Category: 82-73-5

Namm, Joshua D; Morris, Randal P; Speck, Fred L 3rd; Lindsey, Ronald W published the artcile< The Impact of Eccentric Diaphyseal Plate and Screw Placement on the Risk of Peri-Implant Fracture.>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is .

BACKGROUND: The objective of this study was to determine the impact of the type and orientation of peripheral screw placement in an eccentrically positioned locking plate on the structural integrity of the plate-diaphyseal bone interface. We hypothesized that central placement of the screw at the end of the plate in this setting is more important than screw type (locking versus nonlocking) to limiting the risk of subsequent fracture. METHODS: Twenty osteoporotic fourth-generation composite left humeri were divided into 4 groups and plated with stainless-steel 6-hole locking plates and 4.5-mm screws. Group 1 (control group) consisted of a centrally positioned plate with a centrally placed non-locking end screw at the sixth, most-proximal hole. Group 2 consisted of an eccentrically positioned plate with a non-locking proximal end screw placed through the center of the bone. Group 3 consisted of an eccentrically positioned plate with a locking proximal end screw placed perpendicular to the plate and eccentrically across the cortex. Group 4 consisted of an eccentrically positioned plate with a non-locking proximal end screw placed perpendicular to the plate and eccentrically across the cortex. Each group was tested with a single load to failure in torsion at a rate of 1°/second. RESULTS: The control group (Group 1) failed at significantly higher peak torque values (51.62 ± 7.35 Nm) than Group 2 (38.98 ± 6.78 Nm; p = 0.006), Group 3 (34.75 ± 1.81 Nm; p < 0.001), and Group 4 (31.55 ± 1.23 Nm; p < 0.001). Failure energy absorbed in Group 1 (2,591.49 ± 819.63 Nm/degree) was significantly higher than Group 3 (1,430.51 ± 449.99 Nm/degree; p = 0.04) and Group 4 (952.49 ± 123.52 Nm/degree; p = 0.004), but not significantly higher than Group 2 (1,847.73 ± 827.35 Nm/degree; p = 0.27). CONCLUSIONS: Eccentrically placed plating of humeral shaft fractures significantly increases the risk of peri-implant fracture compared with a centrally placed plate. Directing the proximal-end screw centrally in an eccentrically placed plate may help to mitigate this risk at the proximal end. CLINICAL RELEVANCE: When possible, care should be taken to place the plate centrally on the bone to avoid increased risk of peri-implant fracture at the proximal plate-bone interface. The Journal of bone and joint surgery. American volume published new progress about 82-73-5. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Sha; Jia, Zhehui; Xiong, Lixia; Yan, Tao; Yang, Na; Wu, Guiping; Song, Haibin; Li, Zhengming published the artcile< Chiral Dicarboxamide Scaffolds Containing a Sulfiliminyl Moiety as Potential Ryanodine Receptor Activators>, HPLC of Formula: 82-73-5, the main research area is chiral dicarboxamide scaffold sulfiliminyl moiety potential ryanodine receptor activator; optically active sulfiliminyl insecticidal activity.

To search for new environmentally benign insecticides with high activity, low toxicity, and low residue, novel chiral configurations introduced into dicarboxamide scaffolds containing N-cyano sulfiliminyl moieties were first studied. Four series of phthalamides with sulfur-containing side chains were designed, synthesized, and evaluated against oriental armyworm (Pseudaletia separata Walker) and diamondback moth (Plutella xylostella (L.)) for their insecticidal activities. All structures were characterized by 1H NMR, 13C NMR, and HRMS (or elemental anal.), and their configurations were confirmed by optical polarimetry. The biol. assessment indicated that some title compounds exhibited significant insecticidal activities. For oriental armyworm, these stereoisomers exerted different impacts on biol. activity following the sequence (Sc, Ss) ≥ (Sc, Rs) ≫ (Rc, Ss) > (Rc, Rs), and carbon chirality influenced the activities more strongly than sulfur. Compounds Ia and IIa reached as high an activity as com. flubendiamide, with LC50 values of 0.0504 and 0.0699 mg L-1, resp., lower than that of flubendiamide (0.1230 mg L-1). For diamondback moth, the sequence of activity was (Sc, Ss) > (Sc, Rs), and the sulfur chirality influenced the activities more greatly than carbon. Compound IIe exhibited even higher activity than flubendiamide, whereas Ie and Ic,d reached the activity of the latter. The results indicated that the improvement of insecticidal activity probably required a coordination of both carbon and sulfur chirality. Comparative mol. field anal. calculation indicated that stereoisomers with Rs configurations containing strong electron-withdrawing groups such as CN are important in maintaining the high activity. The chiral scaffolds containing the N-cyano sulfiliminyl moiety are also essential for high larvicidal activity. Some title compounds could be considered as potential candidates for ryanodine receptor activators.

Journal of Agricultural and Food Chemistry published new progress about Amides Role: BSU (Biological Study, Unclassified), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation) (phthalamides). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, HPLC of Formula: 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Haixia; Ding, Xinyu; Liu, Linyi; Mi, Qianglong; Zhao, Quanju; Shao, YuBao; Ren, Chaowei; Chen, Jinju; Kong, Ying; Qiu, Xing; Elvassore, Nicola; Yang, Xiaobao; Yin, Qianqian; Jiang, Biao published the artcile< Discovery of novel BCR-ABL PROTACs based on the cereblon E3 ligase design, synthesis, and biological evaluation>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is BCR ABL PROTAC cereblon E3 ligase drug design; BCR-ABL; CRBN; Degradation; Leukemia; PROTAC.

Protein degradation is a promising strategy for drug development. Proteolysis-targeting chimeras (PROTACs) hijacking the E3 ligase cereblon (CRBN) exhibit enormous potential and universal degradation performance due to the small mol. weight of CRBN ligands. In this study, the CRBN-recruiting PROTACs were explored on the degradation of oncogenic fusion protein BCR-ABL, which drives the pathogenesis of chronic myeloid leukemia (CML). A series of novel PROTACs were synthesized by conjugating BCR-ABL inhibitor dasatinib to the CRBN ligand including pomalidomide and lenalidomide, and the extensive structure-activity relationship (SAR) studies were performed focusing on optimization of linker parameters. Therein, we uncovered that pomalidomide-based degrader 17 (SIAIS056), possessing sulfur-substituted carbon chain linker, exhibits the most potent degradative activity in vitro and favorable pharmacokinetics in vivo. Besides, degrader 17 also degrades a variety of clin. relevant resistance-conferring mutations of BCR-ABL. Furthermore, degrader 17 induces significant tumor regression against K562 xenograft tumors. Our study indicates that 17 as an efficacious BCR-ABL degrader warrants intensive investigation for the future treatment of BCR-ABL+ leukemia.

European Journal of Medicinal Chemistry published new progress about Absorption. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nikitine, Serge published the artcile< Anisotropic absorption of different radiations by some dyes>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is .

The photodichroism, after insolation in white light polarized rectilinearly, of several dyes (cyanine, pinacyanol, etc.) is measured as a function of λ.

Compt. rend. published new progress about Dichroism. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Bing; Hu, Jiantao; Xu, Fuming; Chen, Zhuo; Bai, Longchuan; Fernandez-Salas, Ester; Lin, Mei; Liu, Liu; Yang, Chao-Yie; Zhao, Yujun; McEachern, Donna; Przybranowski, Sally; Wen, Bo; Sun, Duxin; Wang, Shaomeng published the artcile< Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression>, Related Products of 82-73-5, the main research area is preparation degrader bromodomain extra terminal protein cancer.

The bromodomain and extra-terminal (BET) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT members, are epigenetic “”readers”” and play a key role in the regulation of gene transcription. BET proteins are considered to be attractive therapeutic targets for cancer and other human diseases. Recently, heterobifunctional small-mol. BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation Herein, we present our design, synthesis, and evaluation of a new class of PROTAC BET degraders. One of the most promising compounds, 23, effectively degrades BRD4 protein at concentrations as low as 30 pM in the RS4;11 leukemia cell line, achieves an IC50 value of 51 pM in inhibition of RS4;11 cell growth and induces rapid tumor regression in vivo against RS4;11 xenograft tumors. These data establish that compound 23 (BETd-260/ZBC260) is a highly potent and efficacious BET degrader.

Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Related Products of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ariano, R. published the artcile< Determining the proportion of cement in finished concrete>, COA of Formula: C8H3BrO3, the main research area is .

The methods of Kriege (cf. C. A. 25, 4680) and Florentin (cf. C. A. 21, 3440) consist in solubilizing the SiO2 of the cement (which is present as Ca silicates) by treating with HCl and then determining it by the usual methods. In Scheibe’s method (cf. C. A. 29, 8273.5) the coarse aggregate is eliminated, the residue (sand and cement) is pulverized and the portions soluble and insoluble in HCl are determined after calcination; it is assumed arbitrarily that the sum of the loss on ignition and the insoluble matter in the cement = 3%. It is then easy to calculate the amount of cement. None of these methods gives reliable results, and the same is true of indirect methods based only on the finished concrete and on samples of the sand and gravel entering into its composition There always remains a certain degree of uncertainty if the complete composition of the cement and the loss on ignition are not known. It should be noted that in all cases where the concrete itself is analyzed, the results give the composition of the finished concrete, and not that of the original mix. For the water also, it is possible to establish only the quantity which is actually combined in the concrete.

Ricerche studi ist. sper. stradale published new progress about Cement. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, COA of Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Koishi, Hideo published the artcile< A critical examination of Folin's method for determination of creatinine concentration in the urine>, Formula: C8H3BrO3, the main research area is .

A critical examination of Folin’s method (CA 8,2735) showed that the intensity of the color is sensitive to temperature with an increase in values of 0.5 to 1.1% per degree within 10 to 30 °.

Osaka City Medical Journal published new progress about Esters. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Formula: C8H3BrO3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Allahdad, Ahmad; Knight, David W. published the artcile< An investigation of the Wittig reaction between a series of monosubstituted phthalic anhydrides and ethoxycarbonylmethylidenetriphenylphosphorane>, Safety of 4-Bromoisobenzofuran-1,3-dione, the main research area is Wittig phthalic anhydride ethoxycarbonylmethylidenetriphenylphosphorane regiochem; ylidenephthalide; phthalide ylidene.

The reaction was examined of EtO2CCH:PPh3 (I) with II (Z = Z1 = O, R = x-OMe, x-NMe2, x-Me, x-CO2Me, x-NO2, x-Cl, x-Br; x = 3,4) in refluxing dry CHCl3 for 18 h. The structures of the products II (Z ≠ Z1 = O, CHCO2Et, R as before) were determined by chem. and spectral methods. The regioselectivity of the reaction is governed by substituent electronic effects which render one of the anhydride CO groups more susceptible to nucleophilic attack. Generally, (E)-ylidenephthalides were formed predominantly. II (Z = Z1 = O, R = 3-Me) with I gave a 73:23:4 mixture of (E)-II (Z = CHCO2Et, Z1 = O, R = 3-Me) [(E)-III], (Z)-III, and (Z)-II (Z = O, Z1 = CHCO2Et, R = 3-Me); II (Z = Z1 = O, R = 3-Cl) gave a 43:52:5 mixture of (E)-II (Z = CHCO2Et, Z1 = O, R = 3-Cl) [(E)-IV], (Z)-IV, and (Z)-II (Z = O, Z1 = CHCO2Et, R = 3-Cl), resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Regiochemistry. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Safety of 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Tianyue; Liu, Fengbo; Hu, Xianchen; Zhao, Zhiyong; Liu, Simin published the artcile< Cucurbit[n]uril-based host-guest interaction enhancing organic room-temperature phosphorescence of phthalic anhydride derivatives in aqueous solution>, Electric Literature of 82-73-5, the main research area is cucurbituril ammonium chloride inclusion reaction phosphorescence.

Purely organic room temperature phosphorescence (RTP) materials in the solid state have been widely researched, while water-soluble mols. with single structure and RTP emission in water are still rare. Here, cyan RTP in aqueous solution of water-soluble halogen-substituted phthalic anhydride (PA) derivatives was enhanced by supramol. host-guest complexation with cucurbit[n]urils (CB[n]s). This successful attempt further suggests a feasible strategy for creating visible RTP materials in aqueous solution through CB[n]-based host-guest complexation.

New Journal of Chemistry published new progress about Cucurbiturils Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Electric Literature of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wales, David J. published the artcile< Symmetry, near-symmetry and energetics. [Erratum to document cited in CA128:313179]>, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione, the main research area is erratum symmetry energetic correlation; symmetry energetic correlation erratum; total energy symmetry correlation erratum; mean energy symmetry correlation erratum.

On page 332, there is a missing < and r appears in the wrong font in the sentence beginning : ""The {εt'} set..."". In Eq. (4) and on the top of page 333, the variance is missing the term 〈(A'ε')2〉n' - 〈A'ε'〉n2. Brackets are missing around Reference [24]. In the Fig. 1 caption, ""39809 and 81534"" should be ""39809 and 82735"". Chemical Physics Letters published new progress about Cluster structure. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Recommanded Product: 4-Bromoisobenzofuran-1,3-dione.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary