Category: 5445-17-0

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, Reference of 5445-17-0

Gunter, Kevin;Sorci, Mirco;Belfort, Georges research published 《 A Simplified Predictive Tool for Design and Analysis of SET-LRP Reactions with Mechanistic Insight》, the research content is summarized as follows. Single-electron transfer (SET)-living radical polymerization (LRP) is a robust, fast, “green,” grafting method, similar but different from atom transfer radical polymerization, that operates at ambient temperature in the presence of oxygen and is industrially attractive. Solving a simplified reaction model with only five rather than 12 reactions in solution, for describing the SET-LRP scheme and verifying it with exptl. data, we provide (i) a useful tool to predict conversion given initial conditions and rate constants, and (ii) key mechanistic insights with a parametric sensitivity anal., illustrating the effects of initial conditions, kinetic rate constants, temperature, and copper particle size. Findings include: (i) Increasing the formation rate of radicals (i.e., k_act) exhibited a maximum in monomer conversion. (ii) The optimal ratio of initial conditions was found to be [MA]₀/[P_nX]₀/[Cu^IIX₂/L]₀ = 222/1/1.5, where [MA]₀ = 7.4 M. (iii) Increasing the temperature strongly improved monomer conversion with an inflection point. (iv) Using an order-of-magnitude and Damköhler number anal., we provide a rationale for selecting small diameter particles and specify how they are likely to perform with SET-LRP reactions. Assumptions of the model include: Solid copper concentration was an infinite source of dissolved Cu^I and Cu^II and was available instantaneously (with Damkohler number ≪ 1, for reaction rather than diffusion limitation). Also, the reverse reaction of the disproportionation of Cu^I was negligible, polymer chain length did not affect reaction kinetics, and all intermediate reactions were neglected.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Reference of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, COA of Formula: C4H7BrO2

Guo, Wengang;Luo, Yuzheng;Sung, Herman H.-Y.;Williams, Ian D.;Li, Pingfan;Sun, Jianwei research published 《 Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of α-Tertiary Amino Ketones from Sulfonium Ylides》, the research content is summarized as follows. Herein we disclose a new catalytic asym. approach for the synthesis of chiral α-amino ketones, which is particularly useful for the less accessible acyclic α-tertiary cases. By a protonation-amination sequence, our approach represents a rare asym. H-heteroatom bond insertion by α-carbonyl sulfonium ylides, an attractive surrogate of diazocarbonyls. The mild intermol. C-N bond formation was catalyzed by chiral phosphoric acids with excellent efficiency and enantioselectivity. The products are precursors to other important chiral amine derivatives, including drug mols. and chiral ligands. The enantioselectivity was controlled by dynamic kinetic resolution in the amination step, rather than the initial protonation. This process opens up a new platform for the development of other related insertion reactions.

COA of Formula: C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate, HPLC of Formula: 5445-17-0

Grandes Reyes, Carlos Fitzgerald;Chen, Sung-Po R.;Bobrin, Valentin A.;Jia, Zhongfan;Monteiro, Michael J. research published 《 Temperature-Induced Formation of Uniform Polymer Nanocubes Directly in Water》, the research content is summarized as follows. Conventional self-assembly methods of block copolymers in cosolvents (i.e., usually water and organic solvents) has yet to produce a pure and monodisperse population of nanocubes. The requirement to assemble a nanocube is for the second block to have a high mol. weight However, such high mol. weight block copolymers usually result in the formation of kinetically trapped nanostructures even with the addition of organic cosolvents. Here, we demonstrate the rapid production of well-defined polymer nanocubes directly in water by utilizing the thermoresponsive nature of the second block (with 263 monomer units), in which the block copolymer was fully water-soluble below its lower critical solution temperature (LCST) and would produce a pure population of nanocubes when heated above this temperature Incorporating a pH-responsive monomer in the second block allowed us to control the size of the nanocubes in water with pH and the LCST of the block copolymer. We then used the temperature and pH responsiveness to create an adaptive system that changes morphol. when using a unique fuel. This fuel (H₂O₂ + MnO₂) is highly exothermic, and the solution pH increases with the consumption of H₂O₂. Initially, a nonequilibrium spherical nanostructure formed, which transformed over time into nanocubes, and by controlling the exotherm of the reaction, we controlled the time for this transformation. This block copolymer and the water-only method of self-assembly have provided some insights into designing biomimetic systems that can readily adapt to the environmental conditions.

HPLC of Formula: 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5445-17-0, formula is C4H7BrO2, The most pervasive is the naturally produced bromomethane. Recommanded Product: Methyl 2-bromopropanoate

Grenet, Erwann;Geant, Pierre-Yves;Salom-Roig, Xavier J. research published 《 Crystallization-Induced Diastereomer Transformation of α-Bromo α’-Sulfinyl Ketones. Diastereodivergent Synthesis of (+)-α-Conhydrine and (-)-β-Conhydrine》, the research content is summarized as follows. Crystallization-Induced Diastereomer Transformation (CIDT) of α-Bromo α’-(R)-sulfinylketones RCH(Br)C(O)CH₂S(O)(CH₃)4-CH₃C₆H₅ (R = Me, cyclohexylmethyl) were reported. This process provides not readily accessible enantiopure stereolabile α-bromoketones, which after diastereoselective carbonyl group reduction lead to the corresponding highly value-added anti and syn-bromohydrins RCH(Br)C(OH)CH₂S(O)(CH₃)4-CH₃C₆H₅ with excellent diastereoselectivities. As an application, a diastereodivergent synthesis of enantiopure hemlock alkaloid (+)-α-conhydrine and its diastereomer (-)-β-conhydrine were also described.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Recommanded Product: Methyl 2-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Reference of 5445-17-0.

Georgiou, Panagiotis G.;Marton, Huba L.;Baker, Alexander N.;Congdon, Thomas R.;Whale, Thomas F.;Gibson, Matthew I. research published 《 Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition》, the research content is summarized as follows. Ice binding proteins modulate ice nucleation/growth and have huge (bio)technol. potential. There are few synthetic materials that reproduce their function, and rational design is challenging due to the outstanding questions about the mechanisms of ice binding, including whether ice binding is essential to reproduce all their macroscopic properties. Here we report that nanoparticles obtained by polymerization-induced self-assembly (PISA) inhibit ice recrystallization (IRI) despite their constituent polymers having no apparent activity. Poly(ethylene glycol), poly(dimethylacrylamide), and poly(vinylpyrrolidone) coronas were all IRI-active when assembled into nanoparticles. Different core-forming blocks were also screened, revealing the core chem. had no effect. These observations show ice binding domains are not essential for macroscopic IRI activity and suggest that the size, and crowding, of polymers may increase the IRI activity of “non-active” polymers. Poly(vinylpyrrolidone) particles had ice crystal shaping activity, indicating this polymer can engage ice crystal surfaces, even though on its own it does not show any appreciable ice recrystallization inhibition. Larger (vesicle) nanoparticles are shown to have higher ice recrystallization inhibition activity compared to smaller (sphere) particles, whereas ice nucleation activity was not found for any material. This shows that assembly into larger structures can increase IRI activity and that increasing the “size” of an IRI does not always lead to ice nucleation. This nanoparticle approach offers a platform toward ice-controlling soft materials and insight into how IRI activity scales with mol. size of additives.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Reference of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Product Details of C4H7BrO2.

Fung, Alfred. K. K.;Yu, Li-Juan;Sherburn, Michael S.;Coote, Michelle L. research published 《 Atom Transfer Radical Polymerization-Inspired Room Temperature (sp³)C-N Coupling》, the research content is summarized as follows. A simple nonphotochem. procedure is reported for Cu(I)-catalyzed C-N coupling of aliphatic halides with amines and amides. The process is loosely based on the Goldberg reaction but takes place readily at room temperature It uses Cu(I)Br, a commonly used and inexpensive atom transfer radical polymerization precatalyst, along with the cheap ligand N,N,N’,N”,N”-pentamethyldiethylenetriamine, to activate the R-X bond of the substrate via inner-sphere electron transfer. The procedure brings about productive C-N bond formation between a range of alkyl halide substrates with heterocyclic aromatic amines and amides. The mechanism of the coupling step, which was elucidated through application of computational methods, proceeds via a unique Cu(I) → Cu(II) → Cu(III) → Cu(I) catalytic cycle, involving (a) inner-sphere electron transfer from Cu(I) to the alkyl halide to generate the alkyl radical; (b) successive coordination of the N-nucleophile and the radical to Cu(II); and finally reductive elimination. In the absence of a nucleophile, debrominative homocoupling of the alkyl halide occurs. Control experiments rule out SN-type mechanisms for C-N bond formation.

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Product Details of C4H7BrO2.

Gambhir, Geetu;Gautam, Drashya;Saya, Laishram;Kumar, Amit;Kumar, Subodh;Singh, Aarushi;Singh, Snigdha;Chandra, Ramesh;Hooda, Sunita research published 《 A novel terpolymer membrane-based electrode sensor for selective determination of Cd(II) ions》, the research content is summarized as follows. A new polymeric membrane sensor for Cd(II) ion based on Me acrylate-acrylonitrile-Me methacrylate terpolymer as membrane carrier has been synthesized via atom transfer radical polymerization (ATRP) method at 60°C. Preliminary investigation with the membrane exhibited promising selectivity for Cd(II) ion with a slope of 32.02 mV/decade and the same could be estimated in the concentration range of 1 x 10-6 – 1 x 10-1 M in the working pH range of 4-6 for up to 90 days. The potentials generated across the membrane were reproducible and the response time was less than one minute. The electrode works well even in a partially non-aqueous media. The effect of surfactant and detergent on the working of Cd(II) selective electrode was also studied. A decrease in potential was observed in the presence of appreciable amount of surfactant and detergent. Addition of plasticisers was found to greatly improve the performance of membrane, best results being obtained with the membrane ratio (NaTPB:TP:TBP: 1:100:06), exhibiting a working concentration range of 1 x 10-6 – 1 x 10-1 mol L-1 with a short response time of 10 s. The proposed sensor shows significantly good selectivity toward Cd(II) ion in comparison with some alkali, alk. earth, transition and heavy metal ions. It was successfully employed as an indicator electrode in potentiometric titration of cadmium(II) ions against EDTA solution

Product Details of C4H7BrO2, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 5445-17-0.

Fan, Bo;Wan, Jing;McKay, Alasdair;Qu, Zhenyuan;Thang, San H. research published 《 Facile synthesis of well-controlled poly(1-vinyl imidazole) by the RAFT process》, the research content is summarized as follows. Poly(vinyl imidazole)s, which contain heterocyclic aromatic rings on the polymer side chains, are of increasing interest for a wide variety of applications ranging from catalysis, polymeric ionic liquids to membrane material. However, the controlled radical polymerization of vinyl imidazoles, including 1-vinyl imidazole (1VIM), 2-vinyl imidazole (2VIM) and 4-vinyl imidazole (4VIM), proved to be extremely challenging in the past decades. Here, we demonstrate, for the first time, that well-controlled and low dispersity (D as low as 1.05) poly(1VIM) could be synthesized via RAFT polymerization by using acetic acid as a special solvent. Acetic acid not only works as a solvent that allows homogeneous polymerization, it also protonates 1VIM, thereby, allowing the stabilization of propagating radicals during polymerization To verify the efficacy of the RAFT polymerization of 1VIM in acetic acid, various polymerization parameters including different RAFT agents, initiator and monomer concentrations, temperatures, etc. had been examined Moreover, detailed kinetic studies revealed a linear, pseudo-first-order polymerization behavior of 1VIM in acetic acid, and the apparent rate constants were calculated Furthermore, the living characteristic of this RAFT process was demonstrated by chain extension with Bu acrylate (nBA) and N,N-di-Me acrylamide (DMA) to form resp. block copolymers with low dispersities. Overall, the synthesis of well-controlled poly(1VIM) is expected to greatly expand the design and utility of vinyl imidazole-based materials and their applications in catalysis, membrane material, heavy metal removal, fuel cells and many other fields.

Electric Literature of 5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Dietrich, Justin D.;Longenecker, Kenton L.;Wilson, Noel S.;Goess, Christian;Panchal, Sanjay C.;Swann, Steven L.;Petros, Andrew M.;Hobson, Adrian D.;Ihle, David;Song, Danying;Richardson, Paul;Comess, Kenneth M.;Cox, Philip B.;Dombrowski, Amanda;Sarris, Kathy;Donnelly-Roberts, Diana L.;Duignan, David B.;Gomtsyan, Arthur;Jung, Paul;Krueger, A. Chris;Mathieu, Suzanne;McClure, Andrea;Stoll, Vincent S.;Wetter, Jill;Mankovich, John A.;Hajduk, Philip J.;Vasudevan, Anil;Stoffel, Robert H.;Sun, Chaohong research published 《 Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design》, the research content is summarized as follows. Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biol. drugs that inhibit TNFα has led to improved clin. outcomes for patients with rheumatoid arthritis and other chronic autoimmune diseases; however, TNFα has proven to be difficult to drug with small mols. Herein, we present a two-phase, fragment-based drug discovery (FBDD) effort in which we first identified isoquinoline fragments that disrupt TNFα ligand-receptor binding through an allosteric desymmetrization mechanism as observed in high-resolution crystal structures. The second phase of discovery focused on the de novo design and optimization of fragments with improved binding efficiency and drug-like properties. The 3-indolinone-based lead compound 12 (I) presented here displays oral, in vivo efficacy in a mouse glucose-6-phosphate isomerase (GPI)-induced paw swelling model comparable to that seen with a TNFα antibody.

Category: bromides-buliding-blocks, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., 5445-17-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5445-17-0, formula is C4H7BrO2, Name is Methyl 2-bromopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Computed Properties of 5445-17-0.

Dittrich, Jonas;Kather, Michael;Holzberger, Anna;Pich, Andrij;Gohlke, Holger research published 《 Cumulative submillisecond all-atom simulations of the temperature-induced coil-to-globule transition of poly(N-vinylcaprolactam) in aqueous solution》, the research content is summarized as follows. Poly(N-vinylcaprolactam) (PNVCL) polymers are stimuli-responsive and change their conformation in aqueous solutions upon changes in salt concentration, concentration of organic solvents, or temperature, making these mols. highly interesting for tailored release of drugs or fabrication of sensors or actuators. At lower critical solution temperature (LCST), PNVCL chains undergo a transition from a coil to a globule and become insoluble In contrast to other polymers, however, PNVCL has received much less attention as to elucidating driving forces of its coil-to-globule transition at an atomistic level. Here, we show by a combined computational and exptl. study that upon temperature increase, PNVCL chains dissolved in water experience an increase of intramol. interactions between C₃ and C₄ of the caprolactam ring. Therefore, more favorable cavity formation energies and the increase of intramol. interactions outweigh the loss in polar and hydrophobic solvation, and the loss of configurational entropy in the coil-to-globule transition and, thus, may be considered driving forces of the polymer’s collapse at LCST. These results are based on mol. dynamics simulations of in total 600μs length and transition (free) energy computations that have been validated internally and against exptl. data. We systematically tested the influence of the polymer’s length, concentration, tacticity, of the thermodn. ensemble, and of the water model. Tacticity was found to be most influential, with atactic polymers showing the strongest tendency to collapse. The presented approach should be applicable to scrutinize at the atomistic level the impact of, for example, ion and polymer dispersity on the coil-to-globule transition of PNVCL, and the LCST behavior of other polymers.

5445-17-0, Methyl 2-bromopropionate, also known as Methyl 2-bromopropionate, is a useful research compound. Its molecular formula is C4H7BrO2 and its molecular weight is 167 g/mol. The purity is usually 95%.
Methyl 2-bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
Methyl 2-bromopropanoate is a chemical compound that can be synthesized in an asymmetric manner. The reaction of methyl 2-bromopropanoate with hydrochloric acid gives the corresponding carboxylic acid, methyl propanoate, and hydrogen bromide in a 1:1 ratio. It has been shown that methyl 2-bromopropanoate is a potential catalyst for the reduction of chloride to chloride ion via the borohydride reduction method. Methyl 2-bromopropanoate has also been used as a model system for studying halides and copper complexes. Magnetic resonance spectroscopy studies have revealed that this chemical compound has a high redox potential and kinetic properties., Computed Properties of 5445-17-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary