76006-33-2 Archives - Page 7 of 9 - Bromides-buliding-blocks

Curtin, Michael L.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2004 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.HPLC of Formula: 76006-33-2 Organobromine compounds have fallen under increased scrutiny for their environmental impact.

In 2004,Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Sarris, Kathy A.; Steinman, Douglas H.; Holmes, James H.; Bousquet, Peter F.; Cunha, George A.; Moskey, Maria D.; Ahmed, Asma A.; Pease, Lori J.; Glaser, Keith B.; Stewart, Kent D.; Davidsen, Steven K.; Michaelides, Michael R. published 《Isoindolinone ureas: a novel class of KDR kinase inhibitors》.Bioorganic & Medicinal Chemistry Letters published the findings.HPLC of Formula: 76006-33-2 The information in the text is summarized as follows:

A series of substituted isoindolinone ureas was prepared and evaluated for enzymic and cellular inhibition of KDR kinase activity. Several of these analogs, such as I, are potent inhibitors of KDR both enzymically (<50 nM) and cellularly (≤100 nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2HPLC of Formula: 76006-33-2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, C. Kishor’s team published research in Journal of Pharmaceutical Science & Technology in 2010 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 76006-33-2 Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.

In 2010,Kumar, C. Kishor; Kumar, H. Vijay; Vijaya Kumar, Giriyapura R.; Naik, Nagaraja published 《3-Oxoisoindoline-5-carboxamides. Synthesis and their antioxidant activity studies》.Journal of Pharmaceutical Science & Technology published the findings.Application of 76006-33-2 The information in the text is summarized as follows:

3-Oxoisoindoline-5-carboxamides were synthesized from 3-oxoisoindoline-5-carboxylate. The synthesized compounds were evaluated for their antioxidant properties using 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical scavenging assay and inhibition of human low-d. lipoprotein (LDL) oxidation assay. The results showed that all 3-oxoisoindoline-5-carboxamides possessed antioxidant activity. Among the synthesized analogous, one compound showed dominant activity. In the experiment, the researchers used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Application of 76006-33-2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zherikova, Kseniya V.’s team published research in Journal of Thermal Analysis and Calorimetry in 2019 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Related Products of 76006-33-2 The most pervasive is the naturally produced bromomethane.

The author of 《Energetic structure-property relationships in thermochemistry of halogenosubstituted benzoic acids》 were Zherikova, Kseniya V.; Verevkin, Sergey P.. And the article was published in Journal of Thermal Analysis and Calorimetry in 2019. Related Products of 76006-33-2 The author mentioned the following in the article:

Exptl. thermodn. properties of halogenosubstituted benzoic acids have been evaluated with the help of complementary in silico methods. The study encompassed benzoic acids with fluoro, chloro-, bromo-, and iodo-substituents in the 2-, 3-, and 4-position in the benzene ring, as well as a series of methyl-substituted bromobenzoic acids and dibromobenzoic acids. The high-level quantum-chem. composite method G4 was addnl. used for mutual validation of the theor. and exptl. gaseous standard molar enthalpies of formation. A simple group contribution procedure has been developed for a quick appraisal of the gas-phase and liquid-phase enthalpies of formation as well as of vaporization enthalpies of halogenosubstituted benzoic acids and their poly-Me or poly-halogen-substituted derivatives The system of group-additivity parameters developed in this work can help in the evaluation of new exptl. results or for validation of already available data compiled in comprehensive databases. Moreover, the reliable additive estimates are essential for material sciences or for assessment of chems. fate in environment and in atm.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2) was used in this study.

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Related Products of 76006-33-2 The most pervasive is the naturally produced bromomethane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qiang’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C8H7BrO2 In contrast, terrestrial plants account only for a few bromine-containing compounds.

Hu, Xiao-Qiang; Liu, Zi-Kui; Hou, Ye-Xing; Zhang, Guodong; Gao, Yang published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Ru-catalyzed C(sp2)-H vinylation/annulation of benzoic acids and alkynes: rapid access to medium-sized lactones》.Formula: C8H7BrO2 The article contains the following contents:

An unprecedented ruthenium catalyzed [4+4] annulation of readily available benzoic acids and alkynes was reported. The carboxylate group acted as both a directing group and an internal nucleophilic reagent to facilitated a C(sp2)-H vinylation/annulation cascade. This reaction avoided the classically oxidative [4+2] annulation, allowed the efficient synthesis of a wide array of eight-membered lactones under oxidant-free conditions. Moreover, this catalytic system would be successfully extended to [4+3] and [4+5] annulations for the assembly of seven- and nine-membered lactones. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Formula: C8H7BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Varakala, Saiprasad Dasugari’s team published research in European Journal of Medicinal Chemistry in 2022 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 3-Bromo-2-methylbenzoic acid Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

In 2022,Varakala, Saiprasad Dasugari; Reshma, Rudraraju Srilakshmi; Schnell, Robert; Dharmarajan, Sriram published an article in European Journal of Medicinal Chemistry. The title of the article was 《Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens》.Reference of 3-Bromo-2-methylbenzoic acid The author mentioned the following in the article:

Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and Et 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit mols. which ended up with forty-three analogs (twenty-nine analogs from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound I (effective against EcFabG, AbFabG, StFabG, MtFabG1) and II (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Reference of 3-Bromo-2-methylbenzoic acid)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 3-Bromo-2-methylbenzoic acid Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Maity, Supriya’s team published research in Novel Science International Journal of Pharmaceutical Science in 2012 | CAS: 76006-33-2

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. SDS of cas: 76006-33-2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.

SDS of cas: 76006-33-2In 2012 ,《Synthesis, characterization and in vitro antimicrobial screening of quinoline nucleus containing some novel 1,3,4-oxadiazole derivatives》 appeared in Novel Science International Journal of Pharmaceutical Science. The author of the article were Maity, Supriya; Khan, Suroor A.; Ahmad, Shamim. The article conveys some information:

A novel series of 1,3,4-oxadiazole (3a-j) has been synthesized and characterized by means of TLC, m.p. and spectral data like IR, 1H-NMR & Mass spectroscopy. Synthesized compounds were screened for their antibacterial activity against four different strains like Staphylococcus aureus (NCIM 2079), Bacillus subtilis (NCIM 2708), Pseudomonas aeruginosa (NCIM 2242) and Escherichia coli (NCIM 2685) with standard drug ampicillin while antifungal activity was determined against strains like Candida albicans (NCIM 22491) with standard drug griseofulvin. On the basis of statistical anal., it was observed that compounds had significant co-relation. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2SDS of cas: 76006-33-2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Awesome Chemistry Experiments For C8H7BrO2

Application of 76006-33-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 76006-33-2.

Application of 76006-33-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 76006-33-2, Name is 3-Bromo-2-methylbenzoic acid, SMILES is O=C(O)C1=CC=CC(Br)=C1C, belongs to bromides-buliding-blocks compound. In a article, author is Dinamarca, Robinson, introduce new discover of the category.

Magnetic Fe3O4@SiO2-Pt and Fe3O4@SiO2-Pt@SiO2 Structures for HDN of Indole

The effect of a second porous SiO2 shell in the activity and selectivity of the Fe3O4@SiO2-Pt catalyst in the hydrodenitrogenation of indole is reported. The double Fe3O4@SiO2-Pt@SiO2 structure was prepared by coating Fe3O4 nanoparticles with tetraethyl orthosilicate (TEOS) with a further impregnation of 1.0 wt.% of Pt on the (3-aminopropyl)triethoxysilane functionalized Fe3O4@SiO2 structures. The second porous SiO2 shell, obtained by using a hexadecyltrimethylammonium bromide (CTAB) template, covered the Fe3O4@SiO2-Pt catalyst with a well-defined and narrow pore-sized distribution. The full characterization by TEM, inductively coupled plasma-optical emission spectroscopy (ICP-OES), XRD, and N-2 adsorption isotherm at 77 K and vibrating sample magnetometry (VSM) of the catalysts indicates homogeneous core@shell structures with a controlled nano-size of metallic Pt. A significant effect of the double SiO2 shell in the catalytic performance was demonstrated by both a higher activity to eliminate the nitrogen atom of the indole molecule present in model liquid fuel and the improvement of the catalytic stability reaching four consecutive reaction cycles with only a slight conversion level decrease.

Extended knowledge of 3-Bromo-2-methylbenzoic acid

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 76006-33-2. COA of Formula: C8H7BrO2.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, COA of Formula: C8H7BrO2, 76006-33-2, Name is 3-Bromo-2-methylbenzoic acid, molecular formula is C8H7BrO2, belongs to bromides-buliding-blocks compound. In a document, author is Shi, He, introduce the new discover.

Honokiol inhibits the growth of SKBR3 cells

Background: Breast cancer is one of the most malignant tumors in the reproductive system and has a poor prognosis. Finding drugs with high efficiency, low side-effects, and low cost has become a research hotspot. Methods: In the present study, we treated SK-BR-3 cells with different doses of honokiol. Crystal violet staining method was used to detect changes in the total number of living cells; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to detect the effect of honokiol on SK-BR-3 cell proliferation. Cell migration ability change was determined by wound healing assay. Cell invasion ability change was determined by Transwell migration assay. Flow cytometry was used to detect the apoptotic rate of SK-BR-3 cells, and Western blot was used to detect the expression levels of proliferation-associated protein (PCNA); migration- and invasion-related protein matrix metalloproteinase-2 (MMP-2); vimentin; apoptosis-related proteins Bcl-xl, caspase 3, and cleaved caspase 3 (CC3); and beta-catenin and its downstream target molecule c-Myc. Results: Compared with the control group, different doses of honokiol have different degrees of inhibitory effects on cells, including proliferation and invasion and migration (P<0.01). After treatment with 50 or 60 mu mol.L-1 honokiol, the apoptotic rate of SK-BR-3 cells increased (both P<0.01); PCNA expression was significantly downregulated (P<0.01). Intracellular accumulation of apoptosis-related proteins Bcl-xl and caspase-3 decreased but C-C3 increased. We also found downregulation of MMP-2 expression, a protein related to invasion and migration (P<0.01), and a decrease in the expression levels of the Wnt/beta-catenin signaling pathway-related proteins beta-catenin and c-Myc (P<0.01). Conclusions: Honokiol can promote the apoptosis of SK-BR-3 cells and can inhibit the proliferation, migration, and invasion of human breast cancer SK-BR-3 cells. The underlying mechanism may be through inhibiting the activation of the Wnt signaling pathway. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 76006-33-2. COA of Formula: C8H7BrO2.

Simple exploration of 3-Bromo-2-methylbenzoic acid

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 76006-33-2 is helpful to your research. Application In Synthesis of 3-Bromo-2-methylbenzoic acid.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of 3-Bromo-2-methylbenzoic acid, 76006-33-2, Name is 3-Bromo-2-methylbenzoic acid, SMILES is O=C(O)C1=CC=CC(Br)=C1C, belongs to bromides-buliding-blocks compound. In a document, author is Ren, Qing, introduce the new discover.

Quantitative description of surface adsorption of surfactant in aqueous solution without the Gibbs equation

A new equation related to the surface tension and concentration of solute in the surface region is derived and a three-step procedure is proposed to determine the molecular area of surfactants in aqueous solution at saturation of the air-liquid surface. Based on their surface tension data, the molecular areas of hexyl, octyl and decyl trimethylammonium bromide (HTABr, OTABr and DTABr) in aqueous solutions have been calculated and are in agreement with the computational results of density functional theory. Gibbs analysis has also been carried out for these surfactants. As the surface tension data are fitted with the Gibbs equation, it is found that there exist two line segments for both OTABr and DTABr, which lead to two molecular areas for each of them. This arbitrariness indicates that no unique molecular area could be obtained for OTABr and DTABr. As for HTABr, its molecular area obtained with Gibbs analysis is out of the range estimated with density functional theory. These results show the failure of the Gibbs equation.

The important role of C8H7BrO2

Synthetic Route of 76006-33-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 76006-33-2 is helpful to your research.

Synthetic Route of 76006-33-2, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 76006-33-2, Name is 3-Bromo-2-methylbenzoic acid, SMILES is O=C(O)C1=CC=CC(Br)=C1C, belongs to bromides-buliding-blocks compound. In a article, author is Li, Mengfei, introduce new discover of the category.

Micelles of Mesoporous Silica with Inserted Iron Complexes as a Platform for Constructing Efficient Electrocatalysts for Oxygen Reduction

Iron, N-codoped carbon materials (Fe-N-C) are promising electrocatalysts toward oxygen reduction reactions due to their high atom utilization efficiency and intrinsic activity. Nanostructuring of the Fe-N-C materials, such as introducing porosity into the carbon structure, would be conducive to further increasing the exposure of active sites as well as improving the mass transfer. Herein, we explore the potential of iron complexfunctionalized micelles of mesoporous SiO2 as a platform for constructing porous Fe-N-C materials. The classical three-dimensional MCM-48 was selected as a proof-of-concept example, which was utilized as the hard template, and cetyltrimethylammonium bromide micelles inside it played the role of the main carbon source. Fe-N-x sites were derived from Fe-1,10-phenanthroline complexes in the micelles introduced by in situ incorporation of 1,10-phenanthroline and post Fe2+ insertion in an aqueous solution. After thermal annealing in a nitrogen atmosphere and subsequent removal of the MCM-48 framework, a carbon material that possesses porous structural features with uniformly dispersed Fe-N-x sites (MPC@PhFe) was obtained, which shows superior ORR activity in a 0.1 M KOH solution and great potential for Zn-air battery applications as well. This work demonstrates the feasibility as well as the effectiveness of turning micelles of mesoporous SiO2 into porous carbon structures and might offer a universal strategy for manufacturing carbon materials for future application in energy storage and conversion.