585-76-2 Archives - Page 7 of 14 - Bromides-buliding-blocks

Li, Wanwan team published research in Medicinal Chemistry Research in 2021 | 585-76-2

Reference of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid, Reference of 585-76-2

Li, Wanwan;Cao, Zhongqiang;Cheng, Junjie;Chen, Feiyu;Li, Shuai;Huang, Yiwei;Zheng, Long Tai;Ye, Na research published 《 Discovery of N-phenyl-1-(phenylsulfonamido)cyclopropane-1-carboxamide analogs as NLRP3 inflammasome inhibitors》, the research content is summarized as follows. Two series of novel NLRP3 inflammasome inhibitors are designed, synthesized, and evaluated in an effort to develop diversified analogs based on the N-(phenylcarbamoyl)benzenesulfonamide scaffold. SAR studies reveal that the sulfonylurea linker can tolerate chem. modifications with either simply changing over the position of carbonyl and sulfonyl group or structurally flexibly inserting a cyclopropyl group, leading to identification of several more potent and diversified NLRP3 antagonists (e.g., 9) with low nanomolar inhibitory activities. Further studies indicate that these two series of compounds with low cytotoxicity exhibited weak effects on the generation of NO and TNF-a. The findings may serve as good starting points for the development of more potent NLRP3 inflammasome inhibitors as valuable pharmacol. probes or potential drug candidates.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Xin-yang team published research in Bioorganic Chemistry in 2022 | 585-76-2

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 585-76-2.

Li, Xin-yang;Wang, De-pu;Li, Shuai;Xue, Wen-han;Qian, Xin-hua;Liu, Kai-li;Li, Yu-heng;Lin, Qi-qi;Dong, Gang;Meng, Fan-hao;Jian, Ling-yan research published 《 Discovery of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure as novel EGFR/HER-2 dual-target inhibitors against cancer growth and angiogenesis》, the research content is summarized as follows. Targeting EGFR and HER-2 is an essential direction for cancer treatment. Here, a series of N-(1,3,4-thiadiazol-2-yl)benzamide derivatives containing a 6,7-methoxyquinoline structure was designed and synthesized to serve as EGFR/HER-2 dual-target inhibitors. The kinase assays verified that target compounds could inhibit the kinase activity of EGFR and HER-2 selectively. The results of CCK-8 and 3D cell viability assays confirmed that target compounds had excellent anti-proliferation ability against breast cancer cells (MCF-7 and SK-BR-3) and lung cancer cells (A549 and H1975), particularly against SK-BR-3 cells, while the inhibitory effect on healthy breast cells (MCF-10A) and lung cells (Beas-2B) was weak. Among them, the hit compound YH-9 binded to EGFR and HER-2 stably in mol. dynamics studies. Further studies found that YH-9 could induce the release of cytochrome c and inhibit proliferation by promoting ROS expression in SK-BR-3 cells. Moreover, YH-9 could diminish the secretion of VEGF and bFGF factors in SK-BR-3 cells, then inhibited tube formation and angiogenesis. Notably, YH-9 could effectively inhibit breast cancer growth and angiogenesis with little toxicity in the SK-BR-3 cell xenograft model. Taken together, in vitro and in vivo results revealed that YH-9 had high drug potential as a dual-target inhibitor of EGFR/HER-2 to inhibit breast cancer growth and angiogenesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Jing-wei team published research in Bioorganic Chemistry in 2022 | 585-76-2

Product Details of C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Product Details of C7H5BrO2.

Liang, Jing-wei;Li, Wan-qiu;Nian, Qing-yang;Xie, Si-hua;Yang, Lulu;Meng, Fan-hao research published 《 Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities》, the research content is summarized as follows. CDK4/6 were attractive chemotherapeutic targets for the treatment of malignant tumors, CDK4/6 selective inhibitors have made outstanding contributions in the treatment of breast cancer. However, these inhibitors share a single skeleton of N-(pyridin-2-yl) pyrimidin-2-amine which cannot overcome the side effects in clin. application. In our previous study, an N′- acetylpyrrolidine-1-carbohydrazide was hit as the initial fragment by analyzing the active site characteristics of CDK6. Two series of N-(pyridin-3-yl) proline were obtained by fragment growth method. The QSAR study was carried out according to the in vitro activities data against CDK4/6, and two compounds (R)-1-(2-(2-chlorobenzoyl)hydrazine-1-carbonyl)-N-(pyridin-3-yl) pyrrolidine-2-carboxamide and (R)-1-(2-(4-nitrobenzoyl)hydrazine-1-carbonyl)-N-(pyridin-3-yl) pyrrolidine-2-carboxamide with potent inhibitory activities were found to interact with CDK4 in different binding conformation. They showed potential inhibition of cell proliferation against the breast cancer cell, and 7c exhibited promised anti-breast cancer effect in vivo.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Peng team published research in European Journal of Medicinal Chemistry in 2021 | 585-76-2

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Application of C7H5BrO2

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H5BrO2.

Li, Peng;Liu, Ying;Yang, Hua;Liu, Hong-Min research published 《 Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors》, the research content is summarized as follows. The design, synthesis and biol. evaluation of novel I [R¹ = pyrrolyl, Ph, pyridinyl, etc.] and II [R² = Et, furanyl, dimethylaminomethylene, etc.;R³ = H, methyl] as potent USP7 inhibitors was reported. This results indicated that the compounds II [R² = pyrrolidinylmethylene, dimethylaminomethylene;R³ = H, methyl] exhibited the greatest potency against the USP7 catalytic domain, with IC₅₀ values of 4.86μM and 1.537μM, resp. Ub-AMC assays further confirmed IC₅₀ values of 5.048μM and 0.595μM for II [R² = pyrrolidinylmethylene, dimethylaminomethylene; R³ = H, methyl] resp. MTT assays indicated that gastric cancer MGC-803 cells were more sensitive to these compounds than BGC-823 cells. Flow cytometry anal. revealed that II [R² = pyrrolidinylmethylene; R³ = H ] restricted cancer cell growth at the G0/G1 and S phases and inhibited the proliferation and clone formation of MGC-803 cells. Further biochem. experiments indicated that II [R² = pyrrolidinylmethylene; R³ = H ] decreased the MDM2 protein level and increased the levels of the tumor suppressors p53 and p21 in a dose-dependent manner. Docking studies predicted that solvent exposure of the side chains of II [R² = pyrrolidinylmethylene, dimethylaminomethylene; R³ = H, methyl] would uniquely form hydrogen bonds with Met407 of USP7. Addnl., II [R² = pyrrolidinylmethylene; R³ = H ] exhibited a remarkable anticancer effect in a zebrafish gastric cancer MGC-803 cell model. Results demonstrated that I [R¹ = pyrrolyl, Ph, pyridinyl, etc.] and II [R² = Et, furanyl, dimethylaminomethylene etc.; R³ = H, methyl] were suitable as leads for the development of novel USP7 inhibitors and especially for anti-gastric cancer drugs.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kushawaha, Ajay Kishor team published research in Tetrahedron in 2021 | 585-76-2

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C7H5BrO2.

Kushawaha, Ajay Kishor;Jaiswal, Arvind Kumar;Pandey, Shubham;Sashidhara, Koneni V. research published 《 A simple and efficient oxidation of primary and secondary benzylamines to acids using table salt in aqueous medium》, the research content is summarized as follows. A novel, simple, efficient method for the oxidation of aromatic benzylamines RCH₂NH₂ (R = C₆H₅, 4-FC₆H₄, 2-thienyl, etc.), R¹CH₂NHCH₂R¹ (R¹ = C₆H₅, 4-ClC₆H₄, 2-thienyl, etc.) and 4-OCH₃C₆H₄CH₂NHR₂ (R₂ = Me, Et, Pr, n-octyl, t-butyl) to corresponding acids RC(O)OH, R¹C(O)OH and 4-methoxybenzoic acid using common table salt in aqueous medium has been described. Oxidation of benzylamine was achieved by using NaCl (20 mol%) as a catalyst, NaOH (4 equiv) and TBHP (5 equiv) as oxidant, in moderate to good yields (34-84%). Control experiments revealed that in situ generated ClO₂^– ion is the active form of the catalyst. This methodol. can also be scaled up for easy accessibility to the industrially important terephthalic acid as well. This investigation provided a facile entry of various primary as well as secondary benzylamines with wide range of functional group tolerance.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Khalil, Amjad team published research in Arabian Journal for Science and Engineering in 2021 | 585-76-2

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 585-76-2, formula is C7H5BrO2, The most pervasive is the naturally produced bromomethane. Related Products of 585-76-2

Khalil, Amjad;Jaradat, Nidal;Hawash, Mohammed;Issa, Linda research published 《 In Vitro Biological Evaluation of Benzodioxol Derivatives as Antimicrobial and Antioxidant Agents》, the research content is summarized as follows. The 1,3-benzodioxol moiety present in safrole, apiole, and myristicin essential oils and benzodioxol derivatives have shown a wide range of biol. activities including antiepileptic, analgesic, antituberculosis, and antimicrobial potentials. Here, we have tested the antibacterial and antioxidant activities of a series of benzodioxol derivatives Twelve compounds of aryl acetate and acetic acid benzodioxol were evaluated against different types of bacterial strains, including Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Pseudomonas aeruginosa using the broth dilution method, and the most potent compound was 3e, which exhibited the bacterial growth of with MICs of 125 (S. aureus), 250 (E. coli), 220 (E. faecalis), and 100μg/mL (P. aeruginosa). Our pos. control, cinoxacin, had MICs of 250 (S. aureus), 250 (E. coli), 250 (E. faecalis), and 500μg/mL (P. aeruginosa). Antioxidant activity was evaluated for the synthesized compounds utilizing the DPPH assay. The 3a compound was the most active with an IC₅₀ value of 21.44μg/mL, while the IC₅₀ values of compounds 3b, 3e, and 3f were 96.07, 58.45, and 72.17μg/mL, resp. In contrast, all compounds with the acetic acid functional group had weaker activity, with an IC₅₀ range of 193.52-289.78μg/mL compared with the potent antioxidant agent Trolox (IC₅₀ = 1.93μg/mL). In the present paper, new benzodioxol-based aryl acetate and acetic acid derivatives were evaluated for their antibacterial and antioxidant activities. The outcomes revealed that the antibacterial and antioxidant properties of some of the synthesized benzodioxol aryl acetate and acetic acid derivatives can be considered as valuable materials for the pharmaceutical industry. Thus, these mols. should be further evaluated in vivo as lead compounds for the discovery of new drug candidates.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Khokra, Sukhbir Lal team published research in Central Nervous System Agents in Medicinal Chemistry in 2021 | 585-76-2

Khokra, Sukhbir Lal;Kaur, Simranjeet;Banwala, Sahil;Wadhwa, Karan;Husain, Asif research published 《 Synthesis, Molecular Docking, and Biological Evaluation of Some Novel 2- (5-Substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole Derivatives as Anticonvulsant Agents》, the research content is summarized as follows. Benzothiazole is an organosulfur heterocyclic compound that has a considerable place in drug discovery due to significant pharmacol. actions. The main objective of the present study was to synthesize some novel 2-(5-substituted 1,3,4-oxadiazole-2-yl)-1,3-benzothiazole derivatives and evaluate them for their anticonvulsant activity using in silico and in vivo methods. A set of sixteen 2-(5-substituted 1, 3, 4-oxadiazole-2-yl)-1, 3-benzothiazole derivatives were prepared using multi-step reactions starting from o-amino-thiophenol and characterized by suitable spectral techniques. The synthesized compounds were evaluated for anticonvulsant activity using in silico and in vivo methods. In silico mol. docking study was performed using Molegro Virtual Docker software to analyze binding modes of compounds with the internal ligand of PDB ID: 1OHY and 1OHV; and in vivo pharmacol. activities were tested for both generalized tonic-clonic seizures and generalized absence (petit mal) seizures using Maximal Elec. Shock and PTZ-induced seizure models, resp. Some new 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3- benzothiazole (5a-5p) were successfully synthesized by finally refluxing 1, 3-benzothiazole-2-carboxyhydrazide with different aromatic acids in phosphoryl chloride. Docking results showed that compounds 5c, 5j, and 5m were found to have the highest number of H-bond interactions; i.e. 4, 4, and 7 resp. with target proteins 1OHY and 6, 3, and 4 resp. with target protein 1OHV, whereas phenytoin showed only two H-bonding with both proteins. In the Maximal electroshock seizure method, the synthesized compounds 5h, 5k and 5o demonstrated potent anticonvulsant activity against the tonic seizure with a significant decrease in tonic hind leg extension period with a mean duration of 7.9, 7.4, and 7.0 s resp., as compared to the other synthesized compounds In contrast, in the PTZ-induced seizure model, compounds 5c, 5h, and 5m showed protection against clonic convulsion with significant elevation in the onset time of clonic convulsion at 311.2, 308.0, and 333.11 s, resp. Thus, from the results, it can be concluded that compound 5h, a benzothiazole derivative endowed with an oxadiazole ring, can be developed as a potential anticonvulsant agent.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Karki, Bhishma team published research in Materials Letters: X in 2022 | 585-76-2

Karki, Bhishma;Dhobi, Saddam Husain;Yadav, Kishori;Gupta, Suresh Prasad;Nakarmi, Jeevan Jyoti;Pal, Amrindra research published 《 Comparative study of boron oxides crystal with different sources X-ray production sources (Cu, Ag, Mo, and Fe)》, the research content is summarized as follows. This work aims to study the XRD of 5 Boron oxides crystal with different X-ray sources using Quantum Expresso. When XRD was done with angle vs. intensity, a pretty exciting observation was observed: the single high-intensity peak was observed for each source. The high intensity with large Bragg′s angle is observed with Fe-sources among the considered source (Cu, Ag, Mo, and Fe). This shows lower at. mass sources have higher Bragg′s angle when incidence on a sample of Boron oxides. The high-intensity peak when Fe-sources is used for XRD of B6O, BO3, B2O, B8O, B2O3 was observed at an angle of 44.3, 37.5, 11, 44.3, 39.8 degrees, resp.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jin, Wangrui team published research in Journal of Medicinal Chemistry in 2022 | 585-76-2

Computed Properties of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Jin, Wangrui;Zhang, Tao;Zhou, Wenbo;He, Peng;Sun, Yue;Hu, Shijia;Chen, Huang;Ma, Xinglong;Peng, Yangrui;Yi, Zhengfang;Liu, Mingyao;Chen, Yihua research published 《 Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis》, the research content is summarized as follows. A novel class of 2-amino-3-cyanothiophene derivatives I [R⁵ = Ph, 2-pyridyl, pyrimidin-4-yl, etc] and II [R⁶ = methoxy, methylpyrazolyl, anilino, etc] were designed and synthesized to inhibit osteosarcoma by targeting STAT3. Representative compound II [R⁶ = 4-methoxy anilino] showed potent antiproliferative effects against osteosarcoma cells, directly bound to the STAT3 SH2 domain with a KD of 0.46μM, and inhibited the phosphorylation of STAT3 Y705 in a dose-dependent manner. Furthermore, compound II [R⁶ = 4-methoxy anilino] promoted osteosarcoma cell apoptosis in vitro and significantly suppressed the growth and metastasis of osteosarcoma in vivo. These findings demonstrate that targeting STAT3 may be a feasible therapeutic strategy for the treatment of metastatic osteosarcoma.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kalita, Tapasi team published research in Asian Journal of Organic Chemistry in 2021 | 585-76-2

HPLC of Formula: 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Kalita, Tapasi;Dev, Dharm;Mondal, Sandip;Giri, Rajat Subhra;Mandal, Bhubaneswar research published 《 Ethyl 2-Cyano-2-(2-Nitrophenylsulfonyloximino)Acetate (ortho-NosylOXY) Mediated One-Pot Racemization Free Synthesis of Ureas, Carbamates, and Thiocarbamates via Curtius Rearrangement》, the research content is summarized as follows. A detailed NMR-based mechanism study is incorporated here. Direct conversion of to ureas RNHC(O)NHR¹ (R = Ph, 4-methylphenyl, 4-methoxybenzyl, (tert-butoxycarbonylamino)(phenyl)methyl, etc.; R¹ = 4-chlorophenyl, tert-Bu, methoxycarbonylmethyl, etc.), carbamates RNHC(O)OR¹ (R = 4-methoxyphenyl, 4-bromophenyl; R¹ = 4-nitrobenzyl, 4-methoxybenzyl), and thiocarbamate RNHC(O)SR¹ (R = Ph, undecan-1-yl, 2-methoxyphenyl; R¹ = 4-chlorobenzyl) in a single pot via Curtius rearrangement is accomplished. One recently established coupling reagent, ethyl-2-cyano-2-(2-nitrophenylsulfonyloximino)acetate (ortho-NosylOXY), is successfully used for the racemization free synthesis of ureas, di-peptidyl ureas, and carbamates with moderate to good yield (82-69%). This single-pot hassle-free procedure works with a diverse range of N-protecting groups Fmoc, Boc, and Cbz. Various amines R¹NH₂, including aromatic, Me esters of amino acids, tert-butylamine, benzyl alcs. (such as 4-nitrobenzyl alc., 4-methoxybenzyl alc.), and (4-chlorophenyl)-methanethiol, are used as nucleophiles. Racemization suppression, easy removal of byproducts, and less waste generation make this methodol. useful.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary