Category: 83152-22-1

On November 1, 2008, Ju-Nam, Yon; Allen, David W.; Gardiner, Philip H. E.; Bricklebank, Neil published an article.Electric Literature of 83152-22-1 The title of the article was ω-Thioacetylalkylphosphonium salts: Precursors for the preparation of phosphonium-functionalised gold nanoparticles. And the article contained the following:

Two new ω-thioacetylalkylphosphonium salts that function as masked cationic alkanethiolate ligands for the stabilization of gold nanoparticles were prepared Both (3-thioacetylpropyl)triphenylphosphonium bromide and (6-thioacetylhexyl)triphenylphosphonium bromide form water-soluble gold nanoparticles of ∼5-10 nm in size that are stable for up to six months. The related (3-thioacetylpropyl)diphenylphosphine oxide was also prepared but did not act as a stabilizing ligand in gold nanoparticle formation. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Electric Literature of 83152-22-1

The Article related to phosphonium functionalized gold nanoparticle, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Electric Literature of 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 15, 1989, Hill, William E.; Islam, Mohammed Q.; Webb, Thomas R.; McAuliffe, Charles A. published an article.Recommanded Product: (6-Bromohexyl)triphenylphosphonium bromide The title of the article was Solution studies of gold(I) complexes of n-hexyldimethylphosphine, n-butyldiphenylphosphine, 1-dimethylphosphino-6-diphenylphosphinohexane, 1,6-bis(dimethylphosphino)hexane and 1,6-bis(diphenylphosphino)hexane. And the article contained the following:

The 31P{1H} NMR spectra of the monodentate phosphines (L = PMe2(C6H13) (L1) and PPh2Bu (L2)) in the presence of Et4N[AuBr2] in CDCl3 solution were studied at various L:Au ratios and temperatures At 195 K and a P:Au ratio = 1, only [BrAuL] is present. Increasing the amount of phosphine leads to [BrAuL2], [AuL3]Br and [AuL4]Br. When AuBr2-, L1 and L2 are mixed in a 1:1:1 ratio [BrAuL1], [BrAuL12], [BrAuL2], [BrAuL22] and [BrAuL1L2] are present. Addition of more L1 causes the disappearance of [BrAuL1] with formation of [BrAuL12]; however this does not occur for L2 when [BrAuL2] is still present even at a Au:L1:L2 ratio of 1:1:2. Employing the unsym. Ph2P(CH2)6PMe2 (L3) gives [BrAuL3AuBr], 3-coordinate (BrAuL32AuBr] (2 forms) and 3-coordinate AuL3Br. Similar studies for the sym. Ph2P(CH2)6PPh2 (dph) and Me2P(CH2)6PMe2 are reported. The rate constants for the exchange BrAuL1 ⇌ BrAuL12, BrAuL2 ⇌ BrAuL12 and BrAu(dph)AuBr ⇌ BrAu(dph)2AuBr were determined from the 31P〈1H〉 NMR spectra. Activation parameters were calculated by a least-squares method. The activation entropies for the exchange processes range from -1.1 to 13.9 cal(mol deg)-1 depending on the ligand type. An associative mechanism is more probable although the possibility of a dissociative process cannot be ruled out. An improved synthetic method is reported for unsym. bisphosphines with chain length > (CH2)4. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Recommanded Product: (6-Bromohexyl)triphenylphosphonium bromide

The Article related to kinetics exchange gold bromo phosphine, phosphine substitution gold bromo complex, Inorganic Chemicals and Reactions: Reactions (Nonpreparative) and other aspects.Recommanded Product: (6-Bromohexyl)triphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 2, 2015, Kang, Byeong Heon; Lee, Chang Uk; Yoo, Ja Hyeong; Park, Hye Gyeong published a patent.HPLC of Formula: 83152-22-1 The title of the patent was Mitochondria-targeting antitumor compositions. And the patent contained the following:

The title antitumor composition has excellent inhibitory effect on mol. chaperones (e.g. Hsp90 and TRAP1) in tumor cells, by connecting triphenylphosphate into mitochondria-penetrating moiety, by using 8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)adenine as mol. chaperone inhibitor. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).HPLC of Formula: 83152-22-1

The Article related to mitochondria targeting antitumor therapy, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.HPLC of Formula: 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On February 8, 2022, Li, Yingying; Jiang, Zhimin; Duan, Xiaoqun; Wei, Riming; Chen, Yijie; Fan, Xinxin; Liu, Jieyu; Su, Huilin published a patent.Formula: C24H27Br2P The title of the patent was Artesunate derivatives as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer. And the patent contained the following:

The invention relates to the tech. field of medicine, and specifically discloses artesunate derivatives I•Br- and II•Br- (n is 6-20; R1 is C1-6 alkyl) and preparation method and application thereof. Compounds I and II were prepared by using alkylation and esterification as the key steps. All the invention compounds were evaluated for their antitumor activity. The artesunate derivatives provided by the present invention have novel skeleton structure and excellent antitumor activity, and can be used for the preparation of antitumor drugs. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P

The Article related to artesunate derivative preparation antitumor treatment cancer, Terpenes and Terpenoids: Sesquiterpenes (C15), Including Ionones and other aspects.Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On April 8, 2015, Lee, Changwook; Park, Hye-Kyung; Jeong, Hanbin; Lim, Jaehwa; Lee, An-Jung; Cheon, Keun Young; Kim, Chul-Su; Thomas, Ajesh P.; Bae, Boram; Kim, Nam Doo; Kim, Seong Heon; Suh, Pann-Ghill; Ryu, Ja-Hyoung; Kang, Byoung Heon published an article.Formula: C24H27Br2P The title of the article was Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1. And the article contained the following:

The mitochondrial pool of Hsp90 and its mitochondrial paralog, TRAP1, suppresses cell death and reprograms energy metabolism in cancer cells; therefore, Hsp90 and TRAP1 have been suggested as target proteins for anticancer drug development. Here, the authors report that the actual target protein in cancer cell mitochondria is TRAP1, and current Hsp90 inhibitors cannot effectively inactivate TRAP1 because of their insufficient accumulation in the mitochondria. To develop mitochondrial TRAP1 inhibitors, the authors determined the crystal structures of human TRAP1 complexed with Hsp90 inhibitors. The iso-Pr amine of the Hsp90 inhibitor PU-H71 was replaced with the mitochondria-targeting moiety triphenylphosphonium to produce SMTIN-P01. SMTIN-P01 showed a different mode of action from the nontargeted PU-H71, as well as much improved cytotoxicity to cancer cells. In addition, the authors determined the structure of a TRAP1-adenylyl-imidodiphosphate (AMP-PNP) complex. On the basis of comparative anal. of TRAP1 structures, the authors propose a mol. mechanism of ATP hydrolysis that is crucial for chaperone function. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P

The Article related to mitochondria hsp inhibitor crystal structure trap, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 28, 2020, Kim, Jong Seung; Sunwoo, Gyeong; Verwilst, Peter; Won, Mi Ae published a patent.COA of Formula: C24H27Br2P The title of the patent was Modified antibiotics for non-nuclear genotoxic chemotherapy and pharmaceutical composition for anti-cancer containing the same. And the patent contained the following:

The present invention relates to a modified antibiotic compound for the treatment of cancer with minimal nuclear gene damage and an anticancer pharmaceutical composition comprising same. Since the repurposed antibiotic compound has a therapeutic effect in a manner that targets only the mitochondria of cancer cells, the modified antibiotic compound does not cause gene degeneration unlike conventional chemotherapy which damages nuclear DNAs to kill cancer cells, , thereby preventing the recurrence of cancer. In addition, a mitochondria targeted therapy using the compound according to the present invention can effectively treat malignant tumors that are difficult to treat due to acquiring drug resistance by general anticancer treatment. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).COA of Formula: C24H27Br2P

The Article related to nonnuclear genotoxic chemotherapy mitochondria targeting antimetastatic repurposed antibiotic, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.COA of Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 24, 2020, Kim, Jong Seung; Sunwoo, Kyoung; Verwilst, Peter; Won, Miae published a patent.Formula: C24H27Br2P The title of the patent was Repurposed antibiotics for non-nuclear genotoxic chemotherapy and pharmaceutical composition for anti-cancer containing the same. And the patent contained the following:

The present invention relates to a repurposed antibiotic compound for the treatment of cancer with minimal nuclear gene damage and an anticancer pharmaceutical composition comprising same. Since the repurposed antibiotic compound has a therapeutic effect in a manner that targets only the mitochondria of cancer cells, the modified antibiotic compound does not cause gene degeneration unlike conventional chemotherapy which damages nuclear DNAs to kill cancer cells, , thereby preventing the recurrence of cancer. In addition, a mitochondria targeted therapy using the compound according to the present invention can effectively treat malignant tumors that are difficult to treat due to acquiring drug resistance by general anticancer treatment. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Formula: C24H27Br2P

The Article related to nonnuclear genotoxic chemotherapy mitochondria targeting antimetastatic repurposed antibiotic, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Formula: C24H27Br2P

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kreyenschmidt, Friedrich; Koszinowski, Konrad published an article in 2018, the title of the article was Low-Valent Ate Complexes Formed in Cobalt-Catalyzed Cross-Coupling Reactions with 1,3-Dienes as Additives.Related Products of 83152-22-1 And the article contains the following content:

The combination of CoCl2 and 1,3-dienes is known to catalyze challenging alkyl-alkyl cross-coupling reactions between Grignard reagents and alkyl halides, but the mechanism of these valuable transformations remains speculative. Herein, electrospray-ionization mass spectrometry is used to identify and characterize the elusive intermediates of these and related reactions. The vast majority of detected species contain low-valent cobalt(I) centers and diene mols. Charge tagging, deuterium labeling, and gas-phase fragmentation experiments elucidate the likely origin of these species and show that the diene not only binds to Co as a π ligand, but also undergoes migratory insertion reactions into Co-H and Co-R bonds. The resulting species have a strong tendency to form anionic cobalt(I) ate complexes, the superior nucleophilicity of which should render them highly reactive toward electrophilic substrates and, thus, presumably is the key to the high catalytic efficiency of the system under investigation. Upon the reaction of the in situ formed cobalt(I) ate complexes with organyl halides, only the final cross-coupling product could be detected, but no cobalt(III) species. This finding implies that this reaction step proceeds in a direct manner without any intermediate or, alternatively, that it involves an intermediate with a very short lifetime. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Related Products of 83152-22-1

The Article related to low valet cobalt complex cross coupling reaction diene reaction, cobalt diene electrospray ionization mass spectrometry intermediate preparation, ate complexes, cobalt, cross-coupling, mass spectrometry, reactive intermediates and other aspects.Related Products of 83152-22-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Islam, M. Q.; Hill, W. E.; Webb, T. R. published an article in 1989, the title of the article was Synthesis and characterization of long chain unsymmetrical diphosphines.Safety of (6-Bromohexyl)triphenylphosphonium bromide And the article contains the following content:

The long-chain unsym. diphosphines, R2P(CH2)nPPh2 (R = Me, Et; n = 6, 8) have been synthesized and characterized by their 31P and 1H NMR spectra. The purity of product is strictly dependent on the reaction condition. Attempted preparation of the diphosphines with same substituents on P but a longer chain length (10 and 12 methylene bridge) was unsuccessful because of possible disubstitution in the first of the four step synthesis giving mixed products (sym. and unsym. diphosphines). The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Safety of (6-Bromohexyl)triphenylphosphonium bromide

The Article related to diphosphine unsym long chain, dibromoalkane reaction triorganophosphine, oxidation diphosphonium dibromide unsym, bromoalkylphosphonium bromide preparation reaction triorganophosphine, quaternization triorganophosphine dibromoalkane and other aspects.Safety of (6-Bromohexyl)triphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nakayama, Kaii; Kamiya, Hidehiro; Okada, Yohei published an article in 2022, the title of the article was Radical cation Diels-Alder reactions of arylidene cycloalkanes.Name: (6-Bromohexyl)triphenylphosphonium bromide And the article contains the following content:

TiO2 photoelectrochem. and electrochem. radical cation Diels-Alder reactions of arylidene cycloalkanes are described, leading to the construction of spiro ring systems. Although the mechanism remains an open question, arylidene cyclobutanes are found to be much more effective in the reaction than other cycloalkanes. Since the reaction is completed with a substoichiometric amount of electricity, a radical cation chain pathway is likely to be involved. The experimental process involved the reaction of (6-Bromohexyl)triphenylphosphonium bromide(cas: 83152-22-1).Name: (6-Bromohexyl)triphenylphosphonium bromide

The Article related to spiro compound preparation photoelectrochem electrochem reaction, arylidene cycloalkane dimethyl butadiene diels alder reaction, diels–alder reaction, arylidene cycloalkane, radical cation, single-electron transfer, spiro ring system and other aspects.Name: (6-Bromohexyl)triphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary