Category: 57293-19-3

Scalable anti-Markovnikov hydrobromination of aliphatic and aromatic olefins was written by Galli, Marzia;Fletcher, Catherine J.;del Pozo, Marc;Goldup, Stephen M.. And the article was included in Organic & Biomolecular Chemistry in 2016.Recommanded Product: 57293-19-3 This article mentions the following:

To improve access to a key synthetic intermediate a direct hydrobromination-Negishi route was targeted. Unsurprisingly, the anti-Markovnikov addition of HBr to estragole in the presence of AIBN proved successful. However, even in the absence of an added initiator, anti-Markovnikov addition was observed Re-examination of early reports revealed that selective Markovnikov addition, often simply termed “normal” addition, was not always observed with HBr unless air was excluded, leading to the rediscovery of a reproducible and scalable initiator-free protocol. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents was written by Wu, Shuang;Li, Junzhao;He, Ru;Jia, Kunfang;Chen, Yiyun. And the article was included in Organic Letters in 2021.Synthetic Route of C10H13BrO This article mentions the following:

The first terminal trifluoromethylation at aryl and alkyl ketone’s 绾? 鏈? 钄? or more remote sites via selective C-C bond cleavage of cycloalkanols was reported. The noncovalent interactions between alcs. and hypervalent iodines(III) reagents were disclosed to activate both alcs. and the Togni I reagent in the dual photoredox/copper catalysis for the transformation. This reaction was scalable to the gram-scale synthesis, applicable to the structurally complex steroid trifluoromethylation, and extendable to the pentafluoroethylation. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Synthetic Route of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

4-Alkyloxyimino Derivatives of Uridine-5′-triphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y₂, P2Y₄, and P2Y₆ Receptors was written by Jayasekara, P. Suresh;Barrett, Matthew O.;Ball, Christopher B.;Brown, Kyle A.;Hammes, Eva;Balasubramanian, Ramachandran;Harden, T. Kendall;Jacobson, Kenneth A.. And the article was included in Journal of Medicinal Chemistry in 2014.Name: 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

Extended N⁴-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y_2/4R) or UDP (P2Y₆R). The potent P2Y₄R-selective N⁴-(3-phenylpropyl)oxy agonist was Ph ring-substituted or replaced with terminal heterocyclic or naphthyl rings with retention of P2YR potency. This broad tolerance for steric bulk in a distal region was not observed for dinucleoside tetraphosphate agonists with both nucleobases substituted. The potent N⁴-(3-(4-methoxyphenyl)-propyl)oxy analog I (EC₅₀: P2Y₂R, 47 nM; P2Y₄R, 23 nM) was functionalized for chain extension using click tethering of fluorophores as prosthetic groups. The BODIPY conjugate exhibited EC₅₀ values of 70, 66, and 23 nM at the hP2Y_2/4/6Rs, resp., and specifically labeled cells expressing the P2Y₆R. Thus, an extended N⁴-(3-arylpropyl)oxy group accessed a structurally permissive region on three G_q-coupled P2YRs, and potency and selectivity were modulated by distal structural changes. This freedom of substitution was utilized to design of a pan-agonist fluorescent probe of a subset of uracil nucleotide-activated hP2YRs. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Name: 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl Azides as Radical Acceptors in the Vitamin B₁₂-Catalyzed Synthesis of Unsymmetrical Ketones was written by Dworakowski, Krzysztof R.;Pisarek, Sabina;Hassan, Sidra;Gryko, Dorota. And the article was included in Organic Letters in 2021.HPLC of Formula: 57293-19-3 This article mentions the following:

Vitamin B₁₂ catalyzed the reaction of vinyl azides with electrophiles under light irradiation to afforded unsym. carbonyl compounds R¹C(O)CH₂R² [R¹ = Ph, 4-t-BuC₆H₄, 4-ClC₆H₄, etc.; R² = (CH₂)₃CN, (CH₂)₃Ph, (CH₂)₃C(O)OEt, etc.] in decent yields. Mechanistic studies revealed that alkyl radicals were key intermediates in this transformation. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions was written by Chen, Haifeng;Yue, Huifeng;Zhu, Chen;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 57293-19-3 This article mentions the following:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fluorination of orthothioesters through oxidative desulfurization-fluorination was written by Furuta, Satoru;Kuroboshi, Manabu;Hiyama, Tamejiro. And the article was included in Bulletin of the Chemical Society of Japan in 1998.Reference of 57293-19-3 This article mentions the following:

The oxidative desulfurization-fluorination of orthothioesters of type RCH₂C(SMe)₃ using n-Bu₄NH₂F₃ and 1,3-dibromo-5,5-dimethylhydantoin gave bromodifluorination products RCHBrCF₂SMe in good yields. The products were converted into bromodifluoro olefins RCBr:CF₂ via oxidation and thermolysis. In a similar way, the orthothioesters of type RCH(OH)C(SMe)₃ or RCH(OAc)C(SMe)₃ were fluorinated to afford difluoro ketones RCOCF₂SMe or difluoro acetates RCH(OAc)CF₂SMe, resp. The difluoro acetates were reduced to RCH(OAc)CF₂H by radical reduction The mechanisms are discussed for difluorination accompanied by bromination or oxidation In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Reference of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization was written by Yang, Jee Sun;Lee, Chulho;Cho, Misun;Kim, Hyuntae;Kim, Jae Hyun;Choi, Seonghwi;Oh, Soo Jin;Kang, Jong Soon;Jeong, Jin-Hyun;Kim, Hyun-Jung;Han, Gyoonhee. And the article was included in Journal of Medicinal Chemistry in 2015.Category: bromides-buliding-blocks This article mentions the following:

Recently, the authors identified a novel strategy for anticancer chemotherapy by restoring runt-related transcription factor 3 (RUNX3) levels via lactam-based histone deacetylase (HDAC) inhibitors that stabilize RUNX3. Described here are the synthesis, biol. evaluation, and pharmacokinetic evaluation of new synthetic small mols. based on pyridone-based HDAC inhibitors that specifically stabilize RUNX3 by acetylation and regulate its function. Many of the newly synthesized compounds showed favorable RUNX activities, HDAC inhibitory activities, and inhibitory activities on the growth of human cancer cell lines. Notably, one of these new derivatives, I , significantly restored RUNX3 in a dose-dependent manner and showed high metabolic stability, a good pharmacokinetic profile with high oral bioavailability and long half-life, and strong antitumor activity. This study suggests that pyridone-based analogs modulate RUNX3 activity through epigenetic regulation as well as strong transcriptional and post-translational regulation of RUNX3 and could be potential clin. candidates as orally available RUNX3 modulators for the treatment of cancer. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of compounds allied to rhododendrin was written by Kim, Ki-U. And the article was included in Yakugaku Zasshi in 1943.HPLC of Formula: 57293-19-3 This article mentions the following:

In order to exam. the pharmacol. action of compounds allied to rhododendrin, the following compounds were synthesized. 1-(p-Hydroxyphenyl)-2-propanol: p-MeOC₆H₄CH:CHMe(+ Br) 閳?MeOC₆H₄CHBrCHBrMe (+ CaO) 閳?MeOC₆H₄CH(OH)CHBrMe (+ 2.5% alkali) 閳?MeOC₆H₄CH(OH)CH(OH)Me (heating to 180鎺? 閳?MeOC₆H₄CH₂COMe (+ Na + EtOH) 閳?MeOC₆H₄CH₂CH(OH)Me (+ Grignard reagent) 閳?p-HOC₆H₄CH₂CH(OH)Me. 5-(p-Hydroxyphenyl)-2-pentanol: p-MeOC₆H₄CHO + AcOEt (+ Na) 閳?MeOC₆H₄CH:CHCO₂Et (+ H) 閳?MeOC₆H₄CH₂CH₂CO₂Et (+ Na + AmOH) 閳?MeOC₆H₄(CH₂)₃OH (+ PBr₃) 閳?MeOC₆H₄(CH₂)₃Br 閳?MeOC₆H₄(CH₂)₃CN (+ MeMgI) 閳?MeOC₆H₄(CH₂)₃COMe 閳?MeOC₆H₄(CH₂)₃CH(OH)Me 閳?HOC₆H₄(CH₂)₃CH(OH)Me. By similar methods were prepared: 6-(p-hydroxyphenyl)-2-hexanol, from p-MeOC₆H₄CHO and EtCOMe; 1-(m-hydroxyphenyl)-3-butanol, from m-MeOC₆H₄CHO and Me₂CO; 1-(4-hydroxy-3-methoxyphenyl)-3-butanol, from vanillin and Me₂CO; 1-(p-hydroxyphenyl)-3-pentanol, from p-MeOC₆H₄CHO and AcOEt; 1-(4-hydroxy-3-methylphenyl)-3-butanol from 3,4-Me(HO)C₆H₃CHO (prepared from m-MeC₆H₄OH, HCN, AlCl₃, and HCl) and Me₂CO; 1-(4-hydroxy-2-methylphenyl)-3-butanol, from 2,4-Me(HO)C₆H₃CHO and Me₂CO; and 1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-butanol, from 5,2-Me(Me₂CH)C₆H₃OH through 2,5,4-Me(Me₂CH)(HO)C₆H₂CHO. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis was written by Ding, Chao;Ren, Yaoyu;Sun, Caocao;Long, Jiao;Yin, Guoyin. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 57293-19-3 This article mentions the following:

Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Related Products of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lewis base-promoted carbon-carbon sp³-sp³ coupling reactions of 浼?silyl silylethers was written by Brekan, Jonathan A.;Chernyak, Dmitri;White, Kolby L.;Scheidt, Karl A.. And the article was included in Chemical Science in 2012.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

A Lewis base-promoted addition of 浼?silyl silylethers to primary halides has been developed. This new carbon-carbon sp³-sp³ bond-forming process accesses an unconventional reactivity pattern (d¹ synthon) from easily accessible precursors. The strategy accommodates a variety of primary alkyl, allylic and benzylic electrophiles and 浼?silyl silylethers. These d¹ synthons have also been used in the synthesis of cross pinacol and benzil products. Mechanistic studies indicate significant intermol. silyl group exchange during the reaction. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary