Category: 698-00-0

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 698-00-0, Name is 2-Bromo-N,N-dimethylaniline, SMILES is CN(C)C1=CC=CC=C1Br, belongs to bromides-buliding-blocks compound. In a document, author is Wang Shuai, introduce the new discover, Application In Synthesis of 2-Bromo-N,N-dimethylaniline.

Palladium-Catalyzed Reductive Coupling of Aromatic Bromides and Trimethylsilyldiazomethane: Its Application to Methylation of Aromatic Compounds

The introduction of methyl group into aromatic compounds is a valuable transformation. A large number of known methods use organohalides as the starting materials. However, those methods require pre-synthesized methyl metal reagents or toxic methyl electrophiles. Herein, a palladium-catalyzed reductive coupling reaction between aryl bromides and trimethylsilyl- diazomethane is developed, and the following desilicification process can afford the methylated products. This transformation has broad functional group tolerance and allows methylation of (hetero)aryl halides in moderate to good yields. Thus, it has the potential to be an attractive approach for methylation of organic. In addition, this reductive coupling can also serve as an efficient way for the introduction of silylmethyl group.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 698-00-0 is helpful to your research. Application In Synthesis of 2-Bromo-N,N-dimethylaniline.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.698-00-0, Name is 2-Bromo-N,N-dimethylaniline, SMILES is CN(C)C1=CC=CC=C1Br, belongs to bromides-buliding-blocks compound. In a document, author is Yang, Feiyan, introduce the new discover, Safety of 2-Bromo-N,N-dimethylaniline.

Nickel-Catalyzed Directed Cross-Electrophile Coupling of Phenolic Esters with Alkyl Bromides

Herein, we demonstrate the successful use of robust phenolic esters as an electrophilic acyl source in the reaction with diverse primary and secondary unactivated alkyl bromides. The cleavage of the relatively inert C-O bond is facilitated by the neighboring coordinating hydroxyl or sulfonamide moiety. By circumventing the use of pregenerated organometallics, this method allows efficient preparation of a variety of o-hydroxyl and tosyl-protected o-amino aryl ketones with high compatibility with a wide range of functionalities.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 698-00-0 is helpful to your research. Safety of 2-Bromo-N,N-dimethylaniline.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 698-00-0 as follows. name: 2-Bromo-N,N-dimethylaniline

General procedure: In a fume hood, an oven-dried Schlenk flask equipped with magnetic stirring bar was filled with N2 and evacuated (three cycles). Under N2 atmosphere, Pd(OAc)2 (1.1 mg, 0.005 mmol, 1 mol% Pd), SPhos (4.1mg, 0.01 mmol, 2 mol%), K3PO4 (160 mg, 1.5 mmol, 1.5 equiv), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-bis(trifluoromethyl)pyridine (1, 171 mg, 0.5 mmol, 1 equiv), aryl bromide (0.75 mmol,1.5 equiv), and DME (2 mL) were added in order. The Schlenk flask was closed and the mixture was heated at 80 C in an oil bath for 24-48 h. The progress of reaction was monitored by GC-MS and TLC. Upon completion of reaction, the Schlenk flask was cooled to r.t. and exposed to air. The mixture was extracted into EtOAc, washed with water and brine, and dried (anhyd Na2SO4). The crude product was purified by column chromatography (silica gel). For chloro-substituted bromoarenes (2g, 2h, and 2m), Pd(PPh3)4 (23mg, 0.02 mmol, 4 mol% Pd) was used (for 1-mmol scale reaction) in place of Pd(OAc)2 and SPhos. Unless otherwise noted, reactions were performed on a 0.5-mmol 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-bis(trifluoromethyl)pyridine (1) scale.

According to the analysis of related databases, 698-00-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Batool, Farhat; Emwas, Abdul-Hamid; Gao, Xin; Munawar, Munawar A.; Chotana, Ghayoor A.; Synthesis; vol. 49; 6; (2017); p. 1327 – 1334;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 698-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 698-00-0, name is 2-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1512-{4-[4-(2-methoxyphenyl)piperazin- I -yI]-1 H-pyrazolo[3,4-d]pyrimidin- I -yI}-N,Ndimethylaniline 80 mg (0.26 mmo[) 4-[4-(2-methoxypheny[)piperazin-1 -y[]-1 H-pyrazo[o[3,4-d]pyrimidine, 77.4 mg (0.39 mmo[) 2-bromo-N,N-dimethy[ani[ine, 14.7 mg (0.08mmo[) copper(I) iodide, 115 mg (0.54 mmo[) tripotassium phosphate and 22mg (0.16mmo[) trans-N,N?-dimethy[cyc[ohexane-1,2-diamine in 3 mL anhydrous NMP wereheated under microwave irradiation at 180CC for 8 h. The reaction mixture waspoured into water and extracted three times with ethy[ acetate. The combinedorganic phases were washed with 0.5 M aqueous EDTA so[ution and three times with water, dried over magnesium su[fate and concentrated. The residue was purified by HPLC affording 3 mg (3%) product.LC-MS (ana[ytica[ method 3): R = 1 .09 mm, MS (ESipos): mlz = 430 (M+H).1H-NMR (300MHz, CHLOROFORM-d): 6 [ppm]= 2.52 (5, 6H), 3.25 – 3.33 (m, 4H), 3.96 (5, 3H), 4.22 – 4.30 (m, 4H), 6.92 – 7.16 (m, 6H), 7.31 (d, 1H), 7.36 – 7.45 (m, 1H), 8.25 (5, 1H), 8.45 (5, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HEROULT, Melanie; NEUHAUS, Roland; WO2013/182612; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 698-00-0, name is 2-Bromo-N,N-dimethylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 698-00-0, Recommanded Product: 698-00-0

General procedure: Bromo-N,N-dimethylaniline (400 mg, 2.0 mmol), (trimethylsilyl)acetylene (236 mg, 2.4 mmol), Pd(PPh3)4 (116 mg, 0.1 mmol), CuI (19mg, 0.1 mmol), diisopropylamine (5 mL) and toluene (15 mL) wereadded to a flask and the mixture was stirred at 80 C overnight. Thenthe reaction mixture was poured into saturated NH4Cl (50 mL) andextracted with CH2Cl2 (3 x 20 mL), the organic layer was washed withsaturated brine (1 x 50 mL) and dried over MgSO4. After filtration,solvents were removed by rotary evaporation (40-45 C ). The crudeproduct was subjected to column chromatography (SiO2; eluent,hexane/ CH2Cl2, 3:1) to give the corresponding compounds. N,N-Dimethyl-2-[(trimethylsilyl)ethynyl]aniline (3c): Pale yellow oil; yield 81%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Fang, Jing-Kun; Sun, Tengxiao; Fang, Yu; Xu, Zhimin; Zou, Hui; Liu, Yuan; Ge, Fangting; Journal of Chemical Research; vol. 39; 8; (2015); p. 487 – 491;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 698-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 698-00-0, name is 2-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of N,N-dimethylanilines (1, 1.0 mmol) and 2,3-dihydrofuran (2, 10 mmol) in MeCN(20 ml), Co(ClO4)2 (10 mol%) was added. The reactions were performed at 50 C under oxygen atmosphere(O2 balloon) and completed in 48 hours. The products 3 were isolated by flash column chromatographic separation (acetone/petroleum ether = 1:40 to 1:30).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Huo, Congde; Chen, Fengjuan; Quan, Zhengjun; Dong, Jie; Wang, Yajun; Tetrahedron Letters; vol. 57; 46; (2016); p. 5127 – 5131;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 698-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 698-00-0, name is 2-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A dry Schlenk tube under argon atmosphere was charged with the 2-bromo-N,Ndimethylaniline (1.99 g, 10 mmol) in degassed THF (15 mL). The solution was cooled at -78 C and n-BuLi (2,4 M in THF, 1.1 eq.) was added. The mixture was stirred for 30 min at -78 C and then, at 0 C for 15 minutes. Then PPh2Cl (1.93 mL, 10.5 mmol) neat was added at -78 C under an argon atmosphere. The white solution was filtered on a pad of celite, the solid was washed with pentane (20 mL), ether (20 mL) and CH2Cl2 (20 mL). 2-(diphenylphosphino)-N,N-dimethylaniline was obtained after purification by flash chromatography on silica gel (eluent : AcOEt / cyclohexane 10 / 90) as a white solid (1,67 g, 56%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Pagnoux-Ozherelyeva, Anastassiya; Bolien, David; Gaillard, Sylvain; Peudru, Flavie; Lohier, Jean-Francois; Whitby, Richard J.; Renaud, Jean-Luc; Journal of Organometallic Chemistry; vol. 774; (2014); p. 35 – 42;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 698-00-0, The chemical industry reduces the impact on the environment during synthesis 698-00-0, name is 2-Bromo-N,N-dimethylaniline, I believe this compound will play a more active role in future production and life.

Example No. 6: Preparation of Compound No. 6[0294] A solution of 2,8-dimethyl-2,3,4,5-tetrahydro- lH-pyrido[4,3-b]indole (0.2 g, 1 mmol), (2-bromo-phenyl)-dimethyl-amine (600 mg, 3 mmol), K3PO4 (636 mg, 3 mmol), L-Proline (69 mg, 0.6 mmol) and Cul (57 mg, 0.3 mmol) in dry DMF (4 mL) was stirred at 150 C for 16h. The reaction mixture was cooled to RT, diluted with water and extracted with EtOAc. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude material, which was purified by column chromatography using neutral alumina and 10% EtOAc-Hexane followed by reverse phase HPLC purification to yield [2-(2,8- dimethyl-l,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-phenyl]-dimethyl-amine (20 mg). 1H NMR (TFA salt, CD3OD) delta (ppm): 7.50 (m, 1H), 7.38 (m, 2H), 7.18 (m, 2H), 7.0 (m, 2H), 4.75 (d, 1H), 4.40 (m, 1H), 3.80 (m, 1H), 3.58 (m, 1H), 3.15 (s, 3H), 3.0 (m, 1H), 2.70 (m, 1H), 2.56 (s, 6H), 2.42 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; PROTTER, Andrew, Asher; CHAKRAVARTY, Sarvajit; WO2012/112962; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary