A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde.
Karim, Suhana;Dasgupta, Sanchari;Parveen, Rumana;Biswas, Subhendu;Das, Debasis research published 《 A mechanistic approach for in-vitro anticancer activity via nucleic acid fragmentation by copper(II) complex anchored on MCM-41》, the research content is summarized as follows. Three new mononuclear copper Schiff base complexes, namely, ([Cu(L1)Cl]·CH3CN (HmC_1), [Cu(L2)Cl]·CH3CN (HmC_2) and [Cu(L3)Cl]·CH3CN (HmC_3) derived from ONO donor tridentate ligands HL1, HL2 and HL3, resp.), have been synthesized to check their efficacy as target-specific next-generation anticancer therapeutics. All the HmCs have been characterized by using various physicochem. techniques (i.e., single-crystal X-ray anal., Fourier transform IR [FT-IR] spectroscopy and elemental anal.). Among the synthesized Schiff base complexes, HmC_3 was turned out to be most effective in killing cancer cell carried out on cultured human breast cancer cell line (MDA-MB-231) and human lung carcinoma cell line (A549). Finally, in order to improve the cellular permeability, particle size of HmC_3 was scaling down to nano-regime by immobilizing it onto a suitable matrix MCM-41@APTES (MCM-41 = Mobil Composition of Matter Number 41 and APTES = 3-aminopropyltriethoxysilane) to generate MCM-41@APTES@HmC_3 (MCM-41@APTES@HmC_3 = HtC_3). Field-emission scanning electron microscope (FESEM) and dynamic light scattering (DLS) study revealed the particle size of the synthesized HtC_3 nano-composite was within nano-regime and therefore could be further effective for biomedical applications. Furthermore, HtC_3 displayed better cancer cell killing property. To get insight into the mechanism of action of HtC_3, Annexin V-FITC/PI anal. and TUNEL assay revealed that DNA damage phenomenon is accompanied with changes in cellular morphol. leading to cell apoptosis. Cell migration assay on MDA-MB-231 cell with HtC_3 exposed the effectiveness of HtC_3 in arresting cancer cell migration. Therefore, all the in-vitro studies demonstrated that the immobilization of the copper Schiff base complex onto a suitable matrix increased its efficiency and becomes a promising anticancer nano-therapeutic agent.
90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.
3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.
3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).
3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary