Category: 837-52-5

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Product Details of 837-52-5.Musonda, Chitalu C.; Little, Susan; Yardley, Vanessa; Chibale, Kelly published the article 《Application of multicomponent reactions to antimalarial drug discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro》 about this compound( cas:837-52-5 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: aminoquinoline aminoxazole preparation multicomponent reaction antimalarial activity; oxazole amino quinoline preparation multicomponent reaction antimalarial activity. Let’s learn more about this compound (cas:837-52-5).

The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles, e.g. I (R = H, Me; n = 1, 2, 3, 5), against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 837-52-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.

A novel series of semi-synthetic trioxaquines and synthetic trioxolaquines (e.g. I and II) were prepared, in moderate to good yields. Antimalarial activity was evaluated against both the chloroquine-sensitive 3D7 and resistant K1 strain of Plasmodium falciparum and both series of compounds were shown to be active in the low nanomolar range. For comparison the corresponding 9-aminoacridine analogs were also prepared and shown to have low nanomolar activity like their quinoline counterparts.

Here is a brief introduction to this compound(837-52-5)Application of 837-52-5, if you want to know about other compounds related to this compound(837-52-5), you can read my other articles.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary