Category: 76006-33-2

In 2017,Saint-Louis, Carl Jacky; Shavnore, Renee N.; McClinton, Caleb D. C.; Wilson, Julie A.; Magill, Lacey L.; Brown, Breanna M.; Lamb, Robert W.; Webster, Charles Edwin; Schrock, Alan K.; Huggins, Michael T. published 《Synthesis, computational, and spectroscopic analysis of tunable highly fluorescent BN-1,2-azaborine derivatives containing the N-BOH moiety》.Organic & Biomolecular Chemistry published the findings.Application In Synthesis of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Nine new polycyclic aromatic BN-1,2-azaborine analogs containing the N-BOH moiety were synthesized using a convenient two-step, one-pot procedure. Characterization of the prepared compounds show the luminescence wavelength and the quantum yields of the azaborines were tunable by controlling the power and location of the donor and acceptor substituents on the chromophore. UV-visible spectroscopy and d. functional theory (DFT) computations revealed that the addition of electron-donating moieties to the isoindolinone hemisphere raised the energy of the HOMO, resulting in the reduction of the HOMO-LUMO gap. The addition of an electron-accepting moiety to the isoindolinone hemisphere and an electron-donating group to the boronic acid hemisphere decreased the HOMO-LUMO gap considerably, leading to emission properties from partial intramol. charge transfer (ICT) states. The combined effect of an acceptor on the isoindolinone side and a donor on the boronic acid side (strong acceptor-π-donor) gave the most red-shifted absorption. The polycyclic aromatic BN-1,2-azaborines emitted strong fluorescence in solution and in the solid-state with the largest red-shifted emission at 640 nm and a Stokes shift of Δλ = 218 nm, or Δν = 8070 cm-1. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application In Synthesis of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Application In Synthesis of 3-Bromo-2-methylbenzoic acid The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Kusumi, Kensuke; Shinozaki, Koji; Kanaji, Toshiya; Kurata, Haruto; Naganawa, Atsushi; Otsuki, Kazuhiro; Matsushita, Takeshi; Sekiguchi, Tetsuya; Kakuuchi, Akito; Seko, Takuya published 《Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:

The structure-activity relationships of a novel series of sphingosine-1-phosphate receptor antagonists have been examined in detail. The initial hit compound 1 was modified through synthesis to improve its S1P2 activity. The synthesis of a series of analogs revealed that 1,3-bis(aryloxy)benzene derivatives, as represented by 22, are potent and selective S1P2 antagonists.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2012,Tamura, Yuusuke; Omori, Naoki; Kouyama, Naoki; Nishiura, Yuji; Hayashi, Kyouhei; Watanabe, Kana; Tanaka, Yukari; Chiba, Takeshi; Yukioka, Hideo; Sato, Hiroki; Okuno, Takayuki published 《Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles》.Bioorganic & Medicinal Chemistry Letters published the findings.Name: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Optimization of the HTS hit I, mainly focused on modification at the C-2 position of the benzimidazole core, is described. Elimination of the flexible and metabolically labile -S-CH2- part and utilization of less lipophilic pyridone substructure led to identification of novel NPY Y5 receptor antagonists II (R = n-Pr, t-Bu, CF3, F3CCH2), which have low to sub-nanomolar Y5 receptor binding affinity with improved CYP450 inhibition profiles, good solubilities and high metabolic stabilities. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Name: 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Name: 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2b Receptor Antagonist》 was written by Sharif, Ehesan U.; Miles, Dillon H.; Rosen, Brandon R.; Jeffrey, Jenna L.; Debien, Laurent P. P.; Powers, Jay P.; Leleti, Manmohan R.. Reference of 3-Bromo-2-methylbenzoic acid And the article was included in Organic Process Research & Development in 2020. The article conveys some information:

First- and second-generation routes to the dual A2a/A2b receptor antagonist AB928 I are disclosed. The second-generation route (performed on multigram scale) prepared the aminochloropyridinylbenzonitrile II by a route avoiding palladium-catalyzed borylation and Suzuki coupling reactions required in the initial route which generated significant amounts of byproducts. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Reference of 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Khedkar, Nilesh Raghunath; Irlapatti, Nageswara Rao; Dadke, Disha; Kanoje, Vijay; Shaikh, Zubair; Karche, Vijay; Shinde, Vikas; Deshmukh, Gokul; Patil, Amit; Jachak, Santosh; Phukan, Samiron; Kizhakinagath, Praveenkumar Anidil; Gholve, Milind; Bhankhede, Trupti; Daler, Jagadeesh; Nemade, Harshal Narendra; Budhe, Sagar; Pareek, Himani; Yeshodharan, Rajesh; Gupta, Rajesh; Kalia, Anil; Pandey, Dilip; Wagh, Akshaya; Kumar, Swaroop; Patil, Vinod; Modi, Dipak; Sharma, Nidhi; Ahirrao, Prajakta; Mehta, Maneesh; Kumar, Hemant; Nigade, Prashant; Tamane, Kaustubh; Mallurwar, Sadanand; Kuldharan, Sandip; Pawar, Shashikant; Vishwase, Gururaj; Bokan, Sanjay; Singh, Minakshi; Naik, Kumar; Ingawale, Sachin; Shankar, Rajesh; Kamalakannan, Prabakaran; Venugopal, Spinvin; George, Shaji K.; Padiya, Kamlesh J.; Nemmani, Kumar V. S.; Gundu, Jaysagar; Bhonde, Mandar; Narasimham, Lakshmi; Sindkhedkar, Milind; Shah, Chirag; Sinha, Neelima; Sharma, Sharad; Bakhle, Dhananjay; Kamboj, Rajender Kumar; Palle, Venkata P. published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-N-(2′-methyl-3′-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1′-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization》.Safety of 3-Bromo-2-methylbenzoic acid The article contains the following contents:

The role of calcium release-activated calcium (CRAC) channels is well characterized and is of particular importance in T-cell function. CRAC channels are involved in the pathogenesis of several autoimmune diseases, making it an attractive therapeutic target for treating inflammatory diseases, like rheumatoid arthritis (RA). A systematic structure-activity relationship study with the goal of optimizing lipophilicity successfully yielded two lead compounds, 36 and 37. Both compounds showed decent potency and selectivity and a remarkable pharmacokinetic profile. Further characterization in in vivo RA models and subsequent histopathol. evaluation of tissues led to the identification of 36 as a clin. candidate. Compound 36 displayed an excellent safety profile and had a sufficient safety margin to qualify it for use in human testing. Oral administration of 36 in Phase 1 clin. study in healthy volunteers established favorable safety, tolerability, and good target engagement as measured by levels of IL-2 and TNF-α. In the part of experimental materials, we found many familiar compounds, such as 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Safety of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Safety of 3-Bromo-2-methylbenzoic acid The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Regioselective C-H Hydroarylation of Internal Alkynes with Arenecarboxylates: Carboxylates as Deciduous Directing Groups》 was written by Huang, Liangbin; Biafora, Agostino; Zhang, Guodong; Bragoni, Valentina; Goossen, Lukas J.. Application of 76006-33-2This research focused onvinylbenzoic acid ester regioselective synthesis; benzoic acid alkyne hydroarylation Ru catalyst guanidine carbonate; C−H activation; alkynes; decarboxylation; ruthenium; synthetic methods. The article conveys some information:

In the presence of catalytic [Ru(p-cym)I2]2 and the base guanidine carbonate, benzoic acids react with internal alkynes to give the corresponding 2-vinylbenzoic acids. This alkyne hydroarylation is generally applicable to diversely substituted electron-rich and electron-poor benzoic and acrylic acids. Aryl(alkyl)acetylenes react regioselectively with formation of the alkyl-branched hydroarylation products, and propargylic alcs. are converted into γ-alkylidene-δ-lactones. The hydroarylation can also be conducted decarboxylatively with a different choice of catalyst and reaction conditions. This reaction variant, which does not proceed via intermediate formation of 2-vinylbenzoic acids, e. g., I, opens up a regioselective, waste-minimized synthetic entry to vinylarenes.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application of 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Application of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2009,Kasuga, Jun-ichi; Ishida, Seiichi; Yamasaki, Daisuke; Makishima, Makoto; Doi, Takefumi; Hashimoto, Yuichi; Miyachi, Hiroyuki published 《Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ selective antagonists》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

Novel PPARδ antagonists were designed and synthesized based on the crystal structure of the PPARδ full agonist TIPP-204 bound to the PPARδ ligand-binding domain, in combination with the nuclear receptor helix 12 folding modification hypothesis. Representative compound I exhibits PPARδ-preferential antagonistic activity. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 3-Bromo-2-methylbenzoic acid Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2010,Chandrakantha, B.; Shetty, Prakash; Nambiyar, Vijesh; Isloor, Nishitha; Isloor, Arun M. published 《Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-fluoro-4-methoxy phenyl moiety》.European Journal of Medicinal Chemistry published the findings.Name: 3-Bromo-2-methylbenzoic acid The information in the text is summarized as follows:

A series of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety was synthesized and characterized. The title compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds Compound I (Ar = 3-Br-2-Me-Ph, 2,3,4-F3-Ph) showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. Compound I (Ar = 2-Br-5-Cl-Ph) showed significant antifungal activity against C. albicans. In the experimental materials used by the author, we found 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Name: 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3-Bromo-2-methylbenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2013,Bhadra, Sukalyan; Dzik, Wojciech I.; Goossen, Lukas J. published 《Synthesis of Aryl Ethers from Benzoates through Carboxylate-Directed C-H-Activating Alkoxylation with Concomitant Protodecarboxylation》.Angewandte Chemie, International Edition published the findings.Recommanded Product: 76006-33-2 The information in the text is summarized as follows:

A mixture of Ag2CO3 and Cu(OAc)2 catalyzed the ortho-alkoxylation and concomitant protodecarboxylation of potassium benzoates with trialkyl borates. Neither double alkoxylation nor nondecarboxylative alkoxylation was observed, confirming the high efficiency of the decarboxylation step following alkoxylation. The synthesis of the borate ester reagent can be combined with the decarboxylative alkoxylation in a one-pot procedure. The alc. is first treated with an equivalent amount of pinacol borane, and when gas evolution ceases, the carboxylate salt and catalyst are added and the decarboxylative coupling is performed. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Recommanded Product: 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Recommanded Product: 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Bhattarai, Deepak; Jung, Joo Hyun; Han, Seunghyeon; Lee, Hankyu; Oh, Soo Jin; Ko, Hyuk Wan; Lee, Kyeong published 《Design, synthesis, and biological evaluation of structurally modified isoindolinone and quinazolinone derivatives as hedgehog pathway inhibitors》.European Journal of Medicinal Chemistry published the findings.Application of 76006-33-2 The information in the text is summarized as follows:

The Hedgehog (Hh) signaling pathway is associated with diverse aspects of cellular events, such as cell migration, proliferation, and differentiation throughout embryonic development and tissue patterning. An abnormal Hh signaling pathway is linked to numerous human cancers, including basal cell carcinoma (BCC), medulloblastoma (MB), lung cancer, prostate cancer, and ovarian cancer, and it is therefore a promising target in cancer therapy. Using a structure-hopping approach, we designed new Hh signaling pathway inhibitors with isoindolinone or quinazolinone moieties, which were synthesized and biol. evaluated using an 8xGli-luciferase (Gli-Luc) reporter assay in NIH3T3 cells. Compounds with isoindolinone scaffolds demonstrated moderate Hh inhibitory activity; whereas quinazolinone derivatives exhibited good potency with submicromolar IC50 values and the analog I showed nanomolar IC50 value. Although sonidegib shows a decrease in inhibitory effect on vismodegib resistance-conferring Smo mutants, the structurally modified new compounds not only possess the pharmacophoric properties of Hh pathway inhibition but also preserve the suppressive potency in drug-resistant Smo mutants. Mechanistically, quinazolinone derivatives I and II suppress Hh signaling by blocking Smo and Gli translocation into the cilia, similar to vismodegib and sonidegib. Addnl., the human microsomal stability of the representative analogs I and II were determined to be comparable to that of the reference compound sonidegib. Thus, these new scaffolds can serve as a platform for the development of novel cancer therapeutics targeting the Hh pathway. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 76006-33-2 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary