Category: 626-40-4

Recommanded Product: 3,5-DibromoanilineIn 2020 ,《Structurally Informative Isotopic Shifts in Ion Mobility Spectra for Heavier Species》 was published in Journal of the American Society for Mass Spectrometry. The article was written by Pathak, Pratima; Baird, Matthew A.; Shvartsburg, Alexandre A.. The article contains the following contents:

The isotopic mol. envelopes due to stable isotopes for most elements were a staple of mass spectrometry since its origins, often leveraged to identify and quantify compounds However, all isomers share one MS envelope. As the mol. motion in media also depends on the isotopic composition, separations such as liquid chromatog. (LC) and ion mobility spectrometry (IMS) must also feature isotopic envelopes. These were largely not observed because of limited resolution, except for the (structurally uninformative) shifts in LC upon H/D exchange. We recently found the isotopic shifts in FAIMS for small haloanilines (∼130-170 Da) to hinge on the halogen position, opening a novel route to isomer characterization. Here, we extend the capability to heavier species: dibromoanilines (DBAs, ∼250 Da) and tribromoanilines (TBAs, ∼330 Da). The 13C shifts for DBAs and TBAs vary across isomers, some changing sign. While 81Br shifts are less specific, the 2-D 13C/81Br shifts unequivocally differentiate all isomers. The trends for DBAs track those for dichloroanilines, with the 13C shift order preserved for most isomers. The peak broadening due to merged isotopomers is also isomer-specific. The absolute shifts for TBAs are smaller than those for lighter haloanilines, but differentiate isomers as well because of compressed uncertainties. These results showcase the feasibility of broadly distinguishing isomers in the more topical ∼200-300 Da range using the isotopic shifts in IMS spectra. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Greulich, Tobias W.; Suzuki, Naoya; Daniliuc, Constantin G.; Fukazawa, Aiko; Yamaguchi, Eriko; Studer, Armido; Yamaguchi, Shigehiro published 《A biphenyl containing two electron-donating and two electron-accepting moieties: a rigid and small donor-acceptor-donor ladder system》.Chemical Communications (Cambridge, United Kingdom) published the findings.Application In Synthesis of 3,5-Dibromoaniline The information in the text is summarized as follows:

Ladder π-conjugated materials and also push-pull systems belong to important classes of compounds for the development of organic electronic devices. In this communication, a novel π-conjugated material that unifies the properties of both of these classes is presented. The material comprises a rigid biphenyl framework, which bears two bridging electron-accepting phosphine oxide moieties as well as two electron-donating amino groups. The structure and photophys. properties of this compound are discussed and compared with those of a related system lacking the second P-moiety. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Application In Synthesis of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application In Synthesis of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Forlani, Giuseppe; Sabbioni, Giuseppe; Ragno, Daniele; Petrollino, Davide; Borgatti, Monica published an article in 2021. The article was titled 《Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumor cells》, and you may find the article in Journal of Enzyme Inhibition and Medicinal Chemistry.Quality Control of 3,5-Dibromoaniline The information in the text is summarized as follows:

In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalyzing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a higher proline content that exacerbates the effects of the so-called proline-P5C cycle, with tumor cells effectively using this method to increase cell survival. If a method of reducing or inhibiting P5C reductase could be discovered, it would provide new means of treating cancer. To address this point, the effect of some phenyl-substituted derivatives of aminomethylene-bisphosphonic acid, previously found to interfere with the catalytic activity of plant and bacterial P5C reductases, was evaluated in vitro on the human isoform 1 (PYCR1), expressed in E. coli and affinity purified. The 3.5-dibromophenyl- and 3.5-dichlorophenyl-derivatives showed a remarkable effectiveness, with IC50 values lower than 1μM and a mechanism of competitive type against both P5C and NADPH. The actual occurrence in vivo of enzyme inhibition was assessed on myelogenous erythroleukemic K562 and epithelial breast cancer MDA-MB-231 cell lines, whose growth was progressively impaired by concentrations of the dibromo derivative ranging from 10-6 to 10-4 M. Interestingly, growth inhibition was not relieved by the exogenous supply of proline, suggesting that the effect relies on the interference with the proline-P5C cycle, and not on proline starvation. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Quality Control of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Sharma, Vivekanand; De, Dinesh; Saha, Ranajit; Das, Ranjita; Chattaraj, Pratim Kumar; Bharadwaj, Parimal K. published 《A Cu(II)-MOF capable of fixing CO2 from air and showing high capacity H2 and CO2 adsorption》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 3,5-Dibromoaniline The information in the text is summarized as follows:

A porous Cu(II)-MOF shows an adsorption of 6.6 wt% of H2 at 77 K and 62 bar and a very high 60 wt% of CO2 at 298 K and 32 bar. When air is bubbled into a suspension of the activated MOF in the presence of different epoxides at room temperature, the CO2 in air is readily converted into the corresponding cyclic carbonates. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kosikowska, Paulina; Bochno, Marta; Macegoniuk, Katarzyna; Forlani, Giuseppe; Kafarski, Pawel; Berlicki, Lukasz published 《Bisphosphonic acids as effective inhibitors of Mycobacterium tuberculosis glutamine synthetase》.Journal of Enzyme Inhibition and Medicinal Chemistry published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Inhibition of glutamine synthetase (GS) is one of the most promising strategies for the discovery of novel drugs against tuberculosis. Forty-three bisphosphonic and bis-H-phosphinic acids of various scaffolds, bearing aromatic substituents, were screened against recombinant GS from Mycobacterium tuberculosis. Most of the studied compounds exhibited activities in micromolar range, with N-(3,5-dichlorophenyl)-2-aminoethylidenebisphoshonic acid, N-(3,5-difluorophenyl)-2-aminoethylidene-bisphoshonic acid, and N-(3,4-dichlorophenyl)-1-hydroxy-1,1-ethanebisphosphonic acid showing the highest potency with kinetic parameters similar to the reference compound, L-methionine-S-sulfoximine. Moreover, these inhibitors were found to be much more effective against the pathogenic enzyme than against the human ortholog. Thus, with the bone-targeting properties of the bisphosphonate compounds in mind, this activity/selectivity profile makes these compounds attractive agents for the treatment of bone tuberculosis. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Konovalova, Irina S.; Shishkina, Svitlana V.; Kobzev, Dmytro; Semenova, Olha; Tatarets, Anatoliy published their research in Acta Crystallographica, Section E: Crystallographic Communications in 2021. The article was titled 《Crystal structures and Hirshfeld analysis of 4,6-dibromoindolenine and its quaternized salt》.SDS of cas: 626-40-4 The article contains the following contents:

4,6-Dibromo-2,3,3-trimethyl-3H-indole, C11H11Br2N, exists as a neutral mol. in the asym. unit. The asym. unit of 4,6-dibromo-2,3,3-trimethyl-3H-indol-1-ium iodide, C12H14Br2N+·I-, contains one organic cation and one iodine anion. The pos. charge is localized on the quaternized nitrogen atom. In the crystal, mols. of 4,6-dibromoindolenine are linked by C-Br···π halogen bonds, forming zigzag chains propagating in the [001] direction. The mols. of the salt form layers parallel to the (010) plane where they are linked by C-H···Br hydrogen bonds, C-Br···Br and C-Br···I halogen bonds. The Hirshfeld surface anal. and two dimensional fingerprint plots were used to analyze the intermol. contacts present in both crystals. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4SDS of cas: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.SDS of cas: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Dinker, Manish Kumar; Zhao, Kan; Liu, Song; Qi, Shi-Chao; Li, Yu-Xia; Liu, Gong-Ping; Ding, Lifeng; Liu, Xiao-Qin; Sun, Lin-Bing published an article in Journal of Materials Chemistry A: Materials for Energy and Sustainability. The title of the article was 《Permanent cavities in ionic liquids created by metal-organic polyhedra》.Recommanded Product: 626-40-4 The author mentioned the following in the article:

As an emerging type of material, porous liquids combine the fluidity of liquids with the permanent porosity of porous solids, which makes them promising for various applications. Despite several significant attempts earlier, the porous liquid system still requires the novel entries of porous hosts and bulky liquids Here, we report a new porous liquid system based on the coalition of metal-organic polyhedra and well-designed bulky ionic liquids As a proof of concept, the typical metal-organic polyhedra, Pd12L24 where L represents the ligands, are employed as porous hosts. Also, a polyethylene glycol-linked bis-imidazolium-based bulky ionic liquid with a mol. size larger than the pore aperture of Pd12L24 is designed as a solvent, yielding type II porous ionic liquids These liquid materials possessing permanent cavities, good thermal stability and long-term durability have captured high CO2 compared to neat ionic liquids Besides, they are found separating CO2 from N2 and CH4 mols. not only as an entity but also as supported porous liquid membranes. We expect that the present strategy can be used to construct other porous liquids with specific functionality for addnl. applications.3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary