Category: 5437-45-6

Liu, Yong-Liang; Wang, Xiao-Ping; Li, Ya published an article in 2022. The article was titled 《Lewis Base-catalyzed β-Addition of (Arylsulfonyl) fluoromethane Derivatives to Allenoates》, and you may find the article in ChemistrySelect.Quality Control of Benzyl 2-bromoacetate The information in the text is summarized as follows:

A highly selective TMG-catalyzed β-addition of (arylsulfonyl)fluoromethane derivatives to allenoates has been developed. Cyano, nitro, and ester-functionalized (arylsulfonyl)fluoromethanes were all suitable substrates, giving a series of structurally diverse β-addition products bearing a stereogenic fluorinated carbon center. A possible reaction pathway was also presented. After reading the article, we found that the author used Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Uji, Hirotaka; Watabe, Naoki; Komi, Tatsuya; Sakaguchi, Tomoki; Akamatsu, Ryo; Mihara, Kenta; Kimura, Shunsaku published an article in 2022. The article was titled 《Downsizing to 25-nm Reverse Polymeric Micelle Composed of AB3-type Polydepsipeptide with Comprising siRNA》, and you may find the article in Chemistry Letters.Application of 5437-45-6 The information in the text is summarized as follows:

Amphiphilic block polydepsipeptides of AB-type and AB3-type (hydrophilic A block: poly(sarcosine), hydrophobic B block: poly(l-lactic acid)) were prepared, and the N-terminals were arranged by guanidium or guanidino-peptide nucleic acid for loading siRNA in a reverse polymeric micelle. The amphiphilic polymers were successfully dispersed and assembled into reverse micelles in triglyceride or diisopropyl adipate. With loading siRNA into the core of the polymeric micelles, the micelle size was reduced down to a diameter of 25 nm in the case of the guanidino-peptide nucleic acid used as the capturing site. This small-size reverse micelle may be available for a transdermal drug delivery system (DDS) for siRNA. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bisenieks, Egils; Vigante, Brigita; Petrovska, Ramona; Turovska, Baiba; Muhamadejev, Ruslan; Soloduns, Vitalijs; Velena, Astrida; Pajuste, Karlis; Saso, Luciano; Klovins, Janis; Duburs, Gunars; Mandrika, Ilona published an article in 2021. The article was titled 《The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A》, and you may find the article in Pharmaceuticals.Related Products of 5437-45-6 The information in the text is summarized as follows:

The paradigm of ligand-receptor interactions postulated as “”one compound-one target”” has been evolving; a multi-target, pleiotropic approach is now considered to be realistic. Novel series of 1,4,5,6,7,8-hexahydro-5-oxoquinolines, pyranopyrimidines and S-alkyl derivatives of pyranopyrimidines have been synthesized in order to characterize their pleiotropic, multitarget activity on the FFA3/GPR41, FFA2/GPR43, and HCA2/GPR109A receptors. Hexahydroquinoline derivatives have been known to exhibit characteristic activity as FFA3/GPR41 ligands, but during this study we observed their impact on FFA2/GPR43 and HCA2/GPR109A receptors as well as their electron-donating activity. Oxopyranopyrimidine and thioxopyranopyrimidine type compounds have been studied as ligands of the HCA2/GPR109A receptor; nevertheless, they exhibited equal or higher activity towards FFA3/GPR41 and FFA2/GPR43 receptors. S-Alkyl derivatives of pyranopyrimidines that have not yet been studied as ligands of GPCRs were more active towards HCA2/GPR109A and FFA3/GPR41 receptors than towards FFA2/GPR43. Representative compounds from each synthesized series were able to decrease the lipopolysaccharide-induced gene expression and secretion of proinflammatory cytokines (IL-6, TNF-α) and of a chemokine (MCP-1) in THP-1 macrophages, resembling the effect of HCA2/GPR109A ligand niacin and the endogenous ligand propionate. This study revealed groups of compounds possessing multitarget activity towards several receptors. The obtained data could be useful for further development of multitarget ligands. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Related Products of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Related Products of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Tetrahedron Letters included an article by Wang, Hai-Xia; Li, Wen-Peng; Xia, Chao; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming. Quality Control of Benzyl 2-bromoacetate. The article was titled 《Enantioselective synthesis of chiral carbocyclic pyrimidine nucleosides via asymmetric cyclopropanation》. The information in the text is summarized as follows:

An efficient method to construct chiral cyclopropyl pyrimidine carbocyclic nucleoside analogs bearing a quaternary center was developed via asym. Michael-initiated cyclopropanation. The axis chirality was observed in cyclopropyl pyrimidine carbocyclic nucleoside analogs for the first time, which was caused by the rotationally restricted N-C bond in N-COPh moiety. Using (DHQD)2AQN as the organocatalyst, diverse cyclopropyl pyrimidine carbocyclic nucleoside analogs were generated in 76-93% yields and 73-96% ee. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Shengwang; He, Peng; Dhindwal, Sonali; Grum-Tokars, Valerie L.; Li, Ying; Parker, Kelly; Modica, Justin A.; Bleher, Reiner; dos Reis, Roberto; Zuchniarz, Joshua; Dravid, Vinayak P.; Voth, Gregory A.; Roux, Benoit; Mrksich, Milan published an article in 2021. The article was titled 《Synthesis, characterization, and simulation of four-armed megamolecules》, and you may find the article in Biomacromolecules.Name: Benzyl 2-bromoacetate The information in the text is summarized as follows:

This paper describes the synthesis, characterization, and modeling of a series of mols. having four protein domains attached to a central core. The mols. were assembled with the “”megamol.”” strategy, wherein enzymes react with their covalent inhibitors that are substituted on a linker. Three linkers were synthesized, where each had four oligo(ethylene glycol)-based arms terminated in a para-nitrophenyl phosphonate group that is a covalent inhibitor for cutinase. This enzyme is a serine hydrolase and reacts efficiently with the phosphonate to give a new ester linkage at the Ser-120 residue in the active site of the enzyme. Neg.-stain transmission electron microscopy (TEM) images confirmed the architecture of the four-armed megamols. These cutinase tetramers were also characterized by X-ray crystallog., which confirmed the active-site serine-phosphonate linkage by electron-d. maps. Mol. dynamics simulations of the tetracutinase megamols. using three different force field setups were performed and compared with the TEM observations. Using the Amberff99SB-disp + pH7 force field, the two-dimensional projection distances of the megamols. were found to agree with the measured dimensions from TEM. The study described here, which combines high-resolution characterization with mol. dynamics simulations, will lead to a comprehensive understanding of the mol. structures and dynamics for this new class of mols. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Name: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 5437-45-6In 2019 ,《Allenoate Prenucleophiles: A Triply Diastereoselective Approach to β-Hydroxy Esters Containing All-Carbon α-Quaternary Centers》 appeared in Organic Letters. The author of the article were Maki, Samantha L.; Maity, Pradip; Dougherty, Shannon; Johns, Jennifer; Lepore, Salvatore D.. The article conveys some information:

Allenyl esters activated by titanium(IV) underwent additions to a wide range of aldehydes in high regio- and diastereoselectivities leading to products containing an all-carbon quaternary center bearing an α-vinyl group that was installed with high selectivity for the Z-geometry. An aldol product was also converted to an indanone offering a new route to this important compound class. Product triple diastereoselectivity has been rationalized using a concerted transition-state model. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6HPLC of Formula: 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.HPLC of Formula: 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development of an efficient and sustainable synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl)acetic acid under continuous-flow conditions》 was written by Tortoioli, Simone; Friedli, Astrid; Prud’homme, Alice; Richard-Bildstein, Sylvia; Kohler, Philipp; Abele, Stefan; Vile, Gianvito. Related Products of 5437-45-6This research focused ontriazole preparation green chem continuous flow. The article conveys some information:

A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl)acetic acid is reported, which features an efficient construction of the triazole ring under flow conditions. This continuous, one-pot method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatog. and isolation steps. Compared to the earlier batch routes, higher yields were achieved in a flow reactor. In addition, a highly-energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles I (R = CH2CO2Et, CH2CO2CH2C6H5, 4-FC6H4, CH2C6H5, 4-OCH3C6H4CH2, cyclohexyl; R1 = H, 5-bromopyridin-3-yl) were prepared under the described conditions, confirming that the methodol. could find useful applications for the rapid and sustainable construction of differentially-functionalized 1,2,4-triazoles.Benzyl 2-bromoacetate(cas: 5437-45-6Related Products of 5437-45-6) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Related Products of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Ma, Chun-Hua; Zhao, Lu; He, Xing; Jiang, Yu-Qin; Yu, Bing published an article in Organic Chemistry Frontiers. The title of the article was 《Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water》.COA of Formula: C9H9BrO2 The author mentioned the following in the article:

A visible-light-driven rhodamine B-catalyzed transition-metal-free 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles and imidazo[1,2-a]pyridines (40 examples) using com. available α-bromoesters was realized in water. This protocol features sustainability, operational simplicity, mild reaction conditions, and remarkable substrate scope. Importantly, α-bromoamides are also appropriate substrates for affording 3-carbamylmethylation products. It could be used for the synthesis of the drug zolpidem and the late-stage modification of natural products. In the experiment, the researchers used Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Three-component coupling reaction for the synthesis of fully substituted triazoles: reactivity control of Cu-acetylide toward alkyl azides and diazo compounds》 was written by Chen, Fa-Jie; Mamidipalli, Phani; Sabbasani, Venkata Reddy; Liu, Huaqing; Xia, Yuanzhi; Lee, Daesung. Formula: C9H9BrO2This research focused ontriazole preparation; alkyne alkyl azide diazo compound multicomponent coupling copper catalyst. The article conveys some information:

Herein, a Cu-catalyzed three-component coupling reaction of alkynes, azides, and diazo compounds for the synthesis of fully substituted triazoles I [R = n-Bu, CH2OH, CO2Et, etc.; R1 = CH2SiMe3, Bn, 4-MeC6H4CH2, etc.; R2 = Et, n-hexyl, Bn, 2-adamantyl] was reported. The reactivities of alkyl azides and diazo compounds toward Cu-acetylide were controlled by the introduction of a ligand and the stoichiometry of azide and diazo compounds to suppress the undesired protonation or the alkyne-diazo coupling, maximizing the selectivity for the three-component coupling. Besides, the use of aliphatic alkynes was crucial for achieving high selectivity for the three-component coupling reaction. This method featured mild reaction conditions, broad substrate scope, and good functional group tolerance. A variety of fully substituted triazoles and ring-fused triazoles were synthesized by this method in moderate to good yields. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5437-45-6In 2021 ,《Enantioselective Rauhut-Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes》 appeared in Organic Letters. The author of the article were Pitchumani, Venkatachalam; Breugst, Martin; Lupton, David W.. The article conveys some information:

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut-Currier reaction. Exploiting electron-withdrawing protection of the amide, and moderate nucleophilicity N-heterocyclic carbenes (NHCs), such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary