnished (8R,14S)-(-)-javaberine A, corresponding to antipode of natural javaberine A. (8S,14S)-(-)-Javaberine A, which corresponds to C14-epimer of natural javaberine A, was also successfully synthesized.

COA of Formula: C9H9BrO3, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C9H9BrO3.

Sunagatullina, Alisa S.;Lutter, Ferdinand H.;Knochel, Paul research published 《 Preparation of Primary and Secondary Dialkylmagnesiums by a Radical I/Mg-Exchange Reaction Using sBu₂Mg in Toluene》, the research content is summarized as follows. The treatment of primary or secondary alkyl iodides with sBu₂Mg in toluene (25-40°, 2-4 h) provided dialkylmagnesiums that underwent various reactions with aldehydes, ketones, acid chlorides or allylic bromides. 3-Substituted secondary cyclohexyl iodides led to all-cis-3-cyclohexylmagnesium reagents under these exchange conditions in a highly stereoconvergent manner. Enantiomerically enriched 3-silyloxy-substituted secondary alkyl iodides gave after an exchange reaction with sBu₂Mg stereodefined dialkylmagnesiums that after quenching with various electrophiles furnished various 1,3-stereodefined products including homo-aldol products (99% dr and 98% ee). Mechanistic studies confirmed a radical pathway for these new iodine/magnesium-exchange reactions.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Formula: C9H9BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Synthetic Route of 5392-10-9.

Stahlberger, M.;Steinlein, O.;Adam, C. R.;Rotter, M.;Hohmann, J.;Nieger, M.;Koeberle, B.;Braese, S. research published 《 Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay》, the research content is summarized as follows. The development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramol. imidoylative cyclization was reported. X-Ray crystallog. revealed a flat 3D structure of the obtained polyheterocycles. Thus, their interactions with double-stranded DNA was evaluated by establishing a pUC-19 plasmid-based gel electrophoresis mobility shift assay, revealing a stabilizing effect on ds-DNA against strand-break inducing conditions.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Synthetic Route of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Related Products of 5392-10-9.

Stefanik, Michal;Bhosale, Dattatry Shivajirao;Haviernik, Jan;Strakova, Petra;Fojtikova, Martina;Dufkova, Lucie;Huvarova, Ivana;Salat, Jiri;Bartacek, Jan;Svoboda, Jan;Sedlak, Milos;Ruzek, Daniel;Miller, Andrew D.;Eyer, Ludek research published 《 Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses》, the research content is summarized as follows. Diphyllin is a natural arylnaphtalide lignan extracted from tropical plants of particular importance in traditional Chinese medicine. This compound has been described as a potent inhibitor of vacuolar (H⁺)ATPases and hence of the endosomal acidification process that is required by numerous enveloped viruses to trigger their resp. viral infection cascades after entering host cells by receptor-mediated endocytosis. Accordingly, we report here a revised, updated, and improved synthesis of diphyllin, and demonstrate its antiviral activities against a panel of enveloped viruses from Flaviviridae, Phenuiviridae, Rhabdoviridae, and Herpesviridae families. Diphyllin is not cytotoxic for Vero and BHK-21 cells up to 100μM and exerts a sub-micromolar or low-micromolar antiviral activity against tick-borne encephalitis virus, West Nile virus, Zika virus, Rift Valley fever virus, rabies virus, and herpes-simplex virus type 1. Our study shows that diphyllin is a broad-spectrum host cell-targeting antiviral agent that blocks the replication of multiple phylogenetically unrelated enveloped RNA and DNA viruses. In support of this, we also demonstrate that diphyllin is more than just a vacuolar (H⁺)ATPase inhibitor but may employ other antiviral mechanisms of action to inhibit the replication cycles of those viruses that do not enter host cells by endocytosis followed by low pH-dependent membrane fusion.

Related Products of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5392-10-9, formula is C9H9BrO3, The most pervasive is the naturally produced bromomethane. Safety of 2-Bromo-4,5-dimethoxybenzaldehyde

Singh, Akansha;Kumar, Ravindra research published 《 Sustainable Passerini-tetrazole three component reaction (PT-3CR): selective synthesis of oxaborol-tetrazoles》, the research content is summarized as follows. A sustainable catalyst- and solvent-free Passerini-tetrazole three component reaction (PT-3CR) has been developed for the selective synthesis of benzoxaborol-tetrazoles for the first time. The synthetic potential of oxaboroles was demonstrated towards various functionalized tetrazoles, which are otherwise difficult to achieve through conventional PT-3CR from aromatic aldehydes/ketones. The reaction features high practicality, broad substrate scope and excellent yields (80-98%). Preliminary results of the asym. PT-3CR are also shown for the synthesis of chiral benzoxaboroles.

Safety of 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. COA of Formula: C9H9BrO3.

Shi, Chong-Yang;Zhou, Ji-Jia;Hong, Pan;Zhu, Bo-Han;Hong, Feng-Lin;Qian, Peng-Cheng;Sun, Qing;Lu, Xin;Ye, Long-Wu research published 《 Efficient synthesis of tetracyclic γ-lactams via gold-catalyzed oxidative cyclization of alkenyl diynes》, the research content is summarized as follows. An efficient gold-catalyzed cascade cyclization of alkenyl diynes involving alkyne oxidation, carbene-alkyne metathesis and cyclopropanation was developed, furnishing a series of tetracyclic γ-lactams I [R¹ = Ph, 2-thienyl, 1-naphthyl, etc.; R² = H, 7-Me, 7-F, etc.; R³ = H, Me; R⁴ = Ms, SO₂Ph, Ts, etc.] bearing one quaternary carbon center and one tertiary carbon center in moderate to good yields with excellent diastereoselectivities. In addition, the proposed mechanistic rationale for this oxidative cyclization was well supported by theor. calculations

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., COA of Formula: C9H9BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Related Products of 5392-10-9.

Selvaraj, Baskar;Nguyen, Uyen Tran Tu;Huh, Gyewon;Nguyen, Duc Hung;Mok, Il-Kyoon;Lee, Heesu;Kang, Kyungsu;Bae, Ae Nim;Kim, Dae Won;Lee, Jae Wook research published 《 Synthesis and biological evaluation of chalcone derivatives as neuroprotective agents against glutamate-induced HT22 mouse hippocampal neuronal cell death》, the research content is summarized as follows. Seventeen chalcone analogs were synthesized from 7-methoxy-3,4-dihydronaphthalen1(2H)-one and various aromatic aldehydes under basic conditions and their therapeutic properties were studied in mouse hippocampal cell line HT-22 against neuronal cell death induced by glutamate. From this study, we selected an analog I as a active compound which showed significantly high neuroprotection. This compound inhibited Ca²⁺ influx and reactive oxygen species (ROS) accumulation inside cells. The glutamate-induced cell death was analyzed by flow cytometry and it showed that I significantly reduced apoptotic or dead cell induced by 5 mM glutamate. Western blot anal. indicates that glutamate-mediated activation of MAPKs were inhibited by compound I treatment. In addition, the I enhanced Bcl-2 and decreased Bax, the anti and pro apoptotic proteins resp. Further anal. showed that, I prevented the nuclear translocation of AIF (apoptosis inducing factor) and inhibited neuronal cell death. Taken together, compound I treatment resulted in decreased neurotoxicity induced by 5 mM of glutamate. Our finding confirmed that compound I has neuro-therapeutic potential against glutamate-mediated neurotoxicity.

Related Products of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Synthetic Route of 5392-10-9.

Sevim, Melike;Bayrak, Cetin;Menzek, Abdullah research published 《 Chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of CuPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as highly efficient catalyst》, the research content is summarized as follows. Herein, we reported reductions of acid, amide, ester and ketone groups with selectivity (>99%) by the catalytic transfer hydrogenation of with CuPd alloy nanoparticles (NPs) decorated on mesoporous graphitic carbon nitride (Cu50Pd50/mpg-C₃N₄) catalyst under mild conditions in a water/methanol mixture CuPd alloy NPs were synthesized by the co-reduction of palladium (II) acetylacetonate and copper(II) acetylacetonate in oleylamine (OAm) solution by the reduction of morpholine-borane solution and then assembled on mpg-C₃N₄ via liquid phase self-assembly method. The α, β-unsaturated carbonyl compounds were obtained from the condensation reaction of the benzaldehyde derivatives with acetone derivatives Cu50Pd50/mpg-C₃N₄ nanocatalyst was characterized by TEM, XRD, XPS, BET and ICP-MS. Cu50Pd50/mpg-C₃N₄ nanocatalyst is highly active catalyst for the reduction of various organic groups and converted to high yield and 99% selectivity. The superior Cu50Pd50/mpg-C₃N₄ nanocatalyst is highly efficient and reusable catalyst which is reuse after 5 cycle with 98% conversion.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Synthetic Route of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary