90-59-5 Archives - Page 10 of 13 - Bromides-buliding-blocks

Hu, Yijie team published research in European Journal of Organic Chemistry in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Application In Synthesis of 90-59-5

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 90-59-5.

Hu, Yijie;Wang, Xiaoli;Ren, Nan;Li, Na;Li, Jianyang;Chen, Jie;Zhang, Hui;Deng, Hongmei;Cao, Weiguo;Lin, Jin-Hong research published 《 A Convenient Synthesis of Fluoroalkylated Benzimidazole- or Indole-fused Benzoxazines》, the research content is summarized as follows. Herein, the first synthesis of fluoroalkylated benzimidazole- or indole-fused benzoxazines I (R = CF₃, C₂F₅, C₃H₇; R¹ = 2-OMe, 2-Br, 4-Cl, etc.) or II (R² = H, F; R³ = H, 10-Me, 10-Br, 9,11-(Me)₂) by using fluoroalkylated propiolates RCCC(O)₂Me as building blocks is described. The reactions proceeded smoothly under mild conditions to give the desired products I and II in moderate to high yields. Notably, benzimidazole-fused products I were obtained by a convenient one-pot two-step process.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hoolageri, Swati R. team published research in ChemistrySelect in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, HPLC of Formula: 90-59-5

Hoolageri, Swati R.;Nesaragi, Aravind R.;Kamble, Ravindra R.;Dixit, Shruti;Vootla, Shyamkumar;Joshi, Shrinivas D.;Shaikh, Sabakauser J. research published 《 Green Synthesis of Novel Triazolothiadiazine-Coumarins Catalyzed by Agro Waste Extract: An Approach towards In-Silico and In-Vitro Anti-Fungal Activity》, the research content is summarized as follows. A green, commodious, immensely versatile synthetic route for agro waste extract WELPSA catalyzed cyclocondensation of biol. active triazolothiadiazine-coumarin hybrid derivatives has been studied. A proficient synthesis offused heterocycles via dehydrative condensation with cyclization of 4-((4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)methyl)-2-aryl-2,4-dihydro-3H-1,2,4-triazol-3-one and substituted bromoacyl coumarins has been incorporated in presence of different catalysts including WELPSA, a green catalyst. The in silico docking studies of these previously unknown compounds revealed favorable C score and chemscore values and the in vitro antifungal assay against three fungal strains showed excellent to good activity.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hassan, Entesar A. team published research in Frontiers in Molecular Biosciences in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Hassan, Entesar A.;Shehadi, Ihsan A.;Elmaghraby, Awatef M.;Mostafa, Hadir M.;Zayed, Salem E.;Abdelmonsef, Aboubakr H. research published 《 Synthesis, molecular docking analysis and in vitro biological evaluation of some new heterocyclic scaffolds-based indole moiety as possible antimicrobial agents》, the research content is summarized as follows. In the present study, a general approach for the synthesis of 1-(1H-indol-3-yl)-3,3- dimercaptoprop-2-en-1-one (1) and 5-(1H-indol-3-yl)-3H-1,2-dithiole-3-thione (2) was performed. They are currently used as efficient precursors for the synthesis of some new compounds bearing five- and/or six-membered heterocyclic moieties, e.g., chromenol (3, 4), 3,4-dihydroquinoline (7, 8) and thiopyran (10, 12)-based indole core. In addition, mol. docking studies were achieved, which showed that all the newly synthesized compounds are interacting with the active site region of the target enzymes, the targets UDP-N-acetylmuramatel-alanine ligase (MurC), and human lanosterol14α-demethylase, through hydrogen bonds and pi-stacked interactions. Among these docked ligand mols., the compound (9) was found to have the min. binding energy (-11.5 and -8.5 Kcal/mol) as compared to the standard drug ampicillin (-8.0 and -8.1 Kcal/mol) against the target enzymes UDP-N-acetylmuramatel-alanine ligase (MurC), and Human lanosterol14α-demethylase, resp. Subsequently, all new synthesized analogs were screened for their antibacterial activities against Gram-pos. (Bacillus subtilis), and Gram-neg. bacteria (Escherichia coli), as well as for antifungal activities against Candida albicans and Aspergillus flavus. The obtained data suggest that the compounds exhibited good to excellent activity against bacterial and fungi strains. The compound (E)-2-(6-(1H-indole-3-carbonyl)-5-thioxotetrahydrothieno [3,2-b]furan-2(3H)- ylidene)-3-(1H-indol-3-yl)-3-oxopropanedithioic acid (9) showed a high binding affinity as well as an excellent biol. activity. Therefore, it could serve as the lead for further optimization and to arrive at potential antimicrobial agent.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghosh, Subrata team published research in Dalton Transactions in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Ghosh, Subrata;Bagchi, Sukanya;Kamilya, Sujit;Mondal, Abhishake research published 《 Effect of ligand substituents and tuning the spin-state switching in manganese(III) complexes》, the research content is summarized as follows. Three mononuclear manganese(III) complexes based on flexible hexadentate ligands obtained from the condensation of N,N′-bis(3-aminopropyl)ethylenediamine and salicylaldehyde or salicylaldehyde with substitutions at the 5 or 3,5 positions, [Mn(X-sal₂-323)](BPh₄) (X = 5 H, (1); X = 5 Br, (2), and X = 3,5 Br, (3)) were synthesized. The impact of ligand substituents was studied by variable temperature single-crystal X-ray diffraction analyses, and magnetic, spectroscopic and electrochem. investigations. The complexes have an analogous monocationic MnN₄O₂ surrounding offered by the flexible hexadentate ligand in a distorted octahedral geometry. Complex 1 remains in the high spin state over the entire temperature range, while complex 2 shows a reversible and complete two-step thermo-induced spin-state switching. An incomplete spin-state switching from a high spin to an intermediate high-spin low-spin (1:1) state was observed for complex 3. Single-crystal X-ray structural studies show the presence of three different spin states in 2 during the occurrence of the spin-state switching process. Electrochem. investigations showed that the reduced state of manganese(III) centers in 3 is easily accessible in comparison to complexes 1 and 2.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gong, Zhimin team published research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022 | 90-59-5

COA of Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C7H4Br2O2.

Gong, Zhimin;Qian, Li;Shao, Shuai;Fan, Bo;Peng, Jianbiao;Lu, Kun;Gao, Shixiang research published 《 Effects of solvent composition on the synthesis of polydopamine Schiff base Cu complex to activate peroxymonosulfate for methyl-paraben degradation》, the research content is summarized as follows. Solvent composition plays an important role in the synthesis of metal complex materials, but to date little work on this issue has been reported. Herein, a unique Schiff base Cu complex catalyst (DPDA-Cu-95EtOH) was designed based on polydopamine (PDA) and 3, 5-dibromosalicylaldehyde (DBSA), and the influence of H₂O added during the synthesis process on its catalytic performance towards peroxymonosulfate (PMS) activation was comprehensively investigated. Our results demonstrated that adding a small amount (5%, v:v) of H₂O to the solvent absolute ethanol (EtOH) can greatly increase the Cu loading (from 3.56 at% to 10.30 at%) on the catalyst, which significantly enhanced its catalytic ability, and promoted the removal of MeP for about 4.6 times higher than that synthesized without addition of H₂O. ESR (EPR) and quenching tests revealed that ¹O₂, OH and SO^–₄ were responsible for the degradation of Methyl-paraben (MeP). Moreover, the DPDA-Cu-95EtOH/PMS system not only showed excellent stability and reusability, but also exhibited considerable removal efficiency of MeP in real wastewater. Overall, this study provides new insights into the controllable synthesis of Schiff base metal complex used for the efficient activation of PMS to remove micropollutants in wastewater.

COA of Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gan, Jianbo team published research in ChemistrySelect in 2021 | 90-59-5

Related Products of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Related Products of 90-59-5.

Gan, Jianbo;Luo, Naili;Wu, Chengjun;Wan, Xinyi;Wang, Cunde research published 《 Efficient Synthesis of Chromeno[4,3,2-de][1,6]naphthyridine Derivatives via Pseudo Four-Component Reaction》, the research content is summarized as follows. A novel approach for the synthesis of substituted 5-amino-4-cyanochromeno[4,3,2-de][1,6]naphthyridine-1-carboxylates I [R¹ = H, 8-OEt, 10-Cl, etc.; R² = Me, Ph, 4-FC₆H₄, 4-BrC₆H₄; R³ = Me, Et] from a wide range of substituted 2-hydroxybenzaldehydes with alkyl 3-oxo-3-substituted propanoates and malononitrile was investigated via propionic acid-promoted cascade Knoevenagel condensation/Michael addition/intramolecularly nucleophilic addition accompanied by oxidative aromatization. This procedure provided a highly efficient and facile route to functionalized chromenonaphthyridines from readily available substrates under mild reaction conditions.

Related Products of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fok, Emily Y. team published research in Polyhedron in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Fok, Emily Y.;Show, Veronica L.;Johnson, Adam R. research published 《 Intramolecular hydroamination of trisubstituted aminoallenes catalyzed by titanium complexes of diaryl substituted tridentate imine-diols》, the research content is summarized as follows. The authors’ laboratory has developed catalysts based on earth abundant Ti for asym. reactions including intramol. hydroamination. Previously, Ti complexes of imine diol ligands showed improved enantioselectivity relative to complexes with bidentate amino alc. ligands. As the catalyst with the highest selectivity had di-tert-Bu substitution, the authors sought to increase the steric protection by preparing three new ligands with diaryl substitution. These ligands were readily prepared in two steps: 1st, synthesis of diaryl substituted salicylaldehydes by a Suzuki coupling and 2nd, a Schiff base condensation with a chiral amino alc. After characterizing the ligands, in situ hydroamination/cyclization with 6-methyl-hepta-4,5-dienylamine was carried out at 105-135° to give exclusively 2-(2-methyl-propenyl)-pyrrolidine with enantioselectivity up to 22%ee. Unexpected dimerization of the catalyst resulted in reduced activity, so the reaction required a catalyst loading of 10-20%.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fadeev, Alexander A. team published research in Organic Chemistry Frontiers in 2022 | 90-59-5

Category: bromides-buliding-blocks, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Fadeev, Alexander A.;Makarov, Anton S.;Ivanova, Olga A.;Uchuskin, Maxim G.;Trushkov, Igor V. research published 《 Extended Corey-Chaykovsky reactions: transformation of 2-hydroxychalcones to benzannulated 2,8-dioxabicyclo[3.2.1]octanes and 2,3-dihydrobenzofurans》, the research content is summarized as follows. The divergent synthesis of benzannulated 2,8-dioxabicyclo[3.2.1]octanes I [R¹ = H, 4-NO₂, 4-Cl, etc.; R² = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.] and 2,3-dihydrobenzofurans II [X= H, 4-NO₂, 4-Cl, etc.; R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.] using the concept of extended Corey-Chaykovsky reactions was reported. With this concept, 2-hydroxychalcones were treated with the Corey ylide providing highly reactive donor-acceptor cyclopropanes that were introduced in a one pot manner for further transformations. We demonstrated that the nucleophilic three-membered ring opening followed by cyclization under mild reaction conditions afforded the 2,8-dioxabicyclo[3.2.1]octane scaffold. On the other hand, heating the intermediates with a strong Bronsted acid furnished 2-phenacyl-2,3-dihydrobenzofurans. These transformations, resulting in products with crucially different heterocyclic skeletons from the same starting compounds, demonstrate the enormous potential of the extended Corey-Chaykovsky reaction.

Category: bromides-buliding-blocks, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

El-Attar, Mona team published research in Journal of Coordination Chemistry in 2021 | 90-59-5

Synthetic Route of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

El-Attar, Mona;Aazam, Elham research published 《 Redox behavior, spectroscopic investigations, theoretical interpretation and biological effectiveness of some novel prepared bis-azomethine derivatives and their copper(II) complexes》, the research content is summarized as follows. Three new bis-azomethine derivatives were synthesized in a good yield, along with their copper(II) complexes and confirmed by IR, ¹³C-NMR, ¹H-NMR, MS, ESR, powder XRD and UV-visible spectroscopy. The spectral studies indicated that the ligands in all complexes act as dibasic tetradentate, coordinated through two azomethine nitrogen and two deprotonated phenolic oxygen atoms. Square planar geometries were assigned for Cu(II) complexes in monomeric structures. Also, quantum chem. calculations using DFT were conducted to elucidate the effect of quantum chem. parameters on the mol. and electronic structures of the mols. under consideration, and then confirming their electrochem. behavior and biol. effectiveness. There were good correlations between practical and theor. studies. The redox pathway of bis-azomethine derivatives and their Cu(II) complexes was elucidated and confirmed based on exptl. and theor. calculations In vitro antimicrobial effectiveness of the synthesized three ligands and their Cu(II) complexes exhibited varying degrees of inhibitory effect on the growth of the test pathogenic microorganisms, confirming that antimicrobial efficiency is dependent on the mol. structure of the prepared compounds and their liposoly. The MIC was also determined for the compound H₂L_c which exhibited the highest antimicrobial activity against each of Pseudomonas aeruginosa (G-) and Candida albicans.

Synthetic Route of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Di, Jia-Qi team published research in Current Organic Synthesis in 2021 | 90-59-5

Application In Synthesis of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Di, Jia-Qi;Wang, Hao-Jie;Cui, Zhen-Shui;Hu, Jin-Yong;Zhang, Zhan-Hui research published 《 Catalyst-free Synthesis of Aminomethylphenol Derivatives in Cyclopentyl Methyl Ether via Petasis Borono-Mannich Reaction》, the research content is summarized as follows. In order to establish an effective synthetic method for preparing aminomethylphenol derivatives, the Petasis borono-Mannich reaction of salicylaldehyde, phenylboronic acid and 1,2,3,4-tetrahydroisoquinoline was selected as a model reaction. A variety of reaction conditions are investigated, including solvent and temperature The generality and limitation of the established method were also evaluated. It was found that model reaction can be carried out in cyclopentyl Me ether at 80^o under catalyst-free conditions. This protocol, with broad substrate applicability, the reaction of various arylboronic acid, secondary amine and salicylaldehyde proceeded smoothly under optimal reaction conditions to afford various aminomethylphenol derivatives in high yields. A practical, scalable, and high-yielding synthesis of aminomethylphenol derivatives was successfully accomplished.

Application In Synthesis of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary