Category: 837-52-5

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 837-52-5, is researched, Molecular C13H14ClN3, about The synthesis of novel hybrid compounds containing 5-nitrothiazole moiety as potential antiparasitic agents, the main research direction is nitrothiazole hybrid compound preparation antiparasitic trichomoniasis giardiasis.Name: 7-Chloro-4-(piperazin-1-yl)quinoline.

Abstract: A number of novel compounds containing 5-nitrothiazole moiety as potential antiparasitic agents have been synthesized through known chem. routes. The structures of the new compounds were confirmed by spectroscopic techniques, 1H NMR, 13C NMR, and mass spectrometry, and by elemental analyses. The prepared compounds were evaluated in vitro for their antigiardial and antitrichomonal activities. All tested compounds exhibited remarkable antigiardial activity with IC50 values ranging from 2.2 to 6.9 μg/cm3 as compared to the reference drug metronidazole (IC50 = 7.3 μg/cm3). In addition, three of the prepared compounds exhibited significant antitrichomonal activity with IC50 values of 4.3, 5.0, and 7.9 μg/cm3, resp., as compared to the reference drug metronidazole (8.5 μg/cm3). Graphical abstract: [Figure not available: see fulltext.].

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new 4-aminoquinolines and quinoline-acridine hybrids as antimalarial agents》. Authors are Kumar, Ashok; Srivastava, Kumkum; Raja Kumar, S.; Puri, S. K.; Chauhan, Prem M. S..The article about the compound:7-Chloro-4-(piperazin-1-yl)quinolinecas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3).Formula: C13H14ClN3. Through the article, more information about this compound (cas:837-52-5) is conveyed.

In the present study, new side chain modified 4-aminoquinoline derivatives and quinoline-acridine hybrids were synthesized and evaluated in vitro against NF 54 strain of Plasmodium falciparum. Among the evaluated compounds, one compound (MIC = 0.125 μg/mL) was equipotent to standard drug CQ (MIC = 0.125 μg/mL) and it showed the curative response to all the treated swiss mice infected with CQ-resistant N-67 strain of Plasmodium yoelii at the doses 50 mg/kg and 25 mg/kg for four days by i.p. route and was found to be orally active at the dose of 100 mg/kg for four days. Another compound (MIC = 0.031 μg/mL) was four times more potent than CQ. The promising antimalarial potency of these compounds highlight the significance of exploring the privileged 4-aminoquinoline class for new antimalarials.

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Product Details of 837-52-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis, antimalarial activity evaluation and docking studies of some novel tetraoxaquines. Author is Kumawat, Mukesh Kumar; Parida, Pratap; Chetia, Dipak.

Tetraoxaquines, mol. hybrids of 1,2,4,5-tetraoxane and 4-aminoquinoline, were designed via mol. docking anal. against Falcipain-2. Among the studied compounds, 11 top scoring analogs showing low binding energy were further selected for synthesis and evaluated for their in vitro antimalarial activity. In inhibitory assay, five compounds showed significant activity against chloroquine-resistant strain of P. falciparum-RKL-9 with IC50 values of 3.906, 3.942, 4.272, 3.906, 4.814 μg/mL.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline(SMILESS: C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3,cas:837-52-5) is researched.Reference of 2-(Furan-2-yl)-2-oxoacetaldehyde. The article 《Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:837-52-5).

A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC at 5.1-11.9μM and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Bioorganic & Medicinal Chemistry Letters called Synthesis of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolyzate, Author is Srivastava, Sandhya; Tewari, Swati; Srivastave, Sanjay K.; Chauhan, P. M. S.; Bhaduri, A. P.; Puri, S. K.; Pandey, V. C., which mentions a compound: 837-52-5, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3, Formula: C13H14ClN3.

Synthesis of aminoquinoline derivatives and their in vitro effects on metHb formation and metHb reductase activity are delineated. Some of the screened compounds have shown considerable metHb toxicity. An example compound thus prepared was 2-[(7-chloro-4-quinolinyl)amino]ethanol.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Related Products of 837-52-5.El-Azzouny, Aida M. Abd El-Sattar; Aboul-Enein, Mohamed Nabil; Hamissa, Mohamed Farouk published the article 《Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives》 about this compound( cas:837-52-5 ) in Drug Development Research. Keywords: review quinoline antiHIV antimalarial antiparasitic agent medicinal chem; 7-chloro-4-(piperazin-1-yl)quinoline; anti-HIV; anticancer; antidiabetic; antimalarial. Let’s learn more about this compound (cas:837-52-5).

A review. The 7-chloro-4-(piperazin-1-yl)quinoline structure is an important scaffold in medicinal chem. It exhibited either alone or as hybrid with other active pharmacophores diverse pharmacol. profiles such as: antimalarial, antiparasitic, anti-HIV, antidiabetic, anticancer, sirtuin Inhibitors, dopamine-3 ligands, acetylcholinesterase inhibitors, and serotonin antagonists. In the presented review, a comprehensive discussion of compounds having this structural core is surveyed and illustrated.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of novel hybrid molecules from precursors with known antiparasitic activity, the main research direction is nitrofuranylpropenoyl nitropyrazole chloropiperazinylquinoline hybrid preparation antiamoebic antigiardial antiparasitic activity.Product Details of 837-52-5.

Novel new compounds I, II, and III derived from antiparasitic precursors were synthesized and tested for their antiamoebic and antigiardial activities. On the basis of preliminary screening data for these new compounds, compound III exhibited potent lethal activities against Entamoeba histolytica and Giardia intestinalis; its IC50 (about 1 μM) was lower, at least by a factor of five, compared to the standard drug, metronidazole. In addition, the IC50 of compound III against the tested parasites was 600 times below that against Hep-2 and Vero cells. Compounds I and II also exhibited potent or moderate antiamoebic and antigiardial activities with IC50 values of about 5.5 μM, and 140 μM, resp., against the tested parasites. Hybrid mols. I and II were also non-cytotoxic at the lethal concentrations against the parasites.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Reversal Agent and Linker Variants of Reversed Chloroquines: Activities against Plasmodium falciparum, published in 2010-01-28, which mentions a compound: 837-52-5, Name is 7-Chloro-4-(piperazin-1-yl)quinoline, Molecular C13H14ClN3, Application of 837-52-5.

We have shown that “”reversed chloroquine mols.”” constructed from chloroquine-like and resistance “”reversal-agent””-like cores can be powerful drugs against malaria. Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental.

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Sidorin, D. N.; Kozyukov, A. V.; Zakharova, V. A.; Porodenko, N. V.; Kryukov, L. N. published an article about the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3 ).Quality Control of 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:837-52-5) through the article.

Todd-Atherton phosphorylation of (1-piperazinyl)quinoline derivatives with di-Et phosphite afforded the corresponding quinoline piperazinylamidophosphate derivatives in 30-40% yield. Antidepressant activity (inhibition of reverse uptake of serotonin) of the amidophosphate derivatives exceeded that of the starting materials, with title compound I most active (IC50 2.0 nM).

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SDS of cas: 837-52-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity. Author is Bogdanov, Andrei V.; Vazykhova, Al’bina M.; Khasiyatullina, Nadezhda R.; Krivolapov, Dmitry B.; Dobrynin, Alexey B.; Voloshina, Alexandra D.; Mironov, Vladimir F..

A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-[(piperazinyl)methyl]isatins, which were further converted to isoindigo derivatives The antimicrobial activity of the obtained heterocycles was evaluated.

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